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Visible interactions: all affected independent (normal) nothing (blank)

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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)62
The number (and %) of the onco-proteins24 (38.71 %)
The number (and %) of the tumor suppressors9 (14.52 %)
Total number of binary PPIs (saturation %)311 (16.45 %)
The number (and %) of affected PPIs60 (19.29 %)
The number of possible different fusions18
PPI diameter5
PPI radius3
The average degree of PPI9.161
Assortativity coefficient-0.1130
The network average Clustering coefficient0.461
The number (and %) of a zero Clustering coefficients9 (14.52 %)
The number (and %) of a zero Betweenness Centrality9 (14.52 %)

ACTIVE INTERACTORS


List of the fusions

PPI for parental proteins: IRS2,CSNK1G2 All fusions
Proteins found in more fusions PTPN11 (see 1 fusions); APP (see 5 fusions); G3BP1 (see 1 fusions); YWHAG (see 1 fusions); YWHAZ (see 5 fusions); EGFR (see 2 fusions); PIK3R1 (see 1 fusions); SFN (see 1 fusions); JAK1 (see 1 fusions); SRPK2 (see 1 fusions); GRB2 (see 1 fusions); RPTOR (see 3 fusions); MAPK14 (see 1 fusions); NEDD4 (see 1 fusions); MYC (see 2 fusions); YWHAH (see 2 fusions); SMAD3 (see 3 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 IRS2parental protein400.224765.818CAP_N (PF01213, IPR013992): Adenylate cyclase associated (CAP) N terminal
IRS (PF02174, IPR002404, SM00310): PTB domain (IRS-1 type)
PH (PF00169, IPR001849, SM00233): PH domain
Ribosomal_60s (PF00428, IPR001813): 60s Acidic ribosomal protein
PRIMA1 (PF16101): Proline-rich membrane anchor 1
2 CSNK1G2parental protein200.058743.983Pkinase (PF00069, IPR000719): Protein kinase domain
CK1gamma_C (PF12605, IPR022247): Casein kinase 1 gamma C terminal
3 APPprotein found in more fusions190.176475.890APP_N (PF02177, IPR015849, SM00006): Amyloid A4 N-terminal heparin-binding
Beta-APP (PF03494, IPR013803): Beta-amyloid peptide (beta-APP)
BUD22 (PF09073, IPR015158): BUD22
IncA (PF04156, IPR007285): IncA protein
Kunitz_BPTI (PF00014, IPR002223, SM00131): Kunitz/Bovine pancreatic trypsin inhibitor domain
APP_amyloid (PF10515, IPR019543): beta-amyloid precursor protein C-terminus
APP_Cu_bd (PF12924, IPR011178): Copper-binding of amyloid precursor, CuBD
APP_E2 (PF12925, IPR024329): E2 domain of amyloid precursor protein
4 APPBP2interactor30.33326.961TPR_1 (PF00515, IPR001440): Tetratricopeptide repeat
TPR_2 (PF07719, IPR013105): Tetratricopeptide repeat
TPR_10 (PF13374, IPR011990): Tetratricopeptide repeat
TPR_12 (PF13424): Tetratricopeptide repeat
TPR_17 (PF13431): Tetratricopeptide repeat
5 ATL2interactor2015.179GBP (PF02263, IPR015894): Guanylate-binding protein, N-terminal domain
GBP_C (PF02841, IPR003191): Guanylate-binding protein, C-terminal domain
6 BCL2oncoprotein40.6670.250Bcl-2 (PF00452, IPR026298): Apoptosis regulator proteins, Bcl-2 family
BH4 (PF02180, IPR003093, SM00265): Bcl-2 homology region 4
7 COL4A3BPinteractor200Acyl_CoA_thio (PF02551, IPR025652): Acyl-CoA thioesterase
PH (PF00169, IPR001849, SM00233): PH domain
START (PF01852, IPR002913, SM00234): START domain
8 COPS2suppressor2020.820YozE_SAM_like (PF06855, IPR023089): YozE SAM-like fold
TPR_1 (PF00515, IPR001440): Tetratricopeptide repeat
TPR_2 (PF07719, IPR013105): Tetratricopeptide repeat
DUF2087 (PF09860, IPR018656): Uncharacterized protein conserved in bacteria (DUF2087)
PCI (PF01399, IPR000717, SM00088): PCI domain
TPR_7 (PF13176, IPR019734): Tetratricopeptide repeat
9 CSNK1G1interactor70.38151.652Pkinase (PF00069, IPR000719): Protein kinase domain
