Find Fusion Network

Enter
Fusion ID:
Protein names:


Level of PPIs:
or Upload text file:
Update repository
Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: parental proteins HSD17B12, EML1 (from a repository: Mon Jul 29 05:22:05 2019)
Examples

Cytoscape Web will replace the contents your graph
PPI Properties:

Click on nodes
or edges

Layout Tree
Circle
Radial
Force Directed
Preset
Export graph
PDF file
SVG file
SIF file
XML file
GraphML file

Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)52
The number (and %) of the onco-proteins14 (26.92 %)
The number (and %) of the tumor suppressors2 (3.85 %)
Total number of binary PPIs (saturation %)284 (21.42 %)
The number (and %) of affected PPIs51 (17.96 %)
The number of possible different fusions8
PPI diameter5
PPI radius3
The average degree of PPI10.500
Assortativity coefficient-0.0288
The network average Clustering coefficient0.519
The number (and %) of a zero Clustering coefficients4 (7.69 %)
The number (and %) of a zero Betweenness Centrality5 (9.62 %)

ACTIVE INTERACTORS


List of the fusions

PPI for parental proteins: HSD17B12,EML1 All fusions
Proteins found in more fusions UBQLN1 (see 2 fusions); DCTN1 (see 2 fusions); FASN (see 1 fusions); EGFR (see 2 fusions); TUBA1B/TUBA1A (see 2 fusions); COPB1 (see 2 fusions); UBC (see 7 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 HSD17B12parental protein420.232709.644adh_short (PF00106, IPR002198): short chain dehydrogenase
2 EML1parental protein90.250121.460HELP (PF03451, IPR005108): HELP motif
WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
PKcGMP_CC (PF16808, IPR031831): Coiled-coil N-terminus of cGMP-dependent protein kinase
3 ADRB2interactor110.53322.8407tm_1 (PF00001, IPR000276): 7 transmembrane receptor (rhodopsin family)
4 AFG3L2interactor120.68210.405AAA (PF00004, IPR003959, SM00382): ATPase family associated with various cellular activities (AAA)
FtsH_ext (PF06480, IPR011546): FtsH Extracellular
Peptidase_M41 (PF01434, IPR000642): Peptidase family M41
TniB (PF05621, IPR008868): Bacterial TniB protein
FoP_duplication (PF13865, IPR025715): C-terminal duplication domain of Friend of PRMT1
5 AHSA1interactor90.50025.677Aha1_N (PF09229, IPR015310, SM01000): Activator of Hsp90 ATPase, N-terminal
AHSA1 (PF08327, IPR013538): Activator of Hsp90 ATPase homolog 1-like protein
6 ATP1A1interactor240.43885.053Cation_ATPase_C (PF00689, IPR006068): Cation transporting ATPase, C-terminus
Cation_ATPase_N (PF00690, IPR004014, SM00831): Cation transporter/ATPase, N-terminus
E1-E2_ATPase (PF00122, IPR008250): E1-E2 ATPase
Hydrolase_3 (PF08282, IPR023214): haloacid dehalogenase-like hydrolase
Tetraspannin (PF00335, IPR018499): Tetraspanin family
Cation_ATPase (PF13246): Cation transport ATPase (P-type)
7 ATP1B1interactor70.7622.471Na_K-ATPase (PF00287, IPR000402): Sodium / potassium ATPase beta chain
8 ATP5C1interactor130.57715.912ATP-synt (PF00231, IPR000131): ATP synthase
ACT_4 (PF13291, IPR002912): ACT domain
9 CERS2interactor60.6005.275PDR_CDR (PF06422, IPR010929): CDR ABC transporter
TRAM1 (PF08390, IPR013599): TRAM1-like protein
TRAM_LAG1_CLN8 (PF03798, IPR006634): TLC domain
Homeobox (PF00046, IPR001356, SM00389): Homeobox domain
10 CLN3interactor90.8061.395CLN3 (PF02487, IPR003492): CLN3 protein
11 COPB1protein found in more fusions60.7001.156Adaptin_N (PF01602, IPR002553): Adaptin N terminal region
Coatamer_beta_C (PF07718, IPR011710): Coatomer beta C-terminal region
Coatomer_b_Cpla (PF14806, IPR029446): Coatomer beta subunit appendage platform
12 CYC1interactor130.67910.190Cytochrom_C1 (PF02167, IPR002326): Cytochrome C1 family
13 DCTN1protein found in more fusions3013.623Bap31 (PF05529, IPR008417): B-cell receptor-associated protein 31-like
CAP_GLY (PF01302, IPR000938, SM01052): CAP-Gly domain
FlgN (PF05130, IPR007809): FlgN protein
HOOK (PF05622, IPR008636): HOOK protein
SlyX (PF04102, IPR007236): SlyX
TSC22 (PF01166, IPR000580): TSC-22/dip/bun family
DUF2443 (PF10398, IPR019469): Protein of unknown function (DUF2443)
