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Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: parental proteins ESRRG, RNF213 (from a repository: Fri Dec 9 14:23:58 2016)
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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)50
The number (and %) of the onco-proteins14 (28.00 %)
The number (and %) of the tumor suppressors6 (12.00 %)
Total number of binary PPIs (saturation %)124 (10.12 %)
The number (and %) of affected PPIs50 (40.32 %)
The number of possible different fusions10
PPI diameter5
PPI radius3
The average degree of PPI4.200
Assortativity coefficient-0.3209
The network average Clustering coefficient0.348
The number (and %) of a zero Clustering coefficients18 (36.00 %)
The number (and %) of a zero Betweenness Centrality22 (44.00 %)

ACTIVE INTERACTORS


List of the fusions

PPI for parental proteins: RNF213,ESRRG All fusions
Proteins found in more fusions RNF213 (see 4 fusions); PSMC5 (see 2 fusions); GAN (see 1 fusions); APP (see 4 fusions); EGFR (see 2 fusions); MCM2 (see 1 fusions); SP1 (see 1 fusions); UBC (see 1 fusions); NCOA1 (see 2 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 RNF213parental protein220.033949.789AAA (PF00004, IPR003959, SM00382): ATPase family associated with various cellular activities (AAA)
NOB1_Zn_bind (PF08772, IPR014881): Nin one binding (NOB1) Zn-ribbon like
PX (PF00787, IPR001683, SM00312): PX domain
RNA_helicase (PF00910, IPR000605): RNA helicase
RNA_pol_Rpc4 (PF05132, IPR007811): RNA polymerase III RPC4
AAA_16 (PF13191): AAA ATPase domain
zf-C3HC4_3 (PF13920): Zinc finger, C3HC4 type (RING finger)
Nudix_N_2 (PF14803, IPR029401): Nudix N-terminal
2 ESRRGparental protein280.0681067.277zf-C4 (PF00105, IPR001628, SM00399): Zinc finger, C4 type (two domains)
Hormone_recep (PF00104, IPR000536, SM00430): Ligand-binding domain of nuclear hormone receptor
3 APPprotein found in more fusions120.182196.980APP_N (PF02177, IPR015849, SM00006): Amyloid A4 N-terminal heparin-binding
Beta-APP (PF03494, IPR013803): Beta-amyloid peptide (beta-APP)
BUD22 (PF09073, IPR015158): BUD22
IncA (PF04156, IPR007285): IncA protein
Kunitz_BPTI (PF00014, IPR002223, SM00131): Kunitz/Bovine pancreatic trypsin inhibitor domain
APP_amyloid (PF10515, IPR019543): beta-amyloid precursor protein C-terminus
APP_Cu_bd (PF12924, IPR011178): Copper-binding of amyloid precursor, CuBD
APP_E2 (PF12925, IPR024329): E2 domain of amyloid precursor protein
4 ARHGEF15interactor100Med14 (PF08638, IPR013947): Mediator complex subunit MED14
PH (PF00169, IPR001849, SM00233): PH domain
RhoGEF (PF00621, IPR000219, SM00325): RhoGEF domain
5 CBX2interactor21.0000AF-4 (PF05110, IPR007797): AF-4 proto-oncoprotein
Chromo (PF00385, IPR023780, SM00298): Chromo (CHRromatin Organisation MOdifier) domain
SRP-alpha_N (PF04086, IPR007222): Signal recognition particle, alpha subunit, N-terminal
SR-25 (PF10500, IPR019532): Nuclear RNA-splicing-associated protein
CBX7_C (PF17218): CBX family C-terminal motif
6 CBX4oncoprotein40.6671.000Chromo (PF00385, IPR023780, SM00298): Chromo (CHRromatin Organisation MOdifier) domain
Ribosomal_60s (PF00428, IPR001813): 60s Acidic ribosomal protein
SelP_N (PF04592, IPR007671): Selenoprotein P, N terminal region
CBX7_C (PF17218): CBX family C-terminal motif