CK1gamma_C (PF12605, IPR022247): Casein kinase 1 gamma C terminal
10 DBNDD2interactor100Dysbindin (PF04440, IPR007531): Dysbindin (Dystrobrevin binding protein 1)
11 DVL2interactor80.6195.591DEP (PF00610, IPR000591, SM00049): Domain found in Dishevelled, Egl-10, and Pleckstrin (DEP)
Dishevelled (PF02377, IPR003351): Dishevelled specific domain
PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF)
DIX (PF00778, IPR001158, SM00021): DIX domain
Dsh_C (PF12316, IPR024580): Segment polarity protein dishevelled (Dsh) C terminal
12 EGFRoncoprotein230.355176.137Furin-like (PF00757, IPR006211): Furin-like cysteine rich region
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
Recep_L_domain (PF01030, IPR000494): Receptor L domain
GAPT (PF11770, IPR021082): GRB2-binding adapter (GAPT)
GF_recep_IV (PF14843, IPR032778): Growth factor receptor domain IV
13 ELAVL1oncoprotein190.288137.272RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
14 EPN1interactor60.8001.970ENTH (PF01417, IPR001026, SM00273): ENTH domain
UIM (PF02809, IPR003903, SM00726): Ubiquitin interaction motif
15 EPORoncoprotein60.6671.708EpoR_lig-bind (PF09067, IPR015152): Erythropoietin receptor, ligand binding
fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain
16 ESR1suppressor160.31472.696Oest_recep (PF02159, IPR001292): Oestrogen receptor
zf-C4 (PF00105, IPR001628, SM00399): Zinc finger, C4 type (two domains)
Hormone_recep (PF00104, IPR000536, SM00430): Ligand-binding domain of nuclear hormone receptor
ESR1_C (PF12743, IPR024736): Oestrogen-type nuclear receptor final C-terminal
17 FBXW11interactor100.44454.522WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
Beta-TrCP_D (PF12125, IPR021977, SM01028): D domain of beta-TrCP
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
F-box-like (PF12937, IPR001810): F-box-like
18 G3BP1protein found in more fusions70.26755.427NTF2 (PF02136, IPR002075): Nuclear transport factor 2 (NTF2) domain
RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
DUF3306 (PF11748, IPR021735): Protein of unknown function (DUF3306)
PTPRCAP (PF15713, IPR016553): Protein tyrosine phosphatase receptor type C-associated
19 GRB10oncoprotein100.44424.574BPS (PF08947, IPR015042): BPS (Between PH and SH2)
PH (PF00169, IPR001849, SM00233): PH domain
RA (PF00788, IPR000159, SM00314): Ras association (RalGDS/AF-6) domain
SH2 (PF00017, IPR000980, SM00252): SH2 domain
Argos (PF11581, IPR021633): Antagonist of EGFR signalling, Argos
20 GRB2oncoprotein220.43376.720SH2 (PF00017, IPR000980, SM00252): SH2 domain
SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
DUF5093 (PF17011, IPR031533): Domain of unknown function (DUF5093)
21 HOXB5interactor2012.924DUF739 (PF05339, IPR008003): Protein of unknown function (DUF739)
Homeobox (PF00046, IPR001356, SM00389): Homeobox domain
22 INSRinteractor100.6446.991fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain
Furin-like (PF00757, IPR006211): Furin-like cysteine rich region
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
Recep_L_domain (PF01030, IPR000494): Receptor L domain
23 IRS1interactor260.262278.541CAP_N (PF01213, IPR013992): Adenylate cyclase associated (CAP) N terminal
IRS (PF02174, IPR002404, SM00310): PTB domain (IRS-1 type)
PH (PF00169, IPR001849, SM00233): PH domain
24 JAK1oncoprotein130.59128.221FERM_M (PF00373, IPR019748): FERM central domain
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
SH2 (PF00017, IPR000980, SM00252): SH2 domain
25 KRTAP10-7interactor41.0000Keratin_B2 (PF01500, IPR002494): Keratin, high sulfur B2 protein
PMG (PF05287, IPR007951): PMG protein
DUF4106 (PF13388, IPR025179): Protein of unknown function (DUF4106)
