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Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: parental proteins DSC2, GPHN (from a repository: Sat Jul 13 15:30:42 2019)
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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)38
The number (and %) of the onco-proteins9 (23.68 %)
The number (and %) of the tumor suppressors3 (7.89 %)
Total number of binary PPIs (saturation %)94 (13.37 %)
The number (and %) of affected PPIs37 (39.36 %)
The number of possible different fusions6
PPI diameter4
PPI radius2
The average degree of PPI4.316
Assortativity coefficient-0.3427
The network average Clustering coefficient0.482
The number (and %) of a zero Clustering coefficients10 (26.32 %)
The number (and %) of a zero Betweenness Centrality15 (39.47 %)

ACTIVE INTERACTORS


List of the fusions

PPI for parental proteins: GPHN,DSC2 All fusions
Proteins found in more fusions BRCC3 (see 1 fusions); KHDRBS1 (see 1 fusions); GPHN (see 2 fusions); ACADVL (see 2 fusions); MTOR (see 1 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 GPHNparental protein240.071659.167MoCF_biosynth (PF00994, IPR001453, SM00852): Probable molybdopterin binding domain
MoeA_C (PF03454, IPR005111): MoeA C-terminal region (domain IV)
MoeA_N (PF03453, IPR005110): MoeA N-terminal region (domain I and II)
Tubulin-binding (PF00418, IPR001084): Tau and MAP protein, tubulin-binding repeat
2 DSC2parental protein130.231127.206Cadherin_C (PF01049, IPR000233): Cadherin cytoplasmic region
Cadherin_pro (PF08758, IPR014868, SM01055): Cadherin prodomain like
Cadherin (PF00028, IPR002126, SM00112): Cadherin domain
Cadherin_3 (PF16184): Cadherin-like
3 ACADVLprotein found in more fusions31.0000Acyl-CoA_dh_1 (PF00441, IPR009075): Acyl-CoA dehydrogenase, C-terminal domain
Acyl-CoA_dh_M (PF02770, IPR006091): Acyl-CoA dehydrogenase, middle domain
Acyl-CoA_dh_N (PF02771, IPR013786): Acyl-CoA dehydrogenase, N-terminal domain
4 ARHGEF9interactor21.0000PH (PF00169, IPR001849, SM00233): PH domain
RhoGEF (PF00621, IPR000219, SM00325): RhoGEF domain
SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
5 BRCC3protein found in more fusions31.0000JAB (PF01398, IPR000555, SM00232): JAB1/Mov34/MPN/PAD-1 ubiquitin protease
6 CDCA5interactor200Sororin (PF09666, IPR018605): Sororin protein
7 CLK1interactor3015.394PDGF_N (PF04692, IPR006782): Platelet-derived growth factor, N terminal region
Pkinase (PF00069, IPR000719): Protein kinase domain
8 CSNK2A2interactor204.800Pkinase (PF00069, IPR000719): Protein kinase domain
9 DSG1interactor60.40072.310Cadherin_C (PF01049, IPR000233): Cadherin cytoplasmic region
Cadherin (PF00028, IPR002126, SM00112): Cadherin domain
Cadherin_3 (PF16184): Cadherin-like
10 DSG2oncoprotein70.47611.833BAT2_N (PF07001, IPR009738): BAT2 N-terminus
Cadherin_C (PF01049, IPR000233): Cadherin cytoplasmic region
Cadherin (PF00028, IPR002126, SM00112): Cadherin domain
Cadherin_3 (PF16184): Cadherin-like
11 DYNLL1interactor3042.870Dynein_light (PF01221, IPR001372): Dynein light chain type 1
12 ELAVL1oncoprotein100.222202.421RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
13 GLRBinteractor100Neur_chan_LBD (PF02931, IPR006202): Neurotransmitter-gated ion-channel ligand binding domain
Neur_chan_memb (PF02932, IPR006029): Neurotransmitter-gated ion-channel transmembrane region
14 GMCL1interactor40.6670.952BACK (PF07707, IPR011705, SM00875): BTB And C-terminal Kelch
BTB (PF00651, IPR013069, SM00225): BTB/POZ domain
15 JUPsuppressor90.361167.067Arm (PF00514, IPR000225, SM00185): Armadillo/beta-catenin-like repeat
Atx10homo_assoc (PF09759, IPR019156): Spinocerebellar ataxia type 10 protein domain
HEAT_EZ (PF13513): HEAT-like repeat
HEAT_2 (PF13646): HEAT repeats
16 KHDRBS1protein found in more fusions50.33355.714KH_1 (PF00013, IPR004088, SM00322): KH domain
Qua1 (PF16274, IPR032571): Qua1 domain
Sam68-YY (PF16568, IPR032335): Tyrosine-rich domain of Sam68
17 MTA2interactor70.42971.920BAH (PF01426, IPR001025, SM00439): BAH domain
ELM2 (PF01448, IPR000949): ELM2 domain
Resolvase (PF00239, IPR006119, SM00857): Resolvase, N terminal domain
DDA1 (PF10172, IPR018276): Det1 complexing ubiquitin ligase
Myb_DNA-binding (PF00249, IPR001005, SM00717): Myb-like DNA-binding domain
GATA (PF00320, IPR000679, SM00401): GATA zinc finger
18 MTORoncoprotein31.0000DUF1104 (PF06518, IPR009488): Protein of unknown function (DUF1104)
