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Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: parental proteins MARK2, RNF41 (from a repository: Thu Nov 10 14:59:26 2016)
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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)135
The number (and %) of the onco-proteins42 (31.11 %)
The number (and %) of the tumor suppressors9 (6.67 %)
Total number of binary PPIs (saturation %)619 (6.84 %)
The number (and %) of affected PPIs141 (22.78 %)
The number of possible different fusions26
PPI diameter3
PPI radius2
The average degree of PPI8.370
Assortativity coefficient-0.2332
The network average Clustering coefficient0.374
The number (and %) of a zero Clustering coefficients29 (21.48 %)
The number (and %) of a zero Betweenness Centrality33 (24.44 %)

ACTIVE INTERACTORS


List of the fusions

Proteins found in more fusions ITSN2 (see 1 fusions); AP2M1 (see 3 fusions); APP (see 4 fusions); BIRC6 (see 1 fusions); YWHAG (see 1 fusions); VCP (see 4 fusions); GAB2 (see 2 fusions); PKD1 (see 1 fusions); MARK2/RNF41 (see 1 fusions); HDAC7 (see 1 fusions); MARK2 (see 2 fusions); PINK1 (see 3 fusions); YWHAH (see 2 fusions); MAPT (see 1 fusions); UTRN (see 4 fusions); ERBB3 (see 1 fusions); NEDD4L (see 3 fusions); SF1 (see 1 fusions); YWHAZ (see 1 fusions); APC (see 1 fusions); MARK3 (see 1 fusions); RAB11FIP2 (see 1 fusions); PPP2R5E (see 1 fusions); PRKCE (see 3 fusions); NEDD4 (see 1 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 MARK2parental protein870.0778456.374DUF702 (PF05142, IPR007818): Domain of unknown function (DUF702)
KA1 (PF02149, IPR001772): Kinase associated domain 1
Pkinase (PF00069, IPR000719): Protein kinase domain
UBA (PF00627, IPR000449, SM00165): UBA/TS-N domain
2 RNF41parental protein550.0316040.962Sina (PF03145, IPR018121): Seven in absentia protein family
USP8_interact (PF08941, IPR015036): USP8 interacting
zf-C3HC4_2 (PF13923): Zinc finger, C3HC4 type (RING finger)
3 ADRB2interactor50.50011.2607tm_1 (PF00001, IPR000276): 7 transmembrane receptor (rhodopsin family)
4 AKT1oncoprotein200.246200.383PH (PF00169, IPR001849, SM00233): PH domain
Pkinase (PF00069, IPR000719): Protein kinase domain
Pkinase_C (PF00433, IPR017892): Protein kinase C terminal domain
5 AP2M1protein found in more fusions60.30065.214Adap_comp_sub (PF00928, IPR008968): Adaptor complexes medium subunit family
Clat_adaptor_s (PF01217, IPR022775): Clathrin adaptor complex small chain
6 APConcoprotein80.38129.660APC_15aa (PF05972, IPR009240): APC 15 residue motif
APC_basic (PF05956, IPR009234): APC basic domain
APC_r (PF05923): APC repeat
Arm (PF00514, IPR000225, SM00185): Armadillo/beta-catenin-like repeat
DUF972 (PF06156, IPR010377): Protein of unknown function (DUF972)
EB1_binding (PF05937, IPR009232): EB-1 Binding Domain
FYDLN_acid (PF09538, IPR012644): Protein of unknown function (FYDLN_acid)
SAMP (PF05924, IPR009224): SAMP Motif
Suppressor_APC (PF11414, IPR026831): Adenomatous polyposis coli tumour suppressor protein
AIF_C (PF14721, IPR029324): Apoptosis-inducing factor, mitochondrion-associated, C-term
SAS4 (PF15460, IPR029184): Something about silencing, SAS, complex subunit 4
Arm_APC_u3 (PF16629): Armadillo-associated region on APC
APC_u5 (PF16630): Unstructured region on APC between 1st and 2nd catenin-bdg motifs
APC_u9 (PF16633): Unstructured region on APC between 1st two creatine-rich regions
APC_u13 (PF16634): Unstructured region on APC between APC_crr and SAMP
APC_u14 (PF16635): Unstructured region on APC between SAMP and APC_crr
APC_u15 (PF16636): Unstructured region on APC between APC_crr regions 5 and 6
APC_N_CC (PF16689, IPR032038): Coiled-coil N-terminus of APC, dimerisation domain
7 APPprotein found in more fusions280.085800.056APP_N (PF02177, IPR015849, SM00006): Amyloid A4 N-terminal heparin-binding
Beta-APP (PF03494, IPR013803): Beta-amyloid peptide (beta-APP)
BUD22 (PF09073, IPR015158): BUD22
IncA (PF04156, IPR007285): IncA protein
Kunitz_BPTI (PF00014, IPR002223, SM00131): Kunitz/Bovine pancreatic trypsin inhibitor domain
APP_amyloid (PF10515, IPR019543): beta-amyloid precursor protein C-terminus
APP_Cu_bd (PF12924, IPR011178): Copper-binding of amyloid precursor, CuBD
APP_E2 (PF12925, IPR024329): E2 domain of amyloid precursor protein
8 ARHGEF2oncoprotein160.49256.383IncA (PF04156, IPR007285): IncA protein
PH (PF00169, IPR001849, SM00233): PH domain
RhoGEF (PF00621, IPR000219, SM00325): RhoGEF domain
C1_1 (PF00130, IPR002219, SM00109): Phorbol esters/diacylglycerol binding domain (C1 domain)
