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Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: parental proteins ADGRA3, DPP4 (from a repository: Tue Jul 30 07:34:05 2019)
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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)10
The number (and %) of the onco-proteins3 (30.00 %)
The number (and %) of the tumor suppressors2 (20.00 %)
Total number of binary PPIs (saturation %)14 (31.11 %)
The number (and %) of affected PPIs8 (57.14 %)
The number of possible different fusions2
PPI diameter2
PPI radiusinf
The average degree of PPI2.200
Assortativity coefficient0.1721
The network average Clustering coefficient0.481
The number (and %) of a zero Clustering coefficients4 (40.00 %)
The number (and %) of a zero Betweenness Centrality8 (80.00 %)

ACTIVE INTERACTORS


List of the fusions

PPI for parental proteins: DPP4,ADGRA3 All fusions
Proteins found in more fusions IKBKB (see 2 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 DPP4parental protein70.14335.000DPPIV_N (PF00930, IPR002469): Dipeptidyl peptidase IV (DPP IV) N-terminal region
Peptidase_S9 (PF00326, IPR001375): Prolyl oligopeptidase family
2 ADGRA3parental protein1007tm_2 (PF00002, IPR000832): 7 transmembrane receptor (Secretin family)
GPS (PF01825, IPR000203, SM00303): GPCR proteolysis site, GPS, motif
I-set (PF07679, IPR013098): Immunoglobulin I-set domain
MgtE (PF01769, IPR006667): Divalent cation transporter
HRM (PF02793, IPR001879, SM00008): Hormone receptor domain
LRR_8 (PF13855, IPR001611): Leucine rich repeat
TPKR_C2 (PF16920, IPR031635): Tyrosine-protein kinase receptor C2 Ig-like domain
3 ADAinteractor21.0000A_deaminase (PF00962, IPR001365): Adenosine/AMP deaminase
4 BCL10suppressor40.6671.000CARD (PF00619, IPR001315, SM00114): Caspase recruitment domain
5 CARD11oncoprotein31.0000CARD (PF00619, IPR001315, SM00114): Caspase recruitment domain
DUF1664 (PF07889, IPR012458): Protein of unknown function (DUF1664)
Cnn_1N (PF07989, IPR012943): Centrosomin N-terminal motif 1
PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF)
zf-C4H2 (PF10146, IPR018482): Zinc finger-containing protein
Guanylate_kin (PF00625, IPR008145, SM00072): Guanylate kinase
DUF3450 (PF11932, IPR016866): Protein of unknown function (DUF3450)
6 CCL22interactor100IL8 (PF00048, IPR001811, SM00199): Small cytokines (intecrine/chemokine), interleukin-8 like
7 DKK1suppressor100Dickkopf_N (PF04706, IPR006796): Dickkopf N-terminal cysteine-rich region
UPF0506 (PF11703, IPR021712): UPF0506
8 FAPinteractor21.0000DPPIV_N (PF00930, IPR002469): Dipeptidyl peptidase IV (DPP IV) N-terminal region
Peptidase_S9 (PF00326, IPR001375): Prolyl oligopeptidase family
9 IKBKBprotein found in more fusions31.0000FliT (PF05400, IPR008622): Flagellar protein FliT
Glyco_hydro_65m (PF03632, IPR005195): Glycosyl hydrolase family 65 central catalytic domain
Pkinase (PF00069, IPR000719): Protein kinase domain
SlyX (PF04102, IPR007236): SlyX
ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
IKKbetaNEMObind (PF12179, IPR022007): I-kappa-kinase-beta NEMO binding domain
10 RYKoncoprotein100Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
WIF (PF02019, IPR003306, SM00469): WIF domain

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