Keratin_B2_2 (PF13885, IPR002494): Keratin, high sulfur B2 protein
26 MAPK14oncoprotein50.16759.684Pkinase (PF00069, IPR000719): Protein kinase domain
27 MRPL1interactor201.791CUB_2 (PF02408, IPR003366): CUB-like domain
Ribosomal_L1 (PF00687, IPR028364): Ribosomal protein L1p/L10e family
28 MTA1oncoprotein50.30048.841BAH (PF01426, IPR001025, SM00439): BAH domain
ELM2 (PF01448, IPR000949): ELM2 domain
Myb_DNA-binding (PF00249, IPR001005, SM00717): Myb-like DNA-binding domain
GATA (PF00320, IPR000679, SM00401): GATA zinc finger
29 MYConcoprotein130.40954.914HLH (PF00010, IPR011598, SM00353): Helix-loop-helix DNA-binding domain
Myc-LZ (PF02344, IPR003327): Myc leucine zipper domain
Myc_N (PF01056, IPR012682): Myc amino-terminal region
30 NEDD4suppressor70.6005.272Rota_NS26 (PF01525, IPR002512): Rotavirus NS26
WW (PF00397, IPR001202, SM00456): WW domain
HECT (PF00632, IPR000569, SM00119): HECT-domain (ubiquitin-transferase)
31 NETO2interactor21.0000CUB (PF00431, IPR000859, SM00042): CUB domain
Ldl_recept_a (PF00057, IPR002172, SM00192): Low-density lipoprotein receptor domain class A
32 NISCHinteractor31.0000PX (PF00787, IPR001683, SM00312): PX domain
Ribosomal_60s (PF00428, IPR001813): 60s Acidic ribosomal protein
LRR_4 (PF12799, IPR025875): Leucine Rich repeats (2 copies)
LRR_9 (PF14580): Leucine-rich repeat
DUF4611 (PF15387, IPR027893): Domain of unknown function (DUF4611)
33 NTRK1oncoprotein300.254370.300I-set (PF07679, IPR013098): Immunoglobulin I-set domain
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
LRR_8 (PF13855, IPR001611): Leucine rich repeat
TPKR_C2 (PF16920, IPR031635): Tyrosine-protein kinase receptor C2 Ig-like domain
34 PER1oncoprotein3013.970PAS (PF00989, IPR013767, SM00091): PAS fold
PAS_3 (PF08447, IPR013655): PAS fold
SPX (PF03105, IPR004331): SPX domain
SR-25 (PF10500, IPR019532): Nuclear RNA-splicing-associated protein
Period_C (PF12114, IPR022728): Period protein 2/3C-terminal region
35 PIK3CAoncoprotein100.55620.354PI3K_C2 (PF00792, IPR002420, SM00142): Phosphoinositide 3-kinase C2
PI3K_p85B (PF02192, IPR003113, SM00143): PI3-kinase family, p85-binding domain
PI3K_rbd (PF00794, IPR000341, SM00144): PI3-kinase family, ras-binding domain
PI3Ka (PF00613, IPR001263, SM00145): Phosphoinositide 3-kinase family, accessory domain (PIK domain)
DUF2321 (PF10083, IPR016891): Uncharacterized protein conserved in bacteria (DUF2321)
PI3_PI4_kinase (PF00454, IPR000403, SM00146): Phosphatidylinositol 3- and 4-kinase
36 PIK3R1oncoprotein150.46232.859RhoGAP (PF00620, IPR000198, SM00324): RhoGAP domain
SH2 (PF00017, IPR000980, SM00252): SH2 domain
SH3_2 (PF07653, IPR011511): Variant SH3 domain
PI3K_P85_iSH2 (PF16454, IPR032498): Phosphatidylinositol 3-kinase regulatory subunit P85 inter-SH2 domain
37 PIK3R3interactor50.9000.397SH2 (PF00017, IPR000980, SM00252): SH2 domain
PI3K_P85_iSH2 (PF16454, IPR032498): Phosphatidylinositol 3-kinase regulatory subunit P85 inter-SH2 domain
38 PLCG1oncoprotein70.7622.663C2 (PF00168, IPR000008, SM00239): C2 domain
PH (PF00169, IPR001849, SM00233): PH domain
SH2 (PF00017, IPR000980, SM00252): SH2 domain
PI-PLC-X (PF00388, IPR000909, SM00148): Phosphatidylinositol-specific phospholipase C, X domain
PI-PLC-Y (PF00387, IPR001711, SM00149): Phosphatidylinositol-specific phospholipase C, Y domain
SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
PH_12 (PF16457, IPR001849): Pleckstrin homology domain
39 PPP1R14Ainteractor40.66712.549PP1_inhibitor (PF05361, IPR008025): PKC-activated protein phosphatase-1 inhibitor
40 PTPN11suppressor140.57742.401SH2 (PF00017, IPR000980, SM00252): SH2 domain
