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Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)155
The number (and %) of the onco-proteins53 (34.19 %)
The number (and %) of the tumor suppressors12 (7.74 %)
Total number of binary PPIs (saturation %)905 (7.58 %)
The number (and %) of affected PPIs156 (17.24 %)
The number of possible different fusions38
PPI diameter4
PPI radius2
The average degree of PPI10.710
Assortativity coefficient-0.1403
The network average Clustering coefficient0.436
The number (and %) of a zero Clustering coefficients17 (10.97 %)
The number (and %) of a zero Betweenness Centrality27 (17.42 %)

ACTIVE INTERACTORS


List of the fusions

Proteins found in more fusions APP (see 4 fusions); HSP90AA1 (see 2 fusions); TRIM25 (see 2 fusions); UBE2G1 (see 1 fusions); UBE2C (see 1 fusions); U2AF2 (see 2 fusions); CUL7 (see 2 fusions); HUWE1 (see 2 fusions); PABPC1 (see 2 fusions); CUL3 (see 1 fusions); HSP90AB1 (see 1 fusions); GRB2 (see 1 fusions); NCOA1 (see 2 fusions); USH1C (see 1 fusions); UBE2N (see 1 fusions); UBA1 (see 2 fusions); SP1 (see 1 fusions); UBE2R2 (see 1 fusions); UBE2D2 (see 2 fusions); UBE2H (see 4 fusions); UBE2L6 (see 2 fusions); UBE2L3/BIRC2 (see 1 fusions); UBE2E2 (see 1 fusions); BAG3 (see 4 fusions); EZR (see 2 fusions); AIMP2 (see 1 fusions); GAN (see 1 fusions); COPS5 (see 1 fusions); HDAC5 (see 1 fusions); ECHS1 (see 1 fusions); UBE2E1 (see 2 fusions); UBC (see 1 fusions); DDB1 (see 2 fusions); PSMC5 (see 2 fusions); USP11 (see 4 fusions); DNPH1 (see 1 fusions); IBTK (see 2 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 UBA1parental protein1280.07112419.516ThiF (PF00899, IPR000594): ThiF family
E1_UFD (PF09358, IPR018965, SM00985): Ubiquitin fold domain
UBA_e1_thiolCys (PF10585, IPR019572): Ubiquitin-activating enzyme active site
2 ESRRGparental protein280.0682347.485zf-C4 (PF00105, IPR001628, SM00399): Zinc finger, C4 type (two domains)
Hormone_recep (PF00104, IPR000536, SM00430): Ligand-binding domain of nuclear hormone receptor
3 AARSinteractor140.52723.362DHHA1 (PF02272, IPR003156): DHHA1 domain
Syntaxin-6_N (PF09177, IPR015260): Syntaxin 6, N-terminal
tRNA-synt_2c (PF01411, IPR018164): tRNA synthetases class II (A)
tRNA_SAD (PF07973, IPR012947, SM00863): Threonyl and Alanyl tRNA synthetase second additional domain
4 AHSA1interactor130.53847.307Aha1_N (PF09229, IPR015310, SM01000): Activator of Hsp90 ATPase, N-terminal
AHSA1 (PF08327, IPR013538): Activator of Hsp90 ATPase homolog 1-like protein
5 AIMP2suppressor140.48771.484GST_C_2 (PF13410): Glutathione S-transferase, C-terminal domain
GST_C_3 (PF14497, IPR004046): Glutathione S-transferase, C-terminal domain
AIMP2_LysRS_bd (PF16780, IPR031889): AIMP2 lysyl-tRNA synthetase binding domain
6 AP1B1interactor90.50025.830Adaptin_N (PF01602, IPR002553): Adaptin N terminal region
Alpha_adaptinC2 (PF02883, IPR008152, SM00809): Adaptin C-terminal domain
B2-adapt-app_C (PF09066, IPR015151, SM01020): Beta2-adaptin appendage, C-terminal sub-domain
7 AP1G1interactor70.52415.545Adaptin_N (PF01602, IPR002553): Adaptin N terminal region
Alpha_adaptinC2 (PF02883, IPR008152, SM00809): Adaptin C-terminal domain
8 AP1M1interactor50.9001.798Adap_comp_sub (PF00928, IPR008968): Adaptor complexes medium subunit family
Clat_adaptor_s (PF01217, IPR022775): Clathrin adaptor complex small chain
9 AP1S1interactor50.7003.000Clat_adaptor_s (PF01217, IPR022775): Clathrin adaptor complex small chain
10 APPprotein found in more fusions280.1341180.369APP_N (PF02177, IPR015849, SM00006): Amyloid A4 N-terminal heparin-binding
Beta-APP (PF03494, IPR013803): Beta-amyloid peptide (beta-APP)
BUD22 (PF09073, IPR015158): BUD22
IncA (PF04156, IPR007285): IncA protein
Kunitz_BPTI (PF00014, IPR002223, SM00131): Kunitz/Bovine pancreatic trypsin inhibitor domain
APP_amyloid (PF10515, IPR019543): beta-amyloid precursor protein C-terminus
APP_Cu_bd (PF12924, IPR011178): Copper-binding of amyloid precursor, CuBD
APP_E2 (PF12925, IPR024329): E2 domain of amyloid precursor protein
11 ARHGAP1interactor60.6002.400RhoGAP (PF00620, IPR000198, SM00324): RhoGAP domain
CRAL_TRIO_2 (PF13716, IPR001251): Divergent CRAL/TRIO domain
12 ARHGEF15interactor100Med14 (PF08638, IPR013947): Mediator complex subunit MED14
PH (PF00169, IPR001849, SM00233): PH domain
RhoGEF (PF00621, IPR000219, SM00325): RhoGEF domain
13 ARMC6interactor50.5007.369Arm (PF00514, IPR000225, SM00185): Armadillo/beta-catenin-like repeat
