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Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)125
The number (and %) of the onco-proteins35 (28.00 %)
The number (and %) of the tumor suppressors25 (20.00 %)
Total number of binary PPIs (saturation %)666 (8.59 %)
The number (and %) of affected PPIs126 (18.92 %)
The number of possible different fusions33
PPI diameter4
PPI radius2
The average degree of PPI9.632
Assortativity coefficient-0.2064
The network average Clustering coefficient0.364
The number (and %) of a zero Clustering coefficients15 (12.00 %)
The number (and %) of a zero Betweenness Centrality16 (12.80 %)

ACTIVE INTERACTORS


List of the fusions

PPI for parental proteins: RUNX1T1,DYRK1A All fusions
Proteins found in more fusions RUNX1T1/RUNX1 (see 93 fusions); CTBP1 (see 2 fusions); EP300/ETS1 (see 1 fusions); APP (see 5 fusions); VDR (see 2 fusions); YWHAG (see 1 fusions); CBFA2T2 (see 1 fusions); TRIM33 (see 1 fusions); SH3GL2 (see 1 fusions); HIPK2 (see 1 fusions); SFN (see 1 fusions); TCF12 (see 2 fusions); KPNB1 (see 2 fusions); BCL6 (see 2 fusions); RUNX1/CBFA2T2 (see 2 fusions); GSE1 (see 2 fusions); CREB3L1 (see 1 fusions); RUNX1T1 (see 1 fusions); MAP3K1 (see 1 fusions); PARK2 (see 1 fusions); RUNX1 (see 2 fusions); CREBBP (see 6 fusions); UBE2E2 (see 1 fusions); TCF3 (see 4 fusions); SRSF1 (see 1 fusions); ATN1 (see 1 fusions); TROAP (see 1 fusions); EPS8 (see 1 fusions); EP300 (see 1 fusions); MAP3K5 (see 1 fusions); ZBTB16 (see 4 fusions); SMAD3 (see 3 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 RUNX1T1parental protein580.0753914.724NHR2 (PF08788, IPR014896): NHR2 domain like
TAFH (PF07531, IPR003894, SM00549): NHR1 homology to TAF
zf-MYND (PF01753, IPR002893): MYND finger
DUF3731 (PF12531, IPR021030): DNA-K related protein
2 DYRK1Aparental protein680.0795337.312DUF755 (PF05501, IPR008474): Domain of unknown function (DUF755)
Filament_head (PF04732, IPR006821): Intermediate filament head (DNA binding) region
Pkinase (PF00069, IPR000719): Protein kinase domain
FAM199X (PF15814, IPR029672): Protein family FAM199X
3 ABCD3interactor40.6670.751ABC_membrane_2 (PF06472, IPR010509): ABC transporter transmembrane region 2
ABC_tran (PF00005, IPR003439): ABC transporter
4 ABI3interactor40.6671.738Abi_HHR (PF07815, IPR012849): Abl-interactor HHR
Drf_FH1 (PF06346, IPR009408): Formin Homology Region 1
SH3_9 (PF14604, IPR001452): Variant SH3 domain
5 AMPHoncoprotein40.6672.356BAR (PF03114, IPR004148, SM00721): BAR domain
SH3_9 (PF14604, IPR001452): Variant SH3 domain
PBP_N (PF17093, IPR031375): Penicillin-binding protein N-terminus
6 APPprotein found in more fusions210.084648.294APP_N (PF02177, IPR015849, SM00006): Amyloid A4 N-terminal heparin-binding
Beta-APP (PF03494, IPR013803): Beta-amyloid peptide (beta-APP)
BUD22 (PF09073, IPR015158): BUD22
IncA (PF04156, IPR007285): IncA protein
Kunitz_BPTI (PF00014, IPR002223, SM00131): Kunitz/Bovine pancreatic trypsin inhibitor domain
APP_amyloid (PF10515, IPR019543): beta-amyloid precursor protein C-terminus
APP_Cu_bd (PF12924, IPR011178): Copper-binding of amyloid precursor, CuBD
APP_E2 (PF12925, IPR024329): E2 domain of amyloid precursor protein
7 ATN1protein found in more fusions40.33346.180Atrophin-1 (PF03154, IPR002951): Atrophin-1 family
8 BARD1suppressor140.231113.285BRCT (PF00533, IPR001357, SM00292): BRCA1 C Terminus (BRCT) domain
Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies)
Ank_5 (PF13857): Ankyrin repeats (many copies)
zf-RING_6 (PF14835): zf-RING of BARD1-type protein
BRCT_2 (PF16589, IPR001357): BRCT domain, a BRCA1 C-terminus domain
9 BCL6oncoprotein120.65521.351BTB (PF00651, IPR013069, SM00225): BTB/POZ domain
zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type
zf-C2H2_jaz (PF12171, IPR022755): Zinc-finger double-stranded RNA-binding
