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Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: parental proteins CSK, KDM4C (from a repository: Fri Aug 23 04:17:12 2019)
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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)64
The number (and %) of the onco-proteins30 (46.88 %)
The number (and %) of the tumor suppressors8 (12.50 %)
Total number of binary PPIs (saturation %)277 (13.74 %)
The number (and %) of affected PPIs63 (22.74 %)
The number of possible different fusions17
PPI diameter4
PPI radius2
The average degree of PPI7.625
Assortativity coefficient-0.1740
The network average Clustering coefficient0.471
The number (and %) of a zero Clustering coefficients6 (9.38 %)
The number (and %) of a zero Betweenness Centrality13 (20.31 %)

ACTIVE INTERACTORS


List of the fusions

Proteins found in more fusions ERBB3 (see 2 fusions); KHDRBS1 (see 1 fusions); G3BP1 (see 1 fusions); VCP (see 4 fusions); PAG1 (see 1 fusions); EGFR (see 2 fusions); CBL (see 1 fusions); MCM2 (see 1 fusions); ID3 (see 1 fusions); SHC1 (see 1 fusions); PTK2 (see 2 fusions); GRB2 (see 1 fusions); PDCD6 (see 1 fusions); FYN (see 1 fusions); KDM4A (see 1 fusions); SNW1 (see 1 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 CSKparental protein520.1092194.986Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
SH2 (PF00017, IPR000980, SM00252): SH2 domain
SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
2 KDM4Cparental protein110.24476.406JmjC (PF02373, IPR003347, SM00558): JmjC domain, hydroxylase
JmjN (PF02375, IPR003349, SM00545): jmjN domain
LBR_tudor (PF09465, IPR019023): Lamin-B receptor of TUDOR domain
PHD_2 (PF13831): PHD-finger
zf-HC5HC2H_2 (PF13832): PHD-zinc-finger like domain
DUF4609 (PF15382, IPR027930): Domain of unknown function (DUF4609)
3 AKT1oncoprotein100.47241.315PH (PF00169, IPR001849, SM00233): PH domain
Pkinase (PF00069, IPR000719): Protein kinase domain
Pkinase_C (PF00433, IPR017892): Protein kinase C terminal domain
4 AKT2oncoprotein40.33323.560PH (PF00169, IPR001849, SM00233): PH domain
Pkinase (PF00069, IPR000719): Protein kinase domain
Pkinase_C (PF00433, IPR017892): Protein kinase C terminal domain
5 ARRB1interactor100.42226.719Arrestin_C (PF02752, IPR011022, SM01017): Arrestin (or S-antigen), C-terminal domain
Arrestin_N (PF00339, IPR011021): Arrestin (or S-antigen), N-terminal domain
6 ARRB2interactor100.46718.967Arrestin_C (PF02752, IPR011022, SM01017): Arrestin (or S-antigen), C-terminal domain
Arrestin_N (PF00339, IPR011021): Arrestin (or S-antigen), N-terminal domain
7 CAV1suppressor110.21897.290Caveolin (PF01146, IPR001612): Caveolin
8 CBLsuppressor130.57623.524Cbl_N (PF02262, IPR003153): CBL proto-oncogene N-terminal domain 1
Cbl_N2 (PF02761, IPR014741): CBL proto-oncogene N-terminus, EF hand-like domain
Cbl_N3 (PF02762, IPR014742): CBL proto-oncogene N-terminus, SH2-like domain
UBA (PF00627, IPR000449, SM00165): UBA/TS-N domain
Prok-RING_4 (PF14447): Prokaryotic RING finger family 4
zf-RING_4 (PF14570): RING/Ubox like zinc-binding domain
9 CD247interactor40.8330.667ITAM (PF02189, IPR003110, SM00077): Immunoreceptor tyrosine-based activation motif
TCR_zetazeta (PF11628, IPR021663): T-cell surface glycoprotein CD3 zeta chain
10 CD3Einteractor31.0000ITAM (PF02189, IPR003110, SM00077): Immunoreceptor tyrosine-based activation motif
P5-ATPase (PF12409, IPR006544): P5-type ATPase cation transporter
Ig_5 (PF16681): Ig-like domain on T-cell surface glycoprotein CD3 epsilon chain
11 CEP152interactor21.0000bZIP_1 (PF00170, IPR004827): bZIP transcription factor
CDC37_N (PF03234, IPR013855, SM01071): Cdc37 N terminal kinase binding
