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Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: parental proteins EEF2K, TEKT5 (from a repository: Mon Jul 29 01:38:42 2019)
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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)38
The number (and %) of the onco-proteins12 (31.58 %)
The number (and %) of the tumor suppressors0 (0.00 %)
Total number of binary PPIs (saturation %)110 (15.65 %)
The number (and %) of affected PPIs36 (32.73 %)
The number of possible different fusions5
PPI diameter5
PPI radius3
The average degree of PPI5.105
Assortativity coefficient-0.3108
The network average Clustering coefficient0.527
The number (and %) of a zero Clustering coefficients8 (21.05 %)
The number (and %) of a zero Betweenness Centrality12 (31.58 %)

ACTIVE INTERACTORS


List of the fusions

PPI for parental proteins: EEF2K,TEKT5 All fusions
Proteins found in more fusions RANGAP1 (see 2 fusions); CALR (see 8 fusions); UBE3C (see 1 fusions); ACADVL (see 2 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 EEF2Kparental protein340.1071057.600Alpha_kinase (PF02816, IPR004166, SM00811): Alpha-kinase family
Sel1 (PF08238, IPR006597, SM00671): Sel1 repeat
2 TEKT5parental protein2072.000Tektin (PF03148, IPR000435): Tektin family
3 AARSinteractor50.4004.733DHHA1 (PF02272, IPR003156): DHHA1 domain
Syntaxin-6_N (PF09177, IPR015260): Syntaxin 6, N-terminal
tRNA-synt_2c (PF01411, IPR018164): tRNA synthetases class II (A)
tRNA_SAD (PF07973, IPR012947, SM00863): Threonyl and Alanyl tRNA synthetase second additional domain
4 ACACAinteractor21.0000ACC_central (PF08326, IPR013537): Acetyl-CoA carboxylase, central region
Biotin_carb_C (PF02785, IPR005482, SM00878): Biotin carboxylase C-terminal domain
Biotin_lipoyl (PF00364, IPR000089): Biotin-requiring enzyme
Carboxyl_trans (PF01039, IPR000022): Carboxyl transferase domain
Biotin_carb_N (PF00289, IPR005481): Biotin carboxylase, N-terminal domain
CPSase_L_D2 (PF02786, IPR005479): Carbamoyl-phosphate synthase L chain, ATP binding domain
DUF445 (PF04286, IPR007383): Protein of unknown function (DUF445)
5 ACADVLprotein found in more fusions200Acyl-CoA_dh_1 (PF00441, IPR009075): Acyl-CoA dehydrogenase, C-terminal domain
Acyl-CoA_dh_M (PF02770, IPR006091): Acyl-CoA dehydrogenase, middle domain
Acyl-CoA_dh_N (PF02771, IPR013786): Acyl-CoA dehydrogenase, N-terminal domain
6 ACTR2interactor100.51115.633Actin (PF00022, IPR004000, SM00268): Actin
7 ALBinteractor100Serum_albumin (PF00273, IPR014760, SM00103): Serum albumin family
8 BTRConcoprotein60.7003.000WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
Beta-TrCP_D (PF12125, IPR021977, SM01028): D domain of beta-TrCP
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
F-box-like (PF12937, IPR001810): F-box-like
9 CALRoncoprotein70.5334.900Calreticulin (PF00262, IPR001580): Calreticulin family
DDHD (PF02862, IPR004177, SM01127): DDHD domain
10 CALUinteractor100.46717.800EF-hand_6 (PF13405, IPR002048): EF-hand domain
EF-hand_7 (PF13499, IPR011992): EF-hand domain pair
EF-hand_8 (PF13833, IPR002048): EF-hand domain pair
11 CDK1oncoprotein31.0000Pkinase (PF00069, IPR000719): Protein kinase domain
12 DENRoncoprotein31.0000SUI1 (PF01253, IPR001950): Translation initiation factor SUI1
13 DPP9interactor50.5003.167DPPIV_N (PF00930, IPR002469): Dipeptidyl peptidase IV (DPP IV) N-terminal region
Peptidase_S15 (PF02129, IPR000383): X-Pro dipeptidyl-peptidase (S15 family)
Peptidase_S9 (PF00326, IPR001375): Prolyl oligopeptidase family
14 DUS3Linteractor40.6671.067Dus (PF01207, IPR001269): Dihydrouridine synthase (Dus)
zf-CCCH (PF00642, IPR000571): Zinc finger C-x8-C-x5-C-x3-H type (and similar)
15 EEF2interactor40.5002.500EFG_C (PF00679, IPR000640, SM00838): Elongation factor G C-terminus
EFG_IV (PF03764, IPR005517, SM00889): Elongation factor G, domain IV
GTP_EFTU (PF00009, IPR000795): Elongation factor Tu GTP binding domain
GTP_EFTU_D2 (PF03144, IPR004161): Elongation factor Tu domain 2
EFG_II (PF14492, IPR009022): Elongation Factor G, domain II
16 EIF4A3interactor40.6670.667DEAD (PF00270, IPR011545): DEAD/DEAH box helicase
Helicase_C (PF00271, IPR001650, SM00490): Helicase conserved C-terminal domain
17 ELAVL1oncoprotein120.32733.733RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
