Find Fusion Network

Enter
Fusion ID:
Protein names:


Level of PPIs:
or Upload text file:
Update repository
Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: parental proteins COLEC10, DLG2 (from a repository: Mon Aug 12 08:51:37 2019)
Examples

Cytoscape Web will replace the contents your graph
PPI Properties:

Click on nodes
or edges

Layout Tree
Circle
Radial
Force Directed
Preset
Export graph
PDF file
SVG file
SIF file
XML file
GraphML file

Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)38
The number (and %) of the onco-proteins7 (18.42 %)
The number (and %) of the tumor suppressors3 (7.89 %)
Total number of binary PPIs (saturation %)67 (9.53 %)
The number (and %) of affected PPIs36 (53.73 %)
The number of possible different fusions4
PPI diameter5
PPI radius3
The average degree of PPI3.158
Assortativity coefficient-0.4708
The network average Clustering coefficient0.464
The number (and %) of a zero Clustering coefficients18 (47.37 %)
The number (and %) of a zero Betweenness Centrality30 (78.95 %)

ACTIVE INTERACTORS


List of the fusions

PPI for parental proteins: COLEC10,DLG2 All fusions
Proteins found in more fusions CKAP4 (see 5 fusions); KHDRBS1 (see 1 fusions); DLG4 (see 1 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 COLEC10parental protein140736.000Collagen (PF01391, IPR008160): Collagen triple helix repeat (20 copies)
Lectin_C (PF00059, IPR001304, SM00034): Lectin C-type domain
2 DLG2parental protein220.095636.667Chordopox_A33R (PF05966, IPR009238): Chordopoxvirus A33R protein
L27_1 (PF09058, IPR015143): L27_1
PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF)
SH3_2 (PF07653, IPR011511): Variant SH3 domain
MAGUK_N_PEST (PF10608, IPR019590): Polyubiquitination (PEST) N-terminal domain of MAGUK
PDZ_assoc (PF10600, IPR019583): PDZ-associated domain of NMDA receptors
Guanylate_kin (PF00625, IPR008145, SM00072): Guanylate kinase
3 ARL8Ainteractor100Arf (PF00025, IPR006689, SM00177): ADP-ribosylation factor family
4 ATP2B2interactor100Cation_ATPase_C (PF00689, IPR006068): Cation transporting ATPase, C-terminus
Cation_ATPase_N (PF00690, IPR004014, SM00831): Cation transporter/ATPase, N-terminus
DUF106 (PF01956, IPR002809): Integral membrane protein DUF106
E1-E2_ATPase (PF00122, IPR008250): E1-E2 ATPase
Hydrolase_3 (PF08282, IPR023214): haloacid dehalogenase-like hydrolase
ATP_Ca_trans_C (PF12424, IPR022141): Plasma membrane calcium transporter ATPase C terminal
Cation_ATPase (PF13246): Cation transport ATPase (P-type)
5 ATP2B4interactor100Cation_ATPase_C (PF00689, IPR006068): Cation transporting ATPase, C-terminus
Cation_ATPase_N (PF00690, IPR004014, SM00831): Cation transporter/ATPase, N-terminus
E1-E2_ATPase (PF00122, IPR008250): E1-E2 ATPase
Hydrolase (PF00702, IPR023214): haloacid dehalogenase-like hydrolase
Hydrolase_3 (PF08282, IPR023214): haloacid dehalogenase-like hydrolase
ATP_Ca_trans_C (PF12424, IPR022141): Plasma membrane calcium transporter ATPase C terminal
Cation_ATPase (PF13246): Cation transport ATPase (P-type)
6 CKAP4protein found in more fusions200DUF1180 (PF06679, IPR009565): Protein of unknown function (DUF1180)
FPP (PF05911, IPR008587): Filament-like plant protein, long coiled-coil
Fib_alpha (PF08702, IPR012290): Fibrinogen alpha/beta chain family
Reo_sigmaC (PF04582, IPR007662): Reovirus sigma C capsid protein
DUF4200 (PF13863, IPR025252): Domain of unknown function (DUF4200)
7 COLGALT2interactor100Aminotran_4 (PF01063, IPR001544): Amino-transferase class IV
Glyco_transf_25 (PF01755, IPR002654): Glycosyltransferase family 25 (LPS biosynthesis protein)
Glyco_tranf_2_4 (PF13704): Glycosyl transferase family 2
8 DCP2interactor100DCP2 (PF05026, IPR007722, SM01125): Dcp2, box A domain