DZR (PF12773, IPR025874): Double zinc ribbon
zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain
zf-C2HE (PF16278, IPR032566): C2HE / C2H2 / C2HC zinc-binding finger
10 BRCA1suppressor210.263326.750BRCT (PF00533, IPR001357, SM00292): BRCA1 C Terminus (BRCT) domain
zf-C3HC4 (PF00097, IPR018957): Zinc finger, C3HC4 type (RING finger)
BRCT_assoc (PF12820, IPR025994): Serine-rich domain associated with BRCT
11 C19orf57interactor305.520DUF4671 (PF15710, IPR031441): Domain of unknown function (DUF4671)
12 CBFA2T2protein found in more fusions130.318120.449NHR2 (PF08788, IPR014896): NHR2 domain like
Remorin_C (PF03763, IPR005516): Remorin, C-terminal region
TAFH (PF07531, IPR003894, SM00549): NHR1 homology to TAF
zf-MYND (PF01753, IPR002893): MYND finger
BBS1 (PF14779, IPR032728): Ciliary BBSome complex subunit 1
13 CBFA2T3suppressor120.42432.529NHR2 (PF08788, IPR014896): NHR2 domain like
TAFH (PF07531, IPR003894, SM00549): NHR1 homology to TAF
zf-MYND (PF01753, IPR002893): MYND finger
Efg1 (PF10153, IPR019310): rRNA-processing protein Efg1
PRIMA1 (PF16101): Proline-rich membrane anchor 1
14 CCDC36interactor40.33342.400DUF4700 (PF15771, IPR031529): Domain of unknown function (DUF4700)
15 CCDC8interactor90.42926.158Borrelia_P83 (PF05262, IPR007926): Borrelia P83/100 protein
SRP-alpha_N (PF04086, IPR007222): Signal recognition particle, alpha subunit, N-terminal
PNMA (PF14893, IPR026523): PNMA
16 CCNA2oncoprotein100.47221.330Cyclin_C (PF02984, IPR004367): Cyclin, C-terminal domain
Cyclin_N (PF00134, IPR006671): Cyclin, N-terminal domain
Cyclin_N2 (PF16500, IPR032447): N-terminal region of cyclin_N
17 CCNL2interactor30.3336.975Cyclin_C (PF02984, IPR004367): Cyclin, C-terminal domain
Cyclin_N (PF00134, IPR006671): Cyclin, N-terminal domain
K_channel_TID (PF07941, IPR012897): Potassium channel Kv1.4 tandem inactivation domain
PRP38_assoc (PF12871, IPR024767): Pre-mRNA-splicing factor 38-associated hydrophilic C-term
18 CEP170P1interactor50.50033.708NA
19 CLASRPinteractor50.30015.160Corona_nucleoca (PF00937, IPR001218): Coronavirus nucleocapsid protein
OAD_gamma (PF04277, IPR005899): Oxaloacetate decarboxylase, gamma chain
Pap_E4 (PF02711, IPR003861): E4 protein
RAP1 (PF07218, IPR009864): Rhoptry-associated protein 1 (RAP-1)
S-antigen (PF05756, IPR008825): S-antigen protein
Transformer (PF06495, IPR010519): Fruit fly transformer protein
DRY_EERY (PF09750, IPR019147, SM01141): Alternative splicing regulator
LRRFIP (PF09738, IPR019139): LRRFIP family
DUF4554 (PF15091, IPR028040): Domain of unknown function (DUF4554)
20 CLTConcoprotein120.197115.399Clathrin-link (PF09268, IPR015348): Clathrin, heavy-chain linker
Clathrin_propel (PF01394, IPR022365): Clathrin propeller repeat
Clathrin (PF00637, IPR000547, SM00299): Region in Clathrin and VPS
Clathrin_H_link (PF13838): Clathrin-H-link
21 CPSF7interactor70.19055.016CAP_N (PF01213, IPR013992): Adenylate cyclase associated (CAP) N terminal
RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
PRP38_assoc (PF12871, IPR024767): Pre-mRNA-splicing factor 38-associated hydrophilic C-term
PRIMA1 (PF16101): Proline-rich membrane anchor 1
22 CREB3L1suppressor200bZIP_1 (PF00170, IPR004827): bZIP transcription factor
ELP6 (PF09807, IPR018627): Elongation complex protein 6
23 CREBBPsuppressor270.329289.387Creb_binding (PF09030, IPR014744): Creb binding
DUF902 (PF06001, IPR010303): Domain of Unknown Function (DUF902)
Forkhead_N (PF08430, IPR013638): Forkhead N-terminal region
KIX (PF02172, IPR003101): KIX domain
MAS20 (PF02064, IPR002056): MAS20 protein import receptor
TPX2 (PF06886, IPR027329): Targeting protein for Xklp2 (TPX2)
zf-TAZ (PF02135, IPR000197, SM00551): TAZ zinc finger
ANAPC_CDC26 (PF10471, IPR018860): Anaphase-promoting complex APC subunit CDC26
HAT_KAT11 (PF08214, IPR013178): Histone acetylation protein
