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Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: parental proteins RBM47, CBWD2 (from a repository: Sat Aug 3 02:03:16 2019)
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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)19
The number (and %) of the onco-proteins3 (15.79 %)
The number (and %) of the tumor suppressors2 (10.53 %)
Total number of binary PPIs (saturation %)38 (22.22 %)
The number (and %) of affected PPIs17 (44.74 %)
The number of possible different fusions3
PPI diameter5
PPI radius3
The average degree of PPI3.263
Assortativity coefficient-0.0956
The network average Clustering coefficient0.611
The number (and %) of a zero Clustering coefficients3 (15.79 %)
The number (and %) of a zero Betweenness Centrality11 (57.89 %)

ACTIVE INTERACTORS


List of the fusions

PPI for parental proteins: RBM47,CBWD2 All fusions
Proteins found in more fusions CUL3 (see 1 fusions); ECHS1 (see 1 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 RBM47parental protein50.20067.000Ribosomal_60s (PF00428, IPR001813): 60s Acidic ribosomal protein
RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
RRM_5 (PF13893): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
2 CBWD2parental protein120.136179.000cobW (PF02492, IPR003495): CobW/HypB/UreG, nucleotide-binding domain
CobW_C (PF07683, IPR011629, SM00833): Cobalamin synthesis protein cobW C-terminal domain
3 AGO2interactor30.66731.000ArgoL1 (PF08699, IPR014811, SM01163): Argonaute linker 1 domain
PAZ (PF02170, IPR003100, SM00949): PAZ domain
Piwi (PF02171, IPR003165, SM00950): Piwi domain
ArgoN (PF16486, IPR032474): N-terminal domain of argonaute
ArgoMid (PF16487, IPR032473): Mid domain of argonaute
ArgoL2 (PF16488, IPR032472): Argonaute linker 2 domain
4 ATMsuppressor31.0000FAT (PF02259, IPR003151): FAT domain
FATC (PF02260, IPR003152): FATC domain
HEAT (PF02985, IPR000357): HEAT repeat
PI3_PI4_kinase (PF00454, IPR000403, SM00146): Phosphatidylinositol 3- and 4-kinase
TAN (PF11640, IPR021668): Telomere-length maintenance and DNA damage repair
ANAPC5 (PF12862, IPR026000): Anaphase-promoting complex subunit 5
5 C1orf94interactor200DUF4688 (PF15752, IPR031496): Domain of unknown function (DUF4688)
6 CBWD1interactor60.33310.000cobW (PF02492, IPR003495): CobW/HypB/UreG, nucleotide-binding domain
CobW_C (PF07683, IPR011629, SM00833): Cobalamin synthesis protein cobW C-terminal domain
7 CBWD7interactor21.0000cobW (PF02492, IPR003495): CobW/HypB/UreG, nucleotide-binding domain
CobW_C (PF07683, IPR011629, SM00833): Cobalamin synthesis protein cobW C-terminal domain
8 CUL3protein found in more fusions60.40061.000Cullin (PF00888, IPR001373, SM00182): Cullin family
Cullin_Nedd8 (PF10557, IPR019559, SM00884): Cullin protein neddylation domain
WAC_Acf1_DNA_bd (PF10537, IPR013136): ATP-utilising chromatin assembly and remodelling N-terminal
9 ECHS1protein found in more fusions31.0000ECH_1 (PF00378, IPR001753): Enoyl-CoA hydratase/isomerase
10 EGLN1suppressor31.0000zf-MYND (PF01753, IPR002893): MYND finger
2OG-FeII_Oxy_3 (PF13640, IPR005123): 2OG-Fe(II) oxygenase superfamily
11 ELAVL1oncoprotein70.200133.000RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
12 HSFY1interactor100HSF_DNA-bind (PF00447, IPR000232, SM00415): HSF-type DNA-binding
13 HSPA12Ainteractor21.0000HSP70 (PF00012, IPR013126): Hsp70 protein
14 METAP1interactor21.0000Peptidase_M24 (PF00557, IPR001714): Metallopeptidase family M24
zf-C6H2 (PF15801, IPR031615): zf-MYND-like zinc finger, mRNA-binding
15 NEK4interactor21.0000Pkinase (PF00069, IPR000719): Protein kinase domain
Secretin_N_2 (PF07655, IPR011514): Secretin N-terminal domain
16 PAN2interactor2031.000RNase_T (PF00929, IPR013520): Exonuclease
UCH_1 (PF13423, IPR001394): Ubiquitin carboxyl-terminal hydrolase
WD40_like (PF17005, IPR031544): WD40-like domain
17 RNF2interactor31.0000zf-C4_Topoisom (PF01396, IPR013498): Topoisomerase DNA binding C4 zinc finger
zf-C3HC4_2 (PF13923): Zinc finger, C3HC4 type (RING finger)
RAWUL (PF16207, IPR032443): RAWUL domain RING finger- and WD40-associated ubiquitin-like
18 TUBB1interactor21.0000Tubulin (PF00091, IPR003008, SM00864): Tubulin/FtsZ family, GTPase domain
Tubulin_C (PF03953, IPR018316, SM00865): Tubulin C-terminal domain
19 YWHAQinteractor30.6674.00014-3-3 (PF00244, IPR023410, SM00101): 14-3-3 protein

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