NUDIX (PF00293, IPR000086): NUDIX domain
9 DLG4protein found in more fusions200.129290.833L27_1 (PF09058, IPR015143): L27_1
PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF)
MAGUK_N_PEST (PF10608, IPR019590): Polyubiquitination (PEST) N-terminal domain of MAGUK
PDZ_assoc (PF10600, IPR019583): PDZ-associated domain of NMDA receptors
Guanylate_kin (PF00625, IPR008145, SM00072): Guanylate kinase
SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
10 DLGAP1oncoprotein50.8008.500Dicty_REP (PF05086, IPR007778): Dictyostelium (Slime Mold) REP protein
GKAP (PF03359, IPR005026): Guanylate-kinase-associated protein (GKAP) protein
11 DNAJB9interactor20406.167DnaJ (PF00226, IPR001623, SM00271): DnaJ domain
DUF1777 (PF08648, IPR013957): Protein of unknown function (DUF1777)
12 DYNLL1interactor60.600422.167Dynein_light (PF01221, IPR001372): Dynein light chain type 1
13 DYNLL2interactor51.0000Dynein_light (PF01221, IPR001372): Dynein light chain type 1
14 ERBB4suppressor31.0000Furin-like (PF00757, IPR006211): Furin-like cysteine rich region
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
Recep_L_domain (PF01030, IPR000494): Receptor L domain
DUF3951 (PF13131, IPR025028): Protein of unknown function (DUF3951)
GF_recep_IV (PF14843, IPR032778): Growth factor receptor domain IV
15 FASLGinteractor20209.833PAP_PilO (PF06864, IPR009663): Pilin accessory protein (PilO)
TNF (PF00229, IPR006052, SM00207): TNF(Tumour Necrosis Factor) family
PRIMA1 (PF16101): Proline-rich membrane anchor 1
16 GRIN2Asuppressor31.0000ANF_receptor (PF01094, IPR001828): Receptor family ligand binding region
Lig_chan (PF00060, IPR001320): Ligand-gated ion channel
Lig_chan-Glu_bd (PF10613, IPR019594, SM00918): Ligated ion channel L-glutamate- and glycine-binding site
NMDAR2_C (PF10565, IPR018884): N-methyl D-aspartate receptor 2B3 C-terminus
17 GRIN2Binteractor21.0000ANF_receptor (PF01094, IPR001828): Receptor family ligand binding region
Lig_chan (PF00060, IPR001320): Ligand-gated ion channel
Lig_chan-Glu_bd (PF10613, IPR019594, SM00918): Ligated ion channel L-glutamate- and glycine-binding site
NMDAR2_C (PF10565, IPR018884): N-methyl D-aspartate receptor 2B3 C-terminus
18 GUCY1A2oncoprotein21.0000HNOB (PF07700, IPR011644): Haem-NO-binding
HNOBA (PF07701, IPR011645): Heme NO binding associated
Ribosomal_60s (PF00428, IPR001813): 60s Acidic ribosomal protein
Guanylate_cyc (PF00211, IPR001054, SM00044): Adenylate and Guanylate cyclase catalytic domain
19 INHBEoncoprotein100TGF_beta (PF00019, IPR001839, SM00204): Transforming growth factor beta like domain
Anti-TRAP (PF15777, IPR031538): Tryptophan RNA-binding attenuator protein inhibitory protein
20 KCNA4interactor21.0000GRP (PF07172, IPR010800): Glycine rich protein family
Ion_trans (PF00520, IPR005821): Ion transport protein
K_channel_TID (PF07941, IPR012897): Potassium channel Kv1.4 tandem inactivation domain
BTB_2 (PF02214, IPR003131): BTB/POZ domain
RNA_pol_3_Rpc31 (PF11705, IPR024661): DNA-directed RNA polymerase III subunit Rpc31
Sigma_reg_N (PF13800, IPR029101): Sigma factor regulator N-terminal
21 KCNJ12interactor21.0000IRK (PF01007, IPR016449): Inward rectifier potassium channel
IRK_N (PF08466, IPR013673): Inward rectifier potassium channel N-terminal
22 KCNJ4interactor21.0000IRK (PF01007, IPR016449): Inward rectifier potassium channel
IRK_N (PF08466, IPR013673): Inward rectifier potassium channel N-terminal
23 KHDRBS1protein found in more fusions31.0000KH_1 (PF00013, IPR004088, SM00322): KH domain
Qua1 (PF16274, IPR032571): Qua1 domain
Sam68-YY (PF16568, IPR032335): Tyrosine-rich domain of Sam68
24 LRP2oncoprotein21.0000Arylesterase (PF01731, IPR002640): Arylesterase
EGF (PF00008, IPR000742, SM00181): EGF-like domain