Mis14 (PF08641, IPR013950): Kinetochore protein Mis14 like
Atx10homo_assoc (PF09759, IPR019156): Spinocerebellar ataxia type 10 protein domain
14 ASNSoncoprotein170.47846.295Asn_synthase (PF00733, IPR001962): Asparagine synthase
GATase_7 (PF13537, IPR000583): Glutamine amidotransferase domain
15 ATIConcoprotein90.41715.480AICARFT_IMPCHas (PF01808, IPR002695, SM00798): AICARFT/IMPCHase bienzyme
MGS (PF02142, IPR011607, SM00851): MGS-like domain
16 AURKAoncoprotein160.27685.067Pkinase (PF00069, IPR000719): Protein kinase domain
MTBP_C (PF14920, IPR029418): MDM2-binding
17 BAG3oncoprotein210.189137.390BAG (PF02179, IPR003103, SM00264): BAG domain
WW (PF00397, IPR001202, SM00456): WW domain
18 BIRC2oncoprotein150.31950.953BIR (PF00653, IPR001370, SM00238): Inhibitor of Apoptosis domain
CARD (PF00619, IPR001315, SM00114): Caspase recruitment domain
zf-C3HC4_3 (PF13920): Zinc finger, C3HC4 type (RING finger)
19 BIRC3oncoprotein100.5838.801BIR (PF00653, IPR001370, SM00238): Inhibitor of Apoptosis domain
CARD (PF00619, IPR001315, SM00114): Caspase recruitment domain
zf-C3HC4_3 (PF13920): Zinc finger, C3HC4 type (RING finger)
20 BUB3interactor60.7332.344WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
21 CCDC8interactor190.30158.517Borrelia_P83 (PF05262, IPR007926): Borrelia P83/100 protein
SRP-alpha_N (PF04086, IPR007222): Signal recognition particle, alpha subunit, N-terminal
PNMA (PF14893, IPR026523): PNMA
22 CDC34oncoprotein90.5367.644UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme
23 CDK2suppressor240.312204.817Kdo (PF06293, IPR010440): Lipopolysaccharide kinase (Kdo/WaaP) family
Pkinase (PF00069, IPR000719): Protein kinase domain
24 CEP290interactor30.6670.667ATG16 (PF08614, IPR013923): Autophagy protein 16 (ATG16)
DivIC (PF04977, IPR007060): Septum formation initiator
DUF16 (PF01519, IPR002862): Protein of unknown function DUF16
DUF641 (PF04859, IPR006943): Plant protein of unknown function (DUF641)
Fez1 (PF06818): Fez1
HALZ (PF02183, IPR003106, SM00340): Homeobox associated leucine zipper
HemY_N (PF07219, IPR010817): HemY protein N-terminus
Cnn_1N (PF07989, IPR012943): Centrosomin N-terminal motif 1
Mnd1 (PF03962, IPR005647): Mnd1 family
NPV_P10 (PF05531, IPR008702): Nucleopolyhedrovirus P10 protein
OmpH (PF03938, IPR005632, SM00935): Outer membrane protein (OmpH-like)
Pox_A_type_inc (PF04508, IPR007596): Viral A-type inclusion protein repeat
Reo_sigmaC (PF04582, IPR007662): Reovirus sigma C capsid protein
Rho_Binding (PF08912, IPR015008): Rho Binding
Sec20 (PF03908, IPR005606): Sec20
Sec2p (PF06428, IPR009449): GDP/GTP exchange factor Sec2p
Spc7 (PF08317, IPR013253, SM00787): Spc7 kinetochore protein
Swi5 (PF07061, IPR010760): Swi5
TBPIP (PF07106, IPR010776): Tat binding protein 1(TBP-1)-interacting protein (TBPIP)
TSC22 (PF01166, IPR000580): TSC-22/dip/bun family
Uso1_p115_C (PF04871, IPR006955): Uso1 / p115 like vesicle tethering protein, C terminal region
CENP-F_leu_zip (PF10473, IPR019513): Leucine-rich repeats of kinetochore protein Cenp-F/LEK1
LIDHydrolase (PF10230, IPR019363): Lipid-droplet associated hydrolase
KxDL (PF10241, IPR019371): Uncharacterized conserved protein
bZIP_2 (PF07716, IPR004827, SM00338): Basic region leucine zipper
ADIP (PF11559, IPR021622): Afadin- and alpha -actinin-Binding
PRKG1_interact (PF15898, IPR031775): cGMP-dependent protein kinase interacting domain
FAM76 (PF16046, IPR032017): FAM76 protein
TolA_bind_tri (PF16331, IPR032519): TolA binding protein trimerisation
CEP209_CC5 (PF16574, IPR032321): Coiled-coil region of centrosome protein CE290
25 CHEK1suppressor70.52415.488Pkinase (PF00069, IPR000719): Protein kinase domain
26 CHTF8interactor100OGFr_III (PF04680, IPR006770): Opioid growth factor receptor repeat
27 CIAPIN1interactor140.487112.754CIAPIN1 (PF05093, IPR007785): Cytokine-induced anti-apoptosis inhibitor 1, Fe-S biogenesis
Methyltransf_11 (PF08241, IPR013216): Methyltransferase domain
Methyltransf_31 (PF13847, IPR025714): Methyltransferase domain
28 COPS5protein found in more fusions280.285354.159JAB (PF01398, IPR000555, SM00232): JAB1/Mov34/MPN/PAD-1 ubiquitin protease
29 CRY1interactor100.36116.625DNA_photolyase (PF00875, IPR006050): DNA photolyase
FAD_binding_7 (PF03441, IPR005101): FAD binding domain of DNA photolyase
30 CTPS1interactor90.4648.028CTP_synth_N (PF06418, IPR017456): CTP synthase N-terminus
GATase (PF00117, IPR017926): Glutamine amidotransferase class-I
31 CUL3protein found in more fusions440.186939.785Cullin (PF00888, IPR001373, SM00182): Cullin family
