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Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: parental proteins ISM1, UGGT1 (from a repository: Tue Aug 20 19:23:57 2019)
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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)53
The number (and %) of the onco-proteins9 (16.98 %)
The number (and %) of the tumor suppressors5 (9.43 %)
Total number of binary PPIs (saturation %)143 (10.38 %)
The number (and %) of affected PPIs51 (35.66 %)
The number of possible different fusions5
PPI diameter2
PPI radiusinf
The average degree of PPI4.981
Assortativity coefficient-0.3560
The network average Clustering coefficient0.454
The number (and %) of a zero Clustering coefficients18 (33.96 %)
The number (and %) of a zero Betweenness Centrality32 (60.38 %)

ACTIVE INTERACTORS


List of the fusions

PPI for parental proteins: UGGT1,ISM1 All fusions
Proteins found in more fusions CD40 (see 2 fusions); CUL1 (see 3 fusions); CUL3 (see 1 fusions); LGALS3BP (see 2 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 UGGT1parental protein510.0642086.425Glyco_transf_8 (PF01501, IPR002495): Glycosyl transferase family 8
UDP-g_GGTase (PF06427, IPR009448): UDP-glucose:Glycoprotein Glucosyltransferase
2 ISM1interactor000AMOP (PF03782, IPR005533, SM00723): AMOP domain
TSP_1 (PF00090, IPR000884, SM00209): Thrombospondin type 1 domain
3 ACTR3interactor40.8330.286Actin (PF00022, IPR004000, SM00268): Actin
4 ALYREFinteractor80.6193.157FYTT (PF07078, IPR009782): Forty-two-three protein
RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
FoP_duplication (PF13865, IPR025715): C-terminal duplication domain of Friend of PRMT1
5 BAZ1Ainteractor21.0000CENP-B_dimeris (PF09026, IPR015115): Centromere protein B dimerisation domain
DDT (PF02791, IPR004022, SM00571): DDT domain
GBP_C (PF02841, IPR003191): Guanylate-binding protein, C-terminal domain
PHD (PF00628, IPR019787, SM00249): PHD-finger
MIP-T3 (PF10243): Microtubule-binding protein MIP-T3
WAC_Acf1_DNA_bd (PF10537, IPR013136): ATP-utilising chromatin assembly and remodelling N-terminal
Bromodomain (PF00439, IPR001487, SM00297): Bromodomain
RNA_pol_3_Rpc31 (PF11705, IPR024661): DNA-directed RNA polymerase III subunit Rpc31
WHIM1 (PF15612, IPR028942): WSTF, HB1, Itc1p, MBD9 motif 1
WSD (PF15613, IPR028941): Williams-Beuren syndrome DDT (WSD), D-TOX E motif
6 CAND1interactor120.6367.967Adaptin_N (PF01602, IPR002553): Adaptin N terminal region
DUF1981 (PF09324, IPR015403): Domain of unknown function (DUF1981)
HEAT (PF02985, IPR000357): HEAT repeat
TIP120 (PF08623, IPR013932): TATA-binding protein interacting (TIP20)
RTP1_C1 (PF10363, IPR019451): Required for nuclear transport of RNA pol II C-terminus 1
DUF3385 (PF11865, IPR024585): Domain of unknown function (DUF3385)
MMS19_C (PF12460, IPR024687): RNAPII transcription regulator C-terminal
Cnd1 (PF12717, IPR032682): non-SMC mitotic condensation complex subunit 1
Vac14_Fab1_bd (PF12755, IPR032878): Vacuolar 14 Fab1-binding region
HEAT_EZ (PF13513): HEAT-like repeat
HEAT_2 (PF13646): HEAT repeats
