Find Fusion Network

Visualization interactions

Powered by Cytoscape Web for: parental proteins AHR (from a repository: Tue Nov 15 19:02:02 2016)

Examples AFF1 MLL ACTN4 + MLLAFF1 + MLLALK + MSNALK + TFGALK + TPM3ALK + TPM4ASXL2 + KAT6AATF1 + FUSBCR + ABL1BCR + FGFR1CCND1 + TACSTD2CD74 + ROS1CDK6 + MLLCOL1A1 + PDGFBCREB3L2 + PPARGCREB3L2 + FUSCREBBP + KAT6ADAZAP1 + MEF2DELL + MLLEPS15 + MLLERG + EWSR1ERG + FUSERG + TMPRSS2ETV5 + TMPRSS2ETV6 + ABL1ETV6 + NTRK3ETV6 + PAX5EWSR1 + FLI1EWSR1 + WT1FOXO1 + PAX3FOXP1 + PAX5FRYL + MLLGAS7 + MLLGMPS + MLLGOLGA5 + RETHOOK3 + RETHOXC13 + NUP98HOXD13 + NUP98MECOM + RUNX1MKL1 + RBM15MLL + MLLT1MLL + MLLT4MLL + MLLT10MLL + PICALMMLLT10 + PICALMNCOA1 + PAX3NIN + PDGFRBNPM1 + RARANRG1 + ODZ4NTRK1 + TFGNUMA1 + RARANUP98 + PHF23PAX5 + ZNF521PBX1 + TCF3RET + TRIM27ROS1 + SLC34A2PML + RARAPRKAR1A + RARAPRKAR1A + RETRUNX1 + RUNX1T1RUNX1 + SH3D19	Cytoscape Web will replace the contents your graph	PPI Properties: Click on nodes or edges
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Statistics and Network structure information

Statistic of PPI Value(s) The number of interactors (fusion and proteins) 38 The number (and %) of the onco-proteins 18 (47.37 %) The number (and %) of the tumor suppressors 8 (21.05 %) Total number of binary PPIs (saturation %) 184 (26.17 %) The number (and %) of affected PPIs 38 (20.65 %) The number of possible different fusions 10 PPI diameter 2 PPI radius 1 The average degree of PPI 8.684 Assortativity coefficient -0.2821 The network average Clustering coefficient 0.601 The number (and %) of a zero Clustering coefficients 1 (2.63 %) The number (and %) of a zero Betweenness Centrality 3 (7.89 %)

ACTIVE INTERACTORS

List of the fusions
PPI for parental proteins: AHR	All fusions
Proteins found in more fusions	TAF4 (see 4 fusions); EP300 (see 1 fusions); NCOA1 (see 2 fusions); AHR (see 1 fusions); DDB1 (see 2 fusions); HSP90AA1 (see 2 fusions); IVNS1ABP (see 2 fusions); STUB1 (see 1 fusions); SP1 (see 1 fusions);