CENP-H (PF05837, IPR008426): Centromere protein H (CENP-H)
DUF641 (PF04859, IPR006943): Plant protein of unknown function (DUF641)
ZapB (PF06005, IPR009252): Cell division protein ZapB
DUF972 (PF06156, IPR010377): Protein of unknown function (DUF972)
Ribosomal_S13 (PF00416, IPR001892): Ribosomal protein S13/S18
FAD-SLDH (PF12318, IPR024651): Membrane bound FAD containing D-sorbitol dehydrogenase
YtxH (PF12732, IPR024623): YtxH-like protein
ADH_zinc_N_2 (PF13602): Zinc-binding dehydrogenase
TolA_bind_tri (PF16331, IPR032519): TolA binding protein trimerisation
HIP1_clath_bdg (PF16515, IPR032422): Clathrin-binding domain of Huntingtin-interacting protein 1
12 CLIC4oncoprotein40.6671.500GST_C_2 (PF13410): Glutathione S-transferase, C-terminal domain
GST_N_3 (PF13417, IPR004045): Glutathione S-transferase, N-terminal domain
13 DAB2suppressor31.0000PID (PF00640, IPR006020, SM00462): Phosphotyrosine interaction domain (PTB/PID)
zf-C2H2_assoc3 (PF16637): Putative zinc-finger between two C2H2 zinc-fingers on Patz
14 DAG1interactor90.55611.883DAG1 (PF05454, IPR008465): Dystroglycan (Dystrophin-associated glycoprotein 1)
15 DNASE1L2interactor100Exo_endo_phos (PF03372, IPR005135): Endonuclease/Exonuclease/phosphatase family
16 EGFRoncoprotein200.327136.869Furin-like (PF00757, IPR006211): Furin-like cysteine rich region
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
Recep_L_domain (PF01030, IPR000494): Receptor L domain
GAPT (PF11770, IPR021082): GRB2-binding adapter (GAPT)
GF_recep_IV (PF14843, IPR032778): Growth factor receptor domain IV
17 EIF4Eoncoprotein100IF4E (PF01652, IPR001040): Eukaryotic initiation factor 4E
18 ELAVL1oncoprotein110.37826.290RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
19 ERBB3oncoprotein100.61111.297Furin-like (PF00757, IPR006211): Furin-like cysteine rich region
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
Recep_L_domain (PF01030, IPR000494): Receptor L domain
GF_recep_IV (PF14843, IPR032778): Growth factor receptor domain IV
20 FAM188Asuppressor100DUF4205 (PF13898, IPR025257): Domain of unknown function (DUF4205)
21 FHL2oncoprotein50.5008.095LIM (PF00412, IPR001781, SM00132): LIM domain
zf-ribbon_3 (PF13248): zinc-ribbon domain
22 FRKsuppressor40.6670.773Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
SH2 (PF00017, IPR000980, SM00252): SH2 domain
SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
23 FYNoncoprotein140.34645.754Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
SH2 (PF00017, IPR000980, SM00252): SH2 domain
SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
24 G3BP1protein found in more fusions70.33311.421NTF2 (PF02136, IPR002075): Nuclear transport factor 2 (NTF2) domain
RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
DUF3306 (PF11748, IPR021735): Protein of unknown function (DUF3306)
PTPRCAP (PF15713, IPR016553): Protein tyrosine phosphatase receptor type C-associated
25 GRB2oncoprotein220.324186.184SH2 (PF00017, IPR000980, SM00252): SH2 domain
SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
DUF5093 (PF17011, IPR031533): Domain of unknown function (DUF5093)
26 H3F3Aoncoprotein50.40021.519Histone (PF00125, IPR007125): Core histone H2A/H2B/H3/H4
27 HDAC1suppressor80.33329.158FSAP_sig_propep (PF03032, IPR004275): Frog skin active peptide family signal and propeptide
Hist_deacetyl (PF00850, IPR023801): Histone deacetylase domain
28 HDAC3suppressor80.28661.682Hist_deacetyl (PF00850, IPR023801): Histone deacetylase domain
29 HIST1H3Ainteractor80.28658.357Histone (PF00125, IPR007125): Core histone H2A/H2B/H3/H4
30 HIST2H3Cinteractor203.570Histone (PF00125, IPR007125): Core histone H2A/H2B/H3/H4