EPSP_synthase (PF00275, IPR001986): EPSP synthase (3-phosphoshikimate 1-carboxyvinyltransferase)
FAT (PF02259, IPR003151): FAT domain
FATC (PF02260, IPR003152): FATC domain
HEAT (PF02985, IPR000357): HEAT repeat
FRB_dom (PF08771, IPR009076): FKBP12-rapamycin binding domain
V-ATPase_H_N (PF03224, IPR004908): V-ATPase subunit H
PI3_PI4_kinase (PF00454, IPR000403, SM00146): Phosphatidylinositol 3- and 4-kinase
DUF3385 (PF11865, IPR024585): Domain of unknown function (DUF3385)
HEAT_EZ (PF13513): HEAT-like repeat
HEAT_2 (PF13646): HEAT repeats
TPR_19 (PF14559): Tetratricopeptide repeat
19 NTRK1oncoprotein160.162372.084I-set (PF07679, IPR013098): Immunoglobulin I-set domain
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
LRR_8 (PF13855, IPR001611): Leucine rich repeat
TPKR_C2 (PF16920, IPR031635): Tyrosine-protein kinase receptor C2 Ig-like domain
20 ODF3L2interactor100SHIPPO-rpt (PF07004, IPR010736): Sperm-tail PG-rich repeat
21 OTUD4interactor40.33327.448OTU (PF02338, IPR003323): OTU-like cysteine protease
Presenilin (PF01080, IPR001108): Presenilin
Peptidase_C65 (PF10275, IPR019400): Peptidase C65 Otubain
22 PAAF1interactor100WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
23 PCK1interactor100PEPCK (PF00821, IPR008209): Phosphoenolpyruvate carboxykinase
24 PFN1suppressor30.66722.425Profilin (PF00235, IPR005455, SM00392): Profilin
25 PKP2interactor50.8002.333Arm (PF00514, IPR000225, SM00185): Armadillo/beta-catenin-like repeat
DUF383 (PF04063, IPR007205): Domain of unknown function (DUF383)
26 PKP3interactor40.8331.000Arm (PF00514, IPR000225, SM00185): Armadillo/beta-catenin-like repeat
DUF383 (PF04063, IPR007205): Domain of unknown function (DUF383)
27 PPP4R1interactor40.8330.667HEAT (PF02985, IPR000357): HEAT repeat
Cnd1 (PF12717, IPR032682): non-SMC mitotic condensation complex subunit 1
Vac14_Fab1_bd (PF12755, IPR032878): Vacuolar 14 Fab1-binding region
HEAT_2 (PF13646): HEAT repeats
WRNPLPNID (PF15017): Putative WW-binding domain and destruction box
28 PRPF4interactor40.6671.150PRP4 (PF08799, IPR014906): pre-mRNA processing factor 4 (PRP4) like
WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
WD40_like (PF17005, IPR031544): WD40-like domain
29 ROCK2interactor40.83322.425Cortex-I_coil (PF09304, IPR015383): Cortexillin I, coiled coil
DivIC (PF04977, IPR007060): Septum formation initiator
ZapB (PF06005, IPR009252): Cell division protein ZapB
PH (PF00169, IPR001849, SM00233): PH domain
Pkinase (PF00069, IPR000719): Protein kinase domain
Pkinase_C (PF00433, IPR017892): Protein kinase C terminal domain
Rho_Binding (PF08912, IPR015008): Rho Binding
C1_1 (PF00130, IPR002219, SM00109): Phorbol esters/diacylglycerol binding domain (C1 domain)
ADIP (PF11559, IPR021622): Afadin- and alpha -actinin-Binding
TMF_TATA_bd (PF12325, IPR022091): TATA element modulatory factor 1 TATA binding
PRKG1_interact (PF15898, IPR031775): cGMP-dependent protein kinase interacting domain
HIP1_clath_bdg (PF16515, IPR032422): Clathrin-binding domain of Huntingtin-interacting protein 1
BST2 (PF16716, IPR024886): Bone marrow stromal antigen 2
30 RYKoncoprotein30.6672.833Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
WIF (PF02019, IPR003306, SM00469): WIF domain
31 SENP3interactor21.0000Nop53 (PF07767, IPR011687): Nop53 (60S ribosomal biogenesis)
Peptidase_C48 (PF02902, IPR003653): Ulp1 protease family, C-terminal catalytic domain
32 SKA1interactor21.0000SKA1 (PF07160, IPR009829): Spindle and kinetochore-associated protein 1
33 SPATS1interactor100SASRP1 (PF15160, IPR029165): Spermatogenesis-associated serine-rich protein 1
34 SPTAN1oncoprotein31.0000EFhand_Ca_insen (PF08726, IPR014837): Ca2+ insensitive EF hand
Spectrin (PF00435, IPR002017): Spectrin repeat
SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
Tetrabrachion (PF11401, IPR021535): Tetrabrachion
EF-hand_7 (PF13499, IPR011992): EF-hand domain pair
E2F_CC-MB (PF16421, IPR032198): E2F transcription factor CC-MB domain
35 TCF4suppressor30.6671.150CDC45 (PF02724, IPR003874): CDC45-like protein
HLH (PF00010, IPR011598, SM00353): Helix-loop-helix DNA-binding domain
36 TMEM17interactor41.0000Transmemb_17 (PF09799, IPR019184): Predicted membrane protein
DUF3043 (PF11241, IPR021403): Protein of unknown function (DUF3043)
37 TMEM216interactor30.6672.833Transmemb_17 (PF09799, IPR019184): Predicted membrane protein
38 TSSK1Binteractor100Pkinase (PF00069, IPR000719): Protein kinase domain

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