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Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)71
The number (and %) of the onco-proteins18 (25.35 %)
The number (and %) of the tumor suppressors13 (18.31 %)
Total number of binary PPIs (saturation %)284 (11.43 %)
The number (and %) of affected PPIs70 (24.65 %)
The number of possible different fusions16
PPI diameter4
PPI radius3
The average degree of PPI7.042
Assortativity coefficient-0.1820
The network average Clustering coefficient0.483
The number (and %) of a zero Clustering coefficients9 (12.68 %)
The number (and %) of a zero Betweenness Centrality15 (21.13 %)

ACTIVE INTERACTORS


List of the fusions

Proteins found in more fusions CREBBP (see 6 fusions); CTBP1 (see 2 fusions); APP (see 5 fusions); YWHAG (see 1 fusions); SH3GL2 (see 1 fusions); SRSF1 (see 1 fusions); HIPK2 (see 1 fusions); SFN (see 1 fusions); TROAP (see 1 fusions); EP300 (see 1 fusions); MAP3K5 (see 1 fusions); MAP3K1 (see 1 fusions); PARK2 (see 1 fusions); VHL (see 1 fusions); SMAD3 (see 3 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 DYRK1Aparental protein680.0793513.681DUF755 (PF05501, IPR008474): Domain of unknown function (DUF755)
Filament_head (PF04732, IPR006821): Intermediate filament head (DNA binding) region
Pkinase (PF00069, IPR000719): Protein kinase domain
FAM199X (PF15814, IPR029672): Protein family FAM199X
2 CMC2parental protein204.617Cmc1 (PF08583, IPR013892): Cytochrome c oxidase biogenesis protein Cmc1 like
Pet191_N (PF10203, IPR018793): Cytochrome c oxidase assembly protein PET191
3 ABCD3interactor50.50069.670ABC_membrane_2 (PF06472, IPR010509): ABC transporter transmembrane region 2
ABC_tran (PF00005, IPR003439): ABC transporter
4 AMPHoncoprotein40.6671.667BAR (PF03114, IPR004148, SM00721): BAR domain
SH3_9 (PF14604, IPR001452): Variant SH3 domain
PBP_N (PF17093, IPR031375): Penicillin-binding protein N-terminus
5 APPprotein found in more fusions130.21288.683APP_N (PF02177, IPR015849, SM00006): Amyloid A4 N-terminal heparin-binding
Beta-APP (PF03494, IPR013803): Beta-amyloid peptide (beta-APP)
BUD22 (PF09073, IPR015158): BUD22
IncA (PF04156, IPR007285): IncA protein
Kunitz_BPTI (PF00014, IPR002223, SM00131): Kunitz/Bovine pancreatic trypsin inhibitor domain
APP_amyloid (PF10515, IPR019543): beta-amyloid precursor protein C-terminus
APP_Cu_bd (PF12924, IPR011178): Copper-binding of amyloid precursor, CuBD
APP_E2 (PF12925, IPR024329): E2 domain of amyloid precursor protein
6 BARD1suppressor100.38919.000BRCT (PF00533, IPR001357, SM00292): BRCA1 C Terminus (BRCT) domain
Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies)
Ank_5 (PF13857): Ankyrin repeats (many copies)
zf-RING_6 (PF14835): zf-RING of BARD1-type protein
BRCT_2 (PF16589, IPR001357): BRCT domain, a BRCA1 C-terminus domain
7 CCDC8interactor70.6672.633Borrelia_P83 (PF05262, IPR007926): Borrelia P83/100 protein
SRP-alpha_N (PF04086, IPR007222): Signal recognition particle, alpha subunit, N-terminal
PNMA (PF14893, IPR026523): PNMA
8 CCNA2oncoprotein70.5334.067Cyclin_C (PF02984, IPR004367): Cyclin, C-terminal domain
Cyclin_N (PF00134, IPR006671): Cyclin, N-terminal domain
