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Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: parental proteins MRPS25, CYP19A1 (from a repository: Thu Nov 15 13:13:46 2018)
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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)32
The number (and %) of the onco-proteins5 (15.62 %)
The number (and %) of the tumor suppressors2 (6.25 %)
Total number of binary PPIs (saturation %)162 (32.66 %)
The number (and %) of affected PPIs30 (18.52 %)
The number of possible different fusions6
PPI diameter2
PPI radiusinf
The average degree of PPI9.750
Assortativity coefficient-0.2317
The network average Clustering coefficient0.609
The number (and %) of a zero Clustering coefficients2 (6.25 %)
The number (and %) of a zero Betweenness Centrality5 (15.62 %)

ACTIVE INTERACTORS


List of the fusions

PPI for parental proteins: MRPS25,CYP19A1 All fusions
Proteins found in more fusions ERBB3 (see 2 fusions); COPS5 (see 1 fusions); MME (see 1 fusions); PCNA (see 1 fusions); TP53 (see 3 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 MRPS25parental protein300.290330.063L51_S25_CI-B8 (PF05047, IPR007741, SM00916): Mitochondrial ribosomal protein L51 / S25 / CI-B8 domain
2 CYP19A1oncoprotein000p450 (PF00067, IPR001128): Cytochrome P450
3 C1QBPinteractor110.6188.850MAM33 (PF02330, IPR003428): Mitochondrial glycoprotein
DUF3053 (PF11254, IPR021413): Protein of unknown function (DUF3053)
4 CAND1interactor160.50521.333Adaptin_N (PF01602, IPR002553): Adaptin N terminal region
DUF1981 (PF09324, IPR015403): Domain of unknown function (DUF1981)
HEAT (PF02985, IPR000357): HEAT repeat
TIP120 (PF08623, IPR013932): TATA-binding protein interacting (TIP20)
RTP1_C1 (PF10363, IPR019451): Required for nuclear transport of RNA pol II C-terminus 1
DUF3385 (PF11865, IPR024585): Domain of unknown function (DUF3385)
MMS19_C (PF12460, IPR024687): RNAPII transcription regulator C-terminal
Cnd1 (PF12717, IPR032682): non-SMC mitotic condensation complex subunit 1
Vac14_Fab1_bd (PF12755, IPR032878): Vacuolar 14 Fab1-binding region
HEAT_EZ (PF13513): HEAT-like repeat
HEAT_2 (PF13646): HEAT repeats
MMS19_N (PF14500): Dos2-interacting transcription regulator of RNA-Pol-II
5 CEP76interactor40.6670.533Transglut_core (PF01841, IPR002931, SM00460): Transglutaminase-like superfamily
CEP76-C2 (PF15627, IPR028926): CEP76 C2 domain
6 COPS5protein found in more fusions110.5338.080JAB (PF01398, IPR000555, SM00232): JAB1/Mov34/MPN/PAD-1 ubiquitin protease
7 DDX56interactor50.8000.472DEAD (PF00270, IPR011545): DEAD/DEAH box helicase
Helicase_C (PF00271, IPR001650, SM00490): Helicase conserved C-terminal domain
8 ERBB3oncoprotein60.7001.133Furin-like (PF00757, IPR006211): Furin-like cysteine rich region
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
Recep_L_domain (PF01030, IPR000494): Receptor L domain
GF_recep_IV (PF14843, IPR032778): Growth factor receptor domain IV
9 GRSF1interactor70.8100.793RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
TAT_signal (PF10518, IPR019546): TAT (twin-arginine translocation) pathway signal sequence
VWA_N2 (PF16164, IPR032361): VWA N-terminal
10 HNRNPABinteractor70.5713.856CBFNT (PF08143, IPR012956): CBFNT (NUC161) domain
GRP (PF07172, IPR010800): Glycine rich protein family
NID (PF07292, IPR009909): Nmi/IFP 35 domain (NID)
RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
DUF2462 (PF09495, IPR019034): Protein of unknown function (DUF2462)
11 HNRNPUinteractor130.44920.960CDC45 (PF02724, IPR003874): CDC45-like protein
Ribosomal_60s (PF00428, IPR001813): 60s Acidic ribosomal protein
SAP (PF02037, IPR003034, SM00513): SAP domain
SPRY (PF00622, IPR003877, SM00449): SPRY domain
AAA_33 (PF13671): AAA domain
WRNPLPNID (PF15017): Putative WW-binding domain and destruction box
