Find Fusion Network

Enter
Fusion ID:
Protein names:


Level of PPIs:
or Upload text file:
Update repository
Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: parental proteins CNST, COL4A6 (from a repository: Mon Oct 14 16:04:51 2019)
Examples

Cytoscape Web will replace the contents your graph
PPI Properties:

Click on nodes
or edges

Layout Tree
Circle
Radial
Force Directed
Preset
Export graph
PDF file
SVG file
SIF file
XML file
GraphML file

Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)19
The number (and %) of the onco-proteins4 (21.05 %)
The number (and %) of the tumor suppressors4 (21.05 %)
Total number of binary PPIs (saturation %)32 (18.71 %)
The number (and %) of affected PPIs17 (53.12 %)
The number of possible different fusions5
PPI diameter5
PPI radius3
The average degree of PPI2.632
Assortativity coefficient-0.3572
The network average Clustering coefficient0.382
The number (and %) of a zero Clustering coefficients8 (42.11 %)
The number (and %) of a zero Betweenness Centrality12 (63.16 %)

ACTIVE INTERACTORS


List of the fusions

PPI for parental proteins: COL4A6,CNST All fusions
Proteins found in more fusions EWSR1 (see 2 fusions); APP (see 4 fusions); VHL (see 1 fusions); BAG3 (see 4 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 COL4A6parental protein40.33335.000C4 (PF01413, IPR001442, SM00111): C-terminal tandem repeated domain in type 4 procollagen
Collagen (PF01391, IPR008160): Collagen triple helix repeat (20 copies)
2 CNSTparental protein130.051241.667Consortin_C (PF15281, IPR028129): Consortin C-terminus
3 APPprotein found in more fusions60.200114.000APP_N (PF02177, IPR015849, SM00006): Amyloid A4 N-terminal heparin-binding
Beta-APP (PF03494, IPR013803): Beta-amyloid peptide (beta-APP)
BUD22 (PF09073, IPR015158): BUD22
IncA (PF04156, IPR007285): IncA protein
Kunitz_BPTI (PF00014, IPR002223, SM00131): Kunitz/Bovine pancreatic trypsin inhibitor domain
APP_amyloid (PF10515, IPR019543): beta-amyloid precursor protein C-terminus
APP_Cu_bd (PF12924, IPR011178): Copper-binding of amyloid precursor, CuBD
APP_E2 (PF12925, IPR024329): E2 domain of amyloid precursor protein
4 BAG3oncoprotein40.6671.000BAG (PF02179, IPR003103, SM00264): BAG domain
WW (PF00397, IPR001202, SM00456): WW domain
5 EWSR1oncoprotein31.0000RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
SVS_QK (PF10578, IPR018942): Seminal vesicle protein repeat
zf-RanBP (PF00641, IPR001876, SM00547): Zn-finger in Ran binding protein and others
FoP_duplication (PF13865, IPR025715): C-terminal duplication domain of Friend of PRMT1
Keratin_2_head (PF16208, IPR032444): Keratin type II head
6 GJA1suppressor200Connexin43 (PF03508, IPR013124): Gap junction alpha-1 protein (Cx43)
Connexin (PF00029, IPR013092, SM00037): Connexin
SieB (PF14163, IPR025982): Super-infection exclusion protein B
7 GJB1interactor2053.333Connexin (PF00029, IPR013092, SM00037): Connexin
8 GJB2suppressor100Connexin (PF00029, IPR013092, SM00037): Connexin
9 GJB3interactor100Connexin (PF00029, IPR013092, SM00037): Connexin
10 GJB6interactor100Connexin (PF00029, IPR013092, SM00037): Connexin
11 GJC1interactor100Connexin (PF00029, IPR013092, SM00037): Connexin
DUF4407 (PF14362, IPR025519): Domain of unknown function (DUF4407)
Connexin40_C (PF16791, IPR031862): Connexin 40 C-terminal domain
12 OSMinteractor21.0000LIF_OSM (PF01291, IPR001581, SM00080): LIF / OSM family
Sugarporin_N (PF11471, IPR021570): Maltoporin periplasmic N-terminal extension
13 POT1interactor31.0000POT1 (PF02765, IPR011564, SM00976): Telomeric single stranded DNA binding POT1/CDC13
tRNA_anti-codon (PF01336, IPR004365): OB-fold nucleic acid binding domain
POT1PC (PF16686, IPR032042): ssDNA-binding domain of telomere protection protein
14 PPP1CAsuppressor30.6674.333Metallophos (PF00149, IPR004843): Calcineurin-like phosphoesterase
STPPase_N (PF16891, IPR031675): Serine-threonine protein phosphatase N-terminal domain
15 PPP1CConcoprotein30.33366.667Metallophos (PF00149, IPR004843): Calcineurin-like phosphoesterase
STPPase_N (PF16891, IPR031675): Serine-threonine protein phosphatase N-terminal domain
16 PPP1R3Ainteractor21.0000CBM_21 (PF03370, IPR005036): Carbohydrate/starch-binding module (family 21)
17 ROPN1interactor200RIIa (PF02197, IPR003117, SM00394): Regulatory subunit of type II PKA R-subunit
18 SUMF1interactor100FGE-sulfatase (PF03781, IPR005532): Sulfatase-modifying factor enzyme 1
DNA_ligase_IV (PF11411, IPR021536): DNA ligase IV
19 VHLsuppressor31.0000Trypan_PARP (PF05887, IPR008882): Procyclic acidic repetitive protein (PARP)
VHL (PF01847, IPR022772): VHL beta domain
VHL_C (PF17211): VHL box domain

B a c k    t o    T o p ⇑