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Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: parental proteins SAMD4B, VPS13B (from a repository: Mon Sep 30 16:06:19 2019)
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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)21
The number (and %) of the onco-proteins5 (23.81 %)
The number (and %) of the tumor suppressors2 (9.52 %)
Total number of binary PPIs (saturation %)46 (21.90 %)
The number (and %) of affected PPIs19 (41.30 %)
The number of possible different fusions4
PPI diameter5
PPI radius3
The average degree of PPI3.714
Assortativity coefficient-0.2366
The network average Clustering coefficient0.401
The number (and %) of a zero Clustering coefficients8 (38.10 %)
The number (and %) of a zero Betweenness Centrality10 (47.62 %)

ACTIVE INTERACTORS


List of the fusions

PPI for parental proteins: SAMD4B,VPS13B All fusions
Proteins found in more fusions NIN (see 1 fusions); YWHAG (see 1 fusions); YWHAZ (see 5 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 SAMD4Bparental protein150.162219.338PHAT (PF09246, IPR015327): PHAT
SAM_1 (PF00536, IPR021129, SM00454): SAM domain (Sterile alpha motif)
2 VPS13Bparental protein4076.667ATG_C (PF09333, IPR015412): Autophagy-related protein C terminal domain
SHR-BD (PF06650, IPR009543): SHR-binding domain of vacuolar-sorting associated protein 13
Chorein_N (PF12624, IPR026854): N-terminal region of Chorein or VPS13
VPS13 (PF16908, IPR031646): Vacuolar sorting-associated protein 13, N-terminal
VPS13_C (PF16909, IPR031645): Vacuolar-sorting-associated 13 protein C-terminal
3 CEP152interactor100bZIP_1 (PF00170, IPR004827): bZIP transcription factor
CDC37_N (PF03234, IPR013855, SM01071): Cdc37 N terminal kinase binding
CENP-H (PF05837, IPR008426): Centromere protein H (CENP-H)
DUF641 (PF04859, IPR006943): Plant protein of unknown function (DUF641)
ZapB (PF06005, IPR009252): Cell division protein ZapB
DUF972 (PF06156, IPR010377): Protein of unknown function (DUF972)
Ribosomal_S13 (PF00416, IPR001892): Ribosomal protein S13/S18
FAD-SLDH (PF12318, IPR024651): Membrane bound FAD containing D-sorbitol dehydrogenase
YtxH (PF12732, IPR024623): YtxH-like protein
ADH_zinc_N_2 (PF13602): Zinc-binding dehydrogenase
TolA_bind_tri (PF16331, IPR032519): TolA binding protein trimerisation
HIP1_clath_bdg (PF16515, IPR032422): Clathrin-binding domain of Huntingtin-interacting protein 1
4 CEP89interactor21.0000ATG16 (PF08614, IPR013923): Autophagy protein 16 (ATG16)
CorA (PF01544, IPR002523): CorA-like Mg2+ transporter protein
Exonuc_VII_L (PF02601, IPR020579): Exonuclease VII, large subunit
Lectin_N (PF03954, IPR005640): Hepatic lectin, N-terminal domain
Spc24 (PF08286, IPR013252): Spc24 subunit of Ndc80
DUF3450 (PF11932, IPR016866): Protein of unknown function (DUF3450)
BST2 (PF16716, IPR024886): Bone marrow stromal antigen 2
5 CSNK1Einteractor40.33377.110APH (PF01636, IPR002575): Phosphotransferase enzyme family
Pkinase (PF00069, IPR000719): Protein kinase domain
6 DNAJC7interactor2019.557DnaJ (PF00226, IPR001623, SM00271): DnaJ domain
TPR_1 (PF00515, IPR001440): Tetratricopeptide repeat
TPR_2 (PF07719, IPR013105): Tetratricopeptide repeat
Rapsyn_N (PF10579, IPR019568): Rapsyn N-terminal myristoylation and linker region
ANAPC3 (PF12895): Anaphase-promoting complex, cyclosome, subunit 3
TPR_11 (PF13414, IPR011990): TPR repeat
TPR_17 (PF13431): Tetratricopeptide repeat
7 ELAVL1oncoprotein70.46747.638RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
8 FAM177A1interactor100Ribosomal_60s (PF00428, IPR001813): 60s Acidic ribosomal protein
