Statistic of PPI	Value(s)
The number of interactors (fusion and proteins)	71
The number (and %) of the onco-proteins	18 (25.35 %)
The number (and %) of the tumor suppressors	12 (16.90 %)
Total number of binary PPIs (saturation %)	281 (11.31 %)
The number (and %) of affected PPIs	70 (24.91 %)
The number of possible different fusions	15
PPI diameter	4
PPI radius	2
The average degree of PPI	7.014
Assortativity coefficient	-0.1908
The network average Clustering coefficient	0.491
The number (and %) of a zero Clustering coefficients	9 (12.68 %)
The number (and %) of a zero Betweenness Centrality	15 (21.13 %)

ACTIVE INTERACTORS

List of the fusions
PPI for parental proteins: TP53INP2,DYRK1A	All fusions
Proteins found in more fusions	CREBBP (see 6 fusions); CTBP1 (see 2 fusions); APP (see 5 fusions); YWHAG (see 1 fusions); SH3GL2 (see 1 fusions); SRSF1 (see 1 fusions); HIPK2 (see 1 fusions); SFN (see 1 fusions); TROAP (see 1 fusions); EP300 (see 1 fusions); MAP3K5 (see 1 fusions); MAP3K1 (see 1 fusions); PARK2 (see 1 fusions); SMAD3 (see 3 fusions);

List of the fusions

PPI for parental proteins: TP53INP2,DYRK1A

All fusions

Proteins found in more fusions

CREBBP (see 6 fusions); CTBP1 (see 2 fusions); APP (see 5 fusions); YWHAG (see 1 fusions); SH3GL2 (see 1 fusions); SRSF1 (see 1 fusions); HIPK2 (see 1 fusions); SFN (see 1 fusions); TROAP (see 1 fusions); EP300 (see 1 fusions); MAP3K5 (see 1 fusions); MAP3K1 (see 1 fusions); PARK2 (see 1 fusions); SMAD3 (see 3 fusions);