9 ARL6IP4interactor200SR-25 (PF10500, IPR019532): Nuclear RNA-splicing-associated protein
10 ASB6interactor30.6670.371Ank (PF00023, IPR002110, SM00248): Ankyrin repeat
Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies)
Ank_4 (PF13637): Ankyrin repeats (many copies)
Ank_5 (PF13857): Ankyrin repeats (many copies)
SOCS_box (PF07525, IPR001496): SOCS box
11 AURKBinteractor120.27388.872Pkinase (PF00069, IPR000719): Protein kinase domain
12 BAIAP2interactor90.50024.557IMD (PF08397, IPR013606): IRSp53/MIM homology domain
SH3_9 (PF14604, IPR001452): Variant SH3 domain
13 BIRC6oncoprotein40.33310.145BIR (PF00653, IPR001370, SM00238): Inhibitor of Apoptosis domain
SlyX (PF04102, IPR007236): SlyX
UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme
BIRC6 (PF12356, IPR022103): Baculoviral IAP repeat-containing protein 6
ABC_tran_CTD (PF16326, IPR032524): ABC transporter C-terminal domain
14 C11orf58interactor3038.204DUF3408 (PF11888, IPR021823): Protein of unknown function (DUF3408)
SMAP (PF15477, IPR028124): Small acidic protein family
15 C1GALT1C1interactor100NA
16 C1orf109interactor50.5007.479CK2S (PF15011, IPR029159): Casein Kinase 2 substrate
17 CACYBPinteractor50.5009.315CS (PF04969, IPR007052): CS domain
SGS (PF05002, IPR007699): SGS domain
Siah-Interact_N (PF09032, IPR015120): Siah interacting protein, N terminal
18 CAMK1interactor201.858Pkinase (PF00069, IPR000719): Protein kinase domain
Tyrosinase (PF00264, IPR002227): Common central domain of tyrosinase
19 CAMSAP2interactor40.6673.366Bundlin (PF05307, IPR007971): Bundlin
IncA (PF04156, IPR007285): IncA protein
Presenilin (PF01080, IPR001108): Presenilin
CAMSAP_CKK (PF08683, IPR014797, SM01051): Microtubule-binding calmodulin-regulated spectrin-associated
CAMSAP_CH (PF11971, IPR022613): CAMSAP CH domain
FAM60A (PF15396, IPR026065): Protein Family FAM60A
CAMSAP_CC1 (PF17095, IPR031372): Spectrin-binding region of Ca2+-Calmodulin
20 CAPZA1interactor80.60712.025F-actin_cap_A (PF01267, IPR002189): F-actin capping protein alpha subunit
21 CAPZA2interactor90.30675.832F-actin_cap_A (PF01267, IPR002189): F-actin capping protein alpha subunit
22 CAPZBinteractor70.6195.096Cytochrom_B562 (PF07361, IPR009155): Cytochrome b562
F_actin_cap_B (PF01115, IPR001698): F-actin capping protein, beta subunit
23 CCDC8interactor210.305162.731Borrelia_P83 (PF05262, IPR007926): Borrelia P83/100 protein
SRP-alpha_N (PF04086, IPR007222): Signal recognition particle, alpha subunit, N-terminal
PNMA (PF14893, IPR026523): PNMA
24 CCDC82interactor100RNA_pol_3_Rpc31 (PF11705, IPR024661): DNA-directed RNA polymerase III subunit Rpc31
Spt5_N (PF11942, IPR022581): Spt5 transcription elongation factor, acidic N-terminal
DUF4196 (PF13846, IPR025244): Domain of unknown function (DUF4196)
DUF4211 (PF13926, IPR025451): Domain of unknown function (DUF4211)
25 CDC5Linteractor200.339131.171OmpH (PF03938, IPR005632, SM00935): Outer membrane protein (OmpH-like)
Pox_A_type_inc (PF04508, IPR007596): Viral A-type inclusion protein repeat
Cir_N (PF10197, IPR019339, SM01083): N-terminal domain of CBF1 interacting co-repressor CIR
Myb_DNA-binding (PF00249, IPR001005, SM00717): Myb-like DNA-binding domain
Myb_Cef (PF11831, IPR021786): pre-mRNA splicing factor component
Myb_DNA-bind_6 (PF13921): Myb-like DNA-binding domain
26 CDK15interactor100Pkinase (PF00069, IPR000719): Protein kinase domain
ACT_5 (PF13710): ACT domain
27 CDKN1Aoncoprotein80.35729.989CDI (PF02234, IPR003175): Cyclin-dependent kinase inhibitor
28 CEP192interactor40.16733.866Motile_Sperm (PF00635, IPR000535): MSP (Major sperm protein) domain
TMEM131_like (PF12371, IPR022113): Transmembrane protein 131-like
MYCBPAP (PF14646, IPR032707): MYCBP-associated protein family
ASH (PF15780, IPR031549): Abnormal spindle-like microcephaly-assoc'd, ASPM-SPD-2-Hydin
29 CEP57interactor50.4006.271Cep57_MT_bd (PF06657, IPR024957): Centrosome microtubule-binding domain of Cep57
Tup_N (PF08581, IPR013890): Tup N-terminal
CENP-Q (PF13094, IPR025212): CENP-Q, a CENPA-CAD centromere complex subunit
Cep57_CLD (PF14073, IPR025913): Centrosome localisation domain of Cep57
TRIQK (PF15168, IPR024842): Triple QxxK/R motif-containing protein family
30 CEP85Linteractor100ATG16 (PF08614, IPR013923): Autophagy protein 16 (ATG16)
DUF16 (PF01519, IPR002862): Protein of unknown function DUF16
Phage_GP20 (PF06810, IPR009636): Phage minor structural protein GP20
Reo_sigmaC (PF04582, IPR007662): Reovirus sigma C capsid protein
SlyX (PF04102, IPR007236): SlyX