EGF_CA (PF07645, IPR001881, SM00179): Calcium-binding EGF domain
Form-deh_trans (PF09163, IPR015246): Formate dehydrogenase N, transmembrane
SGL (PF08450, IPR013658): SMP-30/Gluconolaconase/LRE-like region
Ldl_recept_a (PF00057, IPR002172, SM00192): Low-density lipoprotein receptor domain class A
Ldl_recept_b (PF00058, IPR000033, SM00135): Low-density lipoprotein receptor repeat class B
cEGF (PF12662, IPR026823): Complement Clr-like EGF-like
FXa_inhibition (PF14670): Coagulation Factor Xa inhibitory site
25 MAP1Ainteractor21.0000Borrelia_P83 (PF05262, IPR007926): Borrelia P83/100 protein
DUF1777 (PF08648, IPR013957): Protein of unknown function (DUF1777)
DUF572 (PF04502, IPR007590): Family of unknown function (DUF572)
DUF3552 (PF12072, IPR022711): Domain of unknown function (DUF3552)
Lactamase_B_6 (PF16661, IPR001279): Metallo-beta-lactamase superfamily domain
26 MCUinteractor100MCU (PF04678, IPR006769): Mitochondrial calcium uniporter
27 MIA3interactor100bZIP_1 (PF00170, IPR004827): bZIP transcription factor
CENP-B_dimeris (PF09026, IPR015115): Centromere protein B dimerisation domain
DUF1664 (PF07889, IPR012458): Protein of unknown function (DUF1664)
IncA (PF04156, IPR007285): IncA protein
NPIP (PF06409): Nuclear pore complex interacting protein (NPIP)
OmpH (PF03938, IPR005632, SM00935): Outer membrane protein (OmpH-like)
SH3_2 (PF07653, IPR011511): Variant SH3 domain
Spc24 (PF08286, IPR013252): Spc24 subunit of Ndc80
DUF3450 (PF11932, IPR016866): Protein of unknown function (DUF3450)
TMF_DNA_bd (PF12329, IPR022092): TATA element modulatory factor 1 DNA binding
DUF4407 (PF14362, IPR025519): Domain of unknown function (DUF4407)
KELK (PF15796, IPR031597): KELK-motif containing domain of MRCK Ser/Thr protein kinase
28 NLGN1interactor21.0000COesterase (PF00135, IPR002018): Carboxylesterase family
Sarcoglycan_2 (PF05510, IPR008908): Sarcoglycan alpha/epsilon
29 NLGN2interactor21.0000COesterase (PF00135, IPR002018): Carboxylesterase family
SMN (PF06003, IPR010304): Survival motor neuron protein (SMN)
PRIMA1 (PF16101): Proline-rich membrane anchor 1
30 NLGN3interactor21.0000COesterase (PF00135, IPR002018): Carboxylesterase family
Lamp (PF01299, IPR002000): Lysosome-associated membrane glycoprotein (Lamp)
31 NOS1interactor21.0000FAD_binding_1 (PF00667, IPR003097): FAD binding domain
Flavodoxin_1 (PF00258, IPR008254): Flavodoxin
NAD_binding_1 (PF00175, IPR001433): Oxidoreductase NAD-binding domain
NO_synthase (PF02898, IPR004030): Nitric oxide synthase, oxygenase domain
PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF)
32 NUCB2interactor100Bap31 (PF05529, IPR008417): B-cell receptor-associated protein 31-like
Histone_HNS (PF00816, IPR001801): H-NS histone family
Peptidase_U57 (PF05582, IPR008764): YabG peptidase U57
Put_DNA-bind_N (PF06971, IPR009718): Putative DNA-binding protein N-terminus
EF-hand_7 (PF13499, IPR011992): EF-hand domain pair
33 P3H4interactor20193.833TPR_9 (PF13371, IPR011990): Tetratricopeptide repeat
TPR_16 (PF13432): Tetratricopeptide repeat
TPR_18 (PF13512): Tetratricopeptide repeat
34 PTX3interactor100FUSC (PF04632, IPR006726): Fusaric acid resistance protein family
Pentaxin (PF00354, IPR001759, SM00159): Pentaxin family
35 SEMA4Cinteractor21.0000DUF1049 (PF06305, IPR010445): Protein of unknown function (DUF1049)
PSI (PF01437, IPR002165, SM00423): Plexin repeat
Sema (PF01403, IPR001627, SM00630): Sema domain
Ig_2 (PF13895, IPR007110): Immunoglobulin domain
36 SOD1interactor200Sod_Cu (PF00080, IPR001424): Copper/zinc superoxide dismutase (SODC)
37 STC2interactor100Stanniocalcin (PF03298, IPR004978): Stanniocalcin family
38 TIMP3suppressor100TIMP (PF00965, IPR001820): Tissue inhibitor of metalloproteinase

B a c k    t o    T o p ⇑