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Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: parental proteins MRPL15, AHSG (from a repository: Wed Jul 24 01:09:05 2019)
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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)69
The number (and %) of the onco-proteins15 (21.74 %)
The number (and %) of the tumor suppressors2 (2.90 %)
Total number of binary PPIs (saturation %)512 (21.82 %)
The number (and %) of affected PPIs67 (13.09 %)
The number of possible different fusions6
PPI diameter5
PPI radius3
The average degree of PPI14.435
Assortativity coefficient-0.0042
The network average Clustering coefficient0.570
The number (and %) of a zero Clustering coefficients8 (11.59 %)
The number (and %) of a zero Betweenness Centrality13 (18.84 %)

ACTIVE INTERACTORS


List of the fusions

PPI for parental proteins: AHSG,MRPL15 All fusions
Proteins found in more fusions GRB2 (see 1 fusions); MRPL12 (see 1 fusions); FKBP8 (see 1 fusions); AHSG/ALB (see 1 fusions); COPS5 (see 1 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 AHSGparental protein130.064705.941Cystatin (PF00031, IPR000010, SM00043): Cystatin domain
2 MRPL15parental protein540.2891275.547Ribosomal_L27A (PF00828, IPR021131): Ribosomal proteins 50S-L15, 50S-L18e, 60S-L27A
3 ALBprotein found in more fusions40.500166.541Serum_albumin (PF00273, IPR014760, SM00103): Serum albumin family
4 ATF2oncoprotein3069.210bZIP_1 (PF00170, IPR004827): bZIP transcription factor
zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type
5 BTRConcoprotein120.49163.512WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
Beta-TrCP_D (PF12125, IPR021977, SM01028): D domain of beta-TrCP
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
F-box-like (PF12937, IPR001810): F-box-like
6 CAND1interactor220.53844.127Adaptin_N (PF01602, IPR002553): Adaptin N terminal region
DUF1981 (PF09324, IPR015403): Domain of unknown function (DUF1981)
HEAT (PF02985, IPR000357): HEAT repeat
TIP120 (PF08623, IPR013932): TATA-binding protein interacting (TIP20)
RTP1_C1 (PF10363, IPR019451): Required for nuclear transport of RNA pol II C-terminus 1
DUF3385 (PF11865, IPR024585): Domain of unknown function (DUF3385)
MMS19_C (PF12460, IPR024687): RNAPII transcription regulator C-terminal
Cnd1 (PF12717, IPR032682): non-SMC mitotic condensation complex subunit 1
Vac14_Fab1_bd (PF12755, IPR032878): Vacuolar 14 Fab1-binding region
HEAT_EZ (PF13513): HEAT-like repeat
HEAT_2 (PF13646): HEAT repeats
MMS19_N (PF14500): Dos2-interacting transcription regulator of RNA-Pol-II
7 CCNDBP1suppressor21.0000CheF-arch (PF04283, IPR007381): Chemotaxis signal transduction system protein F from archaea
GCIP (PF13324): Grap2 and cyclin-D-interacting
8 CDC42oncoprotein40.33373.237Ras (PF00071, IPR001806, SM00173): Ras family
9 COPS5protein found in more fusions150.61540.401JAB (PF01398, IPR000555, SM00232): JAB1/Mov34/MPN/PAD-1 ubiquitin protease
10 COX15interactor41.0000COX15-CtaA (PF02628, IPR003780): Cytochrome oxidase assembly protein
Peptidase_S3 (PF00944, IPR000930): Alphavirus core protein
11 CYC1interactor110.400185.243Cytochrom_C1 (PF02167, IPR002326): Cytochrome C1 family
12 DCNsuppressor100LRRNT (PF01462, IPR000372, SM00013): Leucine rich repeat N-terminal domain
LRR_4 (PF12799, IPR025875): Leucine Rich repeats (2 copies)
LRR_8 (PF13855, IPR001611): Leucine rich repeat
13 DLSToncoprotein50.7001.1502-oxoacid_dh (PF00198, IPR001078): 2-oxoacid dehydrogenases acyltransferase (catalytic domain)
Biotin_lipoyl (PF00364, IPR000089): Biotin-requiring enzyme
DUF4106 (PF13388, IPR025179): Protein of unknown function (DUF4106)
14 EIF3Concoprotein21.0000eIF-3c_N (PF05470, IPR008905): Eukaryotic translation initiation factor 3 subunit 8 N-terminus
PCI (PF01399, IPR000717, SM00088): PCI domain
15 FBXO2interactor100FBA (PF04300, IPR007397): F-box associated region