Spc42p (PF11544, IPR021611): Spindle pole body component Spc42p
31 CEP89interactor60.26749.761ATG16 (PF08614, IPR013923): Autophagy protein 16 (ATG16)
CorA (PF01544, IPR002523): CorA-like Mg2+ transporter protein
Exonuc_VII_L (PF02601, IPR020579): Exonuclease VII, large subunit
Lectin_N (PF03954, IPR005640): Hepatic lectin, N-terminal domain
Spc24 (PF08286, IPR013252): Spc24 subunit of Ndc80
DUF3450 (PF11932, IPR016866): Protein of unknown function (DUF3450)
BST2 (PF16716, IPR024886): Bone marrow stromal antigen 2
32 CLASP1interactor100.62260.080HEAT (PF02985, IPR000357): HEAT repeat
TAN (PF11640, IPR021668): Telomere-length maintenance and DNA damage repair
CTK3 (PF12243, IPR024638): CTD kinase subunit gamma CTK3
CLASP_N (PF12348, IPR024395): CLASP N terminal
Cnd1 (PF12717, IPR032682): non-SMC mitotic condensation complex subunit 1
Sec7_N (PF12783, IPR032691): Guanine nucleotide exchange factor in Golgi transport N-terminal
33 CLASP2interactor60.7331.827HEAT (PF02985, IPR000357): HEAT repeat
TAN (PF11640, IPR021668): Telomere-length maintenance and DNA damage repair
CLASP_N (PF12348, IPR024395): CLASP N terminal
Cnd1 (PF12717, IPR032682): non-SMC mitotic condensation complex subunit 1
Sec7_N (PF12783, IPR032691): Guanine nucleotide exchange factor in Golgi transport N-terminal
HEAT_EZ (PF13513): HEAT-like repeat
34 CLEC16Ainteractor100AF-4 (PF05110, IPR007797): AF-4 proto-oncoprotein
FPL (PF09758, IPR019155): Uncharacterised conserved protein
35 COL4A3BPinteractor31.0000Acyl_CoA_thio (PF02551, IPR025652): Acyl-CoA thioesterase
PH (PF00169, IPR001849, SM00233): PH domain
START (PF01852, IPR002913, SM00234): START domain
36 CREB3interactor200bZIP_1 (PF00170, IPR004827): bZIP transcription factor
GIT_CC (PF16559, IPR032352): GIT coiled-coil Rho guanine nucleotide exchange factor
37 DCTN1interactor120.32729.329Bap31 (PF05529, IPR008417): B-cell receptor-associated protein 31-like
CAP_GLY (PF01302, IPR000938, SM01052): CAP-Gly domain
FlgN (PF05130, IPR007809): FlgN protein
HOOK (PF05622, IPR008636): HOOK protein
SlyX (PF04102, IPR007236): SlyX
TSC22 (PF01166, IPR000580): TSC-22/dip/bun family
DUF2443 (PF10398, IPR019469): Protein of unknown function (DUF2443)
ADIP (PF11559, IPR021622): Afadin- and alpha -actinin-Binding
TMF_DNA_bd (PF12329, IPR022092): TATA element modulatory factor 1 DNA binding
Dynactin (PF12455, IPR022157): Dynein associated protein
Lebercilin (PF15619, IPR028933): Ciliary protein causing Leber congenital amaurosis disease
KELK (PF15796, IPR031597): KELK-motif containing domain of MRCK Ser/Thr protein kinase
38 DLG5interactor30.6670.400Takusan (PF04822, IPR006907): Takusan
DUF972 (PF06156, IPR010377): Protein of unknown function (DUF972)
EMP24_GP25L (PF01105, IPR009038): emp24/gp25L/p24 family/GOLD
Occludin_ELL (PF07303, IPR010844): Occludin homology domain
PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF)
Guanylate_kin (PF00625, IPR008145, SM00072): Guanylate kinase
SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
GAS (PF13851, IPR025593): Growth-arrest specific micro-tubule binding
Cep57_CLD_2 (PF14197, IPR025925): Centrosome localisation domain of PPC89
dbPDZ_assoc (PF16610): Unstructured region between two PDZ domains on Dlg5
39 DMDoncoprotein50.30018.282CH (PF00307, IPR001715, SM00033): Calponin homology (CH) domain
DUF1664 (PF07889, IPR012458): Protein of unknown function (DUF1664)
DUF972 (PF06156, IPR010377): Protein of unknown function (DUF972)
EF-hand_2 (PF09068, IPR015153): EF hand
EF-hand_3 (PF09069, IPR015154): EF-hand
FliD_N (PF02465, IPR003481): Flagellar hook-associated protein 2 N-terminus
IncA (PF04156, IPR007285): IncA protein
Spectrin (PF00435, IPR002017): Spectrin repeat
WW (PF00397, IPR001202, SM00456): WW domain
Jnk-SapK_ap_N (PF09744, IPR019143): JNK_SAPK-associated protein-1
ZZ (PF00569, IPR000433, SM00291): Zinc finger, ZZ type
DinB_2 (PF12867, IPR024775): DinB superfamily
CCDC-167 (PF15188, IPR028194): Coiled-coil domain-containing protein 167
40 DTNAinteractor30.6670.733ATG16 (PF08614, IPR013923): Autophagy protein 16 (ATG16)
CRISPR_Cse2 (PF09485, IPR013382): CRISPR-associated protein Cse2 (CRISPR_cse2)
EF-hand_2 (PF09068, IPR015153): EF hand
EF-hand_3 (PF09069, IPR015154): EF-hand
PMC2NT (PF08066, IPR012588): PMC2NT (NUC016) domain
ZZ (PF00569, IPR000433, SM00291): Zinc finger, ZZ type
41 ELAVL1oncoprotein340.1361001.522RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
42 ERBB3oncoprotein40.33314.816Furin-like (PF00757, IPR006211): Furin-like cysteine rich region