List of active interactors

#	Name	Type	Number of PPI (degree)	Clustering Coefficient	Betweenness Centrality	Domains (Pfam, InterPro, SMART): description
1	TP53INP2	parental protein	2	0	1.376	DOR (PF14839, IPR029431): DOR family
2	DYRK1A	parental protein	68	0.079	3491.205	DUF755 (PF05501, IPR008474): Domain of unknown function (DUF755) Filament_head (PF04732, IPR006821): Intermediate filament head (DNA binding) region Pkinase (PF00069, IPR000719): Protein kinase domain FAM199X (PF15814, IPR029672): Protein family FAM199X
3	ABCD3	interactor	4	0.667	0.900	ABC_membrane_2 (PF06472, IPR010509): ABC transporter transmembrane region 2 ABC_tran (PF00005, IPR003439): ABC transporter
4	AMPH	oncoprotein	4	0.667	2.200	BAR (PF03114, IPR004148, SM00721): BAR domain SH3_9 (PF14604, IPR001452): Variant SH3 domain PBP_N (PF17093, IPR031375): Penicillin-binding protein N-terminus
5	APP	protein found in more fusions	14	0.192	179.757	APP_N (PF02177, IPR015849, SM00006): Amyloid A4 N-terminal heparin-binding Beta-APP (PF03494, IPR013803): Beta-amyloid peptide (beta-APP) BUD22 (PF09073, IPR015158): BUD22 IncA (PF04156, IPR007285): IncA protein Kunitz_BPTI (PF00014, IPR002223, SM00131): Kunitz/Bovine pancreatic trypsin inhibitor domain APP_amyloid (PF10515, IPR019543): beta-amyloid precursor protein C-terminus APP_Cu_bd (PF12924, IPR011178): Copper-binding of amyloid precursor, CuBD APP_E2 (PF12925, IPR024329): E2 domain of amyloid precursor protein
6	BARD1	suppressor	10	0.389	16.846	BRCT (PF00533, IPR001357, SM00292): BRCA1 C Terminus (BRCT) domain Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies) Ank_5 (PF13857): Ankyrin repeats (many copies) zf-RING_6 (PF14835): zf-RING of BARD1-type protein BRCT_2 (PF16589, IPR001357): BRCT domain, a BRCA1 C-terminus domain
7	CCDC8	interactor	7	0.667	3.591	Borrelia_P83 (PF05262, IPR007926): Borrelia P83/100 protein SRP-alpha_N (PF04086, IPR007222): Signal recognition particle, alpha subunit, N-terminal PNMA (PF14893, IPR026523): PNMA
8	CCNA2	oncoprotein	7	0.533	4.067	Cyclin_C (PF02984, IPR004367): Cyclin, C-terminal domain Cyclin_N (PF00134, IPR006671): Cyclin, N-terminal domain Cyclin_N2 (PF16500, IPR032447): N-terminal region of cyclin_N
9	CCNL2	interactor	2	1.000	0	Cyclin_C (PF02984, IPR004367): Cyclin, C-terminal domain Cyclin_N (PF00134, IPR006671): Cyclin, N-terminal domain K_channel_TID (PF07941, IPR012897): Potassium channel Kv1.4 tandem inactivation domain PRP38_assoc (PF12871, IPR024767): Pre-mRNA-splicing factor 38-associated hydrophilic C-term
10	CLASRP	interactor	4	0.500	1.701	Corona_nucleoca (PF00937, IPR001218): Coronavirus nucleocapsid protein OAD_gamma (PF04277, IPR005899): Oxaloacetate decarboxylase, gamma chain Pap_E4 (PF02711, IPR003861): E4 protein RAP1 (PF07218, IPR009864): Rhoptry-associated protein 1 (RAP-1) S-antigen (PF05756, IPR008825): S-antigen protein Transformer (PF06495, IPR010519): Fruit fly transformer protein DRY_EERY (PF09750, IPR019147, SM01141): Alternative splicing regulator LRRFIP (PF09738, IPR019139): LRRFIP family DUF4554 (PF15091, IPR028040): Domain of unknown function (DUF4554)
11	CLTC	oncoprotein	11	0.200	104.841	Clathrin-link (PF09268, IPR015348): Clathrin, heavy-chain linker Clathrin_propel (PF01394, IPR022365): Clathrin propeller repeat Clathrin (PF00637, IPR000547, SM00299): Region in Clathrin and VPS Clathrin_H_link (PF13838): Clathrin-H-link
