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Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: parental proteins DUSP18, CDV3 (from a repository: Sat Jul 13 05:58:24 2019)
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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)47
The number (and %) of the onco-proteins7 (14.89 %)
The number (and %) of the tumor suppressors2 (4.26 %)
Total number of binary PPIs (saturation %)117 (10.82 %)
The number (and %) of affected PPIs45 (38.46 %)
The number of possible different fusions5
PPI diameter2
PPI radiusinf
The average degree of PPI4.596
Assortativity coefficient-0.4596
The network average Clustering coefficient0.603
The number (and %) of a zero Clustering coefficients9 (19.15 %)
The number (and %) of a zero Betweenness Centrality26 (55.32 %)

ACTIVE INTERACTORS


List of the fusions

PPI for parental proteins: CDV3,DUSP18 All fusions
Proteins found in more fusions QKI (see 3 fusions); ILK (see 2 fusions); EWSR1 (see 1 fusions); U2AF2 (see 2 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 CDV3parental protein440.0671544.952TraT (PF05818, IPR008874): Enterobacterial TraT complement resistance protein
CDV3 (PF15359, IPR026806): Carnitine deficiency-associated protein 3
2 DUSP18parental protein100DSPc (PF00782, IPR020422, SM00195): Dual specificity phosphatase, catalytic domain
3 CHMP2Ainteractor31.0000Snf7 (PF03357, IPR005024): Snf7
4 COBLinteractor100CAP_N (PF01213, IPR013992): Adenylate cyclase associated (CAP) N terminal
Cobl (PF09469, IPR019025): Cordon-bleu ubiquitin-like domain
RBD (PF02196, IPR003116, SM00455): Raf-like Ras-binding domain
WH2 (PF02205, IPR003124, SM00246): WH2 motif
PRIMA1 (PF16101): Proline-rich membrane anchor 1
5 ELAVL1oncoprotein140.20561.000RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
6 ELMSAN1interactor21.0000ELM2 (PF01448, IPR000949): ELM2 domain
FYDLN_acid (PF09538, IPR012644): Protein of unknown function (FYDLN_acid)
Ndc1_Nup (PF09531, IPR019049): Nucleoporin protein Ndc1-Nup
zf-UBP (PF02148, IPR001607, SM00290): Zn-finger in ubiquitin-hydrolases and other protein
Myb_DNA-binding (PF00249, IPR001005, SM00717): Myb-like DNA-binding domain
7 EWSR1oncoprotein90.35716.667RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
SVS_QK (PF10578, IPR018942): Seminal vesicle protein repeat
zf-RanBP (PF00641, IPR001876, SM00547): Zn-finger in Ran binding protein and others
FoP_duplication (PF13865, IPR025715): C-terminal duplication domain of Friend of PRMT1
Keratin_2_head (PF16208, IPR032444): Keratin type II head
8 FIS1interactor200Fis1_TPR_N (PF14852, IPR028058): Fis1 N-terminal tetratricopeptide repeat
Fis1_TPR_C (PF14853, IPR028061): Fis1 C-terminal tetratricopeptide repeat
9 GIPC1interactor21.0000PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF)
10 GLIPR2interactor21.0000CAP (PF00188, IPR014044, SM00198): Cysteine-rich secretory protein family
11 GNAI3interactor30.6671.000G-alpha (PF00503, IPR001019, SM00275): G-protein alpha subunit
12 IDH3Ginteractor40.6672.000Iso_dh (PF00180, IPR024084): Isocitrate/isopropylmalate dehydrogenase
13 ILKsuppressor50.5002.667Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies)
Ank_4 (PF13637): Ankyrin repeats (many copies)
Ank_5 (PF13857): Ankyrin repeats (many copies)