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
Recep_L_domain (PF01030, IPR000494): Receptor L domain
GF_recep_IV (PF14843, IPR032778): Growth factor receptor domain IV
43 ERBB4oncoprotein50.16726.215Furin-like (PF00757, IPR006211): Furin-like cysteine rich region
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
Recep_L_domain (PF01030, IPR000494): Receptor L domain
DUF3951 (PF13131, IPR025028): Protein of unknown function (DUF3951)
GF_recep_IV (PF14843, IPR032778): Growth factor receptor domain IV
44 EVI5interactor30.33311.313bZIP_1 (PF00170, IPR004827): bZIP transcription factor
DUF1129 (PF06570, IPR009214): Protein of unknown function (DUF1129)
DUF724 (PF05266, IPR007930): Protein of unknown function (DUF724)
Fib_alpha (PF08702, IPR012290): Fibrinogen alpha/beta chain family
LMBR1 (PF04791, IPR006876): LMBR1-like membrane protein
PAP_central (PF04928, IPR007012): Poly(A) polymerase central domain
RabGAP-TBC (PF00566, IPR000195, SM00164): Rab-GTPase-TBC domain
CENP-F_leu_zip (PF10473, IPR019513): Leucine-rich repeats of kinetochore protein Cenp-F/LEK1
DUF2730 (PF10805, IPR020269): Protein of unknown function (DUF2730)
DUF4140 (PF13600, IPR025554): N-terminal domain of unknown function (DUF4140)
BST2 (PF16716, IPR024886): Bone marrow stromal antigen 2
45 FBXL16interactor21.0000LRR_1 (PF00560, IPR001611): Leucine Rich Repeat
LRR_4 (PF12799, IPR025875): Leucine Rich repeats (2 copies)
F-box-like (PF12937, IPR001810): F-box-like
LRR_6 (PF13516, IPR001611): Leucine Rich repeat
LRR_8 (PF13855, IPR001611): Leucine rich repeat
46 FRYLoncoprotein41.0000MOR2-PAG1_N (PF14222, IPR025614): Cell morphogenesis N-terminal
MOR2-PAG1_C (PF14225, IPR025481): Cell morphogenesis C-terminal
MOR2-PAG1_mid (PF14228, IPR029473): Cell morphogenesis central region
PI3K_P85_iSH2 (PF16454, IPR032498): Phosphatidylinositol 3-kinase regulatory subunit P85 inter-SH2 domain
47 FUCA1interactor30.3334.389Alpha_L_fucos (PF01120, IPR000933, SM00812): Alpha-L-fucosidase
Fucosidase_C (PF16757, IPR031919): Alpha-L-fucosidase C-terminal domain
48 GAB1oncoprotein60.4676.562PH (PF00169, IPR001849, SM00233): PH domain
49 GAB2oncoprotein60.7002.365PH (PF00169, IPR001849, SM00233): PH domain
Pheromone (PF08015, IPR012597): Fungal mating-type pheromone
50 GPRASP1interactor100Arm_2 (PF04826, IPR006911): Armadillo-like
FXMRP1_C_core (PF12235, IPR022034): Fragile X-related 1 protein core C terminal
51 H3F3Aoncoprotein206.248Histone (PF00125, IPR007125): Core histone H2A/H2B/H3/H4
52 HDAC7protein found in more fusions100.9170.559Hist_deacetyl (PF00850, IPR023801): Histone deacetylase domain
PRIMA1 (PF16101): Proline-rich membrane anchor 1
CBP_BcsO (PF17037, IPR031484): Cellulose biosynthesis protein BcsO
53 HERC2interactor90.214150.258ANAPC10 (PF03256, IPR004939): Anaphase-promoting complex, subunit 10 (APC10)
Cyt-b5 (PF00173, IPR001199, SM01117): Cytochrome b5-like Heme/Steroid binding domain
MIB_HERC2 (PF06701, IPR010606): Mib_herc2
RCC1 (PF00415, IPR000408): Regulator of chromosome condensation (RCC1) repeat
zf-UBR (PF02207, IPR003126): Putative zinc finger in N-recognin (UBR box)
HECT (PF00632, IPR000569, SM00119): HECT-domain (ubiquitin-transferase)
ZZ (PF00569, IPR000433, SM00291): Zinc finger, ZZ type
Cul7 (PF11515, IPR021097): Mouse development and cellular proliferation protein Cullin-7
Med3 (PF11593, IPR020998): Mediator complex subunit 3 fungal
RCC1_2 (PF13540): Regulator of chromosome condensation (RCC1) repeat
54 HNRNPA1interactor160.419188.313RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
HnRNPA1 (PF11627, IPR021662): Nuclear factor hnRNPA1
55 HOMER2suppressor30.6677.293MerR-DNA-bind (PF09278, IPR015358): MerR, DNA binding
WH1 (PF00568, IPR000697, SM00461): WH1 domain
Macoilin (PF09726, IPR019130): Transmembrane protein
56 IL23Ainteractor100IL23 (PF16649, IPR010831): Interleukin 23 subunit alpha
57 ISCA2interactor100Fe-S_biosyn (PF01521, IPR000361): Iron-sulphur cluster biosynthesis
58 ITSN2protein found in more fusions3028.472C2 (PF00168, IPR000008, SM00239): C2 domain
RhoGEF (PF00621, IPR000219, SM00325): RhoGEF domain
SH3_2 (PF07653, IPR011511): Variant SH3 domain
SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
EF-hand_4 (PF12763, IPR000261): Cytoskeletal-regulatory complex EF hand
DUF4407 (PF14362, IPR025519): Domain of unknown function (DUF4407)
SH3_9 (PF14604, IPR001452): Variant SH3 domain
MRP-S26 (PF14943, IPR026140): Mitochondrial ribosome subunit S26
VIR_N (PF15912, IPR031801): Virilizer, N-terminal