12	CREBBP	suppressor	14	0.397	33.182	Creb_binding (PF09030, IPR014744): Creb binding DUF902 (PF06001, IPR010303): Domain of Unknown Function (DUF902) Forkhead_N (PF08430, IPR013638): Forkhead N-terminal region KIX (PF02172, IPR003101): KIX domain MAS20 (PF02064, IPR002056): MAS20 protein import receptor TPX2 (PF06886, IPR027329): Targeting protein for Xklp2 (TPX2) zf-TAZ (PF02135, IPR000197, SM00551): TAZ zinc finger ANAPC_CDC26 (PF10471, IPR018860): Anaphase-promoting complex APC subunit CDC26 HAT_KAT11 (PF08214, IPR013178): Histone acetylation protein Bromodomain (PF00439, IPR001487, SM00297): Bromodomain ZZ (PF00569, IPR000433, SM00291): Zinc finger, ZZ type DUF3729 (PF12526, IPR022202): Protein of unknown function (DUF3729) DUF4834 (PF16118, IPR032272): Domain of unknown function (DUF4834)
13	CTBP1	protein found in more fusions	10	0.639	7.686	2-Hacid_dh_C (PF02826, IPR006140): D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain Cellsynth_D (PF03500, IPR022798): Cellulose synthase subunit D
14	DCAF7	interactor	15	0.248	71.020	WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
15	DNM1	interactor	5	0.667	1.667	Dynamin_M (PF01031, IPR000375): Dynamin central region GED (PF02212, IPR003130, SM00302): Dynamin GTPase effector domain PH (PF00169, IPR001849, SM00233): PH domain Dynamin_N (PF00350, IPR001401, SM00053): Dynamin family
16	DYNLL1	interactor	8	0.333	15.559	Dynein_light (PF01221, IPR001372): Dynein light chain type 1
17	DYNLL2	interactor	3	1.000	0	Dynein_light (PF01221, IPR001372): Dynein light chain type 1
18	EGLN2	interactor	2	0	0	2OG-FeII_Oxy_3 (PF13640, IPR005123): 2OG-Fe(II) oxygenase superfamily
19	ELAVL1	oncoprotein	21	0.216	235.674	RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
20	EP300	oncoprotein	15	0.363	45.709	Creb_binding (PF09030, IPR014744): Creb binding DUF902 (PF06001, IPR010303): Domain of Unknown Function (DUF902) Forkhead_N (PF08430, IPR013638): Forkhead N-terminal region KIX (PF02172, IPR003101): KIX domain RR_TM4-6 (PF06459, IPR009460): Ryanodine Receptor TM 4-6 TPX2 (PF06886, IPR027329): Targeting protein for Xklp2 (TPX2) zf-TAZ (PF02135, IPR000197, SM00551): TAZ zinc finger HAT_KAT11 (PF08214, IPR013178): Histone acetylation protein Bromodomain (PF00439, IPR001487, SM00297): Bromodomain ZZ (PF00569, IPR000433, SM00291): Zinc finger, ZZ type
21	FAM117A	oncoprotein	1	0	0	FAM117 (PF15388, IPR026642): Protein Family FAM117
22	FAM117B	interactor	4	0.500	3.917	FAM117 (PF15388, IPR026642): Protein Family FAM117 PRIMA1 (PF16101): Proline-rich membrane anchor 1
23	FAM53C	interactor	6	0.467	6.000	FAM53 (PF15242, IPR029356): Family of FAM53
24	FNTA	interactor	2	1.000	0	CAP_N (PF01213, IPR013992): Adenylate cyclase associated (CAP) N terminal PPTA (PF01239, IPR002088): Protein prenyltransferase alpha subunit repeat TPR_14 (PF13428): Tetratricopeptide repeat DUF4219 (PF13961, IPR025314): Domain of unknown function (DUF4219)
25	FNTB	interactor	5	0.400	5.333	Prenyltrans (PF00432, IPR001330): Prenyltransferase and squalene oxidase repeat
26	FOXR2	interactor	1	0	0	Forkhead (PF00250, IPR001766, SM00339): Forkhead domain
27	GABARAPL2	interactor	3	0	70.202	Atg8 (PF02991, IPR004241): Autophagy protein Atg8 ubiquitin like
28	GLCCI1	interactor	3	0.667	0.500	Herpes_LMP2 (PF07415, IPR010881): Gammaherpesvirus latent membrane protein (LMP2) protein Pap_E4 (PF02711, IPR003861): E4 protein DUF2076 (PF09849, IPR018648): Uncharacterized protein conserved in bacteria (DUF2076) FAM117 (PF15388, IPR026642): Protein Family FAM117
29	HIPK2	suppressor	7	0.667	3.667	Kdo (PF06293, IPR010440): Lipopolysaccharide kinase (Kdo/WaaP) family Pkinase (PF00069, IPR000719): Protein kinase domain
30	HIST1H2BB	interactor	7	0.571	10.112	Histone (PF00125, IPR007125): Core histone H2A/H2B/H3/H4
31	HIST1H3A	interactor	9	0.464	13.333	Histone (PF00125, IPR007125): Core histone H2A/H2B/H3/H4
32	HIST1H4A	interactor	5	1.000	0	CENP-T_C (PF15511): Centromere kinetochore component CENP-T histone fold
33	ID2	oncoprotein	5	0.667	1.067	HLH (PF00010, IPR011598, SM00353): Helix-loop-helix DNA-binding domain
34	ISG15	suppressor	4	0.500	2.443	ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
