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Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: parental proteins IL34, SAMD3 (from a repository: Fri Aug 9 04:58:44 2019)
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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)10
The number (and %) of the onco-proteins4 (40.00 %)
The number (and %) of the tumor suppressors2 (20.00 %)
Total number of binary PPIs (saturation %)14 (31.11 %)
The number (and %) of affected PPIs8 (57.14 %)
The number of possible different fusions4
PPI diameter2
PPI radiusinf
The average degree of PPI1.800
Assortativity coefficient-0.1367
The network average Clustering coefficient0.205
The number (and %) of a zero Clustering coefficients7 (70.00 %)
The number (and %) of a zero Betweenness Centrality9 (90.00 %)

ACTIVE INTERACTORS


List of the fusions

PPI for parental proteins: SAMD3,IL34 All fusions
Proteins found in more fusions ATXN1 (see 3 fusions); KDM1A (see 3 fusions); FANCG (see 1 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 SAMD3parental protein70.04840.000SAM_1 (PF00536, IPR021129, SM00454): SAM domain (Sterile alpha motif)
RecG_wedge (PF17191): RecG wedge domain
2 IL34parental protein100IL34 (PF15036, IPR020415): Interleukin 34
3 AKAP9oncoprotein21.0000ACCA (PF03255, IPR001095): Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit
ATG16 (PF08614, IPR013923): Autophagy protein 16 (ATG16)
DUF1664 (PF07889, IPR012458): Protein of unknown function (DUF1664)
DUF724 (PF05266, IPR007930): Protein of unknown function (DUF724)
ZYG-11_interact (PF05884, IPR008574): Interactor of ZYG-11
FlaC_arch (PF05377, IPR008039): Flagella accessory protein C (FlaC)
Hema_stalk (PF08720, IPR014831): Influenza C hemagglutinin stalk
IncA (PF04156, IPR007285): IncA protein
Laminin_II (PF06009, IPR010307): Laminin Domain II
Pox_A_type_inc (PF04508, IPR007596): Viral A-type inclusion protein repeat
Reo_sigmaC (PF04582, IPR007662): Reovirus sigma C capsid protein
Seryl_tRNA_N (PF02403, IPR015866): Seryl-tRNA synthetase N-terminal domain
Spc24 (PF08286, IPR013252): Spc24 subunit of Ndc80
TBPIP (PF07106, IPR010776): Tat binding protein 1(TBP-1)-interacting protein (TBPIP)
Uso1_p115_C (PF04871, IPR006955): Uso1 / p115 like vesicle tethering protein, C terminal region
ApoO (PF09769, IPR019166): Apolipoprotein O
Golgin_A5 (PF09787, IPR019177): Golgin subfamily A member 5
Jnk-SapK_ap_N (PF09744, IPR019143): JNK_SAPK-associated protein-1
Macoilin (PF09726, IPR019130): Transmembrane protein
PACT_coil_coil (PF10495, IPR019528): Pericentrin-AKAP-450 domain of centrosomal targeting protein
bZIP_2 (PF07716, IPR004827, SM00338): Basic region leucine zipper
DUF4200 (PF13863, IPR025252): Domain of unknown function (DUF4200)
FlxA (PF14282, IPR025577): FlxA-like protein
DUF4404 (PF14357, IPR025516): Domain of unknown function (DUF4404)
DUF4407 (PF14362, IPR025519): Domain of unknown function (DUF4407)
UPF0449 (PF15136, IPR028227): Uncharacterised protein family UPF0449
PRKG1_interact (PF15898, IPR031775): cGMP-dependent protein kinase interacting domain
FAM76 (PF16046, IPR032017): FAM76 protein
ABC_tran_CTD (PF16326, IPR032524): ABC transporter C-terminal domain
HIP1_clath_bdg (PF16515, IPR032422): Clathrin-binding domain of Huntingtin-interacting protein 1
PKcGMP_CC (PF16808, IPR031831): Coiled-coil N-terminus of cGMP-dependent protein kinase
4 ATXN1protein found in more fusions200AXH (PF08517, IPR013723, SM00536): Ataxin-1 and HBP1 module (AXH)
Spt20 (PF12090, IPR021950): Spt20 family
ATXN-1_C (PF12547, IPR020997): Capicua transcriptional repressor modulator
Cnd1_N (PF12922, IPR024324): non-SMC mitotic condensation complex subunit 1, N-term
5 CFAP206interactor200THP2 (PF09432, IPR018557): Tho complex subunit THP2
DUF3508 (PF12018, IPR021897): Domain of unknown function (DUF3508)
6 FANCGsuppressor200BTAD (PF03704, IPR005158, SM01043): Bacterial transcriptional activator domain
Hpt (PF01627, IPR008207, SM00073): Hpt domain
TPR_9 (PF13371, IPR011990): Tetratricopeptide repeat
TPR_12 (PF13424): Tetratricopeptide repeat
TPR_14 (PF13428): Tetratricopeptide repeat
TPR_19 (PF14559): Tetratricopeptide repeat
7 HSPD1suppressor100Cpn60_TCP1 (PF00118, IPR002423): TCP-1/cpn60 chaperonin family
8 KDM1Aprotein found in more fusions31.0000Amino_oxidase (PF01593, IPR002937): Flavin containing amine oxidoreductase
CAP_N (PF01213, IPR013992): Adenylate cyclase associated (CAP) N terminal
K_channel_TID (PF07941, IPR012897): Potassium channel Kv1.4 tandem inactivation domain
SWIRM (PF04433, IPR007526): SWIRM domain
DUF4298 (PF14131, IPR025384): Domain of unknown function (DUF4298)
9 LMO3oncoprotein100LIM (PF00412, IPR001781, SM00132): LIM domain
10 PRMT1interactor200Methyltransf_25 (PF13649): Methyltransferase domain

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