Bromodomain (PF00439, IPR001487, SM00297): Bromodomain
ZZ (PF00569, IPR000433, SM00291): Zinc finger, ZZ type
DUF3729 (PF12526, IPR022202): Protein of unknown function (DUF3729)
DUF4834 (PF16118, IPR032272): Domain of unknown function (DUF4834)
24 CTBP1protein found in more fusions200.439148.9032-Hacid_dh_C (PF02826, IPR006140): D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain
Cellsynth_D (PF03500, IPR022798): Cellulose synthase subunit D
25 DCAF7interactor150.248130.780WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
26 DNM1interactor50.6679.697Dynamin_M (PF01031, IPR000375): Dynamin central region
GED (PF02212, IPR003130, SM00302): Dynamin GTPase effector domain
PH (PF00169, IPR001849, SM00233): PH domain
Dynamin_N (PF00350, IPR001401, SM00053): Dynamin family
27 DNMT1suppressor110.62222.805BAH (PF01426, IPR001025, SM00439): BAH domain
DMAP_binding (PF06464, IPR010506, SM01137): DMAP1-binding Domain
DNA_methylase (PF00145, IPR001525): C-5 cytosine-specific DNA methylase
zf-CXXC (PF02008, IPR002857): CXXC zinc finger domain
DNMT1-RFD (PF12047, IPR022702): Cytosine specific DNA methyltransferase replication foci domain
28 DYNLL1interactor110.222135.792Dynein_light (PF01221, IPR001372): Dynein light chain type 1
29 DYNLL2interactor60.200101.985Dynein_light (PF01221, IPR001372): Dynein light chain type 1
30 EFHC2interactor21.0000DUF1126 (PF06565, IPR010554): DUF1126 PH-like domain
EF-hand_6 (PF13405, IPR002048): EF-hand domain
31 EGLN2interactor3022.0222OG-FeII_Oxy_3 (PF13640, IPR005123): 2OG-Fe(II) oxygenase superfamily
32 ELAVL1oncoprotein330.161798.605RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
33 EP300oncoprotein290.291383.968Creb_binding (PF09030, IPR014744): Creb binding
DUF902 (PF06001, IPR010303): Domain of Unknown Function (DUF902)
Forkhead_N (PF08430, IPR013638): Forkhead N-terminal region
KIX (PF02172, IPR003101): KIX domain
RR_TM4-6 (PF06459, IPR009460): Ryanodine Receptor TM 4-6
TPX2 (PF06886, IPR027329): Targeting protein for Xklp2 (TPX2)
zf-TAZ (PF02135, IPR000197, SM00551): TAZ zinc finger
HAT_KAT11 (PF08214, IPR013178): Histone acetylation protein
Bromodomain (PF00439, IPR001487, SM00297): Bromodomain
ZZ (PF00569, IPR000433, SM00291): Zinc finger, ZZ type
34 EPS8oncoprotein200DEC-1_N (PF04625, IPR006719): DEC-1 protein, N-terminal region
Mito_fiss_reg (PF05308, IPR007972): Mitochondrial fission regulator
PTB (PF08416, IPR013625): Phosphotyrosine-binding domain
SAM_PNT (PF02198, IPR003118, SM00251): Sterile alpha motif (SAM)/Pointed domain
SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
35 ETS1oncoprotein100.40045.613Ets (PF00178, IPR000418, SM00413): Ets-domain
SAM_PNT (PF02198, IPR003118, SM00251): Sterile alpha motif (SAM)/Pointed domain
36 FAM117Aoncoprotein100FAM117 (PF15388, IPR026642): Protein Family FAM117
37 FAM117Binteractor40.5009.751FAM117 (PF15388, IPR026642): Protein Family FAM117
PRIMA1 (PF16101): Proline-rich membrane anchor 1
38 FAM53Cinteractor60.46711.991FAM53 (PF15242, IPR029356): Family of FAM53
39 FNTAinteractor21.0000CAP_N (PF01213, IPR013992): Adenylate cyclase associated (CAP) N terminal
PPTA (PF01239, IPR002088): Protein prenyltransferase alpha subunit repeat
TPR_14 (PF13428): Tetratricopeptide repeat
DUF4219 (PF13961, IPR025314): Domain of unknown function (DUF4219)
40 FNTBinteractor50.4005.333Prenyltrans (PF00432, IPR001330): Prenyltransferase and squalene oxidase repeat
41 FOXR2interactor100Forkhead (PF00250, IPR001766, SM00339): Forkhead domain
42 GFI1oncoprotein31.0000zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type
zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain
zf-C2H2_4 (PF13894): C2H2-type zinc finger
43 GLCCI1interactor30.6671.510Herpes_LMP2 (PF07415, IPR010881): Gammaherpesvirus latent membrane protein (LMP2) protein