Cyclin_N2 (PF16500, IPR032447): N-terminal region of cyclin_N
9 CCNL2interactor21.0000Cyclin_C (PF02984, IPR004367): Cyclin, C-terminal domain
Cyclin_N (PF00134, IPR006671): Cyclin, N-terminal domain
K_channel_TID (PF07941, IPR012897): Potassium channel Kv1.4 tandem inactivation domain
PRP38_assoc (PF12871, IPR024767): Pre-mRNA-splicing factor 38-associated hydrophilic C-term
10 CLASRPinteractor40.5001.233Corona_nucleoca (PF00937, IPR001218): Coronavirus nucleocapsid protein
OAD_gamma (PF04277, IPR005899): Oxaloacetate decarboxylase, gamma chain
Pap_E4 (PF02711, IPR003861): E4 protein
RAP1 (PF07218, IPR009864): Rhoptry-associated protein 1 (RAP-1)
S-antigen (PF05756, IPR008825): S-antigen protein
Transformer (PF06495, IPR010519): Fruit fly transformer protein
DRY_EERY (PF09750, IPR019147, SM01141): Alternative splicing regulator
LRRFIP (PF09738, IPR019139): LRRFIP family
DUF4554 (PF15091, IPR028040): Domain of unknown function (DUF4554)
11 CLTConcoprotein100.22230.350Clathrin-link (PF09268, IPR015348): Clathrin, heavy-chain linker
Clathrin_propel (PF01394, IPR022365): Clathrin propeller repeat
Clathrin (PF00637, IPR000547, SM00299): Region in Clathrin and VPS
Clathrin_H_link (PF13838): Clathrin-H-link
12 COQ9interactor40.33329.526COQ9 (PF08511, IPR013718): COQ9
13 CREBBPsuppressor140.39730.400Creb_binding (PF09030, IPR014744): Creb binding
DUF902 (PF06001, IPR010303): Domain of Unknown Function (DUF902)
Forkhead_N (PF08430, IPR013638): Forkhead N-terminal region
KIX (PF02172, IPR003101): KIX domain
MAS20 (PF02064, IPR002056): MAS20 protein import receptor
TPX2 (PF06886, IPR027329): Targeting protein for Xklp2 (TPX2)
zf-TAZ (PF02135, IPR000197, SM00551): TAZ zinc finger
ANAPC_CDC26 (PF10471, IPR018860): Anaphase-promoting complex APC subunit CDC26
HAT_KAT11 (PF08214, IPR013178): Histone acetylation protein
Bromodomain (PF00439, IPR001487, SM00297): Bromodomain
ZZ (PF00569, IPR000433, SM00291): Zinc finger, ZZ type
DUF3729 (PF12526, IPR022202): Protein of unknown function (DUF3729)
DUF4834 (PF16118, IPR032272): Domain of unknown function (DUF4834)
14 CTBP1protein found in more fusions100.6396.3672-Hacid_dh_C (PF02826, IPR006140): D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain
Cellsynth_D (PF03500, IPR022798): Cellulose synthase subunit D
15 DCAF7interactor150.24865.431WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
16 DNM1interactor50.6671.667Dynamin_M (PF01031, IPR000375): Dynamin central region
GED (PF02212, IPR003130, SM00302): Dynamin GTPase effector domain
PH (PF00169, IPR001849, SM00233): PH domain
Dynamin_N (PF00350, IPR001401, SM00053): Dynamin family
17 DYNLL1interactor80.33313.000Dynein_light (PF01221, IPR001372): Dynein light chain type 1
18 DYNLL2interactor31.0000Dynein_light (PF01221, IPR001372): Dynein light chain type 1
19 EGLN2interactor2002OG-FeII_Oxy_3 (PF13640, IPR005123): 2OG-Fe(II) oxygenase superfamily
20 ELAVL1oncoprotein210.216195.811RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
21 EP300oncoprotein160.31499.978Creb_binding (PF09030, IPR014744): Creb binding
DUF902 (PF06001, IPR010303): Domain of Unknown Function (DUF902)