Cullin_Nedd8 (PF10557, IPR019559, SM00884): Cullin protein neddylation domain
WAC_Acf1_DNA_bd (PF10537, IPR013136): ATP-utilising chromatin assembly and remodelling N-terminal
32 CUL7protein found in more fusions260.260233.455ANAPC10 (PF03256, IPR004939): Anaphase-promoting complex, subunit 10 (APC10)
Cullin (PF00888, IPR001373, SM00182): Cullin family
DUF1918 (PF08940, IPR015035): Domain of unknown function (DUF1918)
Cullin_Nedd8 (PF10557, IPR019559, SM00884): Cullin protein neddylation domain
Cul7 (PF11515, IPR021097): Mouse development and cellular proliferation protein Cullin-7
33 DDB1protein found in more fusions140.38525.367CPSF_A (PF03178, IPR004871): CPSF A subunit region
MMS1_N (PF10433): Mono-functional DNA-alkylating methyl methanesulfonate N-term
34 DEUP1suppressor31.0000APG6 (PF04111, IPR007243): Autophagy protein Apg6
TPR_MLP1_2 (PF07926, IPR012929): TPR/MLP1/MLP2-like protein
bZIP_2 (PF07716, IPR004827, SM00338): Basic region leucine zipper
Lebercilin (PF15619, IPR028933): Ciliary protein causing Leber congenital amaurosis disease
CEP63 (PF17045, IPR031470): Centrosomal protein of 63 kDa
35 DNMT3Linteractor100CEBP_ZZ (PF16366, IPR032296): Cytoplasmic polyadenylation element-binding protein ZZ domain
36 DNPH1protein found in more fusions200Nuc_deoxyrib_tr (PF05014, IPR007710): Nucleoside 2-deoxyribosyltransferase
37 DPP3interactor30.3339.195Peptidase_M49 (PF03571): Peptidase family M49
38 DUTinteractor30.33325.679dUTPase (PF00692, IPR008180): dUTPase
39 EBPinteractor21.0000Phage_holin_3_6 (PF07332, IPR009937): Putative Actinobacterial Holin-X, holin superfamily III
EBP (PF05241, IPR007905): Emopamil binding protein
40 ECHS1protein found in more fusions50.6670.660ECH_1 (PF00378, IPR001753): Enoyl-CoA hydratase/isomerase
41 EEF1E1suppressor90.8332.256GST_C (PF00043, IPR004046): Glutathione S-transferase, C-terminal domain
42 EPRSinteractor270.365117.759GST_C (PF00043, IPR004046): Glutathione S-transferase, C-terminal domain
HGTP_anticodon (PF03129, IPR004154): Anticodon binding domain
ProRS-C_1 (PF09180, IPR016061, SM00946): Prolyl-tRNA synthetase, C-terminal
tRNA-synt_1c (PF00749, IPR020058): tRNA synthetases class I (E and Q), catalytic domain
tRNA-synt_1c_C (PF03950, IPR020059): tRNA synthetases class I (E and Q), anti-codon binding domain
tRNA-synt_2b (PF00587, IPR002314): tRNA synthetase class II core domain (G, H, P, S and T)
WHEP-TRS (PF00458, IPR000738, SM00991): WHEP-TRS domain
43 ESRRAoncoprotein120.242326.994zf-C4 (PF00105, IPR001628, SM00399): Zinc finger, C4 type (two domains)
Hormone_recep (PF00104, IPR000536, SM00430): Ligand-binding domain of nuclear hormone receptor
44 EZRprotein found in more fusions190.24889.397DUF106 (PF01956, IPR002809): Integral membrane protein DUF106
ERM (PF00769, IPR011259): Ezrin/radixin/moesin family
FERM_C (PF09380, IPR018980): FERM C-terminal PH-like domain
FERM_M (PF00373, IPR019748): FERM central domain
FERM_N (PF09379, IPR018979): FERM N-terminal domain
45 FBXW11interactor150.29777.722WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
Beta-TrCP_D (PF12125, IPR021977, SM01028): D domain of beta-TrCP
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
F-box-like (PF12937, IPR001810): F-box-like
46 FHsuppressor70.4295.760Lyase_1 (PF00206, IPR022761): Lyase
FumaraseC_C (PF10415, IPR018951): Fumarase C C-terminus
47 FUSsuppressor210.348343.646Herpes_PAP (PF03325, IPR004997): Herpesvirus polymerase accessory protein
RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
SVS_QK (PF10578, IPR018942): Seminal vesicle protein repeat
zf-RanBP (PF00641, IPR001876, SM00547): Zn-finger in Ran binding protein and others
Limkain-b1 (PF11608, IPR024582): Limkain b1
FoP_duplication (PF13865, IPR025715): C-terminal duplication domain of Friend of PRMT1
Keratin_2_head (PF16208, IPR032444): Keratin type II head
48 GANprotein found in more fusions90.464189.450BACK (PF07707, IPR011705, SM00875): BTB And C-terminal Kelch
BTB (PF00651, IPR013069, SM00225): BTB/POZ domain
Kelch_1 (PF01344, IPR006652, SM00612): Kelch motif
Kelch_3 (PF13415): Galactose oxidase, central domain
Kelch_5 (PF13854): Kelch motif
49 GARSinteractor180.39276.421HGTP_anticodon (PF03129, IPR004154): Anticodon binding domain
tRNA-synt_2b (PF00587, IPR002314): tRNA synthetase class II core domain (G, H, P, S and T)
WHEP-TRS (PF00458, IPR000738, SM00991): WHEP-TRS domain
50 GDAinteractor60.4676.137Amidohydro_1 (PF01979, IPR006680): Amidohydrolase family
