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Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: parental proteins CHMP5, WFDC3 (from a repository: Fri Jul 26 13:41:57 2019)
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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)36
The number (and %) of the onco-proteins8 (22.22 %)
The number (and %) of the tumor suppressors2 (5.56 %)
Total number of binary PPIs (saturation %)80 (12.70 %)
The number (and %) of affected PPIs35 (43.75 %)
The number of possible different fusions5
PPI diameter2
PPI radiusinf
The average degree of PPI3.778
Assortativity coefficient-0.3406
The network average Clustering coefficient0.447
The number (and %) of a zero Clustering coefficients13 (36.11 %)
The number (and %) of a zero Betweenness Centrality18 (50.00 %)

ACTIVE INTERACTORS


List of the fusions

PPI for parental proteins: CHMP5,WFDC3 All fusions
Proteins found in more fusions VPS4A (see 1 fusions); HNRNPD (see 1 fusions); EWSR1 (see 1 fusions); AURKA (see 1 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 CHMP5parental protein350.061998.233Snf7 (PF03357, IPR005024): Snf7
2 WFDC3interactor000NA
3 ACTR6interactor21.0000Actin (PF00022, IPR004000, SM00268): Actin
4 APPBP2interactor100TPR_1 (PF00515, IPR001440): Tetratricopeptide repeat
TPR_2 (PF07719, IPR013105): Tetratricopeptide repeat
TPR_10 (PF13374, IPR011990): Tetratricopeptide repeat
TPR_12 (PF13424): Tetratricopeptide repeat
TPR_17 (PF13431): Tetratricopeptide repeat
5 ATP6V1B1interactor40.8330.500ATP-synt_ab (PF00006, IPR000194): ATP synthase alpha/beta family, nucleotide-binding domain
ATP-synt_ab_N (PF02874, IPR004100): ATP synthase alpha/beta family, beta-barrel domain
DUF3533 (PF12051, IPR022703): Protein of unknown function (DUF3533)
6 AURKAoncoprotein40.6671.000Pkinase (PF00069, IPR000719): Protein kinase domain
MTBP_C (PF14920, IPR029418): MDM2-binding
7 BAG6interactor50.6672.000DUF1179 (PF06678, IPR009564): Protein of unknown function (DUF1179)
Mito_fiss_reg (PF05308, IPR007972): Mitochondrial fission regulator
ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
DUF2939 (PF11159, IPR021330): Protein of unknown function (DUF2939)
DUF3538 (PF12057, IPR021925): Domain of unknown function (DUF3538)
PRIMA1 (PF16101): Proline-rich membrane anchor 1
8 CAMK2Ainteractor200CaMKII_AD (PF08332, IPR013543): Calcium/calmodulin dependent protein kinase II association domain
Pkinase (PF00069, IPR000719): Protein kinase domain
9 CHMP1Binteractor70.6003.333Snf7 (PF03357, IPR005024): Snf7
10 CHMP4Ainteractor70.6004.167Snf7 (PF03357, IPR005024): Snf7
11 CHMP4Binteractor100.47214.900Snf7 (PF03357, IPR005024): Snf7
12 EWSR1oncoprotein60.5005.000RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
SVS_QK (PF10578, IPR018942): Seminal vesicle protein repeat
zf-RanBP (PF00641, IPR001876, SM00547): Zn-finger in Ran binding protein and others
FoP_duplication (PF13865, IPR025715): C-terminal duplication domain of Friend of PRMT1
Keratin_2_head (PF16208, IPR032444): Keratin type II head
13 GTF3Ainteractor100zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type
zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain
14 HABP4interactor100HABP4_PAI-RBP1 (PF04774, IPR006861): Hyaluronan / mRNA binding family
FoP_duplication (PF13865, IPR025715): C-terminal duplication domain of Friend of PRMT1
IHABP4_N (PF16174, IPR032381): Intracellular hyaluronan-binding protein 4 N-terminal
15 HIST1H2BGoncoprotein30.6671.000Histone (PF00125, IPR007125): Core histone H2A/H2B/H3/H4
16 HNRNPDoncoprotein50.6672.000CBFNT (PF08143, IPR012956): CBFNT (NUC161) domain
NID (PF07292, IPR009909): Nmi/IFP 35 domain (NID)
RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
Keratin_2_head (PF16208, IPR032444): Keratin type II head
17 ISG15suppressor100ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
18 MITD1interactor40.8330.500MIT (PF04212, IPR007330, SM00745): MIT (microtubule interacting and transport) domain
MIT_C (PF16565, IPR032341): Phospholipase D-like domain at C-terminus of MIT
19 PDCD10interactor21.0000DUF1241 (PF06840, IPR009652): Protein of unknown function (DUF1241)
CENP-L (PF13092, IPR025204): Kinetochore complex Sim4 subunit Fta1
