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Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)19
The number (and %) of the onco-proteins4 (21.05 %)
The number (and %) of the tumor suppressors4 (21.05 %)
Total number of binary PPIs (saturation %)32 (18.71 %)
The number (and %) of affected PPIs17 (53.12 %)
The number of possible different fusions5
PPI diameter5
PPI radius3
The average degree of PPI2.632
Assortativity coefficient-0.3572
The network average Clustering coefficient0.382
The number (and %) of a zero Clustering coefficients8 (42.11 %)
The number (and %) of a zero Betweenness Centrality12 (63.16 %)


List of the fusions

PPI for parental proteins: COL4A6,CNST All fusions
Proteins found in more fusions EWSR1 (see 2 fusions); APP (see 4 fusions); VHL (see 1 fusions); BAG3 (see 4 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Domains (Pfam, InterPro, SMART): description
1 COL4A6parental protein40.33335.000C4 (PF01413, IPR001442, SM00111): C-terminal tandem repeated domain in type 4 procollagen
Collagen (PF01391, IPR008160): Collagen triple helix repeat (20 copies)
2 CNSTparental protein130.051241.667Consortin_C (PF15281, IPR028129): Consortin C-terminus
3 APPprotein found in more fusions60.200114.000APP_N (PF02177, IPR015849, SM00006): Amyloid A4 N-terminal heparin-binding
Beta-APP (PF03494, IPR013803): Beta-amyloid peptide (beta-APP)
BUD22 (PF09073, IPR015158): BUD22
IncA (PF04156, IPR007285): IncA protein
Kunitz_BPTI (PF00014, IPR002223, SM00131): Kunitz/Bovine pancreatic trypsin inhibitor domain
APP_amyloid (PF10515, IPR019543): beta-amyloid precursor protein C-terminus
APP_Cu_bd (PF12924, IPR011178): Copper-binding of amyloid precursor, CuBD
APP_E2 (PF12925, IPR024329): E2 domain of amyloid precursor protein
4 BAG3oncoprotein40.6671.000BAG (PF02179, IPR003103, SM00264): BAG domain
WW (PF00397, IPR001202, SM00456): WW domain
5 EWSR1oncoprotein31.0000RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
SVS_QK (PF10578, IPR018942): Seminal vesicle protein repeat
zf-RanBP (PF00641, IPR001876, SM00547): Zn-finger in Ran binding protein and others
FoP_duplication (PF13865, IPR025715): C-terminal duplication domain of Friend of PRMT1
Keratin_2_head (PF16208, IPR032444): Keratin type II head
6 GJA1suppressor200Connexin43 (PF03508, IPR013124): Gap junction alpha-1 protein (Cx43)
Connexin (PF00029, IPR013092, SM00037): Connexin
SieB (PF14163, IPR025982): Super-infection exclusion protein B
7 GJB1interactor2053.333Connexin (PF00029, IPR013092, SM00037): Connexin
8 GJB2suppressor100Connexin (PF00029, IPR013092, SM00037): Connexin
9 GJB3interactor100Connexin (PF00029, IPR013092, SM00037): Connexin
10 GJB6interactor100Connexin (PF00029, IPR013092, SM00037): Connexin
11 GJC1interactor100Connexin (PF00029, IPR013092, SM00037): Connexin
DUF4407 (PF14362, IPR025519): Domain of unknown function (DUF4407)
Connexin40_C (PF16791, IPR031862): Connexin 40 C-terminal domain
12 OSMinteractor21.0000LIF_OSM (PF01291, IPR001581, SM00080): LIF / OSM family
Sugarporin_N (PF11471, IPR021570): Maltoporin periplasmic N-terminal extension
13 POT1interactor31.0000POT1 (PF02765, IPR011564, SM00976): Telomeric single stranded DNA binding POT1/CDC13
tRNA_anti-codon (PF01336, IPR004365): OB-fold nucleic acid binding domain
POT1PC (PF16686, IPR032042): ssDNA-binding domain of telomere protection protein
14 PPP1CAsuppressor30.6674.333Metallophos (PF00149, IPR004843): Calcineurin-like phosphoesterase
STPPase_N (PF16891, IPR031675): Serine-threonine protein phosphatase N-terminal domain
15 PPP1CConcoprotein30.33366.667Metallophos (PF00149, IPR004843): Calcineurin-like phosphoesterase
STPPase_N (PF16891, IPR031675): Serine-threonine protein phosphatase N-terminal domain
16 PPP1R3Ainteractor21.0000CBM_21 (PF03370, IPR005036): Carbohydrate/starch-binding module (family 21)
17 ROPN1interactor200RIIa (PF02197, IPR003117, SM00394): Regulatory subunit of type II PKA R-subunit
18 SUMF1interactor100FGE-sulfatase (PF03781, IPR005532): Sulfatase-modifying factor enzyme 1
DNA_ligase_IV (PF11411, IPR021536): DNA ligase IV
19 VHLsuppressor31.0000Trypan_PARP (PF05887, IPR008882): Procyclic acidic repetitive protein (PARP)
VHL (PF01847, IPR022772): VHL beta domain
VHL_C (PF17211): VHL box domain

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