Connexin (PF00029, IPR013092, SM00037): Connexin
FAM177 (PF14774, IPR028260): FAM177 family
9 MKS1interactor30.33342.890B9-C2 (PF07162, IPR010796): Ciliary basal body-associated, B9 protein
10 MUS81suppressor100ERCC4 (PF02732, IPR006166, SM00891): ERCC4 domain
MutL (PF13941, IPR006230): MutL protein
HHH_8 (PF14716, IPR010996): Helix-hairpin-helix domain
11 NANOGinteractor31.0000Homeobox (PF00046, IPR001356, SM00389): Homeobox domain
12 NINoncoprotein31.0000BRE1 (PF08647, IPR013956): BRE1 E3 ubiquitin ligase
bZIP_1 (PF00170, IPR004827): bZIP transcription factor
DivIC (PF04977, IPR007060): Septum formation initiator
DivIVA (PF05103, IPR007793): DivIVA protein
DUF342 (PF03961, IPR005646): Protein of unknown function (DUF342)
ZapB (PF06005, IPR009252): Cell division protein ZapB
FlaC_arch (PF05377, IPR008039): Flagella accessory protein C (FlaC)
Fzo_mitofusin (PF04799, IPR006884): fzo-like conserved region
Cnn_1N (PF07989, IPR012943): Centrosomin N-terminal motif 1
Rho_Binding (PF08912, IPR015008): Rho Binding
TSC22 (PF01166, IPR000580): TSC-22/dip/bun family
Uso1_p115_C (PF04871, IPR006955): Uso1 / p115 like vesicle tethering protein, C terminal region
DUF2205 (PF10224, IPR019357): Predicted coiled-coil protein (DUF2205)
Kinetocho_Slk19 (PF12709, IPR024312): Central kinetochore-associated
EF-hand_6 (PF13405, IPR002048): EF-hand domain
EF-hand_7 (PF13499, IPR011992): EF-hand domain pair
EF-hand_8 (PF13833, IPR002048): EF-hand domain pair
Cep57_CLD_2 (PF14197, IPR025925): Centrosome localisation domain of PPC89
FlxA (PF14282, IPR025577): FlxA-like protein
DUF4472 (PF14739, IPR029329): Domain of unknown function (DUF4472)
Muted (PF14942, IPR017243): Organelle biogenesis, Muted-like protein
DUF4665 (PF15679, IPR031389): Domain of unknown function (DUF4665)
PRKG1_interact (PF15898, IPR031775): cGMP-dependent protein kinase interacting domain
JIP_LZII (PF16471, IPR032486): JNK-interacting protein leucine zipper II
HIP1_clath_bdg (PF16515, IPR032422): Clathrin-binding domain of Huntingtin-interacting protein 1
13 PTPN6suppressor100SH2 (PF00017, IPR000980, SM00252): SH2 domain
Y_phosphatase (PF00102, IPR000242, SM00194): Protein-tyrosine phosphatase
PolyA_pol_arg_C (PF12626, IPR025866): Polymerase A arginine-rich C-terminus
14 RGMAinteractor100RGM_C (PF06534, IPR009496): Repulsive guidance molecule (RGM) C-terminus
RGM_N (PF06535, IPR010536): Repulsive guidance molecule (RGM) N-terminus
15 SOX2oncoprotein50.6674.167HMG_box (PF00505, IPR009071, SM00398): HMG (high mobility group) box
SOXp (PF12336, IPR022097): SOX transcription factor
16 SPACA1interactor100DUF912 (PF06024, IPR009261): Nucleopolyhedrovirus protein of unknown function (DUF912)
PRIMA1 (PF16101): Proline-rich membrane anchor 1
17 XPO1interactor70.42958.138CRM1_C (PF08767, IPR014877, SM01102): CRM1 C terminal
Hydrolase_3 (PF08282, IPR023214): haloacid dehalogenase-like hydrolase
IBN_N (PF03810, IPR001494, SM00913): Importin-beta N-terminal domain
Xpo1 (PF08389, IPR013598): Exportin 1-like protein
Vac14_Fab1_bd (PF12755, IPR032878): Vacuolar 14 Fab1-binding region
18 YWHABinteractor50.8002.35714-3-3 (PF00244, IPR023410, SM00101): 14-3-3 protein
Virulence_fact (PF13769, IPR025989): Virulence factor
19 YWHAGprotein found in more fusions80.57113.11414-3-3 (PF00244, IPR023410, SM00101): 14-3-3 protein
20 YWHAQinteractor41.000014-3-3 (PF00244, IPR023410, SM00101): 14-3-3 protein
21 YWHAZprotein found in more fusions70.6675.02414-3-3 (PF00244, IPR023410, SM00101): 14-3-3 protein

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