Find Fusion Network

Enter
Fusion ID:
Protein names:


Level of PPIs:
or Upload text file:
Update repository
Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: parental proteins CTSK, GALNT12 (from a repository: Sun Jan 13 23:25:11 2019)
Examples

Cytoscape Web will replace the contents your graph
PPI Properties:

Click on nodes
or edges

Layout Tree
Circle
Radial
Force Directed
Preset
Export graph
PDF file
SVG file
SIF file
XML file
GraphML file

Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)19
The number (and %) of the onco-proteins6 (31.58 %)
The number (and %) of the tumor suppressors0 (0.00 %)
Total number of binary PPIs (saturation %)20 (11.70 %)
The number (and %) of affected PPIs17 (85.00 %)
The number of possible different fusions3
PPI diameter2
PPI radiusinf
The average degree of PPI1.789
Assortativity coefficient0
The network average Clustering coefficient0.000
The number (and %) of a zero Clustering coefficients19 (100.00 %)
The number (and %) of a zero Betweenness Centrality17 (89.47 %)

ACTIVE INTERACTORS


List of the fusions

PPI for parental proteins: GALNT12,CTSK All fusions
Proteins found in more fusions APP (see 4 fusions); ERBIN (see 4 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 GALNT12parental protein10090.000Glyco_transf_7C (PF02709, IPR027791): N-terminal domain of galactosyltransferase
Glycos_transf_2 (PF00535, IPR001173): Glycosyl transferase family 2
Ricin_B_lectin (PF00652, IPR000772, SM00458): Ricin-type beta-trefoil lectin domain
2 CTSKparental protein7042.000Inhibitor_I29 (PF08246, IPR013201, SM00848): Cathepsin propeptide inhibitor domain (I29)
Peptidase_C1 (PF00112, IPR000668, SM00645): Papain family cysteine protease
3 APPprotein found in more fusions200APP_N (PF02177, IPR015849, SM00006): Amyloid A4 N-terminal heparin-binding
Beta-APP (PF03494, IPR013803): Beta-amyloid peptide (beta-APP)
BUD22 (PF09073, IPR015158): BUD22
IncA (PF04156, IPR007285): IncA protein
Kunitz_BPTI (PF00014, IPR002223, SM00131): Kunitz/Bovine pancreatic trypsin inhibitor domain
APP_amyloid (PF10515, IPR019543): beta-amyloid precursor protein C-terminus
APP_Cu_bd (PF12924, IPR011178): Copper-binding of amyloid precursor, CuBD
APP_E2 (PF12925, IPR024329): E2 domain of amyloid precursor protein
4 ARID4Binteractor100ARID (PF01388, IPR001606, SM00501): ARID/BRIGHT DNA binding domain
CDC45 (PF02724, IPR003874): CDC45-like protein
DUF755 (PF05501, IPR008474): Domain of unknown function (DUF755)
E7 (PF00527, IPR000148): E7 protein, Early protein
NOA36 (PF06524, IPR010531): NOA36 protein
PWWP (PF00855, IPR000313, SM00293): PWWP domain
RBB1NT (PF08169, IPR012603): RBB1NT (NUC162) domain
Ribosomal_60s (PF00428, IPR001813): 60s Acidic ribosomal protein
Tudor-knot (PF11717, IPR025995): RNA binding activity-knot of a chromodomain
WRNPLPNID (PF15017): Putative WW-binding domain and destruction box
5 B3GNT3interactor100Galactosyl_T (PF01762, IPR002659): Galactosyltransferase
6 C18orf25interactor100RNF111_N (PF15303, IPR029306): E3 ubiquitin-protein ligase Arkadia N-terminus
7 CD1Binteractor100C1-set (PF07654, IPR003597, SM00407): Immunoglobulin C1-set domain
MLANA (PF14991, IPR029242): Protein melan-A