PH_13 (PF16652, IPR001849): Pleckstrin homology domain
59 KIF13Binteractor31.0000CAP_GLY (PF01302, IPR000938, SM01052): CAP-Gly domain
DUF342 (PF03961, IPR005646): Protein of unknown function (DUF342)
FHA (PF00498, IPR000253, SM00240): FHA domain
Kinesin (PF00225, IPR001752, SM00129): Kinesin motor domain
KIF1B (PF12423, IPR022140): Kinesin protein 1B
DUF3694 (PF12473, IPR022164): Kinesin protein
NCKAP5 (PF15246, IPR032769): Nck-associated protein 5, Peripheral clock protein
Kinesin_assoc (PF16183, IPR032405): Kinesin-associated
60 KIF5Binteractor130.57750.429ATG16 (PF08614, IPR013923): Autophagy protein 16 (ATG16)
Reo_sigmaC (PF04582, IPR007662): Reovirus sigma C capsid protein
Sec2p (PF06428, IPR009449): GDP/GTP exchange factor Sec2p
Kinesin (PF00225, IPR001752, SM00129): Kinesin motor domain
DUF3584 (PF12128, IPR021979): Protein of unknown function (DUF3584)
HAUS-augmin3 (PF14932, IPR032733): HAUS augmin-like complex subunit 3
DUF4226 (PF10774, IPR019710): Domain of unknown function (DUF4226)
PRKG1_interact (PF15898, IPR031775): cGMP-dependent protein kinase interacting domain
61 KIFC3oncoprotein100.222102.828Spc7 (PF08317, IPR013253, SM00787): Spc7 kinetochore protein
KxDL (PF10241, IPR019371): Uncharacterized conserved protein
Kinesin (PF00225, IPR001752, SM00129): Kinesin motor domain
DUF4200 (PF13863, IPR025252): Domain of unknown function (DUF4200)
HIP1_clath_bdg (PF16515, IPR032422): Clathrin-binding domain of Huntingtin-interacting protein 1
62 LDHDinteractor21.0000FAD-oxidase_C (PF02913, IPR004113): FAD linked oxidases, C-terminal domain
FAD_binding_4 (PF01565, IPR006094): FAD binding domain
63 LEPRinteractor100fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain
Lep_receptor_Ig (PF06328, IPR010457): Ig-like C2-type domain
64 LPGAT1interactor21.0000Acyltransferase (PF01553, IPR002123, SM00563): Acyltransferase
Acyltransf_C (PF16076, IPR032098): Acyltransferase C-terminus
65 LZTS2suppressor40.6672.632CAP_N (PF01213, IPR013992): Adenylate cyclase associated (CAP) N terminal
DUF1127 (PF06568, IPR009506): Domain of unknown function (DUF1127)
Fez1 (PF06818): Fez1
ADIP (PF11559, IPR021622): Afadin- and alpha -actinin-Binding
DUF4250 (PF14056, IPR025346): Domain of unknown function (DUF4250)
66 MAP3K3oncoprotein80.42928.988PB1 (PF00564, IPR000270, SM00666): PB1 domain
Pkinase (PF00069, IPR000719): Protein kinase domain
67 MAPTprotein found in more fusions130.37937.539Tubulin-binding (PF00418, IPR001084): Tau and MAP protein, tubulin-binding repeat
68 MARK1interactor80.5005.956KA1 (PF02149, IPR001772): Kinase associated domain 1
Pkinase (PF00069, IPR000719): Protein kinase domain
UBA (PF00627, IPR000449, SM00165): UBA/TS-N domain
69 MARK3protein found in more fusions210.321171.077KA1 (PF02149, IPR001772): Kinase associated domain 1
Pex14_N (PF04695, IPR006785): Peroxisomal membrane anchor protein (Pex14p) conserved region
Pkinase (PF00069, IPR000719): Protein kinase domain
UBA (PF00627, IPR000449, SM00165): UBA/TS-N domain
70 MARK4oncoprotein140.275150.000KA1 (PF02149, IPR001772): Kinase associated domain 1
Pkinase (PF00069, IPR000719): Protein kinase domain
UBA (PF00627, IPR000449, SM00165): UBA/TS-N domain
71 MNAT1interactor100MAT1 (PF06391, IPR015877): CDK-activating kinase assembly factor MAT1
Mu-like_Com (PF10122, IPR019294): Mu-like prophage protein Com
zf-C3HC4_5 (PF17121, IPR001841): Zinc finger, C3HC4 type (RING finger)
72 MTCL1interactor80.42942.435bZIP_1 (PF00170, IPR004827): bZIP transcription factor
Cnn_1N (PF07989, IPR012943): Centrosomin N-terminal motif 1
TPR_MLP1_2 (PF07926, IPR012929): TPR/MLP1/MLP2-like protein
SOGA (PF11365, IPR027881): Protein SOGA
DUF4140 (PF13600, IPR025554): N-terminal domain of unknown function (DUF4140)
DUF4201 (PF13870, IPR025254): Domain of unknown function (DUF4201)
DUF4407 (PF14362, IPR025519): Domain of unknown function (DUF4407)
DUF4482 (PF14818, IPR027882): Domain of unknown function (DUF4482)
HIP1_clath_bdg (PF16515, IPR032422): Clathrin-binding domain of Huntingtin-interacting protein 1
73 N4BP3oncoprotein3019.393Fez1 (PF06818): Fez1
YqzE (PF14038, IPR025622): YqzE-like protein
74 NAP1L5interactor21.0000NAP (PF00956, IPR002164): Nucleosome assembly protein (NAP)
SspB (PF04386, IPR007481): Stringent starvation protein B
Trypan_PARP (PF05887, IPR008882): Procyclic acidic repetitive protein (PARP)
75 NAV1oncoprotein60.26766.222ATG16 (PF08614, IPR013923): Autophagy protein 16 (ATG16)
ZapB (PF06005, IPR009252): Cell division protein ZapB
Fez1 (PF06818): Fez1
