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Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: parental proteins CLYBL, PCCA (from a repository: Fri Feb 17 03:30:50 2017)
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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)15
The number (and %) of the onco-proteins5 (33.33 %)
The number (and %) of the tumor suppressors2 (13.33 %)
Total number of binary PPIs (saturation %)25 (23.81 %)
The number (and %) of affected PPIs13 (52.00 %)
The number of possible different fusions4
PPI diameter2
PPI radiusinf
The average degree of PPI2.533
Assortativity coefficient-0.5210
The network average Clustering coefficient0.367
The number (and %) of a zero Clustering coefficients8 (53.33 %)
The number (and %) of a zero Betweenness Centrality12 (80.00 %)

ACTIVE INTERACTORS


List of the fusions

PPI for parental proteins: CLYBL,PCCA All fusions
Proteins found in more fusions HUWE1 (see 2 fusions); LGALS3 (see 2 fusions); UBE2N (see 1 fusions); SGK1 (see 2 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 CLYBLparental protein202.000HpcH_HpaI (PF03328, IPR005000): HpcH/HpaI aldolase/citrate lyase family
C-C_Bond_Lyase (PF15617): C-C_Bond_Lyase of the TIM-Barrel fold
2 PCCAparental protein110.10989.000Biotin_carb_C (PF02785, IPR005482, SM00878): Biotin carboxylase C-terminal domain
Biotin_lipoyl (PF00364, IPR000089): Biotin-requiring enzyme
Biotin_carb_N (PF00289, IPR005481): Biotin carboxylase, N-terminal domain
CPSase_L_D2 (PF02786, IPR005479): Carbamoyl-phosphate synthase L chain, ATP binding domain
SLT_beta (PF02258, IPR003189): Shiga-like toxin beta subunit
3 HUWE1oncoprotein31.0000BUD22 (PF09073, IPR015158): BUD22
DUF908 (PF06012, IPR010309): Domain of Unknown Function (DUF908)
DUF913 (PF06025, IPR010314): Domain of Unknown Function (DUF913)
FdhE (PF04216, IPR006452): Protein involved in formate dehydrogenase formation
HABP4_PAI-RBP1 (PF04774, IPR006861): Hyaluronan / mRNA binding family
Ku_C (PF03730, IPR005160): Ku70/Ku80 C-terminal arm
Merozoite_SPAM (PF07133, IPR010784): Merozoite surface protein (SPAM)
Mucin (PF01456, IPR000458): Mucin-like glycoprotein
Nop14 (PF04147, IPR007276): Nop14-like family
PBP_sp32 (PF07222, IPR009865): Proacrosin binding protein sp32
RNA_pol_Rpc4 (PF05132, IPR007811): RNA polymerase III RPC4
TFIIA (PF03153, IPR004855): Transcription factor IIA, alpha/beta subunit
UBA (PF00627, IPR000449, SM00165): UBA/TS-N domain
WWE (PF02825, IPR004170, SM00678): WWE domain
HECT (PF00632, IPR000569, SM00119): HECT-domain (ubiquitin-transferase)
Tim54 (PF11711, IPR021056): Inner membrane protein import complex subunit Tim54
U1snRNP70_N (PF12220, IPR022023): U1 small nuclear ribonucleoprotein of 70kDa MW N terminal
DUF4414 (PF14377, IPR025527): Domain of unknown function (DUF4414)
4 IFIT1interactor21.0000TPR_1 (PF00515, IPR001440): Tetratricopeptide repeat
ANAPC5 (PF12862, IPR026000): Anaphase-promoting complex subunit 5
Sec16_C (PF12931, IPR024298): Sec23-binding domain of Sec16
TPR_6 (PF13174, IPR019734): Tetratricopeptide repeat
TPR_11 (PF13414, IPR011990): TPR repeat
TPR_12 (PF13424): Tetratricopeptide repeat
TPR_17 (PF13431): Tetratricopeptide repeat
DUF4268 (PF14088, IPR025364): Domain of unknown function (DUF4268)
TPR_19 (PF14559): Tetratricopeptide repeat
5 INPP5Dinteractor100Exo_endo_phos (PF03372, IPR005135): Endonuclease/Exonuclease/phosphatase family
SH2 (PF00017, IPR000980, SM00252): SH2 domain
6 IP6K3interactor100IPK (PF03770, IPR005522): Inositol polyphosphate kinase
7 LATinteractor100LAT (PF15234, IPR008359): Linker for activation of T-cells
8 LGALS3oncoprotein200Gal-bind_lectin (PF00337, IPR001079, SM00908): Galactoside-binding lectin
9 PARK2suppressor41.0000IBR (PF01485, IPR002867, SM00647): IBR domain, a half RING-finger domain
ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
10 PCCBinteractor60.4009.000Carboxyl_trans (PF01039, IPR000022): Carboxyl transferase domain
11 PTENsuppressor21.0000DSPc (PF00782, IPR020422, SM00195): Dual specificity phosphatase, catalytic domain
PTEN_C2 (PF10409, IPR014020): C2 domain of PTEN tumour-suppressor protein
12 RARS2interactor100DALR_1 (PF05746, IPR008909, SM00836): DALR anticodon binding domain
tRNA-synt_1d (PF00750, IPR015945): tRNA synthetases class I (R)
13 SGK1oncoprotein200Pkinase (PF00069, IPR000719): Protein kinase domain
Pkinase_C (PF00433, IPR017892): Protein kinase C terminal domain
PX (PF00787, IPR001683, SM00312): PX domain
14 THBS3oncoprotein200EGF (PF00008, IPR000742, SM00181): EGF-like domain
EGF_CA (PF07645, IPR001881, SM00179): Calcium-binding EGF domain
Laminin_G_2 (PF02210, IPR001791): Laminin G domain
TSP_3 (PF02412, IPR003367): Thrombospondin type 3 repeat
TSP_C (PF05735, IPR008859): Thrombospondin C-terminal region
COMP (PF11598, IPR024665): Cartilage oligomeric matrix protein
cEGF (PF12662, IPR026823): Complement Clr-like EGF-like
EGF_3 (PF12947, IPR024731): EGF domain
15 UBE2Nprotein found in more fusions41.0000UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme

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