Pap_E4 (PF02711, IPR003861): E4 protein
DUF2076 (PF09849, IPR018648): Uncharacterized protein conserved in bacteria (DUF2076)
FAM117 (PF15388, IPR026642): Protein Family FAM117
44 GSE1oncoprotein80.57115.302CENP-B_dimeris (PF09026, IPR015115): Centromere protein B dimerisation domain
DUF719 (PF05334, IPR007998): Protein of unknown function (DUF719)
DUF972 (PF06156, IPR010377): Protein of unknown function (DUF972)
FYDLN_acid (PF09538, IPR012644): Protein of unknown function (FYDLN_acid)
Pheromone (PF08015, IPR012597): Fungal mating-type pheromone
Plasmodium_Vir (PF05795, IPR008780): Plasmodium vivax Vir protein
Trypan_PARP (PF05887, IPR008882): Procyclic acidic repetitive protein (PARP)
DUF3736 (PF12540, IPR022207): Protein of unknown function (DUF3736)
AAA_11 (PF13086): AAA domain
DUF4228 (PF14009, IPR025322): Domain of unknown function (DUF4228)
45 HDAC1suppressor270.268383.761FSAP_sig_propep (PF03032, IPR004275): Frog skin active peptide family signal and propeptide
Hist_deacetyl (PF00850, IPR023801): Histone deacetylase domain
46 HDAC2suppressor290.246407.525Hist_deacetyl (PF00850, IPR023801): Histone deacetylase domain
NARP1 (PF12569, IPR021183): NMDA receptor-regulated protein 1
47 HDAC3suppressor180.316191.310Hist_deacetyl (PF00850, IPR023801): Histone deacetylase domain
48 HDAC8interactor50.20029.099DNase-RNase (PF02577, IPR003729): Bifunctional nuclease
Hist_deacetyl (PF00850, IPR023801): Histone deacetylase domain
49 HIPK2suppressor80.61916.929Kdo (PF06293, IPR010440): Lipopolysaccharide kinase (Kdo/WaaP) family
Pkinase (PF00069, IPR000719): Protein kinase domain
50 HIST1H2BBinteractor70.57116.500Histone (PF00125, IPR007125): Core histone H2A/H2B/H3/H4
51 HIST1H3Ainteractor150.308137.216Histone (PF00125, IPR007125): Core histone H2A/H2B/H3/H4
52 HIST1H4Ainteractor110.54575.399CENP-T_C (PF15511): Centromere kinetochore component CENP-T histone fold
53 HOMER3interactor50.16755.955COG2 (PF06148, IPR024602): COG (conserved oligomeric Golgi) complex component, COG2
MerR-DNA-bind (PF09278, IPR015358): MerR, DNA binding
WH1 (PF00568, IPR000697, SM00461): WH1 domain
bZIP_2 (PF07716, IPR004827, SM00338): Basic region leucine zipper
54 ID2oncoprotein90.28641.738HLH (PF00010, IPR011598, SM00353): Helix-loop-helix DNA-binding domain
55 ISG15suppressor50.30014.147ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
56 KIAA0232interactor100DUF4603 (PF15376, IPR027871): Domain of unknown function (DUF4603)
57 KPNA1interactor60.46711.734Arm (PF00514, IPR000225, SM00185): Armadillo/beta-catenin-like repeat
IBB (PF01749, IPR002652): Importin beta binding domain
Arm_3 (PF16186, IPR032413): Atypical Arm repeat
58 KPNB1protein found in more fusions90.17962.314Arm (PF00514, IPR000225, SM00185): Armadillo/beta-catenin-like repeat
HEAT (PF02985, IPR000357): HEAT repeat
IBN_N (PF03810, IPR001494, SM00913): Importin-beta N-terminal domain
V-ATPase_H_C (PF11698, IPR011987): V-ATPase subunit H
CLASP_N (PF12348, IPR024395): CLASP N terminal
Cnd1 (PF12717, IPR032682): non-SMC mitotic condensation complex subunit 1
HEAT_EZ (PF13513): HEAT-like repeat
59 LATS2suppressor70.53310.298Pkinase (PF00069, IPR000719): Protein kinase domain
Pkinase_C (PF00433, IPR017892): Protein kinase C terminal domain
UBA (PF00627, IPR000449, SM00165): UBA/TS-N domain
60 LIN52interactor21.0000LIN52 (PF10044, IPR018737): Retinal tissue protein
61 LIPHinteractor204.980Lipase (PF00151, IPR013818): Lipase
62 LPXNinteractor100LIM (PF00412, IPR001781, SM00132): LIM domain
zf-dskA_traR (PF01258, IPR000962): Prokaryotic dksA/traR C4-type zinc finger
63 LZTS2suppressor60.333335.646CAP_N (PF01213, IPR013992): Adenylate cyclase associated (CAP) N terminal
DUF1127 (PF06568, IPR009506): Domain of unknown function (DUF1127)
Fez1 (PF06818): Fez1
