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Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: parental proteins VPS13B, CAMKMT (from a repository: Thu Aug 22 11:23:52 2019)
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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)33
The number (and %) of the onco-proteins9 (27.27 %)
The number (and %) of the tumor suppressors0 (0.00 %)
Total number of binary PPIs (saturation %)90 (17.05 %)
The number (and %) of affected PPIs31 (34.44 %)
The number of possible different fusions7
PPI diameter5
PPI radius3
The average degree of PPI4.909
Assortativity coefficient-0.1681
The network average Clustering coefficient0.455
The number (and %) of a zero Clustering coefficients9 (27.27 %)
The number (and %) of a zero Betweenness Centrality12 (36.36 %)

ACTIVE INTERACTORS


List of the fusions

PPI for parental proteins: VPS13B,CAMKMT All fusions
Proteins found in more fusions HECTD1 (see 1 fusions); COL1A1 (see 14 fusions); HSP90AA1 (see 6 fusions); COL1A1/COL1A2 (see 1 fusions); APP (see 5 fusions); HSP90AB1 (see 3 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 VPS13Bparental protein4074.433ATG_C (PF09333, IPR015412): Autophagy-related protein C terminal domain
SHR-BD (PF06650, IPR009543): SHR-binding domain of vacuolar-sorting associated protein 13
Chorein_N (PF12624, IPR026854): N-terminal region of Chorein or VPS13
VPS13 (PF16908, IPR031646): Vacuolar sorting-associated protein 13, N-terminal
VPS13_C (PF16909, IPR031645): Vacuolar-sorting-associated 13 protein C-terminal
2 CAMKMTparental protein270.120646.569Methyltransf_16 (PF10294, IPR019410): Lysine methyltransferase
3 AMBRA1interactor80.50016.367Acyl_CoA_thio (PF02551, IPR025652): Acyl-CoA thioesterase
eIF2A (PF08662, IPR013979): Eukaryotic translation initiation factor eIF2A
WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
Spt20 (PF12090, IPR021950): Spt20 family
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
4 APPprotein found in more fusions80.28650.276APP_N (PF02177, IPR015849, SM00006): Amyloid A4 N-terminal heparin-binding
Beta-APP (PF03494, IPR013803): Beta-amyloid peptide (beta-APP)
BUD22 (PF09073, IPR015158): BUD22
IncA (PF04156, IPR007285): IncA protein
Kunitz_BPTI (PF00014, IPR002223, SM00131): Kunitz/Bovine pancreatic trypsin inhibitor domain
APP_amyloid (PF10515, IPR019543): beta-amyloid precursor protein C-terminus
APP_Cu_bd (PF12924, IPR011178): Copper-binding of amyloid precursor, CuBD
APP_E2 (PF12925, IPR024329): E2 domain of amyloid precursor protein
5 CALM2interactor100EF-hand_7 (PF13499, IPR011992): EF-hand domain pair
6 CCT2interactor80.5719.067Cpn60_TCP1 (PF00118, IPR002423): TCP-1/cpn60 chaperonin family
7 CCT3interactor60.60023.024Cpn60_TCP1 (PF00118, IPR002423): TCP-1/cpn60 chaperonin family
8 CCT6Ainteractor41.0000Cpn60_TCP1 (PF00118, IPR002423): TCP-1/cpn60 chaperonin family
9 CCT8interactor60.6675.667Cpn60_TCP1 (PF00118, IPR002423): TCP-1/cpn60 chaperonin family
10 COL1A1oncoprotein40.6672.111COLFI (PF01410, IPR000885, SM00038): Fibrillar collagen C-terminal domain
Collagen (PF01391, IPR008160): Collagen triple helix repeat (20 copies)
VWC (PF00093, IPR001007, SM00214): von Willebrand factor type C domain
EKLF_TAD1 (PF16832, IPR031786): Erythroid krueppel-like transcription factor, transactivation 1
11 COL1A2oncoprotein21.0000COLFI (PF01410, IPR000885, SM00038): Fibrillar collagen C-terminal domain
Collagen (PF01391, IPR008160): Collagen triple helix repeat (20 copies)
DUF1860 (PF08949, IPR015044): Domain of unknown function (DUF1860)
12 CSNK1Einteractor4035.121APH (PF01636, IPR002575): Phosphotransferase enzyme family
Pkinase (PF00069, IPR000719): Protein kinase domain
