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Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: parental proteins CD109, DPP4 (from a repository: Fri Dec 4 04:42:12 2020)
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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)23
The number (and %) of the onco-proteins4 (17.39 %)
The number (and %) of the tumor suppressors4 (17.39 %)
Total number of binary PPIs (saturation %)37 (14.62 %)
The number (and %) of affected PPIs21 (56.76 %)
The number of possible different fusions4
PPI diameter5
PPI radius3
The average degree of PPI2.783
Assortativity coefficient-0.3138
The network average Clustering coefficient0.473
The number (and %) of a zero Clustering coefficients9 (39.13 %)
The number (and %) of a zero Betweenness Centrality17 (73.91 %)

ACTIVE INTERACTORS


List of the fusions

PPI for parental proteins: DPP4,CD109 All fusions
Proteins found in more fusions IKBKB (see 2 fusions); MAPRE1 (see 1 fusions); LGALS3 (see 2 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 DPP4parental protein70.143185.000DPPIV_N (PF00930, IPR002469): Dipeptidyl peptidase IV (DPP IV) N-terminal region
Peptidase_S9 (PF00326, IPR001375): Prolyl oligopeptidase family
2 CD109parental protein140.077374.000A2M (PF00207, IPR001599): Alpha-2-macroglobulin family
A2M_comp (PF07678, IPR011626): A-macroglobulin complement component
A2M_N (PF01835, IPR002890): MG2 domain
A2M_N_2 (PF07703, IPR011625): Alpha-2-macroglobulin family N-terminal region
A2M_recep (PF07677, IPR009048): A-macroglobulin receptor
Thiol-ester_cl (PF10569, IPR019565): Alpha-macro-globulin thiol-ester bond-forming region
Lipocalin_4 (PF13648, IPR024311): Lipocalin-like domain
3 ADAinteractor21.0000A_deaminase (PF00962, IPR001365): Adenosine/AMP deaminase
4 BCL10suppressor40.6671.000CARD (PF00619, IPR001315, SM00114): Caspase recruitment domain
5 CARD11oncoprotein31.0000CARD (PF00619, IPR001315, SM00114): Caspase recruitment domain
DUF1664 (PF07889, IPR012458): Protein of unknown function (DUF1664)
Cnn_1N (PF07989, IPR012943): Centrosomin N-terminal motif 1
PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF)
zf-C4H2 (PF10146, IPR018482): Zinc finger-containing protein
Guanylate_kin (PF00625, IPR008145, SM00072): Guanylate kinase
DUF3450 (PF11932, IPR016866): Protein of unknown function (DUF3450)
6 CCL22interactor100IL8 (PF00048, IPR001811, SM00199): Small cytokines (intecrine/chemokine), interleukin-8 like
7 CELA2Binteractor100Trypsin (PF00089, IPR001254, SM00020): Trypsin
8 DKK1suppressor100Dickkopf_N (PF04706, IPR006796): Dickkopf N-terminal cysteine-rich region
UPF0506 (PF11703, IPR021712): UPF0506
9 ERLIN2interactor20224.000Band_7 (PF01145, IPR001107, SM00244): SPFH domain / Band 7 family
DUF4346 (PF14251, IPR025595): Domain of unknown function (DUF4346)
10 FAPinteractor30.333210.000DPPIV_N (PF00930, IPR002469): Dipeptidyl peptidase IV (DPP IV) N-terminal region
Peptidase_S9 (PF00326, IPR001375): Prolyl oligopeptidase family
11 FCGR3Binteractor100Ig_2 (PF13895, IPR007110): Immunoglobulin domain
12 IKBKBprotein found in more fusions31.0000FliT (PF05400, IPR008622): Flagellar protein FliT
Glyco_hydro_65m (PF03632, IPR005195): Glycosyl hydrolase family 65 central catalytic domain
Pkinase (PF00069, IPR000719): Protein kinase domain
SlyX (PF04102, IPR007236): SlyX
ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
IKKbetaNEMObind (PF12179, IPR022007): I-kappa-kinase-beta NEMO binding domain
13 ISLRinteractor100I-set (PF07679, IPR013098): Immunoglobulin I-set domain
LRRCT (PF01463, IPR000483, SM00082): Leucine rich repeat C-terminal domain
LRR_8 (PF13855, IPR001611): Leucine rich repeat
TPKR_C2 (PF16920, IPR031635): Tyrosine-protein kinase receptor C2 Ig-like domain
14 LGALS3oncoprotein41.0000Gal-bind_lectin (PF00337, IPR001079, SM00908): Galactoside-binding lectin
15 LGALS9interactor31.0000Gal-bind_lectin (PF00337, IPR001079, SM00908): Galactoside-binding lectin
Peptidase_C62 (PF12380, IPR024348): Gill-associated viral 3C-like peptidase
16 MAPRE1oncoprotein31.0000CH (PF00307, IPR001715, SM00033): Calponin homology (CH) domain
EB1 (PF03271, IPR004953): EB1-like C-terminal motif
SUIM_assoc (PF16619): Unstructured region C-term to UIM in Ataxin3
17 MYH9suppressor31.0000IQ (PF00612, IPR000048, SM00015): IQ calmodulin-binding motif
Myosin_N (PF02736, IPR004009): Myosin N-terminal SH3-like domain
Myosin_tail_1 (PF01576, IPR002928): Myosin tail
Myosin_head (PF00063, IPR001609, SM00242): Myosin head (motor domain)
18 MYO5Cinteractor31.0000DIL (PF01843, IPR018444, SM01132): DIL domain
DUF1664 (PF07889, IPR012458): Protein of unknown function (DUF1664)
ERM (PF00769, IPR011259): Ezrin/radixin/moesin family
IQ (PF00612, IPR000048, SM00015): IQ calmodulin-binding motif
Myosin_N (PF02736, IPR004009): Myosin N-terminal SH3-like domain
Pilus_CpaD (PF09476, IPR019027): Pilus biogenesis CpaD protein (pilus_cpaD)
Myosin_head (PF00063, IPR001609, SM00242): Myosin head (motor domain)
YtxH (PF12732, IPR024623): YtxH-like protein
Lebercilin (PF15619, IPR028933): Ciliary protein causing Leber congenital amaurosis disease
19 PTPRKsuppressor31.0000fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain
I-set (PF07679, IPR013098): Immunoglobulin I-set domain
MAM (PF00629, IPR000998, SM00137): MAM domain, meprin/A5/mu
Protocadherin (PF08374, IPR013585): Protocadherin
Y_phosphatase (PF00102, IPR000242, SM00194): Protein-tyrosine phosphatase
20 RNASE13interactor100RnaseA (PF00074, IPR023412, SM00092): Pancreatic ribonuclease
21 SYNPOinteractor40.6672.000Calsarcin (PF05556, IPR008438): Calcineurin-binding protein (Calsarcin)
22 TAZinteractor100Acyltransferase (PF01553, IPR002123, SM00563): Acyltransferase
23 TMEM185Ainteractor100Tmemb_185A (PF10269, IPR019396): Transmembrane Fragile-X-F protein

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