AAA_16 (PF13191): AAA ATPase domain
DUF4201 (PF13870, IPR025254): Domain of unknown function (DUF4201)
76 NEDD4suppressor150.121282.737Rota_NS26 (PF01525, IPR002512): Rotavirus NS26
WW (PF00397, IPR001202, SM00456): WW domain
HECT (PF00632, IPR000569, SM00119): HECT-domain (ubiquitin-transferase)
77 NEDD4Loncoprotein150.429145.583WW (PF00397, IPR001202, SM00456): WW domain
HECT (PF00632, IPR000569, SM00119): HECT-domain (ubiquitin-transferase)
78 NPATinteractor100Rxt3 (PF08642, IPR013951): Histone deacetylation protein Rxt3
TERB2 (PF15101, IPR028065): Telomere-associated protein TERB2
NPAT_C (PF15712, IPR031442): NPAT C terminus
79 NTRK1oncoprotein370.227753.863I-set (PF07679, IPR013098): Immunoglobulin I-set domain
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
LRR_8 (PF13855, IPR001611): Leucine rich repeat
TPKR_C2 (PF16920, IPR031635): Tyrosine-protein kinase receptor C2 Ig-like domain
80 NUPL2interactor21.0000zf-CCCH (PF00642, IPR000571): Zinc finger C-x8-C-x5-C-x3-H type (and similar)
81 P4HA1interactor21.0000P4Ha_N (PF08336, IPR013547): Prolyl 4-Hydroxylase alpha-subunit, N-terminal region
TPR_2 (PF07719, IPR013105): Tetratricopeptide repeat
2OG-FeII_Oxy_3 (PF13640, IPR005123): 2OG-Fe(II) oxygenase superfamily
82 PARD3interactor120.53017.060PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF)
DUF3534 (PF12053, IPR021922): Domain of unknown function (DUF3534)
PRP38_assoc (PF12871, IPR024767): Pre-mRNA-splicing factor 38-associated hydrophilic C-term
83 PARD6Ainteractor90.44444.047PB1 (PF00564, IPR000270, SM00666): PB1 domain
PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF)
84 PARD6Ginteractor51.0000PB1 (PF00564, IPR000270, SM00666): PB1 domain
PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF)
85 PARK2suppressor130.258137.041IBR (PF01485, IPR002867, SM00647): IBR domain, a half RING-finger domain
ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
86 PDCD7interactor303.766PDCD7 (PF16021, IPR031974): Programmed cell death protein 7
87 PHLPP1oncoprotein40.16717.512LRR_1 (PF00560, IPR001611): Leucine Rich Repeat
PH (PF00169, IPR001849, SM00233): PH domain
PP2C (PF00481, IPR001932): Protein phosphatase 2C
Ribosomal_60s (PF00428, IPR001813): 60s Acidic ribosomal protein
LRR_4 (PF12799, IPR025875): Leucine Rich repeats (2 copies)
LRR_8 (PF13855, IPR001611): Leucine rich repeat
PRIMA1 (PF16101): Proline-rich membrane anchor 1
88 PINK1protein found in more fusions40.3335.870Pkinase (PF00069, IPR000719): Protein kinase domain
89 PKD1suppressor200Stress-antifung (PF01657, IPR002902): Salt stress response/antifungal
LRRCT (PF01463, IPR000483, SM00082): Leucine rich repeat C-terminal domain
LRRNT (PF01462, IPR000372, SM00013): Leucine rich repeat N-terminal domain
PKD (PF00801, IPR000601, SM00089): PKD domain
PKD_channel (PF08016, IPR013122): Polycystin cation channel
PLAT (PF01477, IPR001024, SM00308): PLAT/LH2 domain
REJ (PF02010, IPR002859): REJ domain
WSC (PF01822, IPR002889, SM00321): WSC domain
Lectin_C (PF00059, IPR001304, SM00034): Lectin C-type domain
LRR_8 (PF13855, IPR001611): Leucine rich repeat
fn3_3 (PF14686, IPR029413): Polysaccharide lyase family 4, domain II
90 PMPCAinteractor100Peptidase_M16 (PF00675, IPR011765): Insulinase (Peptidase family M16)
Peptidase_M16_C (PF05193, IPR007863): Peptidase M16 inactive domain
91 PPP2R1Aoncoprotein150.37173.909TAF6_C (PF07571, IPR011442): TAF6 C-terminal HEAT repeat domain
HEAT (PF02985, IPR000357): HEAT repeat
HEAT_PBS (PF03130, IPR004155, SM00567): PBS lyase HEAT-like repeat
HEAT_2 (PF13646): HEAT repeats
92 PPP2R5Eprotein found in more fusions50.3334.880B56 (PF01603, IPR002554): Protein phosphatase 2A regulatory B subunit (B56 family)
93 PRDX3interactor31.0000AhpC-TSA (PF00578, IPR000866): AhpC/TSA family
1-cysPrx_C (PF10417, IPR019479): C-terminal domain of 1-Cys peroxiredoxin
94 PRKAA1suppressor120.39462.268Pkinase (PF00069, IPR000719): Protein kinase domain
AdenylateSensor (PF16579, IPR032270): Adenylate sensor of SNF1-like protein kinase
95 PRKCEsuppressor40.3332.132C2 (PF00168, IPR000008, SM00239): C2 domain
Pkinase (PF00069, IPR000719): Protein kinase domain
Pkinase_C (PF00433, IPR017892): Protein kinase C terminal domain
C1_1 (PF00130, IPR002219, SM00109): Phorbol esters/diacylglycerol binding domain (C1 domain)
96 PRKCIinteractor130.39766.795PB1 (PF00564, IPR000270, SM00666): PB1 domain
Pkinase (PF00069, IPR000719): Protein kinase domain
Pkinase_C (PF00433, IPR017892): Protein kinase C terminal domain
C1_1 (PF00130, IPR002219, SM00109): Phorbol esters/diacylglycerol binding domain (C1 domain)