18 FBXW11interactor60.7003.000WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
Beta-TrCP_D (PF12125, IPR021977, SM01028): D domain of beta-TrCP
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
F-box-like (PF12937, IPR001810): F-box-like
19 FKBP6interactor100FKBP_C (PF00254, IPR001179): FKBP-type peptidyl-prolyl cis-trans isomerase
TPR_2 (PF07719, IPR013105): Tetratricopeptide repeat
TPR_12 (PF13424): Tetratricopeptide repeat
20 KLHL38interactor100BACK (PF07707, IPR011705, SM00875): BTB And C-terminal Kelch
BTB (PF00651, IPR013069, SM00225): BTB/POZ domain
Kelch_1 (PF01344, IPR006652, SM00612): Kelch motif
Kelch_6 (PF13964): Kelch motif
21 METAP2oncoprotein21.0000Peptidase_M24 (PF00557, IPR001714): Metallopeptidase family M24
SRP72 (PF08492, IPR013699): SRP72 RNA-binding domain
TSGP1 (PF07771, IPR011694): Tick salivary peptide group 1
22 OSGEPinteractor70.9330.400Peptidase_M22 (PF00814, IPR000905): Glycoprotease family
23 PA2G4interactor100Peptidase_M24 (PF00557, IPR001714): Metallopeptidase family M24
Ribosomal_S25 (PF03297, IPR004977): S25 ribosomal protein
TraC (PF07820, IPR012930): TraC-like protein
24 PANK4interactor60.7333.333DUF89 (PF01937, IPR002791): Protein of unknown function DUF89
Fumble (PF03630, IPR004567): Fumble
25 PRKAR1Binteractor60.6002.667RIIa (PF02197, IPR003117, SM00394): Regulatory subunit of type II PKA R-subunit
cNMP_binding (PF00027, IPR000595, SM00100): Cyclic nucleotide-binding domain
26 RAE1interactor21.0000Exonuc_X-T_C (PF08411, IPR013620): Exonuclease C-terminal
WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
Nup160 (PF11715, IPR021717): Nucleoporin Nup120/160
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
27 RANGAP1protein found in more fusions90.6794.967RanGAP1_C (PF07834, IPR009109): RanGAP1 C-terminal domain
SDA1 (PF05285, IPR007949): SDA1
LRR_6 (PF13516, IPR001611): Leucine Rich repeat
LRR_8 (PF13855, IPR001611): Leucine rich repeat
28 RPS6KA1oncoprotein30.6671.000Pkinase (PF00069, IPR000719): Protein kinase domain
Pkinase_C (PF00433, IPR017892): Protein kinase C terminal domain
29 RPS6KB1interactor41.0000Pkinase (PF00069, IPR000719): Protein kinase domain
Pkinase_C (PF00433, IPR017892): Protein kinase C terminal domain
30 SKP1oncoprotein41.0000Skp1 (PF01466, IPR016072, SM00512): Skp1 family, dimerisation domain
Skp1_POZ (PF03931, IPR016073): Skp1 family, tetramerisation domain
31 SRP14interactor30.6670.667SRP14 (PF02290, IPR003210): Signal recognition particle 14kD protein
32 SRP9interactor40.5002.333SRP9-21 (PF05486): Signal recognition particle 9 kDa protein (SRP9)
33 THG1Linteractor80.5715.467Thg1 (PF04446, IPR024956): tRNAHis guanylyltransferase
Thg1C (PF14413, IPR025845): Thg1 C terminal domain
34 TNS2interactor20140.000PTB (PF08416, IPR013625): Phosphotyrosine-binding domain
SH2 (PF00017, IPR000980, SM00252): SH2 domain
PTEN_C2 (PF10409, IPR014020): C2 domain of PTEN tumour-suppressor protein
C1_1 (PF00130, IPR002219, SM00109): Phorbol esters/diacylglycerol binding domain (C1 domain)
cEGF (PF12662, IPR026823): Complement Clr-like EGF-like
PRIMA1 (PF16101): Proline-rich membrane anchor 1
35 TP53RKoncoprotein90.5839.867APH (PF01636, IPR002575): Phosphotransferase enzyme family
Kdo (PF06293, IPR010440): Lipopolysaccharide kinase (Kdo/WaaP) family
36 UBE3Cprotein found in more fusions40.6670.500IQ (PF00612, IPR000048, SM00015): IQ calmodulin-binding motif
HECT (PF00632, IPR000569, SM00119): HECT-domain (ubiquitin-transferase)
37 WDFY3interactor20204.000Beach (PF02138, IPR000409, SM01026): Beige/BEACH domain
FYVE (PF01363, IPR000306, SM00064): FYVE zinc finger
WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
Laminin_G_3 (PF13385): Concanavalin A-like lectin/glucanases superfamily
E3_UbLigase_R4 (PF13764, IPR025704): E3 ubiquitin-protein ligase UBR4
PH_BEACH (PF14844, IPR023362): PH domain associated with Beige/BEACH
DUF4704 (PF15787, IPR031570): Domain of unknown function (DUF4704)
DUF4800 (PF16057): Domain of unknown function (DUF4800)
38 XPO1interactor90.33321.000CRM1_C (PF08767, IPR014877, SM01102): CRM1 C terminal
Hydrolase_3 (PF08282, IPR023214): haloacid dehalogenase-like hydrolase
IBN_N (PF03810, IPR001494, SM00913): Importin-beta N-terminal domain
Xpo1 (PF08389, IPR013598): Exportin 1-like protein
Vac14_Fab1_bd (PF12755, IPR032878): Vacuolar 14 Fab1-binding region

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