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Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: parental proteins TUBGCP5, VPS13B (from a repository: Mon Aug 12 21:43:40 2019)
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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)25
The number (and %) of the onco-proteins4 (16.00 %)
The number (and %) of the tumor suppressors2 (8.00 %)
Total number of binary PPIs (saturation %)96 (32.00 %)
The number (and %) of affected PPIs23 (23.96 %)
The number of possible different fusions5
PPI diameter5
PPI radius3
The average degree of PPI7.200
Assortativity coefficient-0.0329
The network average Clustering coefficient0.547
The number (and %) of a zero Clustering coefficients8 (32.00 %)
The number (and %) of a zero Betweenness Centrality7 (28.00 %)

ACTIVE INTERACTORS


List of the fusions

PPI for parental proteins: VPS13B,TUBGCP5 All fusions
Proteins found in more fusions TUBG1 (see 1 fusions); CLU (see 5 fusions); UBC (see 7 fusions); DAPK2 (see 1 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 VPS13Bparental protein4091.000ATG_C (PF09333, IPR015412): Autophagy-related protein C terminal domain
SHR-BD (PF06650, IPR009543): SHR-binding domain of vacuolar-sorting associated protein 13
Chorein_N (PF12624, IPR026854): N-terminal region of Chorein or VPS13
VPS13 (PF16908, IPR031646): Vacuolar sorting-associated protein 13, N-terminal
VPS13_C (PF16909, IPR031645): Vacuolar-sorting-associated 13 protein C-terminal
2 TUBGCP5parental protein190.380216.552Spc97_Spc98 (PF04130, IPR007259): Spc97 / Spc98 family
GCP5-Mod21 (PF14609, IPR032797): gamma-Tubulin ring complex non-core subunit mod21
3 ALDH18A1interactor21.0000AA_kinase (PF00696, IPR001048): Amino acid kinase family
Aldedh (PF00171, IPR015590): Aldehyde dehydrogenase family
4 CDK5RAP2interactor80.8570.894APG6 (PF04111, IPR007243): Autophagy protein Apg6
bZIP_1 (PF00170, IPR004827): bZIP transcription factor
CALCOCO1 (PF07888, IPR012852): Calcium binding and coiled-coil domain (CALCOCO1) like
DUF16 (PF01519, IPR002862): Protein of unknown function DUF16
DUF1993 (PF09351, IPR018531): Domain of unknown function (DUF1993)
IncA (PF04156, IPR007285): IncA protein
LPP (PF04728, IPR006817): Lipoprotein leucine-zipper
Cnn_1N (PF07989, IPR012943): Centrosomin N-terminal motif 1
Reo_sigmaC (PF04582, IPR007662): Reovirus sigma C capsid protein
TPR_MLP1_2 (PF07926, IPR012929): TPR/MLP1/MLP2-like protein
TSC22 (PF01166, IPR000580): TSC-22/dip/bun family
Tup_N (PF08581, IPR013890): Tup N-terminal
CENP-F_leu_zip (PF10473, IPR019513): Leucine-rich repeats of kinetochore protein Cenp-F/LEK1
ADIP (PF11559, IPR021622): Afadin- and alpha -actinin-Binding
TMF_TATA_bd (PF12325, IPR022091): TATA element modulatory factor 1 TATA binding
Snapin_Pallidin (PF14712, IPR028119): Snapin/Pallidin
GIT_CC (PF16559, IPR032352): GIT coiled-coil Rho guanine nucleotide exchange factor
Cyclin_C_2 (PF16899, IPR031658): Cyclin C-terminal domain
5 CLUsuppressor31.0000Clusterin (PF01093, IPR000753): Clusterin
6 CSNK1Einteractor3060.000APH (PF01636, IPR002575): Phosphotransferase enzyme family
Pkinase (PF00069, IPR000719): Protein kinase domain
7 DAPK2suppressor200GvpK (PF05121, IPR007805): Gas vesicle protein K
Pkinase (PF00069, IPR000719): Protein kinase domain
8 DNAJC6oncoprotein100DnaJ (PF00226, IPR001623, SM00271): DnaJ domain