7 CBX6interactor21.0000Chromo (PF00385, IPR023780, SM00298): Chromo (CHRromatin Organisation MOdifier) domain
CBX7_C (PF17218): CBX family C-terminal motif
8 CD244interactor100Receptor_2B4 (PF11465, IPR024303): Natural killer cell receptor 2B4
WBP-1 (PF11669, IPR021684): WW domain-binding protein 1
Ig_2 (PF13895, IPR007110): Immunoglobulin domain
9 DEUP1suppressor40.66726.226APG6 (PF04111, IPR007243): Autophagy protein Apg6
TPR_MLP1_2 (PF07926, IPR012929): TPR/MLP1/MLP2-like protein
bZIP_2 (PF07716, IPR004827, SM00338): Basic region leucine zipper
Lebercilin (PF15619, IPR028933): Ciliary protein causing Leber congenital amaurosis disease
CEP63 (PF17045, IPR031470): Centrosomal protein of 63 kDa
10 DNMT3Linteractor100CEBP_ZZ (PF16366, IPR032296): Cytoplasmic polyadenylation element-binding protein ZZ domain
11 DUTinteractor30.33328.061dUTPase (PF00692, IPR008180): dUTPase
12 EBPinteractor21.0000Phage_holin_3_6 (PF07332, IPR009937): Putative Actinobacterial Holin-X, holin superfamily III
EBP (PF05241, IPR007905): Emopamil binding protein
13 EGFRoncoprotein80.286187.862Furin-like (PF00757, IPR006211): Furin-like cysteine rich region
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
Recep_L_domain (PF01030, IPR000494): Receptor L domain
GAPT (PF11770, IPR021082): GRB2-binding adapter (GAPT)
GF_recep_IV (PF14843, IPR032778): Growth factor receptor domain IV
14 ESRRAoncoprotein110.27375.453zf-C4 (PF00105, IPR001628, SM00399): Zinc finger, C4 type (two domains)
Hormone_recep (PF00104, IPR000536, SM00430): Ligand-binding domain of nuclear hormone receptor
15 GANprotein found in more fusions4031.523BACK (PF07707, IPR011705, SM00875): BTB And C-terminal Kelch
BTB (PF00651, IPR013069, SM00225): BTB/POZ domain
Kelch_1 (PF01344, IPR006652, SM00612): Kelch motif
Kelch_3 (PF13415): Galactose oxidase, central domain
Kelch_5 (PF13854): Kelch motif
16 GOLGA2interactor30.33344.183ATG16 (PF08614, IPR013923): Autophagy protein 16 (ATG16)
Spc7 (PF08317, IPR013253, SM00787): Spc7 kinetochore protein
Rootletin (PF15035): Ciliary rootlet component, centrosome cohesion
GOLGA2L5 (PF15070, IPR024858): Putative golgin subfamily A member 2-like protein 5
17 HGSinteractor50.30055.722FYVE (PF01363, IPR000306, SM00064): FYVE zinc finger
UIM (PF02809, IPR003903, SM00726): Ubiquitin interaction motif
VHS (PF00790, IPR002014, SM00288): VHS domain
EF-1_beta_acid (PF10587, IPR018940): Eukaryotic elongation factor 1 beta central acidic region
Hrs_helical (PF12210, IPR024641): Hepatocyte growth factor-regulated tyrosine kinase substrate
PIEZO (PF15917, IPR031805): Piezo
18 IFI16suppressor50.100115.592HIN (PF02760, IPR004021): HIN-200/IF120x domain
PYRIN (PF02758, IPR004020): PAAD/DAPIN/Pyrin domain
Mitofilin (PF09731, IPR019133): Mitochondrial inner membrane protein
19 KIFC3oncoprotein90.143178.775Spc7 (PF08317, IPR013253, SM00787): Spc7 kinetochore protein
KxDL (PF10241, IPR019371): Uncharacterized conserved protein
Kinesin (PF00225, IPR001752, SM00129): Kinesin motor domain
DUF4200 (PF13863, IPR025252): Domain of unknown function (DUF4200)
HIP1_clath_bdg (PF16515, IPR032422): Clathrin-binding domain of Huntingtin-interacting protein 1
20 KRT40interactor4054.694Filament (PF00038, IPR001664): Intermediate filament protein
UPF0184 (PF03670, IPR022788): Uncharacterised protein family (UPF0184)