35	KIAA0232	interactor	1	0	0	DUF4603 (PF15376, IPR027871): Domain of unknown function (DUF4603)
36	LATS2	suppressor	7	0.533	6.452	Pkinase (PF00069, IPR000719): Protein kinase domain Pkinase_C (PF00433, IPR017892): Protein kinase C terminal domain UBA (PF00627, IPR000449, SM00165): UBA/TS-N domain
37	LIN52	interactor	2	1.000	0	LIN52 (PF10044, IPR018737): Retinal tissue protein
38	LIPH	interactor	1	0	0	Lipase (PF00151, IPR013818): Lipase
39	LZTS2	suppressor	4	0.667	1.400	CAP_N (PF01213, IPR013992): Adenylate cyclase associated (CAP) N terminal DUF1127 (PF06568, IPR009506): Domain of unknown function (DUF1127) Fez1 (PF06818): Fez1 ADIP (PF11559, IPR021622): Afadin- and alpha -actinin-Binding DUF4250 (PF14056, IPR025346): Domain of unknown function (DUF4250)
40	MAP1LC3A	interactor	4	0.333	67.617	Atg8 (PF02991, IPR004241): Autophagy protein Atg8 ubiquitin like
41	MAP3K1	oncoprotein	7	0.733	2.619	zf-Di19 (PF05605, IPR008598): Drought induced 19 protein (Di19), zinc-binding Pkinase (PF00069, IPR000719): Protein kinase domain zf-RING_2 (PF13639, IPR001841, SM00184): Ring finger domain Phostensin_N (PF13916, IPR025903): PP1-regulatory protein, Phostensin N-terminal
42	MAP3K5	oncoprotein	6	0.500	5.272	Pkinase (PF00069, IPR000719): Protein kinase domain DUF4071 (PF13281, IPR025136): Domain of unknown function (DUF4071)
43	MED23	interactor	8	0.607	6.390	Med23 (PF11573, IPR021629): Mediator complex subunit 23
44	MOV10	interactor	7	0.571	5.467	AAA_12 (PF13087): AAA domain AAA_30 (PF13604): AAA domain
45	NTRK1	oncoprotein	18	0.279	87.532	I-set (PF07679, IPR013098): Immunoglobulin I-set domain Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase LRR_8 (PF13855, IPR001611): Leucine rich repeat TPKR_C2 (PF16920, IPR031635): Tyrosine-protein kinase receptor C2 Ig-like domain
46	NXF1	interactor	7	0.533	4.898	NTF2 (PF02136, IPR002075): Nuclear transport factor 2 (NTF2) domain Tap-RNA_bind (PF09162, IPR015245): Tap, RNA-binding TAP_C (PF03943, IPR005637, SM00804): TAP C-terminal domain LRR_8 (PF13855, IPR001611): Leucine rich repeat
47	PARK2	suppressor	6	0.700	2.208	IBR (PF01485, IPR002867, SM00647): IBR domain, a half RING-finger domain ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
48	PPP1R3F	interactor	1	0	0	CBM_21 (PF03370, IPR005036): Carbohydrate/starch-binding module (family 21) K_channel_TID (PF07941, IPR012897): Potassium channel Kv1.4 tandem inactivation domain
49	PRD	interactor	1	0	0	NA
50	PRKACA	interactor	9	0.444	15.142	Pkinase (PF00069, IPR000719): Protein kinase domain
51	PRKACB	interactor	8	0.500	10.519	Pkinase (PF00069, IPR000719): Protein kinase domain
52	PRKAR1A	suppressor	7	0.733	3.221	RIIa (PF02197, IPR003117, SM00394): Regulatory subunit of type II PKA R-subunit cNMP_binding (PF00027, IPR000595, SM00100): Cyclic nucleotide-binding domain
53	RAD54L2	interactor	2	1.000	0	SNF2_N (PF00176, IPR000330): SNF2 family N-terminal domain Helicase_C (PF00271, IPR001650, SM00490): Helicase conserved C-terminal domain FAM176 (PF14851): FAM176 family ERCC3_RAD25_C (PF16203, IPR032438): ERCC3/RAD25/XPB C-terminal helicase
54	RB1	suppressor	9	0.444	15.133	RB_A (PF01858, IPR002720): Retinoblastoma-associated protein A domain RB_B (PF01857, IPR002719): Retinoblastoma-associated protein B domain Rb_C (PF08934, IPR015030): Rb C-terminal domain DUF3452 (PF11934, IPR024599): Domain of unknown function (DUF3452) DUF4592 (PF15262, IPR028030): Domain of unknown function (DUF4592)
55	RBL1	suppressor	7	0.429	8.233	RB_A (PF01858, IPR002720): Retinoblastoma-associated protein A domain RB_B (PF01857, IPR002719): Retinoblastoma-associated protein B domain Rb_C (PF08934, IPR015030): Rb C-terminal domain DUF3452 (PF11934, IPR024599): Domain of unknown function (DUF3452)