14 LARP4Binteractor21.0000La (PF05383, IPR006630, SM00715): La domain
15 LEMD3interactor100LEM (PF03020, IPR003887, SM00540): LEM domain
MSC (PF09402, IPR018996): Man1-Src1p-C-terminal domain
RBM39linker (PF15519, IPR029123): linker between RRM2 and RRM3 domains in RBM39 protein
16 MAPK8IP2interactor200BUD22 (PF09073, IPR015158): BUD22
CENP-B_dimeris (PF09026, IPR015115): Centromere protein B dimerisation domain
PID (PF00640, IPR006020, SM00462): Phosphotyrosine interaction domain (PTB/PID)
Spt5_N (PF11942, IPR022581): Spt5 transcription elongation factor, acidic N-terminal
SH3_9 (PF14604, IPR001452): Variant SH3 domain
17 MPLKIPinteractor31.0000MPLKIP (PF15502, IPR028265): M-phase-specific PLK1-interacting protein
18 MRPL14interactor21.0000Ribosomal_L14 (PF00238, IPR000218): Ribosomal protein L14p/L23e
RTT107_BRCT_6 (PF16771, IPR031906): Regulator of Ty1 transposition protein 107 BRCT domain
19 MRPS28interactor21.0000MRP-S35 (PF10246, IPR019375): Mitochondrial ribosomal protein MRP-S35
20 MRRFinteractor40.5002.286RRF (PF01765, IPR023584): Ribosome recycling factor
YtxH (PF12732, IPR024623): YtxH-like protein
21 NAA50interactor21.0000Acetyltransf_1 (PF00583, IPR000182): Acetyltransferase (GNAT) family
22 NDUFA2interactor70.4297.500L51_S25_CI-B8 (PF05047, IPR007741, SM00916): Mitochondrial ribosomal protein L51 / S25 / CI-B8 domain
23 NDUFA7interactor150.24867.833CI-B14_5a (PF07347, IPR009947): NADH:ubiquinone oxidoreductase subunit B14.5a (Complex I-B14.5a)
24 NDUFAF2interactor100NDUFA12 (PF05071, IPR007763): NADH ubiquinone oxidoreductase subunit NDUFA12
25 NSFL1Cinteractor100SEP (PF08059, IPR012989, SM00553): SEP domain
UBX (PF00789, IPR001012, SM00166): UBX domain
UBA_4 (PF14555): UBA-like domain
26 NUP50interactor100NUP50 (PF08911, IPR015007): NUP50 (Nucleoporin 50 kDa)
Ran_BP1 (PF00638, IPR000156, SM00160): RanBP1 domain
27 PGDoncoprotein21.00006PGD (PF00393, IPR006114): 6-phosphogluconate dehydrogenase, C-terminal domain
NAD_binding_2 (PF03446, IPR006115): NAD binding domain of 6-phosphogluconate dehydrogenase
28 PPP1R12Ainteractor30.6671.000DUF1510 (PF07423, IPR009988): Protein of unknown function (DUF1510)
Mucin (PF01456, IPR000458): Mucin-like glycoprotein
RNA_pol_3_Rpc31 (PF11705, IPR024661): DNA-directed RNA polymerase III subunit Rpc31
DUF3682 (PF12446, IPR022152): Protein of unknown function (DUF3682)
Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies)
DUF4050 (PF13259, IPR025124): Protein of unknown function (DUF4050)
AAA_23 (PF13476): AAA domain
Ank_5 (PF13857): Ankyrin repeats (many copies)
GEMIN8 (PF15348): Gemini of Cajal bodies-associated protein 8
PRKG1_interact (PF15898, IPR031775): cGMP-dependent protein kinase interacting domain
29 PSMD9interactor21.0000Remorin_C (PF03763, IPR005516): Remorin, C-terminal region
DUF2046 (PF09755, IPR019152): Uncharacterized conserved protein H4 (DUF2046)
PDZ_2 (PF13180, IPR001478): PDZ domain
30 QKIprotein found in more fusions60.7001.833KH_1 (PF00013, IPR004088, SM00322): KH domain
STAR_dimer (PF16544, IPR032377): Homodimerisation region of STAR domain protein
Quaking_NLS (PF16551, IPR032367): Putative nuclear localisation signal of quaking
31 RAB31oncoprotein31.0000Ras (PF00071, IPR001806, SM00173): Ras family
32 RFX5oncoprotein40.5001.786RFX_DNA_binding (PF02257, IPR003150): RFX DNA-binding domain
