Find Fusion Network

Enter
Fusion ID:
Protein names:


Level of PPIs:
or Upload text file:
Update repository
Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: parental proteins CTNNA2, PELI1 (from a repository: Mon Feb 19 05:44:46 2018)
Examples

Cytoscape Web will replace the contents your graph
PPI Properties:

Click on nodes
or edges

Layout Tree
Circle
Radial
Force Directed
Preset
Export graph
PDF file
SVG file
SIF file
XML file
GraphML file

Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)39
The number (and %) of the onco-proteins19 (48.72 %)
The number (and %) of the tumor suppressors2 (5.13 %)
Total number of binary PPIs (saturation %)135 (18.22 %)
The number (and %) of affected PPIs37 (27.41 %)
The number of possible different fusions13
PPI diameter5
PPI radius3
The average degree of PPI5.846
Assortativity coefficient-0.1622
The network average Clustering coefficient0.510
The number (and %) of a zero Clustering coefficients6 (15.38 %)
The number (and %) of a zero Betweenness Centrality12 (30.77 %)

ACTIVE INTERACTORS


List of the fusions

PPI for parental proteins: PELI1,CTNNA2 All fusions
Proteins found in more fusions UBE2D2 (see 2 fusions); TRAF6 (see 1 fusions); IKBKB (see 2 fusions); BCL6 (see 2 fusions); SRPK2 (see 1 fusions); UBC (see 1 fusions); RIPK1 (see 1 fusions); GAN (see 1 fusions); UBE2N (see 1 fusions); EGFR (see 2 fusions); MCM2 (see 1 fusions); VAC14 (see 1 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 PELI1parental protein240.149450.047Pellino (PF04710, IPR006800): Pellino
2 CTNNA2parental protein130.192356.587Vinculin (PF01044, IPR006077): Vinculin family
3 BCL6oncoprotein309.354BTB (PF00651, IPR013069, SM00225): BTB/POZ domain
zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type
zf-C2H2_jaz (PF12171, IPR022755): Zinc-finger double-stranded RNA-binding
DZR (PF12773, IPR025874): Double zinc ribbon
zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain
zf-C2HE (PF16278, IPR032566): C2HE / C2H2 / C2HC zinc-binding finger
4 CD27interactor100TNFR_c6 (PF00020, IPR001368, SM00208): TNFR/NGFR cysteine-rich region
5 CTNNB1oncoprotein100.267117.087Arm (PF00514, IPR000225, SM00185): Armadillo/beta-catenin-like repeat
Atx10homo_assoc (PF09759, IPR019156): Spinocerebellar ataxia type 10 protein domain
DUF3361 (PF11841, IPR024574): Domain of unknown function (DUF3361)
HEAT_EZ (PF13513): HEAT-like repeat
6 DEAF1interactor100Ribosomal_60s (PF00428, IPR001813): 60s Acidic ribosomal protein
SAND (PF01342, IPR000770, SM00258): SAND domain
zf-MYND (PF01753, IPR002893): MYND finger
7 EGFRoncoprotein110.31188.133Furin-like (PF00757, IPR006211): Furin-like cysteine rich region
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
Recep_L_domain (PF01030, IPR000494): Receptor L domain
GAPT (PF11770, IPR021082): GRB2-binding adapter (GAPT)
GF_recep_IV (PF14843, IPR032778): Growth factor receptor domain IV
8 FBXW11interactor40.33343.812WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
Beta-TrCP_D (PF12125, IPR021977, SM01028): D domain of beta-TrCP
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
F-box-like (PF12937, IPR001810): F-box-like
9 GANprotein found in more fusions200BACK (PF07707, IPR011705, SM00875): BTB And C-terminal Kelch
BTB (PF00651, IPR013069, SM00225): BTB/POZ domain
Kelch_1 (PF01344, IPR006652, SM00612): Kelch motif
Kelch_3 (PF13415): Galactose oxidase, central domain
Kelch_5 (PF13854): Kelch motif
10 IKBKBprotein found in more fusions70.33327.411FliT (PF05400, IPR008622): Flagellar protein FliT
Glyco_hydro_65m (PF03632, IPR005195): Glycosyl hydrolase family 65 central catalytic domain
Pkinase (PF00069, IPR000719): Protein kinase domain
SlyX (PF04102, IPR007236): SlyX
ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
IKKbetaNEMObind (PF12179, IPR022007): I-kappa-kinase-beta NEMO binding domain
11 IL1R1interactor61.0000TIR (PF01582, IPR000157, SM00255): TIR domain
Ig_2 (PF13895, IPR007110): Immunoglobulin domain
Ig_3 (PF13927): Immunoglobulin domain
12 IRAK1interactor90.60762.234Death (PF00531, IPR000488, SM00005): Death domain
Pkinase (PF00069, IPR000719): Protein kinase domain
13 IRAK2oncoprotein61.0000Death (PF00531, IPR000488, SM00005): Death domain
Pkinase (PF00069, IPR000719): Protein kinase domain
14 IRAK4interactor61.0000Death (PF00531, IPR000488, SM00005): Death domain
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
15 IRS1interactor40.5006.705CAP_N (PF01213, IPR013992): Adenylate cyclase associated (CAP) N terminal
IRS (PF02174, IPR002404, SM00310): PTB domain (IRS-1 type)
PH (PF00169, IPR001849, SM00233): PH domain
