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Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: parental proteins NDUFB1, TTC7B (from a repository: Fri Aug 16 03:56:01 2019)

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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)15
The number (and %) of the onco-proteins4 (26.67 %)
The number (and %) of the tumor suppressors0 (0.00 %)
Total number of binary PPIs (saturation %)56 (53.33 %)
The number (and %) of affected PPIs13 (23.21 %)
The number of possible different fusions5
PPI diameter3
PPI radius2
The average degree of PPI6.400
Assortativity coefficient-0.3086
The network average Clustering coefficient0.625
The number (and %) of a zero Clustering coefficients1 (6.67 %)
The number (and %) of a zero Betweenness Centrality2 (13.33 %)


List of the fusions

PPI for parental proteins: TTC7B,NDUFB1 All fusions
Proteins found in more fusions EWSR1 (see 1 fusions); APP (see 5 fusions); CUL3 (see 1 fusions); NDUFS3 (see 2 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Domains (Pfam, InterPro, SMART): description
1 TTC7Bparental protein100HrpB1_HrpK (PF09613, IPR013394): Bacterial type III secretion protein (HrpB1_HrpK)
TPR_2 (PF07719, IPR013105): Tetratricopeptide repeat
DUF3808 (PF10300, IPR019412): Protein of unknown function (DUF3808)
ANAPC3 (PF12895): Anaphase-promoting complex, cyclosome, subunit 3
TPR_6 (PF13174, IPR019734): Tetratricopeptide repeat
TPR_7 (PF13176, IPR019734): Tetratricopeptide repeat
TPR_12 (PF13424): Tetratricopeptide repeat
TPR_14 (PF13428): Tetratricopeptide repeat
TPR_16 (PF13432): Tetratricopeptide repeat
TPR_19 (PF14559): Tetratricopeptide repeat
2 NDUFB1parental protein120.45528.786NADH_oxidored (PF08040, IPR012575): MNLL subunit
3 APPprotein found in more fusions60.6003.967APP_N (PF02177, IPR015849, SM00006): Amyloid A4 N-terminal heparin-binding
Beta-APP (PF03494, IPR013803): Beta-amyloid peptide (beta-APP)
BUD22 (PF09073, IPR015158): BUD22
IncA (PF04156, IPR007285): IncA protein
Kunitz_BPTI (PF00014, IPR002223, SM00131): Kunitz/Bovine pancreatic trypsin inhibitor domain
APP_amyloid (PF10515, IPR019543): beta-amyloid precursor protein C-terminus
APP_Cu_bd (PF12924, IPR011178): Copper-binding of amyloid precursor, CuBD
APP_E2 (PF12925, IPR024329): E2 domain of amyloid precursor protein
4 C15orf48interactor60.8670.686B12D (PF06522, IPR010530): NADH-ubiquinone reductase complex 1 MLRQ subunit
5 COQ9interactor60.9000.286COQ9 (PF08511, IPR013718): COQ9
6 CUL3protein found in more fusions70.40028.400Cullin (PF00888, IPR001373, SM00182): Cullin family
Cullin_Nedd8 (PF10557, IPR019559, SM00884): Cullin protein neddylation domain
WAC_Acf1_DNA_bd (PF10537, IPR013136): ATP-utilising chromatin assembly and remodelling N-terminal
7 ECSITinteractor50.6671.067ECSIT (PF06239, IPR010418): Evolutionarily conserved signalling intermediate in Toll pathway
ECSIT_C (PF14784, IPR029342): C-terminal domain of the ECSIT protein
8 EWSR1oncoprotein40.6670.800RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
SVS_QK (PF10578, IPR018942): Seminal vesicle protein repeat
zf-RanBP (PF00641, IPR001876, SM00547): Zn-finger in Ran binding protein and others
FoP_duplication (PF13865, IPR025715): C-terminal duplication domain of Friend of PRMT1
Keratin_2_head (PF16208, IPR032444): Keratin type II head
9 GOLT1Binteractor50.9000.286Got1 (PF04178, IPR007305): Got1/Sft2-like family
10 NDUFA4interactor90.60710.152B12D (PF06522, IPR010530): NADH-ubiquinone reductase complex 1 MLRQ subunit
11 NDUFA5interactor100.48920.800ETC_C1_NDUFA5 (PF04716, IPR006806): ETC complex I subunit conserved region
12 NDUFA8interactor80.6075.767CHCH (PF06747, IPR010625): CHCH domain
Pet191_N (PF10203, IPR018793): Cytochrome c oxidase assembly protein PET191
Cdd1 (PF11731, IPR021725): Pathogenicity locus
13 NDUFA9interactor80.7143.819Epimerase (PF01370, IPR001509): NAD dependent epimerase/dehydratase family
14 NDUFS3protein found in more fusions120.50925.186Complex1_30kDa (PF00329, IPR001268): Respiratory-chain NADH dehydrogenase, 30 Kd subunit
15 OCIAD1interactor51.0000OCIA (PF07051, IPR009764): Ovarian carcinoma immunoreactive antigen (OCIA)

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