Y_phosphatase (PF00102, IPR000242, SM00194): Protein-tyrosine phosphatase
41 RAP1GAPsuppressor3013.970GoLoco (PF02188, IPR003109, SM00390): GoLoco motif
Rap_GAP (PF02145, IPR000331): Rap/ran-GAP
42 RPTORprotein found in more fusions70.5334.717HEAT (PF02985, IPR000357): HEAT repeat
WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
Cnd1 (PF12717, IPR032682): non-SMC mitotic condensation complex subunit 1
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
HEAT_2 (PF13646): HEAT repeats
Raptor_N (PF14538, IPR029347): Raptor N-terminal CASPase like domain
43 RUNDC3Binteractor21.0000Drf_FH3 (PF06367, IPR010472, SM01139): Diaphanous FH3 Domain
RUN (PF02759, IPR004012, SM00593): RUN domain
44 SFNsuppressor100.6119.55314-3-3 (PF00244, IPR023410, SM00101): 14-3-3 protein
45 SIRT1suppressor120.34595.072DUF592 (PF04574, IPR007654): Protein of unknown function (DUF592)
SIR2 (PF02146, IPR003000): Sir2 family
TPP_enzyme_M (PF00205, IPR012000): Thiamine pyrophosphate enzyme, central domain
46 SMAD3oncoprotein80.38188.811MH1 (PF03165, IPR003619, SM00523): MH1 domain
MH2 (PF03166, IPR001132, SM00524): MH2 domain
47 SOCS1suppressor90.7507.759SH2 (PF00017, IPR000980, SM00252): SH2 domain
SOCS_box (PF07525, IPR001496): SOCS box
48 SOCS3suppressor100.48937.539SH2 (PF00017, IPR000980, SM00252): SH2 domain
SOCS_box (PF07525, IPR001496): SOCS box
49 SORT1interactor30.33326.565Sortilin_C (PF15901, IPR031777): Sortilin, neurotensin receptor 3, C-terminal
Sortilin-Vps10 (PF15902, IPR031778): Sortilin, neurotensin receptor 3,
50 SRPK2oncoprotein60.5004.406DUF1387 (PF07139, IPR009816): Protein of unknown function (DUF1387)
Mito_fiss_reg (PF05308, IPR007972): Mitochondrial fission regulator
Pkinase (PF00069, IPR000719): Protein kinase domain
S-antigen (PF05756, IPR008825): S-antigen protein
DUF2360 (PF10152, IPR019309): Predicted coiled-coil domain-containing protein (DUF2360)
51 TMEM185Ainteractor21.0000Tmemb_185A (PF10269, IPR019396): Transmembrane Fragile-X-F protein
52 TMEM231interactor100TM231 (PF10149, IPR019306): Transmembrane protein 231
53 TYK2interactor41.0000Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
54 UBTFinteractor50.8000.705Dicty_REP (PF05086, IPR007778): Dictyostelium (Slime Mold) REP protein
HMG_box_2 (PF09011, IPR009071): HMG-box domain
HMG_box (PF00505, IPR009071, SM00398): HMG (high mobility group) box
DUF4473 (PF14747, IPR027913): Domain of unknown function (DUF4473)
HMG_box_5 (PF14887, IPR029215): HMG (high mobility group) box 5
55 WDCPinteractor30.33317.487DUF4613 (PF15390, IPR028041): Domain of unknown function (DUF4613)
56 XPO1interactor170.309219.269CRM1_C (PF08767, IPR014877, SM01102): CRM1 C terminal
Hydrolase_3 (PF08282, IPR023214): haloacid dehalogenase-like hydrolase
IBN_N (PF03810, IPR001494, SM00913): Importin-beta N-terminal domain
Xpo1 (PF08389, IPR013598): Exportin 1-like protein
Vac14_Fab1_bd (PF12755, IPR032878): Vacuolar 14 Fab1-binding region
57 YWHABinteractor150.59027.18214-3-3 (PF00244, IPR023410, SM00101): 14-3-3 protein
Virulence_fact (PF13769, IPR025989): Virulence factor
58 YWHAEoncoprotein140.53837.28614-3-3 (PF00244, IPR023410, SM00101): 14-3-3 protein
59 YWHAGprotein found in more fusions150.59330.83614-3-3 (PF00244, IPR023410, SM00101): 14-3-3 protein
60 YWHAHprotein found in more fusions130.7129.25514-3-3 (PF00244, IPR023410, SM00101): 14-3-3 protein
61 YWHAQinteractor140.54917.26614-3-3 (PF00244, IPR023410, SM00101): 14-3-3 protein
62 YWHAZprotein found in more fusions150.58272.48214-3-3 (PF00244, IPR023410, SM00101): 14-3-3 protein

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