MHC_I_3 (PF16497, IPR011161): MHC-I family domain
8 CHST8interactor100Sulfotransfer_2 (PF03567, IPR005331): Sulfotransferase family
9 CTSVinteractor100Inhibitor_I29 (PF08246, IPR013201, SM00848): Cathepsin propeptide inhibitor domain (I29)
Peptidase_C1 (PF00112, IPR000668, SM00645): Papain family cysteine protease
10 ERBINoncoprotein200LRR_1 (PF00560, IPR001611): Leucine Rich Repeat
Neur_chan_memb (PF02932, IPR006029): Neurotransmitter-gated ion-channel transmembrane region
PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF)
LRR_4 (PF12799, IPR025875): Leucine Rich repeats (2 copies)
LRR_8 (PF13855, IPR001611): Leucine rich repeat
11 FGFR3oncoprotein200I-set (PF07679, IPR013098): Immunoglobulin I-set domain
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
Ig_3 (PF13927): Immunoglobulin domain
Izumo-Ig (PF16706, IPR032699): Izumo-like Immunoglobulin domain
12 GINM1interactor100NA
13 HLA-Einteractor100MHC_I (PF00129, IPR001039): Class I Histocompatibility antigen, domains alpha 1 and 2
MHC_I_C (PF06623, IPR010579): MHC_I C-terminus
C1-set (PF07654, IPR003597, SM00407): Immunoglobulin C1-set domain
AA_permease_C (PF13906, IPR029485): C-terminus of AA_permease
14 HPXinteractor100Hemopexin (PF00045, IPR018487, SM00120): Hemopexin
15 LIG4interactor100APG17 (PF04108, IPR007240): Autophagy protein Apg17
BRCT (PF00533, IPR001357, SM00292): BRCA1 C Terminus (BRCT) domain
DNA_ligase_A_C (PF04679, IPR012309): ATP dependent DNA ligase C terminal region
DNA_ligase_A_M (PF01068, IPR012310): ATP dependent DNA ligase domain
DNA_ligase_A_N (PF04675, IPR012308): DNA ligase N terminus
DNA_ligase_IV (PF11411, IPR021536): DNA ligase IV
RTT107_BRCT_5 (PF16770, IPR001357): Regulator of Ty1 transposition protein 107 BRCT domain
16 MUC1oncoprotein100SEA (PF01390, IPR000082, SM00200): SEA domain
Shisa (PF13908, IPR026910): Wnt and FGF inhibitory regulator
Collectrin (PF16959, IPR031588): Renal amino acid transporter
17 MUC5AConcoprotein100C8 (PF08742, IPR014853, SM00832): C8 domain
MGC-24 (PF05283, IPR007947): Multi-glycosylated core protein 24 (MGC-24), sialomucin
Ndc1_Nup (PF09531, IPR019049): Nucleoporin protein Ndc1-Nup
Nucleo_P87 (PF07267, IPR009893): Nucleopolyhedrovirus capsid protein P87
Pex14_N (PF04695, IPR006785): Peroxisomal membrane anchor protein (Pex14p) conserved region
Pox_F12L (PF03337, IPR005005): Poxvirus F12L protein
TIL (PF01826, IPR002919): Trypsin Inhibitor like cysteine rich domain
VWC (PF00093, IPR001007, SM00214): von Willebrand factor type C domain
VWD (PF00094, IPR001846, SM00216): von Willebrand factor type D domain
Activator_LAG-3 (PF11498, IPR021587): Transcriptional activator LAG-3
TILa (PF12714, IPR025615): TILa domain
Mucin2_WxxW (PF13330, IPR025155): Mucin-2 protein WxxW repeating region
MetallophosN (PF16371, IPR032285): N terminal of Calcineurin-like phosphoesterase
18 SERPINB3oncoprotein100Serpin (PF00079, IPR023796, SM00093): Serpin (serine protease inhibitor)
19 TMEM25interactor100C2-set_2 (PF08205, IPR013162): CD80-like C2-set immunoglobulin domain
Ig_3 (PF13927): Immunoglobulin domain
DUF4674 (PF15719, IPR029779): Domain of unknown function (DUF4674)

B a c k    t o    T o p ⇑