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Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: parental proteins CTNND2, HDAC8 (from a repository: Mon Feb 5 21:18:31 2018)
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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)46
The number (and %) of the onco-proteins18 (39.13 %)
The number (and %) of the tumor suppressors4 (8.70 %)
Total number of binary PPIs (saturation %)107 (10.34 %)
The number (and %) of affected PPIs44 (41.12 %)
The number of possible different fusions12
PPI diameter5
PPI radius3
The average degree of PPI3.913
Assortativity coefficient-0.3519
The network average Clustering coefficient0.332
The number (and %) of a zero Clustering coefficients19 (41.30 %)
The number (and %) of a zero Betweenness Centrality15 (32.61 %)

ACTIVE INTERACTORS


List of the fusions

PPI for parental proteins: HDAC8,CTNND2 All fusions
Proteins found in more fusions DDB1 (see 2 fusions); CREB1 (see 2 fusions); RUNX1T1 (see 1 fusions); SMG6 (see 1 fusions); DCAF1 (see 1 fusions); HSP90AA1 (see 2 fusions); ATN1 (see 1 fusions); MME (see 1 fusions); TPM3 (see 2 fusions); MCM2 (see 1 fusions); NUDT21 (see 2 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 HDAC8parental protein350.0501393.792DNase-RNase (PF02577, IPR003729): Bifunctional nuclease
Hist_deacetyl (PF00850, IPR023801): Histone deacetylase domain
2 CTNND2parental protein90402.900Arm (PF00514, IPR000225, SM00185): Armadillo/beta-catenin-like repeat
HEAT (PF02985, IPR000357): HEAT repeat
3 ACTA1interactor2011.480Actin (PF00022, IPR004000, SM00268): Actin
4 ADD3oncoprotein100Aldolase_II (PF00596, IPR001303, SM01007): Class II Aldolase and Adducin N-terminal domain
5 ATN1protein found in more fusions3020.342Atrophin-1 (PF03154, IPR002951): Atrophin-1 family
6 CBFA2T3suppressor30.33365.842NHR2 (PF08788, IPR014896): NHR2 domain like
TAFH (PF07531, IPR003894, SM00549): NHR1 homology to TAF
zf-MYND (PF01753, IPR002893): MYND finger
Efg1 (PF10153, IPR019310): rRNA-processing protein Efg1
PRIMA1 (PF16101): Proline-rich membrane anchor 1
7 CHCHD3interactor21.0000DUF737 (PF05300, IPR007964): Protein of unknown function (DUF737)
eIF3g (PF12353, IPR024675): Eukaryotic translation initiation factor 3 subunit G
8 CLK1interactor200PDGF_N (PF04692, IPR006782): Platelet-derived growth factor, N terminal region
Pkinase (PF00069, IPR000719): Protein kinase domain
9 CPNE3interactor2011.480C2 (PF00168, IPR000008, SM00239): C2 domain
Copine (PF07002, IPR010734): Copine
10 CREB1oncoprotein50.5002.167bZIP_1 (PF00170, IPR004827): bZIP transcription factor
pKID (PF02173, IPR003102): pKID domain
DUF4988 (PF16378, IPR032149): Domain of unknown function
11 CROCCinteractor100APG6 (PF04111, IPR007243): Autophagy protein Apg6
COG2 (PF06148, IPR024602): COG (conserved oligomeric Golgi) complex component, COG2
DUF1664 (PF07889, IPR012458): Protein of unknown function (DUF1664)
DUF972 (PF06156, IPR010377): Protein of unknown function (DUF972)
Reo_sigmaC (PF04582, IPR007662): Reovirus sigma C capsid protein
Rho_Binding (PF08912, IPR015008): Rho Binding
Spc7 (PF08317, IPR013253, SM00787): Spc7 kinetochore protein
CENP-F_leu_zip (PF10473, IPR019513): Leucine-rich repeats of kinetochore protein Cenp-F/LEK1
KxDL (PF10241, IPR019371): Uncharacterized conserved protein
SOGA (PF11365, IPR027881): Protein SOGA