97 PTPAoncoprotein60.6005.392PTPA (PF03095, IPR004327): Phosphotyrosyl phosphate activator (PTPA) protein
98 RAB11FIP2protein found in more fusions70.9330.333C2 (PF00168, IPR000008, SM00239): C2 domain
RBD-FIP (PF09457, IPR019018): FIP domain
99 RASIP1interactor100DIL (PF01843, IPR018444, SM01132): DIL domain
RA (PF00788, IPR000159, SM00314): Ras association (RalGDS/AF-6) domain
100 RCN1interactor3029.762EF-hand_1 (PF00036, IPR002048, SM00054): EF hand
EF-hand_4 (PF12763, IPR000261): Cytoskeletal-regulatory complex EF hand
EF-hand_7 (PF13499, IPR011992): EF-hand domain pair
101 RFC4interactor40.33310.031AAA (PF00004, IPR003959, SM00382): ATPase family associated with various cellular activities (AAA)
Rad17 (PF03215): Rad17 cell cycle checkpoint protein
Rep_fac_C (PF08542, IPR013748): Replication factor C C-terminal domain
AAA_assoc_2 (PF16193, IPR032423): AAA C-terminal domain
102 RFWD3interactor40.6672.150OmpH (PF03938, IPR005632, SM00935): Outer membrane protein (OmpH-like)
zf-RING_2 (PF13639, IPR001841, SM00184): Ring finger domain
zf-rbx1 (PF12678, IPR024766): RING-H2 zinc finger domain
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
103 RHOAoncoprotein30.6670.500Ras (PF00071, IPR001806, SM00173): Ras family
104 RNF166interactor50.40016.873zf-Di19 (PF05605, IPR008598): Drought induced 19 protein (Di19), zinc-binding
zinc-ribbons_6 (PF07191, IPR010807): zinc-ribbons
Rad50_zn_hook (PF04423, IPR007517): Rad50 zinc hook motif
UIM (PF02809, IPR003903, SM00726): Ubiquitin interaction motif
zinc_ribbon_2 (PF13240, IPR026870): zinc-ribbon domain
zf-RING_UBOX (PF13445, IPR027370): RING-type zinc-finger
zf-RING_4 (PF14570): RING/Ubox like zinc-binding domain
105 RSF1interactor100DDT (PF02791, IPR004022, SM00571): DDT domain
DTHCT (PF08070, IPR012542): DTHCT (NUC029) region
DUF1777 (PF08648, IPR013957): Protein of unknown function (DUF1777)
PHD (PF00628, IPR019787, SM00249): PHD-finger
UPF0239 (PF06783, IPR009621): Uncharacterised protein family (UPF0239)
TFIIE-A_C (PF11521, IPR021600): C-terminal general transcription factor TFIIE alpha
Spt5_N (PF11942, IPR022581): Spt5 transcription elongation factor, acidic N-terminal
WHIM1 (PF15612, IPR028942): WSTF, HB1, Itc1p, MBD9 motif 1
106 SF1protein found in more fusions4012.313UPF0181 (PF03701, IPR005371): Uncharacterised protein family (UPF0181)
zf-CCHC (PF00098, IPR001878): Zinc knuckle
KH_1 (PF00013, IPR004088, SM00322): KH domain
RCDG1 (PF15725, IPR031457): Renal cancer differentiation gene 1 protein
PRIMA1 (PF16101): Proline-rich membrane anchor 1
SF1-HH (PF16275, IPR032570): Splicing factor 1 helix-hairpin domain
107 SFNsuppressor160.46752.27114-3-3 (PF00244, IPR023410, SM00101): 14-3-3 protein
108 SNTB2interactor60.20051.194PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF)
PH (PF00169, IPR001849, SM00233): PH domain
109 SOGA1interactor80.42975.053ATG16 (PF08614, IPR013923): Autophagy protein 16 (ATG16)
bZIP_1 (PF00170, IPR004827): bZIP transcription factor
CENP-H (PF05837, IPR008426): Centromere protein H (CENP-H)
SPT16 (PF08644, IPR013953): FACT complex subunit (SPT16/CDC68)
TPR_MLP1_2 (PF07926, IPR012929): TPR/MLP1/MLP2-like protein
TSC22 (PF01166, IPR000580): TSC-22/dip/bun family
SOGA (PF11365, IPR027881): Protein SOGA
Dscam_C (PF12355, IPR021012): Down syndrome cell adhesion molecule C terminal
DUF4482 (PF14818, IPR027882): Domain of unknown function (DUF4482)
110 STK11oncoprotein60.26727.972Pkinase (PF00069, IPR000719): Protein kinase domain
111 SUGT1interactor70.14381.096CheC (PF04509, IPR007597): CheC-like family
CS (PF04969, IPR007052): CS domain
SGS (PF05002, IPR007699): SGS domain
TPR_2 (PF07719, IPR013105): Tetratricopeptide repeat
TPR_16 (PF13432): Tetratricopeptide repeat
TPR_19 (PF14559): Tetratricopeptide repeat
112 TADA2Ainteractor50.40071.606SWIRM (PF04433, IPR007526): SWIRM domain
Myb_DNA-binding (PF00249, IPR001005, SM00717): Myb-like DNA-binding domain
113 TMEM17interactor60.6004.662Transmemb_17 (PF09799, IPR019184): Predicted membrane protein
DUF3043 (PF11241, IPR021403): Protein of unknown function (DUF3043)
114 TRIM32suppressor110.444122.237NHL (PF01436, IPR001258): NHL repeat
zf-B_box (PF00643, IPR000315, SM00336): B-box zinc finger
Zn_Tnp_IS1595 (PF12760, IPR024442): Transposase zinc-ribbon domain
zf-RING_UBOX (PF13445, IPR027370): RING-type zinc-finger
HIP1_clath_bdg (PF16515, IPR032422): Clathrin-binding domain of Huntingtin-interacting protein 1
115 TRIM8interactor50.50019.191dCache_2 (PF08269, IPR004010, SM01049): Cache domain