56	RBL2	suppressor	6	0.467	9.932	CAP_N (PF01213, IPR013992): Adenylate cyclase associated (CAP) N terminal Pap_E4 (PF02711, IPR003861): E4 protein RB_A (PF01858, IPR002720): Retinoblastoma-associated protein A domain RB_B (PF01857, IPR002719): Retinoblastoma-associated protein B domain SLH (PF00395, IPR001119): S-layer homology domain TFIIB (PF00382, IPR013150): Transcription factor TFIIB repeat DUF3452 (PF11934, IPR024599): Domain of unknown function (DUF3452)
57	RFPL2	interactor	2	1.000	0	SPRY (PF00622, IPR003877, SM00449): SPRY domain PRY (PF13765, IPR006574, SM00589): SPRY-associated domain RDM (PF11002, IPR022723): RFPL defining motif (RDM) zf-C3HC4_4 (PF15227): zinc finger of C3HC4-type, RING
58	RNF169	interactor	2	1.000	0	IncA (PF04156, IPR007285): IncA protein zf-C3HC4_3 (PF13920): Zinc finger, C3HC4 type (RING finger)
59	SFN	suppressor	11	0.311	23.919	14-3-3 (PF00244, IPR023410, SM00101): 14-3-3 protein
60	SH3GL2	oncoprotein	5	0.667	3.900	BAR (PF03114, IPR004148, SM00721): BAR domain SH3_2 (PF07653, IPR011511): Variant SH3 domain
61	SIPA1L1	interactor	4	0.667	1.500	PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF) Rap_GAP (PF02145, IPR000331): Rap/ran-GAP SPAR_C (PF11881, IPR021818): C-terminal domain of SPAR protein DUF4164 (PF13747, IPR025310): Domain of unknown function (DUF4164) IQCJ-SCHIP1 (PF15157, IPR029362): Fusion protein IQCJ-SCHIP1 with IQ-like motif
62	SMAD3	oncoprotein	8	0.524	9.369	MH1 (PF03165, IPR003619, SM00523): MH1 domain MH2 (PF03166, IPR001132, SM00524): MH2 domain
63	SNCA	interactor	8	0.381	53.607	Synuclein (PF01387, IPR001058): Synuclein
64	SRSF1	protein found in more fusions	13	0.424	30.121	Corona_nucleoca (PF00937, IPR001218): Coronavirus nucleocapsid protein RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) FoP_duplication (PF13865, IPR025715): C-terminal duplication domain of Friend of PRMT1
65	SRSF4	interactor	5	0.600	3.586	Corona_nucleoca (PF00937, IPR001218): Coronavirus nucleocapsid protein RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) PRP38_assoc (PF12871, IPR024767): Pre-mRNA-splicing factor 38-associated hydrophilic C-term
66	SRSF5	interactor	7	0.810	1.973	DUF1777 (PF08648, IPR013957): Protein of unknown function (DUF1777) RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) PRP38_assoc (PF12871, IPR024767): Pre-mRNA-splicing factor 38-associated hydrophilic C-term
67	TBP	interactor	7	0.800	1.871	TBP (PF00352, IPR000814): Transcription factor TFIID (or TATA-binding protein, TBP) EPL1 (PF10513, IPR019542): Enhancer of polycomb-like Med3 (PF11593, IPR020998): Mediator complex subunit 3 fungal
68	TRAF3	oncoprotein	6	0.400	4.733	ATG16 (PF08614, IPR013923): Autophagy protein 16 (ATG16) S-AdoMet_synt_M (PF02772, IPR022629): S-adenosylmethionine synthetase, central domain zf-C3HC4 (PF00097, IPR018957): Zinc finger, C3HC4 type (RING finger) zf-TRAF (PF02176, IPR001293): TRAF-type zinc finger zf-RING_2 (PF13639, IPR001841, SM00184): Ring finger domain MPS2 (PF17060, IPR031433): Monopolar spindle protein 2 Spc29 (PF17082, IPR031392): Spindle Pole Component 29
69	TROAP	protein found in more fusions	6	0.400	7.706	Strep_pep (PF14404, IPR025744): Ribosomally synthesized peptide in Streptomyces species
70	XPO1	interactor	17	0.301	76.206	CRM1_C (PF08767, IPR014877, SM01102): CRM1 C terminal Hydrolase_3 (PF08282, IPR023214): haloacid dehalogenase-like hydrolase IBN_N (PF03810, IPR001494, SM00913): Importin-beta N-terminal domain Xpo1 (PF08389, IPR013598): Exportin 1-like protein Vac14_Fab1_bd (PF12755, IPR032878): Vacuolar 14 Fab1-binding region
71	YWHAG	protein found in more fusions	13	0.409	31.921	14-3-3 (PF00244, IPR023410, SM00101): 14-3-3 protein

B a c k t o T o p ⇑

Fusion ID: Protein names:	1859 58476
Level of PPIs:	or Upload text file:	Update repository

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List of active interactors