Find Fusion Network

Visualization interactions

Powered by Cytoscape Web for: parental proteins PODXL, VPS13B (from a repository: Mon Jul 22 19:29:06 2019)

Examples AFF1 MLL ACTN4 + MLLAFF1 + MLLALK + MSNALK + TFGALK + TPM3ALK + TPM4ASXL2 + KAT6AATF1 + FUSBCR + ABL1BCR + FGFR1CCND1 + TACSTD2CD74 + ROS1CDK6 + MLLCOL1A1 + PDGFBCREB3L2 + PPARGCREB3L2 + FUSCREBBP + KAT6ADAZAP1 + MEF2DELL + MLLEPS15 + MLLERG + EWSR1ERG + FUSERG + TMPRSS2ETV5 + TMPRSS2ETV6 + ABL1ETV6 + NTRK3ETV6 + PAX5EWSR1 + FLI1EWSR1 + WT1FOXO1 + PAX3FOXP1 + PAX5FRYL + MLLGAS7 + MLLGMPS + MLLGOLGA5 + RETHOOK3 + RETHOXC13 + NUP98HOXD13 + NUP98MECOM + RUNX1MKL1 + RBM15MLL + MLLT1MLL + MLLT4MLL + MLLT10MLL + PICALMMLLT10 + PICALMNCOA1 + PAX3NIN + PDGFRBNPM1 + RARANRG1 + ODZ4NTRK1 + TFGNUMA1 + RARANUP98 + PHF23PAX5 + ZNF521PBX1 + TCF3RET + TRIM27ROS1 + SLC34A2PML + RARAPRKAR1A + RARAPRKAR1A + RETRUNX1 + RUNX1T1RUNX1 + SH3D19	Cytoscape Web will replace the contents your graph	PPI Properties: Click on nodes or edges
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Statistics and Network structure information

Statistic of PPI Value(s) The number of interactors (fusion and proteins) 16 The number (and %) of the onco-proteins 1 (6.25 %) The number (and %) of the tumor suppressors 1 (6.25 %) Total number of binary PPIs (saturation %) 20 (16.67 %) The number (and %) of affected PPIs 14 (70.00 %) The number of possible different fusions 2 PPI diameter 2 PPI radius inf The average degree of PPI 2.000 Assortativity coefficient -0.1656 The network average Clustering coefficient 0.169 The number (and %) of a zero Clustering coefficients 12 (75.00 %) The number (and %) of a zero Betweenness Centrality 13 (81.25 %)

ACTIVE INTERACTORS

List of the fusions
PPI for parental proteins: VPS13B,PODXL	All fusions
Proteins found in more fusions	LGALS3 (see 2 fusions);

List of active interactors

#	Name	Type	Number of PPI (degree)	Clustering Coefficient	Betweenness Centrality	Domains (Pfam, InterPro, SMART): description
1	VPS13B	parental protein	4	0	12.000	ATG_C (PF09333, IPR015412): Autophagy-related protein C terminal domain SHR-BD (PF06650, IPR009543): SHR-binding domain of vacuolar-sorting associated protein 13 Chorein_N (PF12624, IPR026854): N-terminal region of Chorein or VPS13 VPS13 (PF16908, IPR031646): Vacuolar sorting-associated protein 13, N-terminal VPS13_C (PF16909, IPR031645): Vacuolar-sorting-associated 13 protein C-terminal
2	PODXL	parental protein	10	0.044	85.000	CD34_antigen (PF06365, IPR013836): CD34/Podocalyxin family DUF3439 (PF11921, IPR024592): Domain of unknown function (DUF3439) RHIM (PF12721, IPR025735): RIP homotypic interaction motif CC190 (PF15768, IPR031525): Coiled-coil domain-containing protein 190
3	CDK2	suppressor	2	0	0	Kdo (PF06293, IPR010440): Lipopolysaccharide kinase (Kdo/WaaP) family Pkinase (PF00069, IPR000719): Protein kinase domain
4	CSNK1E	interactor	2	0	0	APH (PF01636, IPR002575): Phosphotransferase enzyme family Pkinase (PF00069, IPR000719): Protein kinase domain
5	DNAJC7	interactor	1	0	0	DnaJ (PF00226, IPR001623, SM00271): DnaJ domain TPR_1 (PF00515, IPR001440): Tetratricopeptide repeat TPR_2 (PF07719, IPR013105): Tetratricopeptide repeat Rapsyn_N (PF10579, IPR019568): Rapsyn N-terminal myristoylation and linker region ANAPC3 (PF12895): Anaphase-promoting complex, cyclosome, subunit 3 TPR_11 (PF13414, IPR011990): TPR repeat TPR_17 (PF13431): Tetratricopeptide repeat
6	FAM177A1	interactor	1	0	0	Ribosomal_60s (PF00428, IPR001813): 60s Acidic ribosomal protein Connexin (PF00029, IPR013092, SM00037): Connexin FAM177 (PF14774, IPR028260): FAM177 family
7	FCN1	interactor	1	0	0	Collagen (PF01391, IPR008160): Collagen triple helix repeat (20 copies) Fibrinogen_C (PF00147, IPR002181, SM00186): Fibrinogen beta and gamma chains, C-terminal globular domain
8	LGALS3	oncoprotein	3	1.000	0	Gal-bind_lectin (PF00337, IPR001079, SM00908): Galactoside-binding lectin
9	LGALS8	interactor	1	0	0	Gal-bind_lectin (PF00337, IPR001079, SM00908): Galactoside-binding lectin
10	LGALS9	interactor	3	0.667	1.000	Gal-bind_lectin (PF00337, IPR001079, SM00908): Galactoside-binding lectin Peptidase_C62 (PF12380, IPR024348): Gill-associated viral 3C-like peptidase
11	NXF1	interactor	2	0	0	NTF2 (PF02136, IPR002075): Nuclear transport factor 2 (NTF2) domain Tap-RNA_bind (PF09162, IPR015245): Tap, RNA-binding TAP_C (PF03943, IPR005637, SM00804): TAP C-terminal domain LRR_8 (PF13855, IPR001611): Leucine rich repeat
12	PILRA	interactor	1	0	0	SKG6 (PF08693, IPR014805): Transmembrane alpha-helix domain V-set (PF07686, IPR013106): Immunoglobulin V-set domain Ig_3 (PF13927): Immunoglobulin domain G6B (PF15096, IPR028070): G6B family
13	SELL	interactor	1	0	0	EGF (PF00008, IPR000742, SM00181): EGF-like domain Sushi (PF00084, IPR000436, SM00032): Sushi repeat (SCR repeat) Lectin_C (PF00059, IPR001304, SM00034): Lectin C-type domain MWFE (PF15879, IPR017384): NADH-ubiquinone oxidoreductase MWFE subunit
14	SLC9A3R2	interactor	2	1.000	0	EBP50_C (PF09007, IPR015098): EBP50, C-terminal GRASP55_65 (PF04495, IPR024958): GRASP55/65 PDZ-like domain PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF)
15	SPACA1	interactor	1	0	0	DUF912 (PF06024, IPR009261): Nucleopolyhedrovirus protein of unknown function (DUF912) PRIMA1 (PF16101): Proline-rich membrane anchor 1
16	TMEM17	interactor	1	0	0	Transmemb_17 (PF09799, IPR019184): Predicted membrane protein DUF3043 (PF11241, IPR021403): Protein of unknown function (DUF3043)

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