ADIP (PF11559, IPR021622): Afadin- and alpha -actinin-Binding
KfrA_N (PF11740, IPR021104): Plasmid replication region DNA-binding N-term
DUF3450 (PF11932, IPR016866): Protein of unknown function (DUF3450)
TMF_DNA_bd (PF12329, IPR022092): TATA element modulatory factor 1 DNA binding
Tropomyosin_1 (PF12718, IPR000533): Tropomyosin like
DUF4404 (PF14357, IPR025516): Domain of unknown function (DUF4404)
DUF4472 (PF14739, IPR029329): Domain of unknown function (DUF4472)
Rootletin (PF15035): Ciliary rootlet component, centrosome cohesion
12 DCAF1protein found in more fusions50.6671.500DUF913 (PF06025, IPR010314): Domain of Unknown Function (DUF913)
LisH (PF08513, IPR013720, SM00667): LisH
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
PTPRCAP (PF15713, IPR016553): Protein tyrosine phosphatase receptor type C-associated
13 DDB1protein found in more fusions50.6671.667CPSF_A (PF03178, IPR004871): CPSF A subunit region
MMS1_N (PF10433): Mono-functional DNA-alkylating methyl methanesulfonate N-term
14 ESRRAoncoprotein100zf-C4 (PF00105, IPR001628, SM00399): Zinc finger, C4 type (two domains)
Hormone_recep (PF00104, IPR000536, SM00430): Ligand-binding domain of nuclear hormone receptor
15 HIST1H3Ainteractor70.40034.147Histone (PF00125, IPR007125): Core histone H2A/H2B/H3/H4
16 HIST1H4Ainteractor30.66711.480CENP-T_C (PF15511): Centromere kinetochore component CENP-T histone fold
17 HIST3H3interactor60.40029.980Histone (PF00125, IPR007125): Core histone H2A/H2B/H3/H4
18 HIST4H4interactor30.66711.480CENP-T_C (PF15511): Centromere kinetochore component CENP-T histone fold
19 HSP90AA1oncoprotein90.250101.900HATPase_c (PF02518, IPR003594, SM00387): Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
HSP90 (PF00183, IPR001404): Hsp90 protein
20 HSPA4interactor40.5004.444Herpes_ICP4_N (PF03584, IPR005206): Herpesvirus ICP4-like protein N-terminal region
HSP70 (PF00012, IPR013126): Hsp70 protein
TP53IP5 (PF15331, IPR029290): Cellular tumour antigen p53-inducible 5
21 LNX1interactor4050.932PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF)
zf-rbx1 (PF12678, IPR024766): RING-H2 zinc finger domain
zf-C3HC4_2 (PF13923): Zinc finger, C3HC4 type (RING finger)
22 LRRC7interactor100LRR_1 (PF00560, IPR001611): Leucine Rich Repeat
PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF)
LRR_4 (PF12799, IPR025875): Leucine Rich repeats (2 copies)
LRR_5 (PF13306, IPR026906): Leucine rich repeats (6 copies)
LRR_8 (PF13855, IPR001611): Leucine rich repeat
23 MCM2oncoprotein130.076345.243AAA_3 (PF07726, IPR011703): ATPase family associated with various cellular activities (AAA)
MCM (PF00493, IPR001208, SM00350): MCM2/3/5 family
MCM2_N (PF12619, IPR008045): Mini-chromosome maintenance protein 2
MCM_N (PF14551, IPR027925): MCM N-terminal domain
MCM_OB (PF17207): MCM OB domain
24 MDC1suppressor40.5004.510FHA (PF00498, IPR000253, SM00240): FHA domain
DUF3274 (PF11678, IPR021692): Protein of unknown function (DUF3274)
Yop-YscD_cpl (PF16697, IPR032030): Inner membrane component of T3SS, cytoplasmic domain
RTT107_BRCT_5 (PF16770, IPR001357): Regulator of Ty1 transposition protein 107 BRCT domain
25 MDM1interactor100MDM1 (PF15501, IPR029136): Nuclear protein MDM1
26 MMEsuppressor31.0000Peptidase_M13 (PF01431, IPR018497): Peptidase family M13
Peptidase_M13_N (PF05649, IPR008753): Peptidase family M13