ADIP (PF11559, IPR021622): Afadin- and alpha -actinin-Binding
TMF_DNA_bd (PF12329, IPR022092): TATA element modulatory factor 1 DNA binding
Dynactin (PF12455, IPR022157): Dynein associated protein
Lebercilin (PF15619, IPR028933): Ciliary protein causing Leber congenital amaurosis disease
KELK (PF15796, IPR031597): KELK-motif containing domain of MRCK Ser/Thr protein kinase
14 DCUN1D1interactor3012.063Cullin_binding (PF03556, IPR005176): Cullin binding
UBA_4 (PF14555): UBA-like domain
15 EGFRoncoprotein220.338171.715Furin-like (PF00757, IPR006211): Furin-like cysteine rich region
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
Recep_L_domain (PF01030, IPR000494): Receptor L domain
GAPT (PF11770, IPR021082): GRB2-binding adapter (GAPT)
GF_recep_IV (PF14843, IPR032778): Growth factor receptor domain IV
16 ELOVL1interactor40.8330.333ELO (PF01151, IPR002076): GNS1/SUR4 family
17 ETFAinteractor60.7331.889ETF (PF01012, IPR014730, SM00893): Electron transfer flavoprotein domain
ETF_alpha (PF00766, IPR014731): Electron transfer flavoprotein FAD-binding domain
18 FASNprotein found in more fusions50.50021.876Acyl_transf_1 (PF00698, IPR014043): Acyl transferase domain
ADH_zinc_N (PF00107, IPR013149): Zinc-binding dehydrogenase
ketoacyl-synt (PF00109, IPR014030): Beta-ketoacyl synthase, N-terminal domain
Ketoacyl-synt_C (PF02801, IPR014031): Beta-ketoacyl synthase, C-terminal domain
KR (PF08659, IPR013968, SM00130): KR domain
L27 (PF02828, IPR014775, SM00569): L27 domain
Methyltransf_12 (PF08242, IPR013217): Methyltransferase domain
PP-binding (PF00550, IPR009081): Phosphopantetheine attachment site
Thioesterase (PF00975, IPR001031): Thioesterase domain
YjeF_N (PF03853, IPR004443): YjeF-related protein N-terminus
ADH_zinc_N_2 (PF13602): Zinc-binding dehydrogenase
PS-DH (PF14765, IPR020807): Polyketide synthase dehydratase
KAsynt_C_assoc (PF16197, IPR032821): Ketoacyl-synthetase C-terminal extension
19 HDAC11interactor100Hist_deacetyl (PF00850, IPR023801): Histone deacetylase domain
20 HECW2interactor41.0000C2 (PF00168, IPR000008, SM00239): C2 domain
WW (PF00397, IPR001202, SM00456): WW domain
HECT (PF00632, IPR000569, SM00119): HECT-domain (ubiquitin-transferase)
Cep57_CLD (PF14073, IPR025913): Centrosome localisation domain of Cep57
RFXA_RFXANK_bdg (PF15289, IPR029316): Regulatory factor X-associated C-terminal binding domain
HECW_N (PF16562, IPR032348): N-terminal domain of E3 ubiquitin-protein ligase HECW1 and 2
21 HSP90B1suppressor90.58310.534CobT (PF06213, IPR006538): Cobalamin biosynthesis protein CobT
HATPase_c (PF02518, IPR003594, SM00387): Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
HSP90 (PF00183, IPR001404): Hsp90 protein
Sigma70_ner (PF04546, IPR007631): Sigma-70, non-essential region
22 IPO5interactor61.0000HEAT (PF02985, IPR000357): HEAT repeat
IBN_N (PF03810, IPR001494, SM00913): Importin-beta N-terminal domain
RTP1_C1 (PF10363, IPR019451): Required for nuclear transport of RNA pol II C-terminus 1
DUF3385 (PF11865, IPR024585): Domain of unknown function (DUF3385)
Vac14_Fab1_bd (PF12755, IPR032878): Vacuolar 14 Fab1-binding region
HEAT_EZ (PF13513): HEAT-like repeat
AAA_30 (PF13604): AAA domain
HEAT_2 (PF13646): HEAT repeats
PBP1_TM (PF14812, IPR032730): Transmembrane domain of transglycosylase PBP1 at N-terminal
23 ISG20L2interactor100RNase_T (PF00929, IPR013520): Exonuclease
Glucosamine_iso (PF01182, IPR006148): Glucosamine-6-phosphate isomerases/6-phosphogluconolactonase
24 MMS19interactor60.8000.944DUF3437 (PF11919, IPR021843): Domain of unknown function (DUF3437)
MMS19_C (PF12460, IPR024687): RNAPII transcription regulator C-terminal
HEAT_2 (PF13646): HEAT repeats
MMS19_N (PF14500): Dos2-interacting transcription regulator of RNA-Pol-II
25 NTRK1oncoprotein290.257405.458I-set (PF07679, IPR013098): Immunoglobulin I-set domain
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
LRR_8 (PF13855, IPR001611): Leucine rich repeat
TPKR_C2 (PF16920, IPR031635): Tyrosine-protein kinase receptor C2 Ig-like domain