31 HNRNPKoncoprotein120.36492.700ROKNT (PF08067, IPR012987): ROKNT (NUC014) domain
KH_1 (PF00013, IPR004088, SM00322): KH domain
32 ID3oncoprotein31.0000HLH (PF00010, IPR011598, SM00353): Helix-loop-helix DNA-binding domain
33 IGF1Roncoprotein90.5839.385fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain
Furin-like (PF00757, IPR006211): Furin-like cysteine rich region
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
Recep_L_domain (PF01030, IPR000494): Receptor L domain
34 ILKAPinteractor100PP2C (PF00481, IPR001932): Protein phosphatase 2C
35 INSRinteractor70.4765.576fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain
Furin-like (PF00757, IPR006211): Furin-like cysteine rich region
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
Recep_L_domain (PF01030, IPR000494): Receptor L domain
36 JUNoncoprotein60.30061.166bZIP_1 (PF00170, IPR004827): bZIP transcription factor
Jun (PF03957, IPR005643): Jun-like transcription factor
37 KDM4Aprotein found in more fusions80.42918.926JmjC (PF02373, IPR003347, SM00558): JmjC domain, hydroxylase
JmjN (PF02375, IPR003349, SM00545): jmjN domain
LBR_tudor (PF09465, IPR019023): Lamin-B receptor of TUDOR domain
PHD_2 (PF13831): PHD-finger
zf-HC5HC2H_2 (PF13832): PHD-zinc-finger like domain
38 KHDRBS1protein found in more fusions110.42223.754KH_1 (PF00013, IPR004088, SM00322): KH domain
Qua1 (PF16274, IPR032571): Qua1 domain
Sam68-YY (PF16568, IPR032335): Tyrosine-rich domain of Sam68
39 MCM2oncoprotein110.267186.949AAA_3 (PF07726, IPR011703): ATPase family associated with various cellular activities (AAA)
MCM (PF00493, IPR001208, SM00350): MCM2/3/5 family
MCM2_N (PF12619, IPR008045): Mini-chromosome maintenance protein 2
MCM_N (PF14551, IPR027925): MCM N-terminal domain
MCM_OB (PF17207): MCM OB domain
40 MOV10interactor60.06742.365AAA_12 (PF13087): AAA domain
AAA_30 (PF13604): AAA domain
41 NXF1interactor100.05695.159NTF2 (PF02136, IPR002075): Nuclear transport factor 2 (NTF2) domain
Tap-RNA_bind (PF09162, IPR015245): Tap, RNA-binding
TAP_C (PF03943, IPR005637, SM00804): TAP C-terminal domain
LRR_8 (PF13855, IPR001611): Leucine rich repeat
42 PAG1protein found in more fusions60.8000.722PAG (PF15347, IPR032748): Phosphoprotein associated with glycosphingolipid-enriched
43 PDCD6oncoprotein70.26734.016EF-hand_7 (PF13499, IPR011992): EF-hand domain pair
44 PDPK1interactor40.6670.889Pkinase (PF00069, IPR000719): Protein kinase domain
PH_3 (PF14593): PH domain
45 PECAM1oncoprotein41.0000C2-set (PF05790, IPR008424): Immunoglobulin C2-set domain
V-set (PF07686, IPR013106): Immunoglobulin V-set domain
V-set_CD47 (PF08204, IPR013270): CD47 immunoglobulin-like domain
Ig_2 (PF13895, IPR007110): Immunoglobulin domain
Ig_3 (PF13927): Immunoglobulin domain
MAP17 (PF15807, IPR031627): Membrane-associated protein 117 kDa, PDZK1-interacting protein 1
46 PPARGsuppressor70.33331.714zf-C4 (PF00105, IPR001628, SM00399): Zinc finger, C4 type (two domains)
Hormone_recep (PF00104, IPR000536, SM00430): Ligand-binding domain of nuclear hormone receptor
PPARgamma_N (PF12577, IPR022590): PPAR gamma N-terminal region
47 PSMD9interactor30.6671.000Remorin_C (PF03763, IPR005516): Remorin, C-terminal region
DUF2046 (PF09755, IPR019152): Uncharacterized conserved protein H4 (DUF2046)
PDZ_2 (PF13180, IPR001478): PDZ domain
48 PTK2protein found in more fusions130.56120.388FERM_M (PF00373, IPR019748): FERM central domain
Focal_AT (PF03623, IPR005189): Focal adhesion targeting region
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
UCMA (PF17085, IPR031386): Unique cartilage matrix associated protein
49 PXNoncoprotein120.348163.177LIM (PF00412, IPR001781, SM00132): LIM domain