27 NUDT21protein found in more fusions3021.342NUDIX_2 (PF13869, IPR016706): Nucleotide hydrolase
28 NUP98suppressor2064.842Nucleoporin2 (PF04096, IPR007230): Nucleoporin autopeptidase
Nup96 (PF12110, IPR021967): Nuclear protein 96
ANAPC3 (PF12895): Anaphase-promoting complex, cyclosome, subunit 3
Nucleoporin_FG (PF13634, IPR025574): Nucleoporin FG repeat region
Keratin_2_head (PF16208, IPR032444): Keratin type II head
29 PDZD2interactor100PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF)
30 PPP1CConcoprotein60.40010.553Metallophos (PF00149, IPR004843): Calcineurin-like phosphoesterase
STPPase_N (PF16891, IPR031675): Serine-threonine protein phosphatase N-terminal domain
31 PRKACAinteractor30.6671.167Pkinase (PF00069, IPR000719): Protein kinase domain
32 RTN1interactor100Reticulon (PF02453, IPR003388): Reticulon
33 RUNX1T1oncoprotein40.33365.842NHR2 (PF08788, IPR014896): NHR2 domain like
TAFH (PF07531, IPR003894, SM00549): NHR1 homology to TAF
zf-MYND (PF01753, IPR002893): MYND finger
DUF3731 (PF12531, IPR021030): DNA-K related protein
34 SEC16Ainteractor2011.480APC_r (PF05923): APC repeat
Sec16_C (PF12931, IPR024298): Sec23-binding domain of Sec16
Sec16 (PF12932, IPR024340): Vesicle coat trafficking protein Sec16 mid-region
35 SMC1Aoncoprotein50.6672.000SMC_N (PF02463, IPR003395): RecF/RecN/SMC N terminal domain
36 SMC3oncoprotein31.0000SMC_N (PF02463, IPR003395): RecF/RecN/SMC N terminal domain
37 SMG5interactor21.0000EST1 (PF10374, IPR019458): Telomerase activating protein Est1
EST1_DNA_bind (PF10373, IPR018834): Est1 DNA/RNA binding domain
PIN_4 (PF13638, IPR002716): PIN domain
38 SMG6oncoprotein40.6671.000EST1 (PF10374, IPR019458): Telomerase activating protein Est1
EST1_DNA_bind (PF10373, IPR018834): Est1 DNA/RNA binding domain
PIN_4 (PF13638, IPR002716): PIN domain
39 STAG2oncoprotein31.0000AdoHcyase_NAD (PF00670, IPR015878, SM00997): S-adenosyl-L-homocysteine hydrolase, NAD binding domain
STAG (PF08514, IPR013721): STAG domain
Cnd3 (PF12719, IPR025977): Nuclear condensing complex subunits, C-term domain
DUF4446 (PF14584, IPR027981): Protein of unknown function (DUF4446)
40 SVILinteractor30.6670.500Gelsolin (PF00626, IPR007123): Gelsolin repeat
VHP (PF02209, IPR003128, SM00153): Villin headpiece domain
DUF4695 (PF15766, IPR031521): Domain of unknown function (DUF4695)
41 TPM3oncoprotein70.46735.004Tropomyosin (PF00261, IPR000533): Tropomyosin
Tropomyosin_1 (PF12718, IPR000533): Tropomyosin like
42 TPM4oncoprotein50.40057.162Tropomyosin (PF00261, IPR000533): Tropomyosin
Tropomyosin_1 (PF12718, IPR000533): Tropomyosin like
43 TTRinteractor200Transthyretin (PF00576, IPR023416, SM00095): HIUase/Transthyretin family
44 UBXN1interactor40.33317.480Selenoprotein_S (PF06936, IPR009703): Selenoprotein S (SelS)
UBA (PF00627, IPR000449, SM00165): UBA/TS-N domain
UBX (PF00789, IPR001012, SM00166): UBX domain
45 ZBTB33oncoprotein2020.342BTB (PF00651, IPR013069, SM00225): BTB/POZ domain
HD-ZIP_N (PF04618, IPR006712): HD-ZIP protein N terminus
zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type
zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain
zf-C2H2_4 (PF13894): C2H2-type zinc finger
46 ZSCAN2interactor100SCAN (PF02023, IPR003309, SM00431): SCAN domain
zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type
zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain

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