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Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: parental proteins DNAJC5, ELK4 (from a repository: Sun Dec 31 12:58:05 2017)
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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)17
The number (and %) of the onco-proteins5 (29.41 %)
The number (and %) of the tumor suppressors5 (29.41 %)
Total number of binary PPIs (saturation %)33 (24.26 %)
The number (and %) of affected PPIs15 (45.45 %)
The number of possible different fusions4
PPI diameter2
PPI radiusinf
The average degree of PPI2.588
Assortativity coefficient-0.4685
The network average Clustering coefficient0.409
The number (and %) of a zero Clustering coefficients8 (47.06 %)
The number (and %) of a zero Betweenness Centrality14 (82.35 %)

ACTIVE INTERACTORS


List of the fusions

PPI for parental proteins: DNAJC5,ELK4 All fusions
Proteins found in more fusions VCL (see 2 fusions); STUB1 (see 1 fusions); MAPK1 (see 1 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 DNAJC5parental protein70.14336.000DnaJ (PF00226, IPR001623, SM00271): DnaJ domain
Baculo_F (PF12259, IPR022048): Baculovirus F protein
2 ELK4parental protein80.14346.000Ets (PF00178, IPR000418, SM00413): Ets-domain
3 ATP6V1B1interactor100ATP-synt_ab (PF00006, IPR000194): ATP synthase alpha/beta family, nucleotide-binding domain
ATP-synt_ab_N (PF02874, IPR004100): ATP synthase alpha/beta family, beta-barrel domain
DUF3533 (PF12051, IPR022703): Protein of unknown function (DUF3533)
4 BLMsuppressor31.0000BDHCT (PF08072, IPR012532): BDHCT (NUC031) domain
DEAD (PF00270, IPR011545): DEAD/DEAH box helicase
HRDC (PF00570, IPR002121, SM00341): HRDC domain
RQC (PF09382, IPR018982, SM00956): RQC domain
Helicase_C (PF00271, IPR001650, SM00490): Helicase conserved C-terminal domain
ALMT (PF11744, IPR020966): Aluminium activated malate transporter
RecQ_Zn_bind (PF16124, IPR032284): RecQ zinc-binding
BLM_N (PF16202, IPR032437): N-terminal region of Bloom syndrome protein
BDHCT_assoc (PF16204, IPR032439): BDHCT-box associated domain on Bloom syndrome protein
5 BRCA1suppressor50.6672.000BRCT (PF00533, IPR001357, SM00292): BRCA1 C Terminus (BRCT) domain
zf-C3HC4 (PF00097, IPR018957): Zinc finger, C3HC4 type (RING finger)
BRCT_assoc (PF12820, IPR025994): Serine-rich domain associated with BRCT
6 CFTRsuppressor41.0000ABC_membrane (PF00664, IPR001140): ABC transporter transmembrane region
ABC_tran (PF00005, IPR003439): ABC transporter
Roc (PF08477, IPR013684): Ras of Complex, Roc, domain of DAPkinase
SMC_N (PF02463, IPR003395): RecF/RecN/SMC N terminal domain
Rotamase_2 (PF13145, IPR000297): PPIC-type PPIASE domain
CFTR_R (PF14396, IPR025837): Cystic fibrosis TM conductance regulator (CFTR), regulator domain
7 ECE1interactor100Peptidase_M13 (PF01431, IPR018497): Peptidase family M13
Peptidase_M13_N (PF05649, IPR008753): Peptidase family M13
8 ELAVL1oncoprotein200RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
9 HSPA4interactor31.0000Herpes_ICP4_N (PF03584, IPR005206): Herpesvirus ICP4-like protein N-terminal region
HSP70 (PF00012, IPR013126): Hsp70 protein
TP53IP5 (PF15331, IPR029290): Cellular tumour antigen p53-inducible 5
10 MAPK1oncoprotein41.0000Pkinase (PF00069, IPR000719): Protein kinase domain
11 MAPK3oncoprotein41.0000Pkinase (PF00069, IPR000719): Protein kinase domain
12 MAPK8oncoprotein200DUF530 (PF04409, IPR007503): Protein of unknown function (DUF530)
Pkinase (PF00069, IPR000719): Protein kinase domain
13 MUS81suppressor100ERCC4 (PF02732, IPR006166, SM00891): ERCC4 domain
MutL (PF13941, IPR006230): MutL protein
HHH_8 (PF14716, IPR010996): Helix-hairpin-helix domain
14 PTGFRinteractor2007tm_1 (PF00001, IPR000276): 7 transmembrane receptor (rhodopsin family)
DUF3784 (PF12650, IPR017259): Domain of unknown function (DUF3784)
15 SRFinteractor200SRF-TF (PF00319, IPR002100, SM00432): SRF-type transcription factor (DNA-binding and dimerisation domain)
16 STUB1suppressor41.0000U-box (PF04564, IPR003613, SM00504): U-box domain
ANAPC3 (PF12895): Anaphase-promoting complex, cyclosome, subunit 3
TPR_11 (PF13414, IPR011990): TPR repeat
TPR_20 (PF14561): Tetratricopeptide repeat
17 VCLoncoprotein200Vinculin (PF01044, IPR006077): Vinculin family

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