Paxillin (PF03535): Paxillin family
50 RASA1oncoprotein110.49121.317C2 (PF00168, IPR000008, SM00239): C2 domain
PH (PF00169, IPR001849, SM00233): PH domain
RasGAP (PF00616, IPR001936, SM00323): GTPase-activator protein for Ras-like GTPase
SH2 (PF00017, IPR000980, SM00252): SH2 domain
SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
51 RGS16interactor31.0000RGS (PF00615, IPR000342, SM00315): Regulator of G protein signaling domain
52 SDC3oncoprotein40.6671.333Glycophorin_A (PF01102, IPR001195): Glycophorin A
Syndecan (PF01034, IPR027789): Syndecan domain
53 SHC1oncoprotein160.343101.358PID (PF00640, IPR006020, SM00462): Phosphotyrosine interaction domain (PTB/PID)
SH2 (PF00017, IPR000980, SM00252): SH2 domain
54 SHMT2interactor204.454SHMT (PF00464, IPR001085): Serine hydroxymethyltransferase
55 SNW1protein found in more fusions60.60010.877SKIP_SNW (PF02731, IPR004015): SKIP/SNW domain
PRP38_assoc (PF12871, IPR024767): Pre-mRNA-splicing factor 38-associated hydrophilic C-term
SIR4_SID (PF16991, IPR031556): Sir4 SID domain
56 SRConcoprotein210.295171.438Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
SH2 (PF00017, IPR000980, SM00252): SH2 domain
SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
57 SRCIN1interactor21.0000AIP3 (PF03915, IPR022782, SM00806): Actin interacting protein 3
Pex14_N (PF04695, IPR006785): Peroxisomal membrane anchor protein (Pex14p) conserved region
58 TGFB1I1interactor31.0000LIM (PF00412, IPR001781, SM00132): LIM domain
Paxillin (PF03535): Paxillin family
59 TNRC6Binteractor30.33312.435DUF1421 (PF07223, IPR010820): Protein of unknown function (DUF1421)
Totivirus_coat (PF05518, IPR008871): Totivirus coat protein
Ago_hook (PF10427, IPR019486): Argonaute hook
DUF4614 (PF15391, IPR027884): Domain of unknown function (DUF4614)
TNRC6-PABC_bdg (PF16608, IPR032226): TNRC6-PABC binding domain
RRM_occluded (PF16842, IPR031766): Occluded RNA-recognition motif
60 TNS2interactor30.6670.500PTB (PF08416, IPR013625): Phosphotyrosine-binding domain
SH2 (PF00017, IPR000980, SM00252): SH2 domain
PTEN_C2 (PF10409, IPR014020): C2 domain of PTEN tumour-suppressor protein
C1_1 (PF00130, IPR002219, SM00109): Phorbol esters/diacylglycerol binding domain (C1 domain)
cEGF (PF12662, IPR026823): Complement Clr-like EGF-like
PRIMA1 (PF16101): Proline-rich membrane anchor 1
61 UBASH3Binteractor90.50056.507His_Phos_1 (PF00300, IPR013078, SM00855): Histidine phosphatase superfamily (branch 1)
UBA (PF00627, IPR000449, SM00165): UBA/TS-N domain
2_5_RNA_ligase2 (PF13563): 2'-5' RNA ligase superfamily
SH3_9 (PF14604, IPR001452): Variant SH3 domain
62 VCPprotein found in more fusions100.44419.590AAA (PF00004, IPR003959, SM00382): ATPase family associated with various cellular activities (AAA)
CDC48_2 (PF02933, IPR004201, SM01072): Cell division protein 48 (CDC48), domain 2
CDC48_N (PF02359, IPR003338, SM01073): Cell division protein 48 (CDC48), N-terminal domain
TniB (PF05621, IPR008868): Bacterial TniB protein
Vps4_C (PF09336, IPR015415): Vps4 C terminal oligomerisation domain
DUF3944 (PF13099, IPR025217): Domain of unknown function (DUF3944)
63 ZAP70interactor120.50922.516Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
SH2 (PF00017, IPR000980, SM00252): SH2 domain
64 ZNF212interactor31.0000KRAB (PF01352, IPR001909, SM00349): KRAB box
zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type
zf-LYAR (PF08790, IPR014898): LYAR-type C2HC zinc finger
DUF3669 (PF12417, IPR022137): Zinc finger protein
zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain
zf-C2H2_6 (PF13912, IPR007087): C2H2-type zinc finger

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