ADIP (PF11559, IPR021622): Afadin- and alpha -actinin-Binding
DUF4250 (PF14056, IPR025346): Domain of unknown function (DUF4250)
64 MAP3K1oncoprotein80.52415.614zf-Di19 (PF05605, IPR008598): Drought induced 19 protein (Di19), zinc-binding
Pkinase (PF00069, IPR000719): Protein kinase domain
zf-RING_2 (PF13639, IPR001841, SM00184): Ring finger domain
Phostensin_N (PF13916, IPR025903): PP1-regulatory protein, Phostensin N-terminal
65 MAP3K5oncoprotein60.50016.167Pkinase (PF00069, IPR000719): Protein kinase domain
DUF4071 (PF13281, IPR025136): Domain of unknown function (DUF4071)
66 MED23interactor140.330123.619Med23 (PF11573, IPR021629): Mediator complex subunit 23
67 MEOX2interactor70.14358.937Homeobox (PF00046, IPR001356, SM00389): Homeobox domain
68 MID2interactor80.28632.249fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain
SPRY (PF00622, IPR003877, SM00449): SPRY domain
zf-B_box (PF00643, IPR000315, SM00336): B-box zinc finger
PRY (PF13765, IPR006574, SM00589): SPRY-associated domain
zf-RING_UBOX (PF13445, IPR027370): RING-type zinc-finger
CEBP_ZZ (PF16366, IPR032296): Cytoplasmic polyadenylation element-binding protein ZZ domain
APC_u15 (PF16636): Unstructured region on APC between APC_crr regions 5 and 6
69 MOV10interactor120.242118.153AAA_12 (PF13087): AAA domain
AAA_30 (PF13604): AAA domain
70 NCOR1oncoprotein180.39282.044BES1_N (PF05687, IPR008540): BES1/BZR1 plant transcription factor, N-terminal
Lamp (PF01299, IPR002000): Lysosome-associated membrane glycoprotein (Lamp)
MAS20 (PF02064, IPR002056): MAS20 protein import receptor
Neur_chan_memb (PF02932, IPR006029): Neurotransmitter-gated ion-channel transmembrane region
Eapp_C (PF10238, IPR019370): E2F-associated phosphoprotein
Hid1 (PF12722): High-temperature-induced dauer-formation protein
Myb_DNA-binding (PF00249, IPR001005, SM00717): Myb-like DNA-binding domain
DUF3915 (PF13054, IPR025026): Protein of unknown function (DUF3915)
GPS2_interact (PF15784, IPR031557): G-protein pathway suppressor 2-interacting domain
DUF4834 (PF16118, IPR032272): Domain of unknown function (DUF4834)
RBR (PF17208): RNA binding Region
71 NCOR2oncoprotein160.57539.173CAP_N (PF01213, IPR013992): Adenylate cyclase associated (CAP) N terminal
MAS20 (PF02064, IPR002056): MAS20 protein import receptor
OAD_gamma (PF04277, IPR005899): Oxaloacetate decarboxylase, gamma chain
PSK (PF06404, IPR009438): Phytosulfokine precursor protein (PSK)
SRP-alpha_N (PF04086, IPR007222): Signal recognition particle, alpha subunit, N-terminal
DUF2360 (PF10152, IPR019309): Predicted coiled-coil domain-containing protein (DUF2360)
Gti1_Pac2 (PF09729, IPR018608): Gti1/Pac2 family
PRCC (PF10253, IPR018800): Mitotic checkpoint regulator, MAD2B-interacting
Myb_DNA-binding (PF00249, IPR001005, SM00717): Myb-like DNA-binding domain
Spt20 (PF12090, IPR021950): Spt20 family
DUF3915 (PF13054, IPR025026): Protein of unknown function (DUF3915)
DUF4518 (PF15008, IPR026698): Domain of unknown function (DUF4518)
GPS2_interact (PF15784, IPR031557): G-protein pathway suppressor 2-interacting domain
DUF4820 (PF16091, IPR032150): Domain of unknown function (DUF4820)
72 NECAB2interactor200ABM (PF03992, IPR007138): Antibiotic biosynthesis monooxygenase
EF-hand_7 (PF13499, IPR011992): EF-hand domain pair
73 NEUROG1interactor50.5008.206HLH (PF00010, IPR011598, SM00353): Helix-loop-helix DNA-binding domain
Transformer (PF06495, IPR010519): Fruit fly transformer protein
74 NTRK1oncoprotein300.167664.533I-set (PF07679, IPR013098): Immunoglobulin I-set domain
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
LRR_8 (PF13855, IPR001611): Leucine rich repeat
TPKR_C2 (PF16920, IPR031635): Tyrosine-protein kinase receptor C2 Ig-like domain
75 NXF1interactor160.105274.530NTF2 (PF02136, IPR002075): Nuclear transport factor 2 (NTF2) domain