F-box (PF00646, IPR001810, SM00256): F-box domain
16 FKBP8protein found in more fusions40.33314.211FKBP_C (PF00254, IPR001179): FKBP-type peptidyl-prolyl cis-trans isomerase
TPR_9 (PF13371, IPR011990): Tetratricopeptide repeat
TPR_16 (PF13432): Tetratricopeptide repeat
Fis1_TPR_C (PF14853, IPR028061): Fis1 C-terminal tetratricopeptide repeat
17 GDPD1interactor21.0000GDPD (PF03009, IPR004129): Glycerophosphoryl diester phosphodiesterase family
PI-PLC-X (PF00388, IPR000909, SM00148): Phosphatidylinositol-specific phospholipase C, X domain
18 GRB2oncoprotein60.50048.945SH2 (PF00017, IPR000980, SM00252): SH2 domain
SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
DUF5093 (PF17011, IPR031533): Domain of unknown function (DUF5093)
19 HNRNPA1interactor320.503702.049RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
HnRNPA1 (PF11627, IPR021662): Nuclear factor hnRNPA1
20 ILF3oncoprotein250.49370.779dsrm (PF00035, IPR014720, SM00358): Double-stranded RNA binding motif
DZF (PF07528, IPR006561, SM00572): DZF domain
21 INSRinteractor30.66743.622fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain
Furin-like (PF00757, IPR006211): Furin-like cysteine rich region
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
Recep_L_domain (PF01030, IPR000494): Receptor L domain
22 MARC1interactor30.6671.000MOSC (PF03473, IPR005302): MOSC domain
MOSC_N (PF03476, IPR005303): MOSC N-terminal beta barrel domain
23 MOV10interactor170.46380.883AAA_12 (PF13087): AAA domain
AAA_30 (PF13604): AAA domain
24 MRPL1interactor290.68233.711CUB_2 (PF02408, IPR003366): CUB-like domain
Ribosomal_L1 (PF00687, IPR028364): Ribosomal protein L1p/L10e family
25 MRPL10interactor160.8503.704Ribosomal_L10 (PF00466, IPR001790): Ribosomal protein L10
26 MRPL11interactor250.61750.946Ribosomal_L11 (PF00298, IPR020783): Ribosomal protein L11, RNA binding domain
Ribosomal_L11_N (PF03946, IPR020784): Ribosomal protein L11, N-terminal domain
27 MRPL12protein found in more fusions170.60814.290Ribosomal_L12 (PF00542, IPR013823): Ribosomal protein L7/L12 C-terminal domain
Ribosomal_L12_N (PF16320, IPR008932): Ribosomal protein L7/L12 dimerisation domain
28 MRPL13interactor260.66538.446Ribosomal_L13 (PF00572, IPR005822): Ribosomal protein L13
29 MRPL14interactor160.9750.296Ribosomal_L14 (PF00238, IPR000218): Ribosomal protein L14p/L23e
RTT107_BRCT_6 (PF16771, IPR031906): Regulator of Ty1 transposition protein 107 BRCT domain
30 MRPL16interactor210.78122.152Ribosomal_L16 (PF00252, IPR016180): Ribosomal protein L16p/L10e
31 MRPL19interactor240.73629.317Ribosomal_L19 (PF01245, IPR001857): Ribosomal protein L19
EABR (PF12180, IPR022008): TSG101 and ALIX binding domain of CEP55
32 MRPL20interactor120.8790.958Herpes_UL49_5 (PF05702, IPR008647): Herpesvirus UL49.5 envelope/tegument protein
Ribosomal_L20 (PF00453, IPR005813): Ribosomal protein L20
33 MRPL28interactor250.76327.139Ribosomal_L28 (PF00830, IPR001383): Ribosomal L28 family
34 MRPL3interactor220.71929.413Ribosomal_L3 (PF00297, IPR000597): Ribosomal protein L3
35 MRPL32interactor210.76714.186Ribosomal_L32p (PF01783, IPR002677): Ribosomal L32p protein family
36 MRPL37interactor270.62466.659PDCD9 (PF07147, IPR010793): Mitochondrial 28S ribosomal protein S30 (PDCD9)
37 MRPL38interactor280.63057.221PBP (PF01161, IPR008914): Phosphatidylethanolamine-binding protein
DUF3095 (PF11294, IPR021445): Protein of unknown function (DUF3095)
38 MRPL39interactor310.583117.729TGS (PF02824, IPR004095): TGS domain
DUF2469 (PF10611, IPR019592): Protein of unknown function (DUF2469)
39 MRPL4interactor310.58383.203Ribosomal_L4 (PF00573, IPR002136): Ribosomal protein L4/L1 family
40 MRPL40interactor230.67629.299MRP-L28 (PF09812, IPR019192): Mitochondrial ribosomal protein L28
41 MRPL45interactor210.79011.833Tim44 (PF04280, IPR007379, SM00978): Tim44-like domain
42 MRPL47interactor290.67533.901MRP-L47 (PF06984, IPR010729): Mitochondrial 39-S ribosomal protein L47 (MRP-L47)