Forkhead_N (PF08430, IPR013638): Forkhead N-terminal region
KIX (PF02172, IPR003101): KIX domain
RR_TM4-6 (PF06459, IPR009460): Ryanodine Receptor TM 4-6
TPX2 (PF06886, IPR027329): Targeting protein for Xklp2 (TPX2)
zf-TAZ (PF02135, IPR000197, SM00551): TAZ zinc finger
HAT_KAT11 (PF08214, IPR013178): Histone acetylation protein
Bromodomain (PF00439, IPR001487, SM00297): Bromodomain
ZZ (PF00569, IPR000433, SM00291): Zinc finger, ZZ type
22 FAM117Aoncoprotein100FAM117 (PF15388, IPR026642): Protein Family FAM117
23 FAM117Binteractor40.5003.806FAM117 (PF15388, IPR026642): Protein Family FAM117
PRIMA1 (PF16101): Proline-rich membrane anchor 1
24 FAM53Cinteractor60.4676.000FAM53 (PF15242, IPR029356): Family of FAM53
25 FNTAinteractor21.0000CAP_N (PF01213, IPR013992): Adenylate cyclase associated (CAP) N terminal
PPTA (PF01239, IPR002088): Protein prenyltransferase alpha subunit repeat
TPR_14 (PF13428): Tetratricopeptide repeat
DUF4219 (PF13961, IPR025314): Domain of unknown function (DUF4219)
26 FNTBinteractor50.4005.333Prenyltrans (PF00432, IPR001330): Prenyltransferase and squalene oxidase repeat
27 FOXR2interactor100Forkhead (PF00250, IPR001766, SM00339): Forkhead domain
28 GLCCI1interactor30.6670.500Herpes_LMP2 (PF07415, IPR010881): Gammaherpesvirus latent membrane protein (LMP2) protein
Pap_E4 (PF02711, IPR003861): E4 protein
DUF2076 (PF09849, IPR018648): Uncharacterized protein conserved in bacteria (DUF2076)
FAM117 (PF15388, IPR026642): Protein Family FAM117
29 HIPK2suppressor70.6674.010Kdo (PF06293, IPR010440): Lipopolysaccharide kinase (Kdo/WaaP) family
Pkinase (PF00069, IPR000719): Protein kinase domain
30 HIST1H2BBinteractor70.5717.163Histone (PF00125, IPR007125): Core histone H2A/H2B/H3/H4
31 HIST1H3Ainteractor90.46414.019Histone (PF00125, IPR007125): Core histone H2A/H2B/H3/H4
32 HIST1H4Ainteractor51.0000CENP-T_C (PF15511): Centromere kinetochore component CENP-T histone fold
33 ID2oncoprotein60.40029.568HLH (PF00010, IPR011598, SM00353): Helix-loop-helix DNA-binding domain
34 ISG15suppressor40.5001.732ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
35 KIAA0232interactor100DUF4603 (PF15376, IPR027871): Domain of unknown function (DUF4603)
36 LATS2suppressor70.5335.936Pkinase (PF00069, IPR000719): Protein kinase domain
Pkinase_C (PF00433, IPR017892): Protein kinase C terminal domain
UBA (PF00627, IPR000449, SM00165): UBA/TS-N domain
37 LIN52interactor21.0000LIN52 (PF10044, IPR018737): Retinal tissue protein
38 LIPHinteractor100Lipase (PF00151, IPR013818): Lipase
39 LZTS2suppressor40.6671.400CAP_N (PF01213, IPR013992): Adenylate cyclase associated (CAP) N terminal
DUF1127 (PF06568, IPR009506): Domain of unknown function (DUF1127)
Fez1 (PF06818): Fez1
ADIP (PF11559, IPR021622): Afadin- and alpha -actinin-Binding
DUF4250 (PF14056, IPR025346): Domain of unknown function (DUF4250)
40 MAP3K1oncoprotein70.7332.619zf-Di19 (PF05605, IPR008598): Drought induced 19 protein (Di19), zinc-binding
Pkinase (PF00069, IPR000719): Protein kinase domain
zf-RING_2 (PF13639, IPR001841, SM00184): Ring finger domain
Phostensin_N (PF13916, IPR025903): PP1-regulatory protein, Phostensin N-terminal
