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Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: parental proteins CNST, ATP9B (from a repository: Thu Dec 5 16:22:05 2019)
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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)15
The number (and %) of the onco-proteins3 (20.00 %)
The number (and %) of the tumor suppressors3 (20.00 %)
Total number of binary PPIs (saturation %)22 (20.95 %)
The number (and %) of affected PPIs13 (59.09 %)
The number of possible different fusions3
PPI diameter2
PPI radiusinf
The average degree of PPI2.267
Assortativity coefficient-0.3822
The network average Clustering coefficient0.359
The number (and %) of a zero Clustering coefficients8 (53.33 %)
The number (and %) of a zero Betweenness Centrality12 (80.00 %)

ACTIVE INTERACTORS


List of the fusions

PPI for parental proteins: CNST,ATP9B All fusions
Proteins found in more fusions EWSR1 (see 2 fusions); BAG3 (see 4 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 CNSTparental protein130.051146.000Consortin_C (PF15281, IPR028129): Consortin C-terminus
2 ATP9Binteractor000E1-E2_ATPase (PF00122, IPR008250): E1-E2 ATPase
Hydrolase (PF00702, IPR023214): haloacid dehalogenase-like hydrolase
GNVR (PF13807, IPR032807): G-rich domain on putative tyrosine kinase
PhoLip_ATPase_N (PF16209, IPR032631): Phospholipid-translocating ATPase N-terminal
PhoLip_ATPase_C (PF16212, IPR032630): Phospholipid-translocating P-type ATPase C-terminal
3 BAG3oncoprotein40.6671.000BAG (PF02179, IPR003103, SM00264): BAG domain
WW (PF00397, IPR001202, SM00456): WW domain
4 EWSR1oncoprotein31.0000RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
SVS_QK (PF10578, IPR018942): Seminal vesicle protein repeat
zf-RanBP (PF00641, IPR001876, SM00547): Zn-finger in Ran binding protein and others
FoP_duplication (PF13865, IPR025715): C-terminal duplication domain of Friend of PRMT1
Keratin_2_head (PF16208, IPR032444): Keratin type II head
5 GJA1suppressor200Connexin43 (PF03508, IPR013124): Gap junction alpha-1 protein (Cx43)
Connexin (PF00029, IPR013092, SM00037): Connexin
SieB (PF14163, IPR025982): Super-infection exclusion protein B
6 GJB1interactor100Connexin (PF00029, IPR013092, SM00037): Connexin
7 GJB2suppressor100Connexin (PF00029, IPR013092, SM00037): Connexin
8 GJB3interactor100Connexin (PF00029, IPR013092, SM00037): Connexin
9 GJB6interactor100Connexin (PF00029, IPR013092, SM00037): Connexin
10 GJC1interactor100Connexin (PF00029, IPR013092, SM00037): Connexin
DUF4407 (PF14362, IPR025519): Domain of unknown function (DUF4407)
Connexin40_C (PF16791, IPR031862): Connexin 40 C-terminal domain
11 POT1interactor31.0000POT1 (PF02765, IPR011564, SM00976): Telomeric single stranded DNA binding POT1/CDC13
tRNA_anti-codon (PF01336, IPR004365): OB-fold nucleic acid binding domain
POT1PC (PF16686, IPR032042): ssDNA-binding domain of telomere protection protein
12 PPP1CAsuppressor30.6671.000Metallophos (PF00149, IPR004843): Calcineurin-like phosphoesterase
STPPase_N (PF16891, IPR031675): Serine-threonine protein phosphatase N-terminal domain
13 PPP1CConcoprotein21.0000Metallophos (PF00149, IPR004843): Calcineurin-like phosphoesterase
STPPase_N (PF16891, IPR031675): Serine-threonine protein phosphatase N-terminal domain
14 PPP1R3Ainteractor21.0000CBM_21 (PF03370, IPR005036): Carbohydrate/starch-binding module (family 21)
15 ROPN1interactor200RIIa (PF02197, IPR003117, SM00394): Regulatory subunit of type II PKA R-subunit

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