List of active interactors

#	Name	Type	Number of PPI (degree)	Clustering Coefficient	Betweenness Centrality	Domains (Pfam, InterPro, SMART): description
1	AHR	parental protein	38	0.192	639.368	HLH (PF00010, IPR011598, SM00353): Helix-loop-helix DNA-binding domain PAS (PF00989, IPR013767, SM00091): PAS fold PAS_3 (PF08447, IPR013655): PAS fold PAS_4 (PF08448, IPR013656): PAS fold
2	AIP	suppressor	5	0.600	3.400	FKBP_C (PF00254, IPR001179): FKBP-type peptidyl-prolyl cis-trans isomerase TPR_1 (PF00515, IPR001440): Tetratricopeptide repeat TPR_2 (PF07719, IPR013105): Tetratricopeptide repeat
3	AR	oncoprotein	20	0.351	65.526	Androgen_recep (PF02166, IPR001103): Androgen receptor zf-C4 (PF00105, IPR001628, SM00399): Zinc finger, C4 type (two domains) Hormone_recep (PF00104, IPR000536, SM00430): Ligand-binding domain of nuclear hormone receptor
4	ARNT	oncoprotein	13	0.359	30.710	HLH (PF00010, IPR011598, SM00353): Helix-loop-helix DNA-binding domain PAS (PF00989, IPR013767, SM00091): PAS fold PAS_11 (PF14598): PAS domain PRAS (PF15798, IPR026682): Proline-rich AKT1 substrate 1
5	ARNTL	suppressor	3	0.667	0.333	HLH (PF00010, IPR011598, SM00353): Helix-loop-helix DNA-binding domain PAS (PF00989, IPR013767, SM00091): PAS fold PAS_11 (PF14598): PAS domain
6	BRCA1	suppressor	18	0.434	41.352	BRCT (PF00533, IPR001357, SM00292): BRCA1 C Terminus (BRCT) domain zf-C3HC4 (PF00097, IPR018957): Zinc finger, C3HC4 type (RING finger) BRCT_assoc (PF12820, IPR025994): Serine-rich domain associated with BRCT
7	CCNT1	oncoprotein	5	0.667	0.800	Cyclin_N (PF00134, IPR006671): Cyclin, N-terminal domain SelP_N (PF04592, IPR007671): Selenoprotein P, N terminal region RP-C_C (PF11800, IPR021760): Replication protein C C-terminal region CENP-Q (PF13094, IPR025212): CENP-Q, a CENPA-CAD centromere complex subunit MDFI (PF15316, IPR026134): MyoD family inhibitor
8	CTNNB1	oncoprotein	9	0.667	5.708	Arm (PF00514, IPR000225, SM00185): Armadillo/beta-catenin-like repeat Atx10homo_assoc (PF09759, IPR019156): Spinocerebellar ataxia type 10 protein domain DUF3361 (PF11841, IPR024574): Domain of unknown function (DUF3361) HEAT_EZ (PF13513): HEAT-like repeat
9	DAP3	interactor	5	0.833	0.133	DAP3 (PF10236, IPR019368): Mitochondrial ribosomal death-associated protein 3
10	DDB1	protein found in more fusions	6	0.700	2.667	CPSF_A (PF03178, IPR004871): CPSF A subunit region MMS1_N (PF10433): Mono-functional DNA-alkylating methyl methanesulfonate N-term
11	EP300	oncoprotein	17	0.467	40.375	Creb_binding (PF09030, IPR014744): Creb binding DUF902 (PF06001, IPR010303): Domain of Unknown Function (DUF902) Forkhead_N (PF08430, IPR013638): Forkhead N-terminal region KIX (PF02172, IPR003101): KIX domain RR_TM4-6 (PF06459, IPR009460): Ryanodine Receptor TM 4-6 TPX2 (PF06886, IPR027329): Targeting protein for Xklp2 (TPX2) zf-TAZ (PF02135, IPR000197, SM00551): TAZ zinc finger HAT_KAT11 (PF08214, IPR013178): Histone acetylation protein Bromodomain (PF00439, IPR001487, SM00297): Bromodomain ZZ (PF00569, IPR000433, SM00291): Zinc finger, ZZ type
12	ESR1	suppressor	21	0.316	83.793	Oest_recep (PF02159, IPR001292): Oestrogen receptor zf-C4 (PF00105, IPR001628, SM00399): Zinc finger, C4 type (two domains) Hormone_recep (PF00104, IPR000536, SM00430): Ligand-binding domain of nuclear hormone receptor ESR1_C (PF12743, IPR024736): Oestrogen-type nuclear receptor final C-terminal
13	FOXA1	suppressor	2	1.000	0	Forkhead_N (PF08430, IPR013638): Forkhead N-terminal region HNF_C (PF09354, IPR018533): HNF3 C-terminal domain Forkhead (PF00250, IPR001766, SM00339): Forkhead domain
14	GNA13	interactor	2	1.000	0	G-alpha (PF00503, IPR001019, SM00275): G-protein alpha subunit
15	GTF2F1	interactor	8	0.500	7.042	TFIIF_alpha (PF05793, IPR008851): Transcription initiation factor IIF, alpha subunit (TFIIF-alpha)
16	GTF2F2	interactor	7	0.571	4.701	TFIIF_beta (PF02270, IPR003196): Transcription initiation factor IIF, beta subunit