51 GFPT1interactor90.61113.190SIS (PF01380, IPR001347): SIS domain
GATase_6 (PF13522): Glutamine amidotransferase domain
52 GRB2oncoprotein150.45143.194SH2 (PF00017, IPR000980, SM00252): SH2 domain
SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
DUF5093 (PF17011, IPR031533): Domain of unknown function (DUF5093)
53 HDAC5protein found in more fusions160.305228.315Hist_deacetyl (PF00850, IPR023801): Histone deacetylase domain
NOA36 (PF06524, IPR010531): NOA36 protein
Activator_LAG-3 (PF11498, IPR021587): Transcriptional activator LAG-3
HDAC4_Gln (PF12203, IPR024643): Glutamine rich N terminal domain of histone deacetylase 4
54 HGSinteractor80.393494.538FYVE (PF01363, IPR000306, SM00064): FYVE zinc finger
UIM (PF02809, IPR003903, SM00726): Ubiquitin interaction motif
VHS (PF00790, IPR002014, SM00288): VHS domain
EF-1_beta_acid (PF10587, IPR018940): Eukaryotic elongation factor 1 beta central acidic region
Hrs_helical (PF12210, IPR024641): Hepatocyte growth factor-regulated tyrosine kinase substrate
PIEZO (PF15917, IPR031805): Piezo
55 HSD17B10interactor130.35956.995adh_short (PF00106, IPR002198): short chain dehydrogenase
56 HSP90AA1oncoprotein310.292364.927HATPase_c (PF02518, IPR003594, SM00387): Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
HSP90 (PF00183, IPR001404): Hsp90 protein
57 HSP90AB1oncoprotein270.329143.708HATPase_c (PF02518, IPR003594, SM00387): Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
HSP90 (PF00183, IPR001404): Hsp90 protein
58 HSPH1oncoprotein90.7225.612HSP70 (PF00012, IPR013126): Hsp70 protein
SICA_alpha (PF12887, IPR024290): SICA extracellular alpha domain
59 HUWE1oncoprotein310.246248.143BUD22 (PF09073, IPR015158): BUD22
DUF908 (PF06012, IPR010309): Domain of Unknown Function (DUF908)
DUF913 (PF06025, IPR010314): Domain of Unknown Function (DUF913)
FdhE (PF04216, IPR006452): Protein involved in formate dehydrogenase formation
HABP4_PAI-RBP1 (PF04774, IPR006861): Hyaluronan / mRNA binding family
Ku_C (PF03730, IPR005160): Ku70/Ku80 C-terminal arm
Merozoite_SPAM (PF07133, IPR010784): Merozoite surface protein (SPAM)
Mucin (PF01456, IPR000458): Mucin-like glycoprotein
Nop14 (PF04147, IPR007276): Nop14-like family
PBP_sp32 (PF07222, IPR009865): Proacrosin binding protein sp32
RNA_pol_Rpc4 (PF05132, IPR007811): RNA polymerase III RPC4
TFIIA (PF03153, IPR004855): Transcription factor IIA, alpha/beta subunit
UBA (PF00627, IPR000449, SM00165): UBA/TS-N domain
WWE (PF02825, IPR004170, SM00678): WWE domain
HECT (PF00632, IPR000569, SM00119): HECT-domain (ubiquitin-transferase)
Tim54 (PF11711, IPR021056): Inner membrane protein import complex subunit Tim54
U1snRNP70_N (PF12220, IPR022023): U1 small nuclear ribonucleoprotein of 70kDa MW N terminal
DUF4414 (PF14377, IPR025527): Domain of unknown function (DUF4414)
60 IARSinteractor260.375159.888Anticodon_1 (PF08264, IPR013155): Anticodon-binding domain of tRNA
tRNA-synt_1 (PF00133, IPR002300): tRNA synthetases class I (I, L, M and V)
61 IBTKprotein found in more fusions50.6670.739BTB (PF00651, IPR013069, SM00225): BTB/POZ domain
RCC1 (PF00415, IPR000408): Regulator of chromosome condensation (RCC1) repeat
Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies)
RCC1_2 (PF13540): Regulator of chromosome condensation (RCC1) repeat
Ank_5 (PF13857): Ankyrin repeats (many copies)
62 IPO5interactor80.5369.132HEAT (PF02985, IPR000357): HEAT repeat
IBN_N (PF03810, IPR001494, SM00913): Importin-beta N-terminal domain
RTP1_C1 (PF10363, IPR019451): Required for nuclear transport of RNA pol II C-terminus 1
DUF3385 (PF11865, IPR024585): Domain of unknown function (DUF3385)
Vac14_Fab1_bd (PF12755, IPR032878): Vacuolar 14 Fab1-binding region
HEAT_EZ (PF13513): HEAT-like repeat
AAA_30 (PF13604): AAA domain
HEAT_2 (PF13646): HEAT repeats
PBP1_TM (PF14812, IPR032730): Transmembrane domain of transglycosylase PBP1 at N-terminal
63 ISG15suppressor120.34825.176ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
64 ITCHinteractor190.275166.617C2 (PF00168, IPR000008, SM00239): C2 domain
WW (PF00397, IPR001202, SM00456): WW domain
HECT (PF00632, IPR000569, SM00119): HECT-domain (ubiquitin-transferase)
65 KARSinteractor130.59021.188tRNA-synt_2 (PF00152, IPR004364): tRNA synthetases class II (D, K and N)
tRNA_anti-codon (PF01336, IPR004365): OB-fold nucleic acid binding domain
66 KIFC3oncoprotein50.33377.652Spc7 (PF08317, IPR013253, SM00787): Spc7 kinetochore protein
