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Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: parental proteins CYP19A1, CPM (from a repository: Mon Feb 12 16:59:19 2018)
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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)18
The number (and %) of the onco-proteins7 (38.89 %)
The number (and %) of the tumor suppressors4 (22.22 %)
Total number of binary PPIs (saturation %)69 (45.10 %)
The number (and %) of affected PPIs16 (23.19 %)
The number of possible different fusions2
PPI diameter2
PPI radiusinf
The average degree of PPI7.333
Assortativity coefficient-0.1353
The network average Clustering coefficient0.763
The number (and %) of a zero Clustering coefficients1 (5.56 %)
The number (and %) of a zero Betweenness Centrality7 (38.89 %)

ACTIVE INTERACTORS


List of the fusions

PPI for parental proteins: CPM,CYP19A1 All fusions
Proteins found in more fusions MAPRE1 (see 1 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 CPMparental protein160.41791.802Peptidase_M14 (PF00246, IPR000834, SM00631): Zinc carboxypeptidase
CarboxypepD_reg (PF13620): Carboxypeptidase regulatory-like domain
2 CYP19A1oncoprotein000p450 (PF00067, IPR001128): Cytochrome P450
3 ANLNoncoprotein81.0000Anillin (PF08174, IPR012966): Cell division protein anillin
PH (PF00169, IPR001849, SM00233): PH domain
Anillin_N (PF16018, IPR031970): Anillin N-terminus
4 ATP6AP2interactor31.0000Phosphodiest (PF01663, IPR002591): Type I phosphodiesterase / nucleotide pyrophosphatase
Renin_r (PF07850, IPR012493): Renin receptor-like protein
5 CAPZA2interactor100.7337.600F-actin_cap_A (PF01267, IPR002189): F-actin capping protein alpha subunit
6 DBN1oncoprotein110.7456.036Pinin_SDK_memA (PF04696, IPR006786): pinin/SDK/memA/ protein conserved region
Cofilin_ADF (PF00241, IPR002108, SM00102): Cofilin/tropomyosin-type actin-binding protein
CAF-1_p150 (PF11600): Chromatin assembly factor 1 complex p150 subunit, N-terminal
MSA-2c (PF12238, IPR021060): Merozoite surface antigen 2c
7 ELAVL1oncoprotein60.4005.250RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
8 FLNAsuppressor110.7645.302CH (PF00307, IPR001715, SM00033): Calponin homology (CH) domain
Filamin (PF00630, IPR017868): Filamin/ABP280 repeat
9 GAKoncoprotein41.0000DnaJ (PF00226, IPR001623, SM00271): DnaJ domain
DSPc (PF00782, IPR020422, SM00195): Dual specificity phosphatase, catalytic domain
Pkinase (PF00069, IPR000719): Protein kinase domain
PTEN_C2 (PF10409, IPR014020): C2 domain of PTEN tumour-suppressor protein
10 GOLT1Binteractor21.0000Got1 (PF04178, IPR007305): Got1/Sft2-like family
11 LIMA1suppressor110.7456.036LIM (PF00412, IPR001781, SM00132): LIM domain
ROKNT (PF08067, IPR012987): ROKNT (NUC014) domain
12 MAPRE1oncoprotein61.0000CH (PF00307, IPR001715, SM00033): Calponin homology (CH) domain
EB1 (PF03271, IPR004953): EB1-like C-terminal motif
SUIM_assoc (PF16619): Unstructured region C-term to UIM in Ataxin3
13 MYH9suppressor100.8442.636IQ (PF00612, IPR000048, SM00015): IQ calmodulin-binding motif
Myosin_N (PF02736, IPR004009): Myosin N-terminal SH3-like domain
Myosin_tail_1 (PF01576, IPR002928): Myosin tail
Myosin_head (PF00063, IPR001609, SM00242): Myosin head (motor domain)
14 MYO19interactor90.9440.536IQ (PF00612, IPR000048, SM00015): IQ calmodulin-binding motif
Myosin_head (PF00063, IPR001609, SM00242): Myosin head (motor domain)
15 PDLIM7interactor51.0000LIM (PF00412, IPR001781, SM00132): LIM domain
PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF)
zinc_ribbon_10 (PF10058, IPR019273): Predicted integral membrane zinc-ribbon metal-binding protein
DUF4749 (PF15936, IPR031847): Domain of unknown function (DUF4749)
16 PPP1CConcoprotein80.7864.000Metallophos (PF00149, IPR004843): Calcineurin-like phosphoesterase
STPPase_N (PF16891, IPR031675): Serine-threonine protein phosphatase N-terminal domain
17 RAB7Asuppressor30.6671.000Ras (PF00071, IPR001806, SM00173): Ras family
18 SYNPOinteractor120.6829.802Calsarcin (PF05556, IPR008438): Calcineurin-binding protein (Calsarcin)

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