26 OTUB1interactor80.5716.302Peptidase_C65 (PF10275, IPR019400): Peptidase C65 Otubain
27 PHBsuppressor140.48428.575Band_7 (PF01145, IPR001107, SM00244): SPFH domain / Band 7 family
DUF4290 (PF14123, IPR025632): Domain of unknown function (DUF4290)
28 PPP2R1Aoncoprotein120.63613.950TAF6_C (PF07571, IPR011442): TAF6 C-terminal HEAT repeat domain
HEAT (PF02985, IPR000357): HEAT repeat
HEAT_PBS (PF03130, IPR004155, SM00567): PBS lyase HEAT-like repeat
HEAT_2 (PF13646): HEAT repeats
29 RAB1Aoncoprotein170.47834.503Ras (PF00071, IPR001806, SM00173): Ras family
30 RAB1Boncoprotein140.53818.058Ras (PF00071, IPR001806, SM00173): Ras family
31 RNF2interactor150.26493.496zf-C4_Topoisom (PF01396, IPR013498): Topoisomerase DNA binding C4 zinc finger
zf-C3HC4_2 (PF13923): Zinc finger, C3HC4 type (RING finger)
RAWUL (PF16207, IPR032443): RAWUL domain RING finger- and WD40-associated ubiquitin-like
32 RPL36interactor30.6670.250Ribosomal_L36e (PF01158, IPR000509): Ribosomal protein L36e
33 RPN1oncoprotein250.397104.656Ribophorin_I (PF04597, IPR007676): Ribophorin I
CtIP_N (PF10482, IPR019518): Tumour-suppressor protein CtIP N-terminal domain
34 SCDinteractor70.4764.587MerC (PF03203, IPR004891): MerC mercury resistance protein
35 SLC25A3interactor170.45637.838Mito_carr (PF00153, IPR018108): Mitochondrial carrier protein
36 SSR3interactor80.5715.340TRAP-gamma (PF07074, IPR009779): Translocon-associated protein, gamma subunit (TRAP-gamma)
37 TCTN2interactor90.4727.774DUF1619 (PF07773, IPR011677): Protein of unknown function (DUF1619)
38 TCTN3interactor110.40019.588DUF1619 (PF07773, IPR011677): Protein of unknown function (DUF1619)
39 TECRinteractor180.40573.807Steroid_dh (PF02544, IPR001104): 3-oxo-5-alpha-steroid 4-dehydrogenase
ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
40 TMCO1interactor130.62810.192DUF106 (PF01956, IPR002809): Integral membrane protein DUF106
41 TMED2interactor60.8001.729EMP24_GP25L (PF01105, IPR009038): emp24/gp25L/p24 family/GOLD
42 TOMM22interactor80.5715.789Ribosomal_60s (PF00428, IPR001813): 60s Acidic ribosomal protein
Tom22 (PF04281, IPR005683): Mitochondrial import receptor subunit Tom22
43 TUBA1Aoncoprotein80.46458.240Tubulin (PF00091, IPR003008, SM00864): Tubulin/FtsZ family, GTPase domain
Tubulin_C (PF03953, IPR018316, SM00865): Tubulin C-terminal domain
44 TUBA1Bprotein found in more fusions70.42938.925Tubulin (PF00091, IPR003008, SM00864): Tubulin/FtsZ family, GTPase domain
Tubulin_C (PF03953, IPR018316, SM00865): Tubulin C-terminal domain
45 TUBB2Ainteractor70.28652.996Tubulin (PF00091, IPR003008, SM00864): Tubulin/FtsZ family, GTPase domain
Tubulin_C (PF03953, IPR018316, SM00865): Tubulin C-terminal domain
46 TUBB2Binteractor40.66716.265Tubulin (PF00091, IPR003008, SM00864): Tubulin/FtsZ family, GTPase domain
Tubulin_C (PF03953, IPR018316, SM00865): Tubulin C-terminal domain
47 TUBB3interactor60.60034.023Tubulin (PF00091, IPR003008, SM00864): Tubulin/FtsZ family, GTPase domain
Tubulin_C (PF03953, IPR018316, SM00865): Tubulin C-terminal domain
48 UBCprotein found in more fusions160.38199.819ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
49 UBL4Ainteractor140.34196.965ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
50 UBQLN1protein found in more fusions60.8000.771Clathrin-link (PF09268, IPR015348): Clathrin, heavy-chain linker
UBA (PF00627, IPR000449, SM00165): UBA/TS-N domain
XPC-binding (PF09280, IPR015360): XPC-binding domain
ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
Fur_reg_FbpB (PF13040, IPR025004): Fur-regulated basic protein B
FAM199X (PF15814, IPR029672): Protein family FAM199X
51 UQCRC2oncoprotein220.40373.650Peptidase_M16 (PF00675, IPR011765): Insulinase (Peptidase family M16)
Peptidase_M16_C (PF05193, IPR007863): Peptidase M16 inactive domain
52 WARSinteractor21.0000tRNA-synt_1b (PF00579, IPR002305): tRNA synthetases class I (W and Y)
WHEP-TRS (PF00458, IPR000738, SM00991): WHEP-TRS domain

B a c k    t o    T o p ⇑