KxDL (PF10241, IPR019371): Uncharacterized conserved protein
Kinesin (PF00225, IPR001752, SM00129): Kinesin motor domain
DUF4200 (PF13863, IPR025252): Domain of unknown function (DUF4200)
HIP1_clath_bdg (PF16515, IPR032422): Clathrin-binding domain of Huntingtin-interacting protein 1
67 KRASoncoprotein140.35964.961Ras (PF00071, IPR001806, SM00173): Ras family
68 LARSinteractor190.45675.053Anticodon_1 (PF08264, IPR013155): Anticodon-binding domain of tRNA
tRNA-synt_1 (PF00133, IPR002300): tRNA synthetases class I (I, L, M and V)
69 LCMT2interactor40.6672.003Kelch_2 (PF07646, IPR011498): Kelch motif
LCM (PF04072, IPR007213): Leucine carboxyl methyltransferase
Kelch_3 (PF13415): Galactose oxidase, central domain
Kelch_4 (PF13418): Galactose oxidase, central domain
Kelch_5 (PF13854): Kelch motif
Kelch_6 (PF13964): Kelch motif
70 MAPK3oncoprotein50.50036.265Pkinase (PF00069, IPR000719): Protein kinase domain
71 MC1Rinteractor31.00007tm_1 (PF00001, IPR000276): 7 transmembrane receptor (rhodopsin family)
7tm_4 (PF13853): Olfactory receptor
72 MCTS1interactor50.5002.900DUF1947 (PF09183, IPR015266): Domain of unknown function (DUF1947)
PUA (PF01472, IPR002478, SM00359): PUA domain
73 MEOX2interactor40.33349.748Homeobox (PF00046, IPR001356, SM00389): Homeobox domain
74 METTL21Binteractor50.9000.154Methyltransf_16 (PF10294, IPR019410): Lysine methyltransferase
75 MTHFD1interactor150.48629.705FTHFS (PF01268, IPR000559): Formate--tetrahydrofolate ligase
THF_DHG_CYH (PF00763, IPR020630): Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain
THF_DHG_CYH_C (PF02882, IPR020631): Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain
76 MTPNinteractor50.5004.000Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies)
77 NCOA1oncoprotein70.267152.795DUF1518 (PF07469, IPR010011, SM01151): Domain of unknown function (DUF1518)
HLH (PF00010, IPR011598, SM00353): Helix-loop-helix DNA-binding domain
Nuc_rec_co-act (PF08815, IPR014920): Nuclear receptor coactivator
PAS (PF00989, IPR013767, SM00091): PAS fold
PAS_3 (PF08447, IPR013655): PAS fold
SRC-1 (PF08832, IPR014935): Steroid receptor coactivator
PAS_11 (PF14598): PAS domain
DUF4927 (PF16279, IPR032565): Domain of unknown function (DUF4927)
NCOA_u2 (PF16665): Unstructured region on nuclear receptor coactivator protein
78 NDUFV3interactor100DUF755 (PF05501, IPR008474): Domain of unknown function (DUF755)
IMUP (PF15761, IPR026621): Immortalisation up-regulated protein
NDUFV3 (PF15880, IPR026193): NADH dehydrogenase [ubiquinone] flavoprotein 3, mitochondrial
79 NMD3interactor140.37436.446DUF1816 (PF08846, IPR014945): Domain of unknown function (DUF1816)
NMD3 (PF04981, IPR007064): NMD3 family
HGTP_anticodon2 (PF12745, IPR024435): Anticodon binding domain of tRNAs
80 NPLOC4interactor80.57111.814NPL4 (PF05021, IPR007717): NPL4 family
zf-NPL4 (PF05020, IPR007716): NPL4 family, putative zinc binding region
UN_NPL4 (PF11543, IPR024682): Nuclear pore localisation protein NPL4
81 NR0B1interactor31.0000zf-C4_ClpX (PF06689, IPR010603, SM00994): ClpX C4-type zinc finger
Hormone_recep (PF00104, IPR000536, SM00430): Ligand-binding domain of nuclear hormone receptor
NR_Repeat (PF14046, IPR025900): Nuclear receptor repeat
82 NR0B2suppressor21.0000Hormone_recep (PF00104, IPR000536, SM00430): Ligand-binding domain of nuclear hormone receptor
83 NRIP1oncoprotein60.400109.473ALMT (PF11744, IPR020966): Aluminium activated malate transporter
NRIP1_repr_1 (PF15687, IPR031405): Nuclear receptor-interacting protein 1 repression 1
NRIP1_repr_2 (PF15688, IPR031406): Nuclear receptor-interacting protein 1 repression 2
NRIP1_repr_3 (PF15689, IPR031407): Nuclear receptor-interacting protein 1 repression 3
NRIP1_repr_4 (PF15690, IPR031408): Nuclear receptor-interacting protein 1 repression 4
84 NSUN2interactor60.6002.597Methyltr_RsmB-F (PF01189, IPR001678): 16S rRNA methyltransferase RsmB/F
85 NTRK1oncoprotein590.1501704.851I-set (PF07679, IPR013098): Immunoglobulin I-set domain
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
LRR_8 (PF13855, IPR001611): Leucine rich repeat
TPKR_C2 (PF16920, IPR031635): Tyrosine-protein kinase receptor C2 Ig-like domain
86 NUP160interactor60.200106.901Nup160 (PF11715, IPR021717): Nucleoporin Nup120/160
87 NUP93oncoprotein110.29129.055Nic96 (PF04097, IPR007231): Nup93/Nic96
88 NVLinteractor21.0000AAA (PF00004, IPR003959, SM00382): ATPase family associated with various cellular activities (AAA)
SRPRB (PF09439, IPR019009): Signal recognition particle receptor beta subunit