Tap-RNA_bind (PF09162, IPR015245): Tap, RNA-binding
TAP_C (PF03943, IPR005637, SM00804): TAP C-terminal domain
LRR_8 (PF13855, IPR001611): Leucine rich repeat
76 OTUD4interactor30.3338.320OTU (PF02338, IPR003323): OTU-like cysteine protease
Presenilin (PF01080, IPR001108): Presenilin
Peptidase_C65 (PF10275, IPR019400): Peptidase C65 Otubain
77 PARK2suppressor90.32169.604IBR (PF01485, IPR002867, SM00647): IBR domain, a half RING-finger domain
ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
78 PCBD2interactor30.33311.712Pterin_4a (PF01329, IPR001533): Pterin 4 alpha carbinolamine dehydratase
79 PPP1R3Finteractor100CBM_21 (PF03370, IPR005036): Carbohydrate/starch-binding module (family 21)
K_channel_TID (PF07941, IPR012897): Potassium channel Kv1.4 tandem inactivation domain
80 PRDinteractor100NA
81 PRDM14interactor21.0000Desulfoferrod_N (PF06397, IPR004462): Desulfoferrodoxin, N-terminal domain
SET (PF00856, IPR001214, SM00317): SET domain
zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type
zf-C2H2_jaz (PF12171, IPR022755): Zinc-finger double-stranded RNA-binding
zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain
zf-C2H2_4 (PF13894): C2H2-type zinc finger
82 PRKACAinteractor120.303111.776Pkinase (PF00069, IPR000719): Protein kinase domain
83 PRKACBinteractor100.400121.844Pkinase (PF00069, IPR000719): Protein kinase domain
84 PRKAR1Asuppressor70.7333.940RIIa (PF02197, IPR003117, SM00394): Regulatory subunit of type II PKA R-subunit
cNMP_binding (PF00027, IPR000595, SM00100): Cyclic nucleotide-binding domain
85 PRKAR2Ainteractor90.278128.780RIIa (PF02197, IPR003117, SM00394): Regulatory subunit of type II PKA R-subunit
cNMP_binding (PF00027, IPR000595, SM00100): Cyclic nucleotide-binding domain
86 RAD54L2interactor30.33371.124SNF2_N (PF00176, IPR000330): SNF2 family N-terminal domain
Helicase_C (PF00271, IPR001650, SM00490): Helicase conserved C-terminal domain
FAM176 (PF14851): FAM176 family
ERCC3_RAD25_C (PF16203, IPR032438): ERCC3/RAD25/XPB C-terminal helicase
87 RB1suppressor160.367137.034RB_A (PF01858, IPR002720): Retinoblastoma-associated protein A domain
RB_B (PF01857, IPR002719): Retinoblastoma-associated protein B domain
Rb_C (PF08934, IPR015030): Rb C-terminal domain
DUF3452 (PF11934, IPR024599): Domain of unknown function (DUF3452)
DUF4592 (PF15262, IPR028030): Domain of unknown function (DUF4592)
88 RBL1suppressor110.41837.590RB_A (PF01858, IPR002720): Retinoblastoma-associated protein A domain
RB_B (PF01857, IPR002719): Retinoblastoma-associated protein B domain
Rb_C (PF08934, IPR015030): Rb C-terminal domain
DUF3452 (PF11934, IPR024599): Domain of unknown function (DUF3452)
89 RBL2suppressor80.39350.846CAP_N (PF01213, IPR013992): Adenylate cyclase associated (CAP) N terminal
Pap_E4 (PF02711, IPR003861): E4 protein
RB_A (PF01858, IPR002720): Retinoblastoma-associated protein A domain
RB_B (PF01857, IPR002719): Retinoblastoma-associated protein B domain
SLH (PF00395, IPR001119): S-layer homology domain
TFIIB (PF00382, IPR013150): Transcription factor TFIIB repeat
DUF3452 (PF11934, IPR024599): Domain of unknown function (DUF3452)
90 RBPJinteractor100.31161.702BTD (PF09270, IPR015350): Beta-trefoil DNA-binding domain
LAG1-DNAbind (PF09271, IPR015351): LAG1, DNA binding
TIG (PF01833, IPR002909): IPT/TIG domain
91 RFPL2interactor21.0000SPRY (PF00622, IPR003877, SM00449): SPRY domain
PRY (PF13765, IPR006574, SM00589): SPRY-associated domain
RDM (PF11002, IPR022723): RFPL defining motif (RDM)
zf-C3HC4_4 (PF15227): zinc finger of C3HC4-type, RING
92 RNF169interactor30.3333.994IncA (PF04156, IPR007285): IncA protein
zf-C3HC4_3 (PF13920): Zinc finger, C3HC4 type (RING finger)
93 RUNX1suppressor220.424135.176Runt (PF00853, IPR013524): Runt domain
RunxI (PF08504, IPR013711): Runx inhibition domain