21 MCM2oncoprotein50.16776.764AAA_3 (PF07726, IPR011703): ATPase family associated with various cellular activities (AAA)
MCM (PF00493, IPR001208, SM00350): MCM2/3/5 family
MCM2_N (PF12619, IPR008045): Mini-chromosome maintenance protein 2
MCM_N (PF14551, IPR027925): MCM N-terminal domain
MCM_OB (PF17207): MCM OB domain
22 MEOX2interactor21.0000Homeobox (PF00046, IPR001356, SM00389): Homeobox domain
23 MRPL50interactor100Ribosomal_L50 (PF10501, IPR018305): Ribosomal subunit 39S
24 NCOA1oncoprotein41.0000DUF1518 (PF07469, IPR010011, SM01151): Domain of unknown function (DUF1518)
HLH (PF00010, IPR011598, SM00353): Helix-loop-helix DNA-binding domain
Nuc_rec_co-act (PF08815, IPR014920): Nuclear receptor coactivator
PAS (PF00989, IPR013767, SM00091): PAS fold
PAS_3 (PF08447, IPR013655): PAS fold
SRC-1 (PF08832, IPR014935): Steroid receptor coactivator
PAS_11 (PF14598): PAS domain
DUF4927 (PF16279, IPR032565): Domain of unknown function (DUF4927)
NCOA_u2 (PF16665): Unstructured region on nuclear receptor coactivator protein
25 NR0B1interactor31.0000zf-C4_ClpX (PF06689, IPR010603, SM00994): ClpX C4-type zinc finger
Hormone_recep (PF00104, IPR000536, SM00430): Ligand-binding domain of nuclear hormone receptor
NR_Repeat (PF14046, IPR025900): Nuclear receptor repeat
26 NR0B2suppressor21.0000Hormone_recep (PF00104, IPR000536, SM00430): Ligand-binding domain of nuclear hormone receptor
27 NRIP1oncoprotein50.6007.420ALMT (PF11744, IPR020966): Aluminium activated malate transporter
NRIP1_repr_1 (PF15687, IPR031405): Nuclear receptor-interacting protein 1 repression 1
NRIP1_repr_2 (PF15688, IPR031406): Nuclear receptor-interacting protein 1 repression 2
NRIP1_repr_3 (PF15689, IPR031407): Nuclear receptor-interacting protein 1 repression 3
NRIP1_repr_4 (PF15690, IPR031408): Nuclear receptor-interacting protein 1 repression 4
28 NUP160interactor4091.647Nup160 (PF11715, IPR021717): Nucleoporin Nup120/160
29 PARK2suppressor90.286124.492IBR (PF01485, IPR002867, SM00647): IBR domain, a half RING-finger domain
ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
30 PLAC9interactor100PLAC9 (PF15205, IPR027941): Placenta-specific protein 9
31 PNRC1interactor100PNRC (PF15365, IPR028322): Proline-rich nuclear receptor coactivator
32 PNRC2interactor21.0000PNRC (PF15365, IPR028322): Proline-rich nuclear receptor coactivator
33 PPARGC1Ainteractor50.50058.559Pap_E4 (PF02711, IPR003861): E4 protein
RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
RSRP (PF17069): Arginine/Serine-Rich protein 1
34 PROX1suppressor21.0000GET2 (PF08690, IPR028143): GET complex subunit GET2
NifQ (PF04891, IPR006975): NifQ
HPD (PF05044, IPR023082): Homeo-prospero domain
PP_kinase_N (PF13089, IPR025198): Polyphosphate kinase N-terminal domain
Metal_resist (PF13801, IPR025961): Heavy-metal resistance
35 PSMC5protein found in more fusions70.40057.496AAA (PF00004, IPR003959, SM00382): ATPase family associated with various cellular activities (AAA)
Laminin_II (PF06009, IPR010307): Laminin Domain II
RILP (PF11461, IPR021563): Rab interacting lysosomal protein
AAA_16 (PF13191): AAA ATPase domain
36 PTPN1suppressor21.0000Y_phosphatase (PF00102, IPR000242, SM00194): Protein-tyrosine phosphatase
37 RELoncoprotein3051.141RHD_DNA_bind (PF00554, IPR011539): Rel homology DNA-binding domain