13 DNAJC7interactor60.40077.640DnaJ (PF00226, IPR001623, SM00271): DnaJ domain
TPR_1 (PF00515, IPR001440): Tetratricopeptide repeat
TPR_2 (PF07719, IPR013105): Tetratricopeptide repeat
Rapsyn_N (PF10579, IPR019568): Rapsyn N-terminal myristoylation and linker region
ANAPC3 (PF12895): Anaphase-promoting complex, cyclosome, subunit 3
TPR_11 (PF13414, IPR011990): TPR repeat
TPR_17 (PF13431): Tetratricopeptide repeat
14 ELAVL1oncoprotein60.30038.183RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
15 FAM177A1interactor100Ribosomal_60s (PF00428, IPR001813): 60s Acidic ribosomal protein
Connexin (PF00029, IPR013092, SM00037): Connexin
FAM177 (PF14774, IPR028260): FAM177 family
16 FEM1Binteractor100Ank (PF00023, IPR002110, SM00248): Ankyrin repeat
Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies)
Ank_5 (PF13857): Ankyrin repeats (many copies)
17 HECTD1protein found in more fusions200Cwf_Cwc_15 (PF04889, IPR006973): Cwf15/Cwc15 cell cycle control protein
MIB_HERC2 (PF06701, IPR010606): Mib_herc2
NOA36 (PF06524, IPR010531): NOA36 protein
Sad1_UNC (PF07738, IPR012919): Sad1 / UNC-like C-terminal
HECT (PF00632, IPR000569, SM00119): HECT-domain (ubiquitin-transferase)
Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies)
PBP1_TM (PF14812, IPR032730): Transmembrane domain of transglycosylase PBP1 at N-terminal
18 HSP90AA1oncoprotein110.51135.904HATPase_c (PF02518, IPR003594, SM00387): Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
HSP90 (PF00183, IPR001404): Hsp90 protein
19 HSP90AB1oncoprotein80.71415.651HATPase_c (PF02518, IPR003594, SM00387): Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
HSP90 (PF00183, IPR001404): Hsp90 protein
20 HSP90AB2Pinteractor40.6671.167NA
21 HSPA5oncoprotein100.47235.318HSP70 (PF00012, IPR013126): Hsp70 protein
22 HSPA8oncoprotein70.66714.943HSP70 (PF00012, IPR013126): Hsp70 protein
23 IREB2interactor21.0000Aconitase (PF00330, IPR001030): Aconitase family (aconitate hydratase)
Aconitase_C (PF00694, IPR000573): Aconitase C-terminal domain
24 NPEPPSinteractor100Peptidase_M1 (PF01433, IPR014782): Peptidase family M1
ERAP1_C (PF11838, IPR024571): ERAP1-like C-terminal domain
25 NXF1interactor90.46416.915NTF2 (PF02136, IPR002075): Nuclear transport factor 2 (NTF2) domain
Tap-RNA_bind (PF09162, IPR015245): Tap, RNA-binding
TAP_C (PF03943, IPR005637, SM00804): TAP C-terminal domain
LRR_8 (PF13855, IPR001611): Leucine rich repeat
26 RIC8Binteractor100Ric8 (PF10165, IPR019318): Guanine nucleotide exchange factor synembryn
27 SHMT2interactor50.4005.833SHMT (PF00464, IPR001085): Serine hydroxymethyltransferase
28 SNX6interactor30.6671.000PX (PF00787, IPR001683, SM00312): PX domain
Vps5 (PF09325, IPR015404): Vps5 C terminal like
29 SPACA1interactor209.172DUF912 (PF06024, IPR009261): Nucleopolyhedrovirus protein of unknown function (DUF912)
PRIMA1 (PF16101): Proline-rich membrane anchor 1
30 SPATA5L1interactor21.0000AAA (PF00004, IPR003959, SM00382): ATPase family associated with various cellular activities (AAA)
TniB (PF05621, IPR008868): Bacterial TniB protein
Vps4_C (PF09336, IPR015415): Vps4 C terminal oligomerisation domain
SbcCD_C (PF13558): Putative exonuclease SbcCD, C subunit
31 TUBB3interactor40.33355.638Tubulin (PF00091, IPR003008, SM00864): Tubulin/FtsZ family, GTPase domain
Tubulin_C (PF03953, IPR018316, SM00865): Tubulin C-terminal domain
32 TUBB4Ainteractor21.0000Tubulin (PF00091, IPR003008, SM00864): Tubulin/FtsZ family, GTPase domain
Tubulin_C (PF03953, IPR018316, SM00865): Tubulin C-terminal domain
33 TUBB6interactor21.0000Tubulin (PF00091, IPR003008, SM00864): Tubulin/FtsZ family, GTPase domain
Tubulin_C (PF03953, IPR018316, SM00865): Tubulin C-terminal domain

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