DUF3037 (PF11236, IPR021398): Protein of unknown function (DUF3037)
94 SFNsuppressor110.31135.92914-3-3 (PF00244, IPR023410, SM00101): 14-3-3 protein
95 SH3GL2oncoprotein50.66713.873BAR (PF03114, IPR004148, SM00721): BAR domain
SH3_2 (PF07653, IPR011511): Variant SH3 domain
96 SIN3Aoncoprotein170.272219.333Sin3_corepress (PF08295, IPR013194, SM00761): Sin3 family co-repressor
PAH (PF02671, IPR003822, SM00309): Paired amphipathic helix repeat
Sin3a_C (PF16879, IPR031693): C-terminal domain of Sin3a protein
97 SIPA1L1interactor40.6673.666PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF)
Rap_GAP (PF02145, IPR000331): Rap/ran-GAP
SPAR_C (PF11881, IPR021818): C-terminal domain of SPAR protein
DUF4164 (PF13747, IPR025310): Domain of unknown function (DUF4164)
IQCJ-SCHIP1 (PF15157, IPR029362): Fusion protein IQCJ-SCHIP1 with IQ-like motif
98 SMAD3oncoprotein210.216323.793MH1 (PF03165, IPR003619, SM00523): MH1 domain
MH2 (PF03166, IPR001132, SM00524): MH2 domain
99 SNCAinteractor80.28642.207Synuclein (PF01387, IPR001058): Synuclein
100 SPENoncoprotein90.47219.119ATP-synt_E (PF05680, IPR008386): ATP synthase E chain
RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
Rxt3 (PF08642, IPR013951): Histone deacetylation protein Rxt3
SPOC (PF07744, IPR012921): SPOC domain
DUF4692 (PF15763, IPR031517): Domain of unknown function (DUF4692)
101 SPERTinteractor31.0000ZapB (PF06005, IPR009252): Cell division protein ZapB
DUF4407 (PF14362, IPR025519): Domain of unknown function (DUF4407)
Chibby (PF14645, IPR028118): Chibby family
JIP_LZII (PF16471, IPR032486): JNK-interacting protein leucine zipper II
102 SPRY2suppressor70.20076.348KAR9 (PF08580, IPR013889): Yeast cortical protein KAR9
Sprouty (PF05210, IPR007875): Sprouty protein (Spry)
103 SRSF1protein found in more fusions140.37280.726Corona_nucleoca (PF00937, IPR001218): Coronavirus nucleocapsid protein
RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
FoP_duplication (PF13865, IPR025715): C-terminal duplication domain of Friend of PRMT1
104 SRSF4interactor50.6003.675Corona_nucleoca (PF00937, IPR001218): Coronavirus nucleocapsid protein
RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
PRP38_assoc (PF12871, IPR024767): Pre-mRNA-splicing factor 38-associated hydrophilic C-term
105 SRSF5interactor70.8102.108DUF1777 (PF08648, IPR013957): Protein of unknown function (DUF1777)
RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
PRP38_assoc (PF12871, IPR024767): Pre-mRNA-splicing factor 38-associated hydrophilic C-term
106 STX11interactor70.20030.057KxDL (PF10241, IPR019371): Uncharacterized conserved protein
Syntaxin (PF00804, IPR006011, SM00503): Syntaxin
SNARE (PF05739, IPR000727, SM00397): SNARE domain
107 TAF9Binteractor4012.184TFIID-31kDa (PF02291, IPR003162): Transcription initiation factor IID, 31kD subunit
108 TAL2oncoprotein50.6005.384HLH (PF00010, IPR011598, SM00353): Helix-loop-helix DNA-binding domain
109 TBPinteractor130.37993.225TBP (PF00352, IPR000814): Transcription factor TFIID (or TATA-binding protein, TBP)
EPL1 (PF10513, IPR019542): Enhancer of polycomb-like
Med3 (PF11593, IPR020998): Mediator complex subunit 3 fungal
110 TCF12oncoprotein170.325168.963HLH (PF00010, IPR011598, SM00353): Helix-loop-helix DNA-binding domain
111 TCF3suppressor170.40887.138CDC45 (PF02724, IPR003874): CDC45-like protein
HLH (PF00010, IPR011598, SM00353): Helix-loop-helix DNA-binding domain
DUF3682 (PF12446, IPR022152): Protein of unknown function (DUF3682)
112 TCF4suppressor160.250159.285CDC45 (PF02724, IPR003874): CDC45-like protein
HLH (PF00010, IPR011598, SM00353): Helix-loop-helix DNA-binding domain
113 THRAP3oncoprotein60.26755.877API5 (PF05918, IPR008383): Apoptosis inhibitory protein 5 (API5)
FXMRP1_C_core (PF12235, IPR022034): Fragile X-related 1 protein core C terminal
DUF4228 (PF14009, IPR025322): Domain of unknown function (DUF4228)