RFX5_DNA_bdg (PF14621, IPR029298): RFX5 DNA-binding domain
33 RRBP1interactor40.5002.500Fez1 (PF06818): Fez1
Fib_alpha (PF08702, IPR012290): Fibrinogen alpha/beta chain family
IncA (PF04156, IPR007285): IncA protein
Pentapeptide_2 (PF01469, IPR002989): Pentapeptide repeats (8 copies)
Rib_recp_KP_reg (PF05104, IPR007794): Ribosome receptor lysine/proline rich region
RTBV_P46 (PF06216, IPR009347): Rice tungro bacilliform virus P46 protein
Spc7 (PF08317, IPR013253, SM00787): Spc7 kinetochore protein
TPR_MLP1_2 (PF07926, IPR012929): TPR/MLP1/MLP2-like protein
Rootletin (PF15035): Ciliary rootlet component, centrosome cohesion
UPF0449 (PF15136, IPR028227): Uncharacterised protein family UPF0449
UPF0767 (PF15990, IPR031933): UPF0767 family
34 SCO2interactor70.6676.000SCO1-SenC (PF02630, IPR003782): SCO1/SenC
35 SNU13interactor31.0000Ribosomal_L7Ae (PF01248, IPR004038): Ribosomal protein L7Ae/L30e/S12e/Gadd45 family
36 STX7interactor80.57110.333SNARE (PF05739, IPR000727, SM00397): SNARE domain
Cep57_CLD_2 (PF14197, IPR025925): Centrosome localisation domain of PPC89
Syntaxin_2 (PF14523): Syntaxin-like protein
37 SUGP1interactor120.40929.452G-patch (PF01585, IPR000467, SM00443): G-patch domain
Herpes_DNAp_acc (PF04929, IPR007013): Herpes DNA replication accessory factor
MAS20 (PF02064, IPR002056): MAS20 protein import receptor
NUDE_C (PF04880, IPR006964): NUDE protein, C-terminal conserved region
OrfB_IS605 (PF01385, IPR001959): Probable transposase
RtcB (PF01139, IPR001233): tRNA-splicing ligase RtcB
Surp (PF01805, IPR000061, SM00648): Surp module
G-patch_2 (PF12656, IPR026822): G-patch domain
38 TBL2suppressor40.8330.286eIF2A (PF08662, IPR013979): Eukaryotic translation initiation factor eIF2A
WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
FdsD (PF11390, IPR021074): NADH-dependant formate dehydrogenase delta subunit FdsD
39 TIMM44interactor60.6672.952Tim44 (PF04280, IPR007379, SM00978): Tim44-like domain
DUF4211 (PF13926, IPR025451): Domain of unknown function (DUF4211)
AIM3 (PF17096, IPR031370): Altered inheritance of mitochondria protein 3
RecG_N (PF17190): RecG N-terminal helical domain
40 TSFMinteractor21.0000EF_TS (PF00889, IPR014039): Elongation factor TS
41 TXLNGinteractor21.0000FlaC_arch (PF05377, IPR008039): Flagella accessory protein C (FlaC)
Taxilin (PF09728, IPR026183): Myosin-like coiled-coil protein
42 U2AF2protein found in more fusions60.7002.333RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
Transformer (PF06495, IPR010519): Fruit fly transformer protein
43 UBAP2Linteractor30.6670.667CUE (PF02845, IPR003892, SM00546): CUE domain
DUF3484 (PF11983, IPR021873): Membrane-attachment and polymerisation-promoting switch
DUF3697 (PF12478, IPR022166): Ubiquitin-associated protein 2
UBA_4 (PF14555): UBA-like domain
Comm (PF15957, IPR031878): Commissureless
44 UBL4Ainteractor50.8000.952ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
45 UQCC3interactor100DUF4574 (PF15141, IPR027896): Domain of unknown function (DUF4574)
46 VDAC3interactor51.0000Porin_3 (PF01459, IPR027246): Eukaryotic porin
47 ZFAND6interactor21.0000zf-A20 (PF01754, IPR002653, SM00259): A20-like zinc finger
zf-AN1 (PF01428, IPR000058, SM00154): AN1-like Zinc finger

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