MMS19_N (PF14500): Dos2-interacting transcription regulator of RNA-Pol-II
7 CCDC8interactor110.28919.476Borrelia_P83 (PF05262, IPR007926): Borrelia P83/100 protein
SRP-alpha_N (PF04086, IPR007222): Signal recognition particle, alpha subunit, N-terminal
PNMA (PF14893, IPR026523): PNMA
8 CD40protein found in more fusions200Glycophorin_A (PF01102, IPR001195): Glycophorin A
TNFR_c6 (PF00020, IPR001368, SM00208): TNFR/NGFR cysteine-rich region
9 CEPT1interactor21.0000CDP-OH_P_transf (PF01066, IPR000462): CDP-alcohol phosphatidyltransferase
10 CHST12interactor100Sulfotransfer_2 (PF03567, IPR005331): Sulfotransferase family
11 CUL1suppressor150.44032.067Cullin (PF00888, IPR001373, SM00182): Cullin family
Cullin_Nedd8 (PF10557, IPR019559, SM00884): Cullin protein neddylation domain
12 CUL3protein found in more fusions150.40733.895Cullin (PF00888, IPR001373, SM00182): Cullin family
Cullin_Nedd8 (PF10557, IPR019559, SM00884): Cullin protein neddylation domain
WAC_Acf1_DNA_bd (PF10537, IPR013136): ATP-utilising chromatin assembly and remodelling N-terminal
13 DAB2IPsuppressor31.0000C2 (PF00168, IPR000008, SM00239): C2 domain
PH_2 (PF08458, IPR013666): Plant pleckstrin homology-like region
RasGAP (PF00616, IPR001936, SM00323): GTPase-activator protein for Ras-like GTPase
DUF3498 (PF12004, IPR021887): Domain of unknown function (DUF3498)
14 DCUN1D1interactor51.0000Cullin_binding (PF03556, IPR005176): Cullin binding
UBA_4 (PF14555): UBA-like domain
15 DNMT3Bsuppressor31.0000DNA_methylase (PF00145, IPR001525): C-5 cytosine-specific DNA methylase
PWWP (PF00855, IPR000313, SM00293): PWWP domain
16 DPF2interactor30.6671.000PHD (PF00628, IPR019787, SM00249): PHD-finger
zf-C2H2_4 (PF13894): C2H2-type zinc finger
Requiem_N (PF14051, IPR025750): N-terminal domain of DPF2/REQ.
PBP1_TM (PF14812, IPR032730): Transmembrane domain of transglycosylase PBP1 at N-terminal
Zf_RING (PF16744, IPR031946): KIAA1045 RING finger
17 EME1interactor100ERCC4 (PF02732, IPR006166, SM00891): ERCC4 domain
18 FBXO6interactor80.4298.576FBA (PF04300, IPR007397): F-box associated region
F-box-like (PF12937, IPR001810): F-box-like
19 FNTBinteractor100Prenyltrans (PF00432, IPR001330): Prenyltransferase and squalene oxidase repeat
20 GLT8D1interactor100Glyco_transf_8 (PF01501, IPR002495): Glycosyl transferase family 8
21 HLA-Aoncoprotein30.6670.222DUF202 (PF02656, IPR003807): Domain of unknown function (DUF202)
MHC_I (PF00129, IPR001039): Class I Histocompatibility antigen, domains alpha 1 and 2
MHC_I_C (PF06623, IPR010579): MHC_I C-terminus
C1-set (PF07654, IPR003597, SM00407): Immunoglobulin C1-set domain
22 HSP90B1suppressor100.40021.777CobT (PF06213, IPR006538): Cobalamin biosynthesis protein CobT
HATPase_c (PF02518, IPR003594, SM00387): Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
HSP90 (PF00183, IPR001404): Hsp90 protein
Sigma70_ner (PF04546, IPR007631): Sigma-70, non-essential region
23 IARS2interactor30.6670.286Anticodon_1 (PF08264, IPR013155): Anticodon-binding domain of tRNA
tRNA-synt_1 (PF00133, IPR002300): tRNA synthetases class I (I, L, M and V)