Vps4_C (PF09336, IPR015415): Vps4 C terminal oligomerisation domain
AAA_16 (PF13191): AAA ATPase domain
AAA_17 (PF13207): AAA domain
Nucleolin_bd (PF16725, IPR031996): Nucleolin binding domain
89 OBSL1interactor150.40744.662BiPBP_C (PF06832, IPR009647): Penicillin-Binding Protein C-terminus Family
fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain
Herpes_gE (PF02480, IPR003404): Alphaherpesvirus glycoprotein E
I-set (PF07679, IPR013098): Immunoglobulin I-set domain
V-set (PF07686, IPR013106): Immunoglobulin V-set domain
Ig_3 (PF13927): Immunoglobulin domain
Ig_4 (PF16680, IPR032052): T-cell surface glycoprotein CD3 delta chain
Izumo-Ig (PF16706, IPR032699): Izumo-like Immunoglobulin domain
90 PABPC1oncoprotein160.31451.991RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
PABP (PF00658, IPR002004, SM00517): Poly-adenylate binding protein, unique domain
YflT (PF11181, IPR025889): Heat induced stress protein YflT
91 PARK2suppressor270.129757.272IBR (PF01485, IPR002867, SM00647): IBR domain, a half RING-finger domain
ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
92 PDCD6IPinteractor100.44415.075BRO1 (PF03097, IPR004328, SM01041): BRO1-like domain
MSA-2c (PF12238, IPR021060): Merozoite surface antigen 2c
ALIX_LYPXL_bnd (PF13949, IPR025304): ALIX V-shaped domain binding to HIV
93 PIAS3oncoprotein100SAP (PF02037, IPR003034, SM00513): SAP domain
zf-MIZ (PF02891, IPR004181): MIZ/SP-RING zinc finger
PINIT (PF14324, IPR023321): PINIT domain
94 PNRC1interactor2023.898PNRC (PF15365, IPR028322): Proline-rich nuclear receptor coactivator
95 PNRC2interactor21.0000PNRC (PF15365, IPR028322): Proline-rich nuclear receptor coactivator
96 PPARGC1Ainteractor40.8331.250Pap_E4 (PF02711, IPR003861): E4 protein
RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
RSRP (PF17069): Arginine/Serine-Rich protein 1
97 PROX1suppressor30.33350.512GET2 (PF08690, IPR028143): GET complex subunit GET2
NifQ (PF04891, IPR006975): NifQ
HPD (PF05044, IPR023082): Homeo-prospero domain
PP_kinase_N (PF13089, IPR025198): Polyphosphate kinase N-terminal domain
Metal_resist (PF13801, IPR025961): Heavy-metal resistance
98 PSMC5protein found in more fusions170.250408.437AAA (PF00004, IPR003959, SM00382): ATPase family associated with various cellular activities (AAA)
Laminin_II (PF06009, IPR010307): Laminin Domain II
RILP (PF11461, IPR021563): Rab interacting lysosomal protein
AAA_16 (PF13191): AAA ATPase domain
99 PSMD14interactor100.57896.624JAB (PF01398, IPR000555, SM00232): JAB1/Mov34/MPN/PAD-1 ubiquitin protease
MitMem_reg (PF13012, IPR024969): Maintenance of mitochondrial structure and function
100 QARSinteractor200.46884.354tRNA-synt_1c (PF00749, IPR020058): tRNA synthetases class I (E and Q), catalytic domain
tRNA-synt_1c_C (PF03950, IPR020059): tRNA synthetases class I (E and Q), anti-codon binding domain
tRNA_synt_1c_R1 (PF04558, IPR007639): Glutaminyl-tRNA synthetase, non-specific RNA binding region part 1
tRNA_synt_1c_R2 (PF04557, IPR007638): Glutaminyl-tRNA synthetase, non-specific RNA binding region part 2
101 RAD21oncoprotein100.44421.290Rad21_Rec8 (PF04824, IPR006909): Conserved region of Rad21 / Rec8 like protein
Rad21_Rec8_N (PF04825, IPR006910): N terminus of Rad21 / Rec8 like protein
FAM176 (PF14851): FAM176 family
WRNPLPNID (PF15017): Putative WW-binding domain and destruction box
102 RAD23Aoncoprotein130.45538.743UBA (PF00627, IPR000449, SM00165): UBA/TS-N domain
XPC-binding (PF09280, IPR015360): XPC-binding domain
ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
103 RAD23Bsuppressor130.44949.030K_channel_TID (PF07941, IPR012897): Potassium channel Kv1.4 tandem inactivation domain
UBA (PF00627, IPR000449, SM00165): UBA/TS-N domain
XPC-binding (PF09280, IPR015360): XPC-binding domain
ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
DUF3123 (PF11321, IPR021470): Protein of unknown function (DUF3123)
104 RIC8Ainteractor40.8332.323PUL (PF08324, IPR013535): PUL domain
Ric8 (PF10165, IPR019318): Guanine nucleotide exchange factor synembryn
105 SAPCD2interactor100SlyX (PF04102, IPR007236): SlyX
TTKRSYEDQ (PF10212, IPR019348): Predicted coiled-coil domain-containing protein
Suppressor_APC (PF11414, IPR026831): Adenomatous polyposis coli tumour suppressor protein
EF-hand_6 (PF13405, IPR002048): EF-hand domain
PRIMA1 (PF16101): Proline-rich membrane anchor 1
106 SEPT6oncoprotein100Septin (PF00735, IPR000038): Septin
