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Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: parental proteins SLC30A7, SNX25 (from a repository: Thu Sep 19 06:30:36 2019)
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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)20
The number (and %) of the onco-proteins4 (20.00 %)
The number (and %) of the tumor suppressors1 (5.00 %)
Total number of binary PPIs (saturation %)21 (11.05 %)
The number (and %) of affected PPIs18 (85.71 %)
The number of possible different fusions2
PPI diameter2
PPI radiusinf
The average degree of PPI1.900
Assortativity coefficient-0.1520
The network average Clustering coefficient0.100
The number (and %) of a zero Clustering coefficients17 (85.00 %)
The number (and %) of a zero Betweenness Centrality18 (90.00 %)

ACTIVE INTERACTORS


List of the fusions

PPI for parental proteins: SLC30A7,SNX25 All fusions
Proteins found in more fusions CD40 (see 2 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 SLC30A7parental protein150.010208.000Cation_efflux (PF01545, IPR002524): Cation efflux family
2 SNX25parental protein306.000Nexin_C (PF08628, IPR013937): Sorting nexin C terminal
PX (PF00787, IPR001683, SM00312): PX domain
PXA (PF02194, IPR003114, SM00313): PXA domain
RGS (PF00615, IPR000342, SM00315): Regulator of G protein signaling domain
3 B3GNT3interactor100Galactosyl_T (PF01762, IPR002659): Galactosyltransferase
4 CD40protein found in more fusions200Glycophorin_A (PF01102, IPR001195): Glycophorin A
TNFR_c6 (PF00020, IPR001368, SM00208): TNFR/NGFR cysteine-rich region
5 CHRNA9interactor100Neur_chan_LBD (PF02931, IPR006202): Neurotransmitter-gated ion-channel ligand binding domain
Neur_chan_memb (PF02932, IPR006029): Neurotransmitter-gated ion-channel transmembrane region
6 CLPSL1interactor100Toxin_3 (PF00537, IPR002061): Scorpion toxin-like domain
7 ELAVL1oncoprotein200RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
8 KATNA1interactor100AAA (PF00004, IPR003959, SM00382): ATPase family associated with various cellular activities (AAA)
ABC_tran (PF00005, IPR003439): ABC transporter
Vps4_C (PF09336, IPR015415): Vps4 C terminal oligomerisation domain
TPR_8 (PF13181, IPR019734): Tetratricopeptide repeat
AAA_22 (PF13401, IPR003593): AAA domain
9 LPAR1oncoprotein21.00007tm_1 (PF00001, IPR000276): 7 transmembrane receptor (rhodopsin family)
10 LYPD3oncoprotein21.0000DUF753 (PF05444, IPR008472): Protein of unknown function (DUF753)
UPAR_LY6 (PF00021, IPR001526): u-PAR/Ly-6 domain
11 LYPD6interactor100UPAR_LY6_2 (PF16975): Ly6/PLAUR domain-containing protein 6, Lypd6
12 MRPL1interactor100CUB_2 (PF02408, IPR003366): CUB-like domain
Ribosomal_L1 (PF00687, IPR028364): Ribosomal protein L1p/L10e family
13 P2RY12interactor1007tm_1 (PF00001, IPR000276): 7 transmembrane receptor (rhodopsin family)
14 RIC3interactor100CHASE3 (PF05227, IPR007891): CHASE3 domain
RIC3 (PF15361, IPR032763): Resistance to inhibitors of cholinesterase homologue 3
15 SIX5interactor100Ribosomal_60s (PF00428, IPR001813): 60s Acidic ribosomal protein
Homeobox (PF00046, IPR001356, SM00389): Homeobox domain
SIX1_SD (PF16878, IPR031701): Transcriptional regulator, SIX1, N-terminal SD domain
16 SPINT2suppressor100Kunitz_BPTI (PF00014, IPR002223, SM00131): Kunitz/Bovine pancreatic trypsin inhibitor domain
17 TCTN3interactor100DUF1619 (PF07773, IPR011677): Protein of unknown function (DUF1619)
18 TSPAN5interactor100Tetraspannin (PF00335, IPR018499): Tetraspanin family
19 VAPBinteractor100ATP-synt_G (PF04718, IPR006808): Mitochondrial ATP synthase g subunit
ZapB (PF06005, IPR009252): Cell division protein ZapB
Motile_Sperm (PF00635, IPR000535): MSP (Major sperm protein) domain
20 WBP1interactor100WBP-1 (PF11669, IPR021684): WW domain-binding protein 1

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