zf-FPG_IleRS (PF06827, IPR010663): Zinc finger found in FPG and IleRS
24 LGALS3BPoncoprotein100.5568.844BACK (PF07707, IPR011705, SM00875): BTB And C-terminal Kelch
SRCR (PF00530, IPR001190): Scavenger receptor cysteine-rich domain
SRCR_2 (PF15494, IPR017448): Scavenger receptor cysteine-rich domain
25 LGR4interactor31.00007tm_1 (PF00001, IPR000276): 7 transmembrane receptor (rhodopsin family)
LRR_1 (PF00560, IPR001611): Leucine Rich Repeat
LRRNT (PF01462, IPR000372, SM00013): Leucine rich repeat N-terminal domain
LRR_4 (PF12799, IPR025875): Leucine Rich repeats (2 copies)
LRR_8 (PF13855, IPR001611): Leucine rich repeat
26 LTN1interactor21.0000zf-RING_2 (PF13639, IPR001841, SM00184): Ring finger domain
27 METTL23interactor21.0000Methyltransf_16 (PF10294, IPR019410): Lysine methyltransferase
28 MRPL55interactor100Mitoc_L55 (PF09776, IPR018615): Mitochondrial ribosomal protein L55
29 NSUN2interactor90.47212.891Methyltr_RsmB-F (PF01189, IPR001678): 16S rRNA methyltransferase RsmB/F
30 NTRK1oncoprotein200.240105.829I-set (PF07679, IPR013098): Immunoglobulin I-set domain
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
LRR_8 (PF13855, IPR001611): Leucine rich repeat
TPKR_C2 (PF16920, IPR031635): Tyrosine-protein kinase receptor C2 Ig-like domain
31 PCSK9interactor100Peptidase_S8 (PF00082, IPR000209): Subtilase family
Inhibitor_I9 (PF05922, IPR010259): Peptidase inhibitor I9
32 PFDN1interactor21.0000Prefoldin_2 (PF01920, IPR002777): Prefoldin subunit
33 PPP2R1Aoncoprotein50.5001.658TAF6_C (PF07571, IPR011442): TAF6 C-terminal HEAT repeat domain
HEAT (PF02985, IPR000357): HEAT repeat
HEAT_PBS (PF03130, IPR004155, SM00567): PBS lyase HEAT-like repeat
HEAT_2 (PF13646): HEAT repeats
34 PSMC1interactor70.3339.444AAA (PF00004, IPR003959, SM00382): ATPase family associated with various cellular activities (AAA)
AAA_3 (PF07726, IPR011703): ATPase family associated with various cellular activities (AAA)
DivIC (PF04977, IPR007060): Septum formation initiator
DUF815 (PF05673, IPR008533): Protein of unknown function (DUF815)
Prot_ATP_ID_OB (PF16450, IPR032501): Proteasomal ATPase OB/ID domain
35 PSMD12interactor50.5001.800Tubulin_C (PF03953, IPR018316, SM00865): Tubulin C-terminal domain
PCI (PF01399, IPR000717, SM00088): PCI domain
36 RAD51interactor200Rad51 (PF08423, IPR013632): Rad51
HHH_5 (PF14520): Helix-hairpin-helix domain
37 REPS2oncoprotein100DUF737 (PF05300, IPR007964): Protein of unknown function (DUF737)
Herpes_DNAp_acc (PF04929, IPR007013): Herpes DNA replication accessory factor
K_channel_TID (PF07941, IPR012897): Potassium channel Kv1.4 tandem inactivation domain
Ribosomal_60s (PF00428, IPR001813): 60s Acidic ribosomal protein
EF-hand_4 (PF12763, IPR000261): Cytoskeletal-regulatory complex EF hand
Rootletin (PF15035): Ciliary rootlet component, centrosome cohesion
38 SF3B1oncoprotein90.44411.863Dopey_N (PF04118, IPR007249): Dopey, N-terminal
HEAT (PF02985, IPR000357): HEAT repeat
SF3b1 (PF08920, IPR015016): Splicing factor 3B subunit 1
UNC45-central (PF11701, IPR024660): Myosin-binding striated muscle assembly central