43 MRPL50interactor250.71018.434Ribosomal_L50 (PF10501, IPR018305): Ribosomal subunit 39S
44 MRPL55interactor150.8861.543Mitoc_L55 (PF09776, IPR018615): Mitochondrial ribosomal protein L55
45 MRPL57interactor120.9701.053MRP-63 (PF14978, IPR016576): Mitochondrial ribosome protein 63
46 MRPL58interactor280.65151.778RF-1 (PF00472, IPR000352): RF-1 domain
47 MRPL9interactor320.60962.277Ribosomal_L9_N (PF01281, IPR020070): Ribosomal protein L9, N-terminal domain
48 MRPS30interactor280.70925.241PDCD9 (PF07147, IPR010793): Mitochondrial 28S ribosomal protein S30 (PDCD9)
49 NDUFA12interactor41.0000NDUFA12 (PF05071, IPR007763): NADH ubiquinone oxidoreductase subunit NDUFA12
50 NDUFS4interactor80.42917.348ETC_C1_NDUFA4 (PF04800, IPR006885): ETC complex I subunit conserved region
51 NOP9interactor21.0000PUF (PF00806, IPR001313, SM00025): Pumilio-family RNA binding repeat
52 NTRK1oncoprotein240.340485.707I-set (PF07679, IPR013098): Immunoglobulin I-set domain
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
LRR_8 (PF13855, IPR001611): Leucine rich repeat
TPKR_C2 (PF16920, IPR031635): Tyrosine-protein kinase receptor C2 Ig-like domain
53 NXF1interactor110.42237.119NTF2 (PF02136, IPR002075): Nuclear transport factor 2 (NTF2) domain
Tap-RNA_bind (PF09162, IPR015245): Tap, RNA-binding
TAP_C (PF03943, IPR005637, SM00804): TAP C-terminal domain
LRR_8 (PF13855, IPR001611): Leucine rich repeat
54 OGDHinteractor100.46722.676E1_dh (PF00676, IPR001017): Dehydrogenase E1 component
Transket_pyr (PF02779, IPR005475, SM00861): Transketolase, pyrimidine binding domain
2-oxogl_dehyd_N (PF16078, IPR032106): 2-oxoglutarate dehydrogenase N-terminus
OxoGdeHyase_C (PF16870, IPR031717): 2-oxoglutarate dehydrogenase C-terminal
55 POTEFoncoprotein100Actin (PF00022, IPR004000, SM00268): Actin
Toxin_16 (PF07945, IPR012499): Janus-atracotoxin
Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies)
CCDC144C (PF14915): CCDC144C protein coiled-coil region
56 PPP5Cinteractor60.400197.079Metallophos (PF00149, IPR004843): Calcineurin-like phosphoesterase
PPP5 (PF08321, IPR013235): PPP5 TPR repeat region
TPR_1 (PF00515, IPR001440): Tetratricopeptide repeat
TPR_17 (PF13431): Tetratricopeptide repeat
57 PSMA3interactor70.200210.962Proteasome (PF00227, IPR001353): Proteasome subunit
Proteasome_A_N (PF10584, IPR000426, SM00948): Proteasome subunit A N-terminal signature
58 RHOUinteractor100Ras (PF00071, IPR001806, SM00173): Ras family
SLBP_RNA_bind (PF15247, IPR029344): Histone RNA hairpin-binding protein RNA-binding domain
59 RPL23Ainteractor90.8332.171Ribosomal_L23 (PF00276, IPR013025): Ribosomal protein L23
Ribosomal_L23eN (PF03939, IPR005633): Ribosomal protein L23, N-terminal domain
60 RPL6interactor170.59622.020Ribosomal_L6e (PF01159, IPR000915): Ribosomal protein L6e
Ribosomal_L6e_N (PF03868, IPR005568): Ribosomal protein L6, N-terminal domain
61 RPS14interactor100.7336.444Ribosomal_S11 (PF00411, IPR001971): Ribosomal protein S11
62 RPS2interactor130.61518.431Ribosomal_S5 (PF00333, IPR013810): Ribosomal protein S5, N-terminal domain
Ribosomal_S5_C (PF03719, IPR005324): Ribosomal protein S5, C-terminal domain
63 RPS8interactor270.53693.571Ribosomal_S8e (PF01201, IPR022309): Ribosomal protein S8e
64 RUNDC3Ainteractor100Phage_GP20 (PF06810, IPR009636): Phage minor structural protein GP20
RUN (PF02759, IPR004012, SM00593): RUN domain
65 SCFD1interactor110.41823.277Sec1 (PF00995, IPR001619): Sec1 family
66 SOX2oncoprotein80.7141.851HMG_box (PF00505, IPR009071, SM00398): HMG (high mobility group) box
SOXp (PF12336, IPR022097): SOX transcription factor
67 TMEM177interactor80.9290.216NA
68 USP38oncoprotein100UCH (PF00443, IPR001394): Ubiquitin carboxyl-terminal hydrolase
69 VKORC1interactor200VKOR (PF07884, IPR012932, SM00756): Vitamin K epoxide reductase family

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