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Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: parental proteins IQGAP3, TTC7B (from a repository: Tue Dec 25 03:03:25 2018)
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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)20
The number (and %) of the onco-proteins9 (45.00 %)
The number (and %) of the tumor suppressors0 (0.00 %)
Total number of binary PPIs (saturation %)41 (21.58 %)
The number (and %) of affected PPIs18 (43.90 %)
The number of possible different fusions5
PPI diameter4
PPI radius2
The average degree of PPI3.000
Assortativity coefficient-0.5684
The network average Clustering coefficient0.270
The number (and %) of a zero Clustering coefficients10 (50.00 %)
The number (and %) of a zero Betweenness Centrality12 (60.00 %)

ACTIVE INTERACTORS


List of the fusions

PPI for parental proteins: TTC7B,IQGAP3 All fusions
Proteins found in more fusions EGFR (see 2 fusions); CUL3 (see 1 fusions); MYC (see 2 fusions); RAC1 (see 1 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 TTC7Bparental protein100HrpB1_HrpK (PF09613, IPR013394): Bacterial type III secretion protein (HrpB1_HrpK)
TPR_2 (PF07719, IPR013105): Tetratricopeptide repeat
DUF3808 (PF10300, IPR019412): Protein of unknown function (DUF3808)
ANAPC3 (PF12895): Anaphase-promoting complex, cyclosome, subunit 3
TPR_6 (PF13174, IPR019734): Tetratricopeptide repeat
TPR_7 (PF13176, IPR019734): Tetratricopeptide repeat
TPR_12 (PF13424): Tetratricopeptide repeat
TPR_14 (PF13428): Tetratricopeptide repeat
TPR_16 (PF13432): Tetratricopeptide repeat
TPR_19 (PF14559): Tetratricopeptide repeat
2 IQGAP3parental protein170.066276.000CH (PF00307, IPR001715, SM00033): Calponin homology (CH) domain
IQ (PF00612, IPR000048, SM00015): IQ calmodulin-binding motif
RasGAP (PF00616, IPR001936, SM00323): GTPase-activator protein for Ras-like GTPase
RasGAP_C (PF03836, IPR000593): RasGAP C-terminus
SHD1 (PF03983, IPR007131): SLA1 homology domain 1, SHD1
3 CALM2interactor30.33315.333EF-hand_7 (PF13499, IPR011992): EF-hand domain pair
4 CBWD1interactor100cobW (PF02492, IPR003495): CobW/HypB/UreG, nucleotide-binding domain
CobW_C (PF07683, IPR011629, SM00833): Cobalamin synthesis protein cobW C-terminal domain
5 CDC42oncoprotein31.0000Ras (PF00071, IPR001806, SM00173): Ras family
6 CRYABoncoprotein200Crystallin (PF00525, IPR003090): Alpha crystallin A chain, N terminal
HSP20 (PF00011, IPR002068): Hsp20/alpha crystallin family
7 CUL3protein found in more fusions50.16737.667Cullin (PF00888, IPR001373, SM00182): Cullin family
Cullin_Nedd8 (PF10557, IPR019559, SM00884): Cullin protein neddylation domain
WAC_Acf1_DNA_bd (PF10537, IPR013136): ATP-utilising chromatin assembly and remodelling N-terminal
8 EGFRoncoprotein40.6670.667Furin-like (PF00757, IPR006211): Furin-like cysteine rich region
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
Recep_L_domain (PF01030, IPR000494): Receptor L domain
GAPT (PF11770, IPR021082): GRB2-binding adapter (GAPT)
GF_recep_IV (PF14843, IPR032778): Growth factor receptor domain IV
9 ELAVL1oncoprotein80.33334.000RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
10 IQCB1interactor30.6670.667DUF1765 (PF08578, IPR013887): Protein of unknown function (DUF1765)
IQ (PF00612, IPR000048, SM00015): IQ calmodulin-binding motif
HJURP_C (PF12347, IPR022102): Holliday junction regulator protein family C-terminal repeat
Condensin2nSMC (PF12422, IPR024741): Condensin II non structural maintenance of chromosomes subunit
11 IST1interactor100Ist1 (PF03398, IPR005061): Regulator of Vps4 activity in the MVB pathway
12 LGR4interactor2007tm_1 (PF00001, IPR000276): 7 transmembrane receptor (rhodopsin family)
LRR_1 (PF00560, IPR001611): Leucine Rich Repeat
LRRNT (PF01462, IPR000372, SM00013): Leucine rich repeat N-terminal domain
LRR_4 (PF12799, IPR025875): Leucine Rich repeats (2 copies)
LRR_8 (PF13855, IPR001611): Leucine rich repeat
13 MBIPinteractor200DUF1192 (PF06698, IPR009579): Protein of unknown function (DUF1192)
14 MYConcoprotein41.0000HLH (PF00010, IPR011598, SM00353): Helix-loop-helix DNA-binding domain
Myc-LZ (PF02344, IPR003327): Myc leucine zipper domain
Myc_N (PF01056, IPR012682): Myc amino-terminal region
15 MYH2interactor100IQ (PF00612, IPR000048, SM00015): IQ calmodulin-binding motif
Myosin_N (PF02736, IPR004009): Myosin N-terminal SH3-like domain
Myosin_tail_1 (PF01576, IPR002928): Myosin tail
XhlA (PF10779, IPR019715): Haemolysin XhlA
Myosin_head (PF00063, IPR001609, SM00242): Myosin head (motor domain)
16 NTRK1oncoprotein60.50021.000I-set (PF07679, IPR013098): Immunoglobulin I-set domain
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
LRR_8 (PF13855, IPR001611): Leucine rich repeat
TPKR_C2 (PF16920, IPR031635): Tyrosine-protein kinase receptor C2 Ig-like domain
17 PASKinteractor100Pkinase (PF00069, IPR000719): Protein kinase domain
PAS_8 (PF13188, IPR000014): PAS domain
PAS_9 (PF13426, IPR000014): PAS domain
18 PEX19interactor30.6670.667Pex19 (PF04614, IPR006708): Pex19 protein family
Rod-binding (PF10135, IPR019301): Rod binding protein
19 RAC1oncoprotein200Ras (PF00071, IPR001806, SM00173): Ras family
20 SOX2oncoprotein200HMG_box (PF00505, IPR009071, SM00398): HMG (high mobility group) box
SOXp (PF12336, IPR022097): SOX transcription factor

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