41 MAP3K5oncoprotein60.5004.467Pkinase (PF00069, IPR000719): Protein kinase domain
DUF4071 (PF13281, IPR025136): Domain of unknown function (DUF4071)
42 MED23interactor80.6075.586Med23 (PF11573, IPR021629): Mediator complex subunit 23
43 MOV10interactor80.46491.607AAA_12 (PF13087): AAA domain
AAA_30 (PF13604): AAA domain
44 NTRK1oncoprotein180.27991.027I-set (PF07679, IPR013098): Immunoglobulin I-set domain
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
LRR_8 (PF13855, IPR001611): Leucine rich repeat
TPKR_C2 (PF16920, IPR031635): Tyrosine-protein kinase receptor C2 Ig-like domain
45 NXF1interactor70.5334.650NTF2 (PF02136, IPR002075): Nuclear transport factor 2 (NTF2) domain
Tap-RNA_bind (PF09162, IPR015245): Tap, RNA-binding
TAP_C (PF03943, IPR005637, SM00804): TAP C-terminal domain
LRR_8 (PF13855, IPR001611): Leucine rich repeat
46 PARK2suppressor60.7001.900IBR (PF01485, IPR002867, SM00647): IBR domain, a half RING-finger domain
ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
47 PPP1R3Finteractor100CBM_21 (PF03370, IPR005036): Carbohydrate/starch-binding module (family 21)
K_channel_TID (PF07941, IPR012897): Potassium channel Kv1.4 tandem inactivation domain
48 PRDinteractor100NA
49 PRKACAinteractor90.44416.826Pkinase (PF00069, IPR000719): Protein kinase domain
50 PRKACBinteractor80.50010.519Pkinase (PF00069, IPR000719): Protein kinase domain
51 PRKAR1Asuppressor70.7332.987RIIa (PF02197, IPR003117, SM00394): Regulatory subunit of type II PKA R-subunit
cNMP_binding (PF00027, IPR000595, SM00100): Cyclic nucleotide-binding domain
52 RAD54L2interactor21.0000SNF2_N (PF00176, IPR000330): SNF2 family N-terminal domain
Helicase_C (PF00271, IPR001650, SM00490): Helicase conserved C-terminal domain
FAM176 (PF14851): FAM176 family
ERCC3_RAD25_C (PF16203, IPR032438): ERCC3/RAD25/XPB C-terminal helicase
53 RB1suppressor90.44415.967RB_A (PF01858, IPR002720): Retinoblastoma-associated protein A domain
RB_B (PF01857, IPR002719): Retinoblastoma-associated protein B domain
Rb_C (PF08934, IPR015030): Rb C-terminal domain
DUF3452 (PF11934, IPR024599): Domain of unknown function (DUF3452)
DUF4592 (PF15262, IPR028030): Domain of unknown function (DUF4592)
54 RBL1suppressor70.4298.233RB_A (PF01858, IPR002720): Retinoblastoma-associated protein A domain
RB_B (PF01857, IPR002719): Retinoblastoma-associated protein B domain
Rb_C (PF08934, IPR015030): Rb C-terminal domain
DUF3452 (PF11934, IPR024599): Domain of unknown function (DUF3452)
55 RBL2suppressor60.4677.500CAP_N (PF01213, IPR013992): Adenylate cyclase associated (CAP) N terminal
Pap_E4 (PF02711, IPR003861): E4 protein
RB_A (PF01858, IPR002720): Retinoblastoma-associated protein A domain
RB_B (PF01857, IPR002719): Retinoblastoma-associated protein B domain
SLH (PF00395, IPR001119): S-layer homology domain
TFIIB (PF00382, IPR013150): Transcription factor TFIIB repeat
DUF3452 (PF11934, IPR024599): Domain of unknown function (DUF3452)
56 RFPL2interactor21.0000SPRY (PF00622, IPR003877, SM00449): SPRY domain
PRY (PF13765, IPR006574, SM00589): SPRY-associated domain
RDM (PF11002, IPR022723): RFPL defining motif (RDM)
zf-C3HC4_4 (PF15227): zinc finger of C3HC4-type, RING