THRAP3_BCLAF1 (PF15440, IPR029199): THRAP3/BCLAF1 family
114 TRAF3oncoprotein60.4004.733ATG16 (PF08614, IPR013923): Autophagy protein 16 (ATG16)
S-AdoMet_synt_M (PF02772, IPR022629): S-adenosylmethionine synthetase, central domain
zf-C3HC4 (PF00097, IPR018957): Zinc finger, C3HC4 type (RING finger)
zf-TRAF (PF02176, IPR001293): TRAF-type zinc finger
zf-RING_2 (PF13639, IPR001841, SM00184): Ring finger domain
MPS2 (PF17060, IPR031433): Monopolar spindle protein 2
Spc29 (PF17082, IPR031392): Spindle Pole Component 29
115 TRIM33oncoprotein140.37283.370PHD (PF00628, IPR019787, SM00249): PHD-finger
Ribosomal_60s (PF00428, IPR001813): 60s Acidic ribosomal protein
Siva (PF05458, IPR022773): Cd27 binding protein (Siva)
Spectrin (PF00435, IPR002017): Spectrin repeat
TFIIA (PF03153, IPR004855): Transcription factor IIA, alpha/beta subunit
zf-B_box (PF00643, IPR000315, SM00336): B-box zinc finger
Bromodomain (PF00439, IPR001487, SM00297): Bromodomain
zf-RING_UBOX (PF13445, IPR027370): RING-type zinc-finger
116 TRIM42interactor80.28652.295CHDCT2 (PF08074, IPR012957): CHDCT2 (NUC038) domain
fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain
zf-B_box (PF00643, IPR000315, SM00336): B-box zinc finger
117 TROAPprotein found in more fusions60.40013.846Strep_pep (PF14404, IPR025744): Ribosomally synthesized peptide in Streptomyces species
118 UBE2E2protein found in more fusions100.30668.390UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme
119 UBQLN4interactor407.090CRF (PF00473, IPR000187, SM00039): Corticotropin-releasing factor family
DUF1180 (PF06679, IPR009565): Protein of unknown function (DUF1180)
Arm_2 (PF04826, IPR006911): Armadillo-like
NUDE_C (PF04880, IPR006964): NUDE protein, C-terminal conserved region
UBA (PF00627, IPR000449, SM00165): UBA/TS-N domain
XPC-binding (PF09280, IPR015360): XPC-binding domain
ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
Fur_reg_FbpB (PF13040, IPR025004): Fur-regulated basic protein B
partial_CstF (PF15861, IPR031721): Partial cleavage stimulation factor domain
120 VDRsuppressor150.39699.992zf-C4 (PF00105, IPR001628, SM00399): Zinc finger, C4 type (two domains)
Hormone_recep (PF00104, IPR000536, SM00430): Ligand-binding domain of nuclear hormone receptor
121 WBP11interactor40.16718.933BUD22 (PF09073, IPR015158): BUD22
Pex14_N (PF04695, IPR006785): Peroxisomal membrane anchor protein (Pex14p) conserved region
SspB (PF04386, IPR007481): Stringent starvation protein B
Wbp11 (PF09429, IPR019007): WW domain binding protein 11
ABC_trans_N (PF14510, IPR029481): ABC-transporter extracellular N-terminal
122 XPO1interactor250.187503.077CRM1_C (PF08767, IPR014877, SM01102): CRM1 C terminal
Hydrolase_3 (PF08282, IPR023214): haloacid dehalogenase-like hydrolase
IBN_N (PF03810, IPR001494, SM00913): Importin-beta N-terminal domain
Xpo1 (PF08389, IPR013598): Exportin 1-like protein
Vac14_Fab1_bd (PF12755, IPR032878): Vacuolar 14 Fab1-binding region
123 YWHAGprotein found in more fusions140.37282.30314-3-3 (PF00244, IPR023410, SM00101): 14-3-3 protein
124 ZBTB16suppressor130.54532.202BTB (PF00651, IPR013069, SM00225): BTB/POZ domain
zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type
zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain
zf-C2H2_4 (PF13894): C2H2-type zinc finger
zf-C2H2_6 (PF13912, IPR007087): C2H2-type zinc finger
125 ZMYM4interactor4032.834YHS (PF04945, IPR007029): YHS domain
DUF2116 (PF09889, IPR019216): Uncharacterized protein containing a Zn-ribbon (DUF2116)
zf-FCS (PF06467, IPR010507): MYM-type Zinc finger with FCS sequence motif
DUF3504 (PF12012, IPR021893): Domain of unknown function (DUF3504)
zinc_ribbon_4 (PF13717): zinc-ribbon domain
YyzF (PF14116, IPR025626): YyzF-like protein

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