12 MMEsuppressor31.0000Peptidase_M13 (PF01431, IPR018497): Peptidase family M13
Peptidase_M13_N (PF05649, IPR008753): Peptidase family M13
13 MRPL58interactor130.61510.011RF-1 (PF00472, IPR000352): RF-1 domain
14 MRPS16interactor70.6193.306Ribosomal_S16 (PF00886, IPR000307): Ribosomal protein S16
FtsK_4TM (PF13491, IPR025199): 4TM region of DNA translocase FtsK/SpoIIIE
15 MRPS18Binteractor130.48718.144Ribosomal_S18 (PF01084, IPR001648): Ribosomal protein S18
HTH_21 (PF13276, IPR025948): HTH-like domain
zf-RING_10 (PF16685, IPR032043): zinc RING finger of MSL2
16 MRPS22interactor180.50332.714MRP-S22 (PF10245, IPR019374): Mitochondrial 28S ribosomal protein S22
17 MRPS31interactor150.60015.628MRP-S31 (PF15433, IPR026299): Mitochondrial 28S ribosomal protein S31
18 MRPS35interactor140.64810.771MRP-S28 (PF10213, IPR019349): Mitochondrial ribosomal subunit protein
19 MRPS5interactor170.52925.308Ribosomal_S5 (PF00333, IPR013810): Ribosomal protein S5, N-terminal domain
Ribosomal_S5_C (PF03719, IPR005324): Ribosomal protein S5, C-terminal domain
20 MRPS7interactor160.45832.671DUF454 (PF04304, IPR007401): Protein of unknown function (DUF454)
Ribosomal_S7 (PF00177, IPR023798): Ribosomal protein S7p/S5e
21 MRPS9interactor200.48941.586Ribosomal_S9 (PF00380, IPR000754): Ribosomal protein S9/S16
22 NOL12interactor51.0000DUF2357 (PF09823, IPR018633): Domain of unknown function (DUF2357)
Nop25 (PF09805, IPR019186): Nucleolar protein 12 (25kDa)
23 PCDHB15oncoprotein100Cadherin_2 (PF08266, IPR013164): Cadherin-like
Cadherin (PF00028, IPR002126, SM00112): Cadherin domain
Cadherin_3 (PF16184): Cadherin-like
Cadherin_C_2 (PF16492, IPR032455): Cadherin cytoplasmic C-terminal
24 PCNAoncoprotein40.6671.000PCNA_C (PF02747, IPR022649): Proliferating cell nuclear antigen, C-terminal domain
PCNA_N (PF00705, IPR022648): Proliferating cell nuclear antigen, N-terminal domain
25 RPS8interactor120.6368.823Ribosomal_S8e (PF01201, IPR022309): Ribosomal protein S8e
26 TP53suppressor100.5838.950DEC-1_N (PF04625, IPR006719): DEC-1 protein, N-terminal region
P53 (PF00870, IPR011615): P53 DNA-binding domain
P53_tetramer (PF07710, IPR010991): P53 tetramerisation motif
27 TRA2Ainteractor100.6893.821DUF1777 (PF08648, IPR013957): Protein of unknown function (DUF1777)
Herpes_PAP (PF03325, IPR004997): Herpesvirus polymerase accessory protein
RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
RSRP (PF17069): Arginine/Serine-Rich protein 1
28 TRMT10Binteractor90.7502.921tRNA_m1G_MT (PF01746, IPR016009): tRNA (Guanine-1)-methyltransferase
29 TUBGCP3interactor50.6000.872Spc97_Spc98 (PF04130, IPR007259): Spc97 / Spc98 family
30 ZC3H3interactor70.7625.000zf-CCCH (PF00642, IPR000571): Zinc finger C-x8-C-x5-C-x3-H type (and similar)
MSA-2c (PF12238, IPR021060): Merozoite surface antigen 2c
CCDC24 (PF15669, IPR031367): Coiled-coil domain-containing protein 24 family
31 ZFC3H1interactor21.0000Bap31 (PF05529, IPR008417): B-cell receptor-associated protein 31-like
LMBR1 (PF04791, IPR006876): LMBR1-like membrane protein
TPR_1 (PF00515, IPR001440): Tetratricopeptide repeat
DUF2277 (PF10041, IPR018735): Uncharacterized conserved protein (DUF2277)
zf-C3H1 (PF10650, IPR019607, SM00356): Putative zinc-finger domain
DUF2570 (PF10828, IPR022538): Protein of unknown function (DUF2570)
TPR_14 (PF13428): Tetratricopeptide repeat
TPR_19 (PF14559): Tetratricopeptide repeat
FNIP_N (PF14636, IPR028084): Folliculin-interacting protein N-terminus
32 ZNF707interactor70.9050.404KRAB (PF01352, IPR001909, SM00349): KRAB box
zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type
zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain
zf-C2H2_4 (PF13894): C2H2-type zinc finger

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