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Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: parental proteins DHRSX, RBM47 (from a repository: Sat Jul 20 12:26:19 2019)
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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)11
The number (and %) of the onco-proteins4 (36.36 %)
The number (and %) of the tumor suppressors1 (9.09 %)
Total number of binary PPIs (saturation %)20 (36.36 %)
The number (and %) of affected PPIs9 (45.00 %)
The number of possible different fusions4
PPI diameter5
PPI radius3
The average degree of PPI2.364
Assortativity coefficient-0.3165
The network average Clustering coefficient0.200
The number (and %) of a zero Clustering coefficients7 (63.64 %)
The number (and %) of a zero Betweenness Centrality4 (36.36 %)

ACTIVE INTERACTORS


List of the fusions

PPI for parental proteins: RBM47,DHRSX All fusions
Proteins found in more fusions APP (see 5 fusions); DHRSX/APP (see 4 fusions); ATXN1 (see 3 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 RBM47parental protein50.20036.000Ribosomal_60s (PF00428, IPR001813): 60s Acidic ribosomal protein
RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
RRM_5 (PF13893): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
2 DHRSXparental protein4038.000adh_short (PF00106, IPR002198): short chain dehydrogenase
MutL (PF13941, IPR006230): MutL protein
3 APPprotein found in more fusions3023.000APP_N (PF02177, IPR015849, SM00006): Amyloid A4 N-terminal heparin-binding
Beta-APP (PF03494, IPR013803): Beta-amyloid peptide (beta-APP)
BUD22 (PF09073, IPR015158): BUD22
IncA (PF04156, IPR007285): IncA protein
Kunitz_BPTI (PF00014, IPR002223, SM00131): Kunitz/Bovine pancreatic trypsin inhibitor domain
APP_amyloid (PF10515, IPR019543): beta-amyloid precursor protein C-terminus
APP_Cu_bd (PF12924, IPR011178): Copper-binding of amyloid precursor, CuBD
APP_E2 (PF12925, IPR024329): E2 domain of amyloid precursor protein
4 ATMsuppressor31.0000FAT (PF02259, IPR003151): FAT domain
FATC (PF02260, IPR003152): FATC domain
HEAT (PF02985, IPR000357): HEAT repeat
PI3_PI4_kinase (PF00454, IPR000403, SM00146): Phosphatidylinositol 3- and 4-kinase
TAN (PF11640, IPR021668): Telomere-length maintenance and DNA damage repair
ANAPC5 (PF12862, IPR026000): Anaphase-promoting complex subunit 5
5 ATXN1protein found in more fusions3015.000AXH (PF08517, IPR013723, SM00536): Ataxin-1 and HBP1 module (AXH)
Spt20 (PF12090, IPR021950): Spt20 family
ATXN-1_C (PF12547, IPR020997): Capicua transcriptional repressor modulator
Cnd1_N (PF12922, IPR024324): non-SMC mitotic condensation complex subunit 1, N-term
6 C1orf94interactor3017.000DUF4688 (PF15752, IPR031496): Domain of unknown function (DUF4688)
7 ELAVL1oncoprotein40.6674.000RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
8 GCNT3oncoprotein100Branch (PF02485, IPR003406): Core-2/I-Branching enzyme
9 HSFY1interactor100HSF_DNA-bind (PF00447, IPR000232, SM00415): HSF-type DNA-binding
10 RNF2interactor40.33325.000zf-C4_Topoisom (PF01396, IPR013498): Topoisomerase DNA binding C4 zinc finger
zf-C3HC4_2 (PF13923): Zinc finger, C3HC4 type (RING finger)
RAWUL (PF16207, IPR032443): RAWUL domain RING finger- and WD40-associated ubiquitin-like
11 ZBED1interactor200Dimer_Tnp_hAT (PF05699, IPR008906): hAT family C-terminal dimerisation region
zf-BED (PF02892, IPR003656, SM00614): BED zinc finger
DUF4413 (PF14372, IPR025525): Domain of unknown function (DUF4413)

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