PTEN_C2 (PF10409, IPR014020): C2 domain of PTEN tumour-suppressor protein
Y_phosphatase (PF00102, IPR000242, SM00194): Protein-tyrosine phosphatase
9 DNAJC7interactor2060.000DnaJ (PF00226, IPR001623, SM00271): DnaJ domain
TPR_1 (PF00515, IPR001440): Tetratricopeptide repeat
TPR_2 (PF07719, IPR013105): Tetratricopeptide repeat
Rapsyn_N (PF10579, IPR019568): Rapsyn N-terminal myristoylation and linker region
ANAPC3 (PF12895): Anaphase-promoting complex, cyclosome, subunit 3
TPR_11 (PF13414, IPR011990): TPR repeat
TPR_17 (PF13431): Tetratricopeptide repeat
10 FAM177A1interactor100Ribosomal_60s (PF00428, IPR001813): 60s Acidic ribosomal protein
Connexin (PF00029, IPR013092, SM00037): Connexin
FAM177 (PF14774, IPR028260): FAM177 family
11 MZT1interactor110.9091.117Rad50_zn_hook (PF04423, IPR007517): Rad50 zinc hook motif
MOZART1 (PF12554, IPR022214): Mitotic-spindle organizing gamma-tubulin ring associated
12 MZT2Ainteractor90.8891.036MOZART2 (PF12926, IPR024332): Mitotic-spindle organizing gamma-tubulin ring associated
13 MZT2Binteractor100.9110.950MOZART2 (PF12926, IPR024332): Mitotic-spindle organizing gamma-tubulin ring associated
14 NEDD1interactor110.9091.117NRBF2 (PF08961, IPR015056): Nuclear receptor-binding factor 2, autophagy regulator
eIF2A (PF08662, IPR013979): Eukaryotic translation initiation factor eIF2A
FliM (PF02154, IPR001689): Flagellar motor switch protein FliM
WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
Mto2_bdg (PF12808, IPR024545): Micro-tubular organiser Mto1 C-term Mto2-binding region
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
15 NME7interactor100.8891.258DUF1126 (PF06565, IPR010554): DUF1126 PH-like domain
NDK (PF00334, IPR001564, SM00562): Nucleoside diphosphate kinase
16 NTRK1oncoprotein100.361198.000I-set (PF07679, IPR013098): Immunoglobulin I-set domain
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
LRR_8 (PF13855, IPR001611): Leucine rich repeat
TPKR_C2 (PF16920, IPR031635): Tyrosine-protein kinase receptor C2 Ig-like domain
17 PLEKHG1interactor100PH (PF00169, IPR001849, SM00233): PH domain
RhoGEF (PF00621, IPR000219, SM00325): RhoGEF domain
18 SCAF11interactor100.9330.644DUF566 (PF04484, IPR007573): Family of unknown function (DUF566)
Phage_XkdX (PF09693, IPR010022): Phage uncharacterised protein (Phage_XkdX)
zf-RING_2 (PF13639, IPR001841, SM00184): Ring finger domain
DUF4834 (PF16118, IPR032272): Domain of unknown function (DUF4834)
19 SPACA1interactor100DUF912 (PF06024, IPR009261): Nucleopolyhedrovirus protein of unknown function (DUF912)
PRIMA1 (PF16101): Proline-rich membrane anchor 1
20 TUBG1protein found in more fusions140.78222.552Tubulin (PF00091, IPR003008, SM00864): Tubulin/FtsZ family, GTPase domain
Tubulin_C (PF03953, IPR018316, SM00865): Tubulin C-terminal domain
21 TUBGCP2interactor140.69232.552Spc97_Spc98 (PF04130, IPR007259): Spc97 / Spc98 family
zf-Tim10_DDP (PF02953, IPR004217): Tim10/DDP family zinc finger
22 TUBGCP3interactor130.78222.552Spc97_Spc98 (PF04130, IPR007259): Spc97 / Spc98 family
23 TUBGCP4interactor110.9091.117Spc97_Spc98 (PF04130, IPR007259): Spc97 / Spc98 family
24 TUBGCP6interactor110.80015.658Spc97_Spc98 (PF04130, IPR007259): Spc97 / Spc98 family
25 UBCprotein found in more fusions50.6677.000ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family

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