Vac14_Fab1_bd (PF12755, IPR032878): Vacuolar 14 Fab1-binding region
HEAT_EZ (PF13513): HEAT-like repeat
HEAT_2 (PF13646): HEAT repeats
39 SIRT7interactor90.25019.538DUF563 (PF04577, IPR007657): Protein of unknown function (DUF563)
SIR2 (PF02146, IPR003000): Sir2 family
40 SSU72interactor100Ssu72 (PF04722, IPR006811): Ssu72-like protein
41 STX3interactor100XhlA (PF10779, IPR019715): Haemolysin XhlA
Syntaxin (PF00804, IPR006011, SM00503): Syntaxin
SNARE (PF05739, IPR000727, SM00397): SNARE domain
42 SUSD2interactor100AMOP (PF03782, IPR005533, SM00723): AMOP domain
VWD (PF00094, IPR001846, SM00216): von Willebrand factor type D domain
Sushi (PF00084, IPR000436, SM00032): Sushi repeat (SCR repeat)
Somatomedin_B (PF01033, IPR001212, SM00201): Somatomedin B domain
43 TCTN1interactor21.0000DUF1619 (PF07773, IPR011677): Protein of unknown function (DUF1619)
44 TCTN3interactor31.0000DUF1619 (PF07773, IPR011677): Protein of unknown function (DUF1619)
45 TLR9interactor100LRR_1 (PF00560, IPR001611): Leucine Rich Repeat
TIR (PF01582, IPR000157, SM00255): TIR domain
LRR_4 (PF12799, IPR025875): Leucine Rich repeats (2 copies)
LRR_6 (PF13516, IPR001611): Leucine Rich repeat
LRR_8 (PF13855, IPR001611): Leucine rich repeat
46 TNFRSF14oncoprotein100Ephrin_rec_like (PF07699, IPR011641): Putative ephrin-receptor like
Hum_adeno_E3A (PF05393, IPR008652): Human adenovirus early E3A glycoprotein
TNFR_c6 (PF00020, IPR001368, SM00208): TNFR/NGFR cysteine-rich region
47 TP53BP1suppressor30.6671.00053-BP1_Tudor (PF09038, IPR015125): Tumour suppressor p53-binding protein-1 Tudor
BRCT (PF00533, IPR001357, SM00292): BRCA1 C Terminus (BRCT) domain
FXMRP1_C_core (PF12235, IPR022034): Fragile X-related 1 protein core C terminal
DUF4772 (PF15997, IPR031940): Domain of unknown function (DUF4772)
BRCT_2 (PF16589, IPR001357): BRCT domain, a BRCA1 C-terminus domain
48 TUBGCP3interactor31.0000Spc97_Spc98 (PF04130, IPR007259): Spc97 / Spc98 family
49 UBXN6interactor100PUB (PF09409, IPR018997): PUB domain
UBX (PF00789, IPR001012, SM00166): UBX domain
50 UNC45Ainteractor21.0000Arm (PF00514, IPR000225, SM00185): Armadillo/beta-catenin-like repeat
RIX1 (PF08167, IPR012583): rRNA processing/ribosome biogenesis
TPR_2 (PF07719, IPR013105): Tetratricopeptide repeat
UNC45-central (PF11701, IPR024660): Myosin-binding striated muscle assembly central
TPR_16 (PF13432): Tetratricopeptide repeat
HEAT_2 (PF13646): HEAT repeats
51 WISP1interactor100Cys_knot (PF00007, IPR006208): Cystine-knot domain
VWC (PF00093, IPR001007, SM00214): von Willebrand factor type C domain
IGFBP (PF00219, IPR000867, SM00121): Insulin-like growth factor binding protein
TSP_1 (PF00090, IPR000884, SM00209): Thrombospondin type 1 domain
52 ZNFX1interactor100zf-NF-X1 (PF01422, IPR000967, SM00438): NF-X1 type zinc finger
AAA_11 (PF13086): AAA domain
AAA_12 (PF13087): AAA domain
betaPIX_CC (PF16523, IPR032409): betaPIX coiled coil
53 ZW10interactor21.0000Zw10 (PF06248, IPR009361): Centromere/kinetochore Zw10
DUF2203 (PF09969, IPR018699): Uncharacterized conserved protein (DUF2203)

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