CASP_C (PF08172, IPR012955): CASP C terminal
zf-B_box (PF00643, IPR000315, SM00336): B-box zinc finger
Zn_ribbon_recom (PF13408, IPR025827): Recombinase zinc beta ribbon domain
zf-C3HC4_4 (PF15227): zinc finger of C3HC4-type, RING
116 TSG101oncoprotein90.28664.853APG6 (PF04111, IPR007243): Autophagy protein Apg6
Laminin_II (PF06009, IPR010307): Laminin Domain II
UEV (PF05743, IPR008883): UEV domain
Vps23_core (PF09454, IPR017916): Vps23 core domain
117 TTC1interactor100TPR_1 (PF00515, IPR001440): Tetratricopeptide repeat
Fis1_TPR_C (PF14853, IPR028061): Fis1 C-terminal tetratricopeptide repeat
118 UBE2D3interactor110.24479.042UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme
119 UBE2Kinteractor3013.797UBA (PF00627, IPR000449, SM00165): UBA/TS-N domain
UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme
120 UBE2Uinteractor30.6672.152UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme
efb-c (PF12199, IPR021033): Extracellular fibrinogen binding protein C terminal
TMEM154 (PF15102, IPR028064): TMEM154 protein family
121 UBE2Zinteractor21.0000UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme
122 UPF3Ainteractor21.0000Smg4_UPF3 (PF03467, IPR005120): Smg-4/UPF3 family
DDRGK (PF09756, IPR019153, SM01128): DDRGK domain
123 USP21interactor110.20077.551UCH (PF00443, IPR001394): Ubiquitin carboxyl-terminal hydrolase
124 USP8interactor130.379175.071DUF1510 (PF07423, IPR009988): Protein of unknown function (DUF1510)
USP8_dimer (PF08969, IPR015063): USP8 dimerisation domain
SET (PF00856, IPR001214, SM00317): SET domain
UCH (PF00443, IPR001394): Ubiquitin carboxyl-terminal hydrolase
Rhodanese (PF00581, IPR001763, SM00450): Rhodanese-like domain
NAM-associated (PF14303, IPR029466): No apical meristem-associated C-terminal domain
125 UTP18interactor100Cytochrom_D1 (PF02239): Cytochrome D1 heme domain
SAMP (PF05924, IPR009224): SAMP Motif
WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
EF-1_beta_acid (PF10587, IPR018940): Eukaryotic elongation factor 1 beta central acidic region
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
126 UTRNprotein found in more fusions70.33311.742bZIP_1 (PF00170, IPR004827): bZIP transcription factor
CH (PF00307, IPR001715, SM00033): Calponin homology (CH) domain
Vfa1 (PF08432, IPR013640): AAA-ATPase Vps4-associated protein 1
EF-hand_2 (PF09068, IPR015153): EF hand
EF-hand_3 (PF09069, IPR015154): EF-hand
Seryl_tRNA_N (PF02403, IPR015866): Seryl-tRNA synthetase N-terminal domain
Spc7 (PF08317, IPR013253, SM00787): Spc7 kinetochore protein
Spectrin (PF00435, IPR002017): Spectrin repeat
TPR_MLP1_2 (PF07926, IPR012929): TPR/MLP1/MLP2-like protein
WW (PF00397, IPR001202, SM00456): WW domain
ZZ (PF00569, IPR000433, SM00291): Zinc finger, ZZ type
Rootletin (PF15035): Ciliary rootlet component, centrosome cohesion
CCDC-167 (PF15188, IPR028194): Coiled-coil domain-containing protein 167
ABC_tran_CTD (PF16326, IPR032524): ABC transporter C-terminal domain
127 VCPprotein found in more fusions220.414245.124AAA (PF00004, IPR003959, SM00382): ATPase family associated with various cellular activities (AAA)
CDC48_2 (PF02933, IPR004201, SM01072): Cell division protein 48 (CDC48), domain 2
CDC48_N (PF02359, IPR003338, SM01073): Cell division protein 48 (CDC48), N-terminal domain
TniB (PF05621, IPR008868): Bacterial TniB protein
Vps4_C (PF09336, IPR015415): Vps4 C terminal oligomerisation domain
DUF3944 (PF13099, IPR025217): Domain of unknown function (DUF3944)
128 VPS52interactor60.30049.615Vps52 (PF04129, IPR007258): Vps52 / Sac2 family
COG5 (PF10392, IPR019465): Golgi transport complex subunit 5
Sec3_C (PF09763, IPR019160): Exocyst complex component Sec3
129 WDR46interactor100BING4CT (PF08149, IPR012952, SM01033): BING4CT (NUC141) domain
WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
130 YWHABinteractor280.325271.83914-3-3 (PF00244, IPR023410, SM00101): 14-3-3 protein
Virulence_fact (PF13769, IPR025989): Virulence factor
131 YWHAEoncoprotein290.318238.51314-3-3 (PF00244, IPR023410, SM00101): 14-3-3 protein
132 YWHAGprotein found in more fusions290.378215.99214-3-3 (PF00244, IPR023410, SM00101): 14-3-3 protein
133 YWHAHprotein found in more fusions270.363202.54714-3-3 (PF00244, IPR023410, SM00101): 14-3-3 protein
134 YWHAQinteractor220.48992.80214-3-3 (PF00244, IPR023410, SM00101): 14-3-3 protein
135 YWHAZprotein found in more fusions290.378195.58114-3-3 (PF00244, IPR023410, SM00101): 14-3-3 protein

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