17	HSP90AA1	oncoprotein	13	0.379	29.252	HATPase_c (PF02518, IPR003594, SM00387): Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HSP90 (PF00183, IPR001404): Hsp90 protein
18	IVNS1ABP	protein found in more fusions	2	0	0	BACK (PF07707, IPR011705, SM00875): BTB And C-terminal Kelch BTB (PF00651, IPR013069, SM00225): BTB/POZ domain Kelch_1 (PF01344, IPR006652, SM00612): Kelch motif
19	MAF	oncoprotein	4	0.667	0.500	bZIP_Maf (PF03131, IPR004826): bZIP Maf transcription factor Maf_N (PF08383, IPR013592): Maf N-terminal region NUDE_C (PF04880, IPR006964): NUDE protein, C-terminal conserved region Sporozoite_P67 (PF05642, IPR008845): Sporozoite P67 surface antigen TraT (PF05818, IPR008874): Enterobacterial TraT complement resistance protein Metal_resist (PF13801, IPR025961): Heavy-metal resistance
20	NCOA1	oncoprotein	10	0.722	2.668	DUF1518 (PF07469, IPR010011, SM01151): Domain of unknown function (DUF1518) HLH (PF00010, IPR011598, SM00353): Helix-loop-helix DNA-binding domain Nuc_rec_co-act (PF08815, IPR014920): Nuclear receptor coactivator PAS (PF00989, IPR013767, SM00091): PAS fold PAS_3 (PF08447, IPR013655): PAS fold SRC-1 (PF08832, IPR014935): Steroid receptor coactivator PAS_11 (PF14598): PAS domain DUF4927 (PF16279, IPR032565): Domain of unknown function (DUF4927) NCOA_u2 (PF16665): Unstructured region on nuclear receptor coactivator protein
21	NCOA2	oncoprotein	10	0.511	13.204	DUF1518 (PF07469, IPR010011, SM01151): Domain of unknown function (DUF1518) HLH (PF00010, IPR011598, SM00353): Helix-loop-helix DNA-binding domain Nuc_rec_co-act (PF08815, IPR014920): Nuclear receptor coactivator PAS (PF00989, IPR013767, SM00091): PAS fold PAS_3 (PF08447, IPR013655): PAS fold SRC-1 (PF08832, IPR014935): Steroid receptor coactivator PAS_11 (PF14598): PAS domain DUF4927 (PF16279, IPR032565): Domain of unknown function (DUF4927) NCOA_u2 (PF16665): Unstructured region on nuclear receptor coactivator protein
22	NCOA7	interactor	3	0.667	0.222	GRAM (PF02893, IPR004182, SM00568): GRAM domain LysM (PF01476, IPR018392, SM00257): LysM domain TLD (PF07534, IPR006571, SM00584): TLD Bclt (PF15318, IPR029296): Putative Bcl-2 like protein of testis SUIM_assoc (PF16619): Unstructured region C-term to UIM in Ataxin3
23	NCOR2	oncoprotein	9	0.639	5.160	CAP_N (PF01213, IPR013992): Adenylate cyclase associated (CAP) N terminal MAS20 (PF02064, IPR002056): MAS20 protein import receptor OAD_gamma (PF04277, IPR005899): Oxaloacetate decarboxylase, gamma chain PSK (PF06404, IPR009438): Phytosulfokine precursor protein (PSK) SRP-alpha_N (PF04086, IPR007222): Signal recognition particle, alpha subunit, N-terminal DUF2360 (PF10152, IPR019309): Predicted coiled-coil domain-containing protein (DUF2360) Gti1_Pac2 (PF09729, IPR018608): Gti1/Pac2 family PRCC (PF10253, IPR018800): Mitotic checkpoint regulator, MAD2B-interacting Myb_DNA-binding (PF00249, IPR001005, SM00717): Myb-like DNA-binding domain Spt20 (PF12090, IPR021950): Spt20 family DUF3915 (PF13054, IPR025026): Protein of unknown function (DUF3915) DUF4518 (PF15008, IPR026698): Domain of unknown function (DUF4518) GPS2_interact (PF15784, IPR031557): G-protein pathway suppressor 2-interacting domain DUF4820 (PF16091, IPR032150): Domain of unknown function (DUF4820)
24	NEDD8	interactor	4	0.667	0.667	ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
25	NFE2L2	oncoprotein	5	0.600	2.556	bZIP_Maf (PF03131, IPR004826): bZIP Maf transcription factor
26	NR2F1	oncoprotein	4	0.833	0.286	zf-C4 (PF00105, IPR001628, SM00399): Zinc finger, C4 type (two domains) Hormone_recep (PF00104, IPR000536, SM00430): Ligand-binding domain of nuclear hormone receptor