16 JUPsuppressor60.66726.458Arm (PF00514, IPR000225, SM00185): Armadillo/beta-catenin-like repeat
Atx10homo_assoc (PF09759, IPR019156): Spinocerebellar ataxia type 10 protein domain
HEAT_EZ (PF13513): HEAT-like repeat
HEAT_2 (PF13646): HEAT repeats
17 MCM2oncoprotein100.41765.734AAA_3 (PF07726, IPR011703): ATPase family associated with various cellular activities (AAA)
MCM (PF00493, IPR001208, SM00350): MCM2/3/5 family
MCM2_N (PF12619, IPR008045): Mini-chromosome maintenance protein 2
MCM_N (PF14551, IPR027925): MCM N-terminal domain
MCM_OB (PF17207): MCM OB domain
18 MYD88oncoprotein80.7627.359Death (PF00531, IPR000488, SM00005): Death domain
TIR (PF01582, IPR000157, SM00255): TIR domain
19 NR2C2suppressor31.0000Flagellin_N (PF00669, IPR001029): Bacterial flagellin N-terminal helical region
zf-C4 (PF00105, IPR001628, SM00399): Zinc finger, C4 type (two domains)
Hormone_recep (PF00104, IPR000536, SM00430): Ligand-binding domain of nuclear hormone receptor
20 NTRK1oncoprotein140.269232.152I-set (PF07679, IPR013098): Immunoglobulin I-set domain
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
LRR_8 (PF13855, IPR001611): Leucine rich repeat
TPKR_C2 (PF16920, IPR031635): Tyrosine-protein kinase receptor C2 Ig-like domain
21 PAN2interactor21.0000RNase_T (PF00929, IPR013520): Exonuclease
UCH_1 (PF13423, IPR001394): Ubiquitin carboxyl-terminal hydrolase
WD40_like (PF17005, IPR031544): WD40-like domain
22 PPP2R1Aoncoprotein50.8008.974TAF6_C (PF07571, IPR011442): TAF6 C-terminal HEAT repeat domain
HEAT (PF02985, IPR000357): HEAT repeat
HEAT_PBS (PF03130, IPR004155, SM00567): PBS lyase HEAT-like repeat
HEAT_2 (PF13646): HEAT repeats
23 RIPK1protein found in more fusions60.50011.469Death (PF00531, IPR000488, SM00005): Death domain
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
RHIM (PF12721, IPR025735): RIP homotypic interaction motif
24 SAPCD1interactor21.0000Suppressor_APC (PF11414, IPR026831): Adenomatous polyposis coli tumour suppressor protein
25 SDHAF2oncoprotein100Sdh5 (PF03937, IPR005631): Flavinator of succinate dehydrogenase
Peroxidase_2 (PF01328, IPR000028): Peroxidase, family 2
Reovirus_cap (PF00979, IPR000153): Reovirus outer capsid protein, Sigma 3
26 SMAD6interactor21.0000MH1 (PF03165, IPR003619, SM00523): MH1 domain
MH2 (PF03166, IPR001132, SM00524): MH2 domain
27 SRPK1interactor30.6672.812FYDLN_acid (PF09538, IPR012644): Protein of unknown function (FYDLN_acid)
Pkinase (PF00069, IPR000719): Protein kinase domain
NARP1 (PF12569, IPR021183): NMDA receptor-regulated protein 1
28 SRPK2oncoprotein50.6673.479DUF1387 (PF07139, IPR009816): Protein of unknown function (DUF1387)
Mito_fiss_reg (PF05308, IPR007972): Mitochondrial fission regulator
Pkinase (PF00069, IPR000719): Protein kinase domain
S-antigen (PF05756, IPR008825): S-antigen protein
DUF2360 (PF10152, IPR019309): Predicted coiled-coil domain-containing protein (DUF2360)
29 TBK1interactor50.33313.029DUF713 (PF05218, IPR007883): Protein of unknown function (DUF713)
NPV_P10 (PF05531, IPR008702): Nucleopolyhedrovirus P10 protein
Pkinase (PF00069, IPR000719): Protein kinase domain
30 TRAF6protein found in more fusions160.314166.608SlyX (PF04102, IPR007236): SlyX
zf-TRAF (PF02176, IPR001293): TRAF-type zinc finger
zf-C3HC4_2 (PF13923): Zinc finger, C3HC4 type (RING finger)
31 TRIP13interactor40.3339.590AAA (PF00004, IPR003959, SM00382): ATPase family associated with various cellular activities (AAA)
32 UBCprotein found in more fusions130.37993.884ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
33 UBE2D1interactor70.60024.978UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme
34 UBE2D2oncoprotein80.61921.951UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme
35 UBE2Iinteractor50.6671.667UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme
36 UBE2Nprotein found in more fusions60.8001.167UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme
37 UBE2V1interactor50.9000.500UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme
38 UTP3oncoprotein100Paf1 (PF03985, IPR007133): Paf1
Prothymosin (PF03247, IPR004931): Prothymosin/parathymosin family
Sas10_Utp3 (PF04000, IPR007146): Sas10/Utp3/C1D family
Sas10 (PF09368, IPR018972): Sas10 C-terminal domain
EF-G-binding_N (PF07299): Elongation factor G-binding protein, N-terminal
39 VAC14oncoprotein50.5008.820TAF6_C (PF07571, IPR011442): TAF6 C-terminal HEAT repeat domain
HEAT (PF02985, IPR000357): HEAT repeat
Vac14_Fig4_bd (PF11916, IPR021841): Vacuolar protein 14 C-terminal Fig4p binding
Cnd1 (PF12717, IPR032682): non-SMC mitotic condensation complex subunit 1
Vac14_Fab1_bd (PF12755, IPR032878): Vacuolar 14 Fab1-binding region

B a c k    t o    T o p ⇑