DUF2959 (PF11172, IPR021342): Protein of unknown function (DUF2959)
107 SHTN1interactor4059.970Asp-B-Hydro_N (PF05279, IPR007943): Aspartyl beta-hydroxylase N-terminal region
VIT1 (PF01988, IPR008217): VIT family
Pinin_SDK_memA (PF04696, IPR006786): pinin/SDK/memA/ protein conserved region
Spc7 (PF08317, IPR013253, SM00787): Spc7 kinetochore protein
BLOC1_2 (PF10046, IPR019269): Biogenesis of lysosome-related organelles complex-1 subunit 2
Atg14 (PF10186, IPR018791): Vacuolar sorting 38 and autophagy-related subunit 14
DUF3484 (PF11983, IPR021873): Membrane-attachment and polymerisation-promoting switch
Dscam_C (PF12355, IPR021012): Down syndrome cell adhesion molecule C terminal
PRKG1_interact (PF15898, IPR031775): cGMP-dependent protein kinase interacting domain
PRIMA1 (PF16101): Proline-rich membrane anchor 1
108 SMAD5interactor40.6671.067MH1 (PF03165, IPR003619, SM00523): MH1 domain
MH2 (PF03166, IPR001132, SM00524): MH2 domain
109 SP1protein found in more fusions70.33382.178zf-Di19 (PF05605, IPR008598): Drought induced 19 protein (Di19), zinc-binding
Herpes_capsid (PF06112, IPR009299): Gammaherpesvirus capsid protein
zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type
Miga (PF10265, IPR019392): Mitoguardin
zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain
FoP_duplication (PF13865, IPR025715): C-terminal duplication domain of Friend of PRMT1
110 SRA1interactor2028.721SRA1 (PF07304, IPR009917): Steroid receptor RNA activator (SRA1)
111 SRPK1interactor120.409207.194FYDLN_acid (PF09538, IPR012644): Protein of unknown function (FYDLN_acid)
Pkinase (PF00069, IPR000719): Protein kinase domain
NARP1 (PF12569, IPR021183): NMDA receptor-regulated protein 1
112 SUMO1P1interactor200NA
113 TAF9interactor30.6677.626TFIID-31kDa (PF02291, IPR003162): Transcription initiation factor IID, 31kD subunit
DUF2457 (PF10446, IPR018853): Protein of unknown function (DUF2457)
114 TLE1interactor200TLE_N (PF03920, IPR005617): Groucho/TLE N-terminal Q-rich domain
WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
115 TLN1interactor90.47211.737DUF1013 (PF06242, IPR010421): Protein of unknown function (DUF1013)
DUF948 (PF06103, IPR009293): Bacterial protein of unknown function (DUF948)
FERM_M (PF00373, IPR019748): FERM central domain
FERM_N (PF09379, IPR018979): FERM N-terminal domain
IRS (PF02174, IPR002404, SM00310): PTB domain (IRS-1 type)
Talin_middle (PF09141, IPR015224): Talin, middle domain
VBS (PF08913, IPR015009): Vinculin Binding Site
CoatB (PF10389, IPR008020): Bacteriophage coat protein B
LOH1CR12 (PF10158, IPR018780): Tumour suppressor protein
I_LWEQ (PF01608, IPR002558, SM00307): I/LWEQ domain
TAN (PF11640, IPR021668): Telomere-length maintenance and DNA damage repair
FERM_f0 (PF16511, IPR032425): N-terminal or F0 domain of Talin-head FERM
116 TRIM25protein found in more fusions120.27329.334Fes1 (PF08609, IPR013918): Nucleotide exchange factor Fes1
Pox_Rif (PF03340, IPR005008): Poxvirus rifampicin resistance protein
SPRY (PF00622, IPR003877, SM00449): SPRY domain
zf-B_box (PF00643, IPR000315, SM00336): B-box zinc finger
PRY (PF13765, IPR006574, SM00589): SPRY-associated domain
zf-RING_UBOX (PF13445, IPR027370): RING-type zinc-finger
Prok-RING_4 (PF14447): Prokaryotic RING finger family 4
117 TRIP13interactor80.42917.508AAA (PF00004, IPR003959, SM00382): ATPase family associated with various cellular activities (AAA)
118 TTC19interactor100ANAPC5 (PF12862, IPR026000): Anaphase-promoting complex subunit 5
TPR_12 (PF13424): Tetratricopeptide repeat
TPR_19 (PF14559): Tetratricopeptide repeat
119 TXLNGinteractor31.0000FlaC_arch (PF05377, IPR008039): Flagella accessory protein C (FlaC)
Taxilin (PF09728, IPR026183): Myosin-like coiled-coil protein
120 U2AF2protein found in more fusions190.44457.644RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
Transformer (PF06495, IPR010519): Fruit fly transformer protein
121 UBCprotein found in more fusions480.173903.233ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
122 UBDinteractor30.33312.918ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
123 UBE2Ainteractor80.6196.028UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme
124 UBE2Binteractor90.6436.640UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme
125 UBE2Concoprotein70.5334.405UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme
126 UBE2D1interactor140.44936.004UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme
127 UBE2D2oncoprotein140.46243.027UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme
128 UBE2D3interactor130.30343.537UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme
129 UBE2D4interactor31.0000UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme
130 UBE2E1protein found in more fusions50.5004.143UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme
SR-25 (PF10500, IPR019532): Nuclear RNA-splicing-associated protein
131 UBE2E2protein found in more fusions60.50017.835UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme
132 UBE2E3interactor60.9000.500UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme
133 UBE2G1protein found in more fusions70.33319.513UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme
134 UBE2G2interactor60.5004.679UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme
135 UBE2Hprotein found in more fusions31.0000UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme
Uteroglobin (PF01099, IPR016126, SM00096): Uteroglobin family
136 UBE2J1interactor30.3335.035UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme
ATPase-cat_bd (PF12156, IPR021993): Putative metal-binding domain of cation transport ATPase
137 UBE2Kinteractor60.6672.315UBA (PF00627, IPR000449, SM00165): UBA/TS-N domain
UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme
138 UBE2L1interactor100NA
139 UBE2L3protein found in more fusions150.352132.912UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme
140 UBE2L6protein found in more fusions70.33315.643UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme
141 UBE2Nprotein found in more fusions150.33059.475UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme
142 UBE2Q2interactor41.0000Josephin (PF02099, IPR006155): Josephin
RWD (PF05773, IPR006575, SM00591): RWD domain
UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme
DUF2890 (PF11081, IPR021304): Protein of unknown function (DUF2890)
143 UBE2R2protein found in more fusions80.3817.555NOA36 (PF06524, IPR010531): NOA36 protein
UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme
144 UBE2Sinteractor90.39335.311ALF (PF03752, IPR005506): Short repeats of unknown function
UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme
145 UBE2Tinteractor40.333200.005UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme
146 UBE2Winteractor31.0000UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme
147 UBE2Zinteractor30.6671.125UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme
148 UBTD2interactor31.0000ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
UBD (PF16455, IPR032752): Ubiquitin-binding domain
149 UCHL3interactor130.36432.236Peptidase_C12 (PF01088, IPR001578): Ubiquitin carboxyl-terminal hydrolase, family 1
150 UNKinteractor170.206363.715MbeD_MobD (PF04899, IPR006983): MbeD/MobD like
NUDE_C (PF04880, IPR006964): NUDE protein, C-terminal conserved region
zf-CCCH (PF00642, IPR000571): Zinc finger C-x8-C-x5-C-x3-H type (and similar)
DUF3450 (PF11932, IPR016866): Protein of unknown function (DUF3450)
zf-C3HC4_3 (PF13920): Zinc finger, C3HC4 type (RING finger)
zf-CCCH_2 (PF14608): RNA-binding, Nab2-type zinc finger
Torus (PF16131, IPR032297): Torus domain
151 USH1Cprotein found in more fusions200CemA (PF03040, IPR004282): CemA family
PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF)
SMN (PF06003, IPR010304): Survival motor neuron protein (SMN)
Saw1 (PF11561, IPR021624): Single strand annealing-weakened 1
DUF3393 (PF11873, IPR024570): Domain of unknown function (DUF3393)
DUF3567 (PF12091, IPR021951): Protein of unknown function (DUF3567)
PRIMA1 (PF16101): Proline-rich membrane anchor 1
152 USP11protein found in more fusions80.5245.095Ribosomal_60s (PF00428, IPR001813): 60s Acidic ribosomal protein
UCH (PF00443, IPR001394): Ubiquitin carboxyl-terminal hydrolase
DUSP (PF06337, IPR006615, SM00695): DUSP domain
Ubiquitin_3 (PF14836, IPR028135): Ubiquitin-like domain
153 USP5interactor130.321110.185UCH (PF00443, IPR001394): Ubiquitin carboxyl-terminal hydrolase
zf-UBP (PF02148, IPR001607, SM00290): Zn-finger in ubiquitin-hydrolases and other protein
154 WDR73interactor100WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
155 XPNPEP1interactor130.34634.575Creatinase_N (PF01321, IPR000587): Creatinase/Prolidase N-terminal domain
Peptidase_M24 (PF00557, IPR001714): Metallopeptidase family M24
Peptidase_M24_C (PF16188, IPR032416): C-terminal region of peptidase_M24
Creatinase_N_2 (PF16189): Creatinase/Prolidase N-terminal domain

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