27	NRIP1	oncoprotein	4	0.833	0.286	ALMT (PF11744, IPR020966): Aluminium activated malate transporter NRIP1_repr_1 (PF15687, IPR031405): Nuclear receptor-interacting protein 1 repression 1 NRIP1_repr_2 (PF15688, IPR031406): Nuclear receptor-interacting protein 1 repression 2 NRIP1_repr_3 (PF15689, IPR031407): Nuclear receptor-interacting protein 1 repression 3 NRIP1_repr_4 (PF15690, IPR031408): Nuclear receptor-interacting protein 1 repression 4
28	PTGES3	interactor	8	0.619	3.937	CS (PF04969, IPR007052): CS domain Pkinase_C (PF00433, IPR017892): Protein kinase C terminal domain
29	RB1	suppressor	8	0.786	1.579	RB_A (PF01858, IPR002720): Retinoblastoma-associated protein A domain RB_B (PF01857, IPR002719): Retinoblastoma-associated protein B domain Rb_C (PF08934, IPR015030): Rb C-terminal domain DUF3452 (PF11934, IPR024599): Domain of unknown function (DUF3452) DUF4592 (PF15262, IPR028030): Domain of unknown function (DUF4592)
30	RELA	oncoprotein	13	0.515	18.463	DEC-1_N (PF04625, IPR006719): DEC-1 protein, N-terminal region RHD_DNA_bind (PF00554, IPR011539): Rel homology DNA-binding domain RHD_dimer (PF16179, IPR032397): Rel homology dimerisation domain
31	SMARCA4	suppressor	10	0.644	6.391	DUF1840 (PF08895, IPR014991): Domain of unknown function (DUF1840) HSA (PF07529, IPR014012, SM00573): HSA QLQ (PF08880, IPR014978, SM00951): QLQ SNF2_N (PF00176, IPR000330): SNF2 family N-terminal domain BRK (PF07533, IPR006576, SM00592): BRK domain Bromodomain (PF00439, IPR001487, SM00297): Bromodomain Helicase_C (PF00271, IPR001650, SM00490): Helicase conserved C-terminal domain Spt5_N (PF11942, IPR022581): Spt5 transcription elongation factor, acidic N-terminal DUF4065 (PF13274, IPR025272): Protein of unknown function (DUF4065) SnAC (PF14619, IPR029295): Snf2-ATP coupling, chromatin remodelling complex WRNPLPNID (PF15017): Putative WW-binding domain and destruction box
32	SP1	protein found in more fusions	16	0.514	26.228	zf-Di19 (PF05605, IPR008598): Drought induced 19 protein (Di19), zinc-binding Herpes_capsid (PF06112, IPR009299): Gammaherpesvirus capsid protein zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type Miga (PF10265, IPR019392): Mitoguardin zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain FoP_duplication (PF13865, IPR025715): C-terminal duplication domain of Friend of PRMT1
33	STUB1	suppressor	7	0.800	0.919	U-box (PF04564, IPR003613, SM00504): U-box domain ANAPC3 (PF12895): Anaphase-promoting complex, cyclosome, subunit 3 TPR_11 (PF13414, IPR011990): TPR repeat TPR_20 (PF14561): Tetratricopeptide repeat
34	TAF4	protein found in more fusions	7	0.667	2.733	TAF4 (PF05236, IPR007900): Transcription initiation factor TFIID component TAF4 family TAFH (PF07531, IPR003894, SM00549): NHR1 homology to TAF TFIIA (PF03153, IPR004855): Transcription factor IIA, alpha/beta subunit DUF3729 (PF12526, IPR022202): Protein of unknown function (DUF3729)
35	TAF6	interactor	5	0.900	0.400	CAP_N (PF01213, IPR013992): Adenylate cyclase associated (CAP) N terminal TAF6_C (PF07571, IPR011442): TAF6 C-terminal HEAT repeat domain Spo0A_C (PF08769, IPR014879): Sporulation initiation factor Spo0A C terminal TAF (PF02969, IPR004823, SM00803): TATA box binding protein associated factor (TAF)
36	TAF9	interactor	6	0.667	3.067	TFIID-31kDa (PF02291, IPR003162): Transcription initiation factor IID, 31kD subunit DUF2457 (PF10446, IPR018853): Protein of unknown function (DUF2457)
37	TBP	interactor	14	0.474	23.202	TBP (PF00352, IPR000814): Transcription factor TFIID (or TATA-binding protein, TBP) EPL1 (PF10513, IPR019542): Enhancer of polycomb-like Med3 (PF11593, IPR020998): Mediator complex subunit 3 fungal
38	XPO1	interactor	8	0.429	8.371	CRM1_C (PF08767, IPR014877, SM01102): CRM1 C terminal Hydrolase_3 (PF08282, IPR023214): haloacid dehalogenase-like hydrolase IBN_N (PF03810, IPR001494, SM00913): Importin-beta N-terminal domain Xpo1 (PF08389, IPR013598): Exportin 1-like protein Vac14_Fab1_bd (PF12755, IPR032878): Vacuolar 14 Fab1-binding region

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