57 RNF169interactor21.0000IncA (PF04156, IPR007285): IncA protein
zf-C3HC4_3 (PF13920): Zinc finger, C3HC4 type (RING finger)
58 SFNsuppressor110.31123.91914-3-3 (PF00244, IPR023410, SM00101): 14-3-3 protein
59 SH3GL2oncoprotein50.6673.117BAR (PF03114, IPR004148, SM00721): BAR domain
SH3_2 (PF07653, IPR011511): Variant SH3 domain
60 SIPA1L1interactor40.6671.500PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF)
Rap_GAP (PF02145, IPR000331): Rap/ran-GAP
SPAR_C (PF11881, IPR021818): C-terminal domain of SPAR protein
DUF4164 (PF13747, IPR025310): Domain of unknown function (DUF4164)
IQCJ-SCHIP1 (PF15157, IPR029362): Fusion protein IQCJ-SCHIP1 with IQ-like motif
61 SMAD3oncoprotein80.5246.567MH1 (PF03165, IPR003619, SM00523): MH1 domain
MH2 (PF03166, IPR001132, SM00524): MH2 domain
62 SNCAinteractor70.4008.972Synuclein (PF01387, IPR001058): Synuclein
63 SRSF1protein found in more fusions130.42430.474Corona_nucleoca (PF00937, IPR001218): Coronavirus nucleocapsid protein
RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
FoP_duplication (PF13865, IPR025715): C-terminal duplication domain of Friend of PRMT1
64 SRSF4interactor50.6003.000Corona_nucleoca (PF00937, IPR001218): Coronavirus nucleocapsid protein
RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
PRP38_assoc (PF12871, IPR024767): Pre-mRNA-splicing factor 38-associated hydrophilic C-term
65 SRSF5interactor70.8102.233DUF1777 (PF08648, IPR013957): Protein of unknown function (DUF1777)
RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
PRP38_assoc (PF12871, IPR024767): Pre-mRNA-splicing factor 38-associated hydrophilic C-term
66 TBPinteractor70.8001.067TBP (PF00352, IPR000814): Transcription factor TFIID (or TATA-binding protein, TBP)
EPL1 (PF10513, IPR019542): Enhancer of polycomb-like
Med3 (PF11593, IPR020998): Mediator complex subunit 3 fungal
67 TRAF3oncoprotein60.4004.733ATG16 (PF08614, IPR013923): Autophagy protein 16 (ATG16)
S-AdoMet_synt_M (PF02772, IPR022629): S-adenosylmethionine synthetase, central domain
zf-C3HC4 (PF00097, IPR018957): Zinc finger, C3HC4 type (RING finger)
zf-TRAF (PF02176, IPR001293): TRAF-type zinc finger
zf-RING_2 (PF13639, IPR001841, SM00184): Ring finger domain
MPS2 (PF17060, IPR031433): Monopolar spindle protein 2
Spc29 (PF17082, IPR031392): Spindle Pole Component 29
68 TROAPprotein found in more fusions60.4005.767Strep_pep (PF14404, IPR025744): Ribosomally synthesized peptide in Streptomyces species
69 VHLsuppressor60112.557Trypan_PARP (PF05887, IPR008882): Procyclic acidic repetitive protein (PARP)
VHL (PF01847, IPR022772): VHL beta domain
VHL_C (PF17211): VHL box domain
70 XPO1interactor170.30175.143CRM1_C (PF08767, IPR014877, SM01102): CRM1 C terminal
Hydrolase_3 (PF08282, IPR023214): haloacid dehalogenase-like hydrolase
IBN_N (PF03810, IPR001494, SM00913): Importin-beta N-terminal domain
Xpo1 (PF08389, IPR013598): Exportin 1-like protein
Vac14_Fab1_bd (PF12755, IPR032878): Vacuolar 14 Fab1-binding region
71 YWHAGprotein found in more fusions130.40927.81714-3-3 (PF00244, IPR023410, SM00101): 14-3-3 protein

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