RHD_dimer (PF16179, IPR032397): Rel homology dimerisation domain
38 RNASEH2Binteractor100RNase_H2-Ydr279 (PF09468, IPR019024): Ydr279p protein family (RNase H2 complex component)
39 SCN2Binteractor2016.976DUF1191 (PF06697, IPR010605): Protein of unknown function (DUF1191)
V-set (PF07686, IPR013106): Immunoglobulin V-set domain
40 SHTN1interactor200Asp-B-Hydro_N (PF05279, IPR007943): Aspartyl beta-hydroxylase N-terminal region
VIT1 (PF01988, IPR008217): VIT family
Pinin_SDK_memA (PF04696, IPR006786): pinin/SDK/memA/ protein conserved region
Spc7 (PF08317, IPR013253, SM00787): Spc7 kinetochore protein
BLOC1_2 (PF10046, IPR019269): Biogenesis of lysosome-related organelles complex-1 subunit 2
Atg14 (PF10186, IPR018791): Vacuolar sorting 38 and autophagy-related subunit 14
DUF3484 (PF11983, IPR021873): Membrane-attachment and polymerisation-promoting switch
Dscam_C (PF12355, IPR021012): Down syndrome cell adhesion molecule C terminal
PRKG1_interact (PF15898, IPR031775): cGMP-dependent protein kinase interacting domain
PRIMA1 (PF16101): Proline-rich membrane anchor 1
41 SP1protein found in more fusions60.30055.508zf-Di19 (PF05605, IPR008598): Drought induced 19 protein (Di19), zinc-binding
Herpes_capsid (PF06112, IPR009299): Gammaherpesvirus capsid protein
zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type
Miga (PF10265, IPR019392): Mitoguardin
zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain
FoP_duplication (PF13865, IPR025715): C-terminal duplication domain of Friend of PRMT1
42 SRA1interactor100SRA1 (PF07304, IPR009917): Steroid receptor RNA activator (SRA1)
43 SRPK1interactor30.66713.743FYDLN_acid (PF09538, IPR012644): Protein of unknown function (FYDLN_acid)
Pkinase (PF00069, IPR000719): Protein kinase domain
NARP1 (PF12569, IPR021183): NMDA receptor-regulated protein 1
44 SUMO1P1interactor3025.576NA
45 TLE1interactor200TLE_N (PF03920, IPR005617): Groucho/TLE N-terminal Q-rich domain
WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
46 TRIM23interactor50.33350.683Arf (PF00025, IPR006689, SM00177): ADP-ribosylation factor family
FemAB (PF02388, IPR003447): FemAB family
zf-B_box (PF00643, IPR000315, SM00336): B-box zinc finger
zf-RING_5 (PF14634, IPR001841): zinc-RING finger domain
47 TRIM27oncoprotein50.50016.578IncA (PF04156, IPR007285): IncA protein
SPRY (PF00622, IPR003877, SM00449): SPRY domain
zf-B_box (PF00643, IPR000315, SM00336): B-box zinc finger
PRY (PF13765, IPR006574, SM00589): SPRY-associated domain
zf-C2H2_4 (PF13894): C2H2-type zinc finger
zf-RING_5 (PF14634, IPR001841): zinc-RING finger domain
zf-C3HC4_4 (PF15227): zinc finger of C3HC4-type, RING
Lebercilin (PF15619, IPR028933): Ciliary protein causing Leber congenital amaurosis disease
48 TRIP6interactor100DEC-1_N (PF04625, IPR006719): DEC-1 protein, N-terminal region
LIM (PF00412, IPR001781, SM00132): LIM domain
49 UBCprotein found in more fusions80.28686.280ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
50 UBXN11interactor100DivIC (PF04977, IPR007060): Septum formation initiator
SEP (PF08059, IPR012989, SM00553): SEP domain
UBX (PF00789, IPR001012, SM00166): UBX domain
DUF4200 (PF13863, IPR025252): Domain of unknown function (DUF4200)
TRPM_tetra (PF16519, IPR032415): Tetramerisation domain of TRPM

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