20 PSMA4interactor30.6671.000Proteasome (PF00227, IPR001353): Proteasome subunit
U79_P34 (PF03064, IPR004138): HSV U79 / HCMV P34
Proteasome_A_N (PF10584, IPR000426, SM00948): Proteasome subunit A N-terminal signature
21 PXNoncoprotein100LIM (PF00412, IPR001781, SM00132): LIM domain
Paxillin (PF03535): Paxillin family
22 RPL38interactor21.0000Ribosomal_L38e (PF01781, IPR002675): Ribosomal L38e protein family
23 SGTBinteractor21.0000TOM20_plant (PF06552, IPR010547): Plant specific mitochondrial import receptor subunit TOM20
TPR_1 (PF00515, IPR001440): Tetratricopeptide repeat
XPC-binding (PF09280, IPR015360): XPC-binding domain
TPR_11 (PF13414, IPR011990): TPR repeat
SGTA_dimer (PF16546, IPR032374): Homodimerisation domain of SGTA
24 SMARCA4suppressor100DUF1840 (PF08895, IPR014991): Domain of unknown function (DUF1840)
HSA (PF07529, IPR014012, SM00573): HSA
QLQ (PF08880, IPR014978, SM00951): QLQ
SNF2_N (PF00176, IPR000330): SNF2 family N-terminal domain
BRK (PF07533, IPR006576, SM00592): BRK domain
Bromodomain (PF00439, IPR001487, SM00297): Bromodomain
Helicase_C (PF00271, IPR001650, SM00490): Helicase conserved C-terminal domain
Spt5_N (PF11942, IPR022581): Spt5 transcription elongation factor, acidic N-terminal
DUF4065 (PF13274, IPR025272): Protein of unknown function (DUF4065)
SnAC (PF14619, IPR029295): Snf2-ATP coupling, chromatin remodelling complex
WRNPLPNID (PF15017): Putative WW-binding domain and destruction box
25 SNCAinteractor200Synuclein (PF01387, IPR001058): Synuclein
26 SNRPD2interactor100LSM (PF01423, IPR001163): LSM domain
27 STAMBPinteractor40.8330.400USP8_dimer (PF08969, IPR015063): USP8 dimerisation domain
JAB (PF01398, IPR000555, SM00232): JAB1/Mov34/MPN/PAD-1 ubiquitin protease
DUF3526 (PF12040, IPR021913): Domain of unknown function (DUF3526)
28 TFGoncoprotein80.42910.567ARS2 (PF04959, IPR007042): Arsenite-resistance protein 2
MucBP (PF06458, IPR009459): MucBP domain
PB1 (PF00564, IPR000270, SM00666): PB1 domain
TFIIA (PF03153, IPR004855): Transcription factor IIA, alpha/beta subunit
29 UBA2interactor30.6671.000ThiF (PF00899, IPR000594): ThiF family
UAE_UbL (PF14732, IPR028077): Ubiquitin/SUMO-activating enzyme ubiquitin-like domain
UBA2_C (PF16195, IPR032426): SUMO-activating enzyme subunit 2 C-terminus
30 UNKinteractor40.5003.000MbeD_MobD (PF04899, IPR006983): MbeD/MobD like
NUDE_C (PF04880, IPR006964): NUDE protein, C-terminal conserved region
zf-CCCH (PF00642, IPR000571): Zinc finger C-x8-C-x5-C-x3-H type (and similar)
DUF3450 (PF11932, IPR016866): Protein of unknown function (DUF3450)
zf-C3HC4_3 (PF13920): Zinc finger, C3HC4 type (RING finger)
zf-CCCH_2 (PF14608): RNA-binding, Nab2-type zinc finger
Torus (PF16131, IPR032297): Torus domain
31 URGCPinteractor100MMR_HSR1 (PF01926, IPR006073): 50S ribosome-binding GTPase
PXA (PF02194, IPR003114, SM00313): PXA domain
32 VPS4Aprotein found in more fusions70.6004.733AAA (PF00004, IPR003959, SM00382): ATPase family associated with various cellular activities (AAA)
MIT (PF04212, IPR007330, SM00745): MIT (microtubule interacting and transport) domain
TIP49 (PF06068, IPR010339): TIP49 C-terminus
Vps4_C (PF09336, IPR015415): Vps4 C terminal oligomerisation domain
YCII (PF03795, IPR005545): YCII-related domain
33 VPS4Binteractor40.8330.667AAA (PF00004, IPR003959, SM00382): ATPase family associated with various cellular activities (AAA)
AAA_2 (PF07724, IPR013093): AAA domain (Cdc48 subfamily)
MIT (PF04212, IPR007330, SM00745): MIT (microtubule interacting and transport) domain
MMR_HSR1 (PF01926, IPR006073): 50S ribosome-binding GTPase
TIP49 (PF06068, IPR010339): TIP49 C-terminus
Vps4_C (PF09336, IPR015415): Vps4 C terminal oligomerisation domain
34 VTA1interactor31.0000Vta1 (PF04652): Vta1 like
35 ZNF142interactor100DUF1610 (PF07754, IPR011668): Domain of unknown function (DUF1610)
FYDLN_acid (PF09538, IPR012644): Protein of unknown function (FYDLN_acid)
zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type
zinc_ribbon_12 (PF11331, IPR021480): Probable zinc-ribbon domain
DUF3505 (PF12013, IPR022698): Protein of unknown function (DUF3505)
zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain
zinc_ribbon_4 (PF13717): zinc-ribbon domain
zf-C2H2_4 (PF13894): C2H2-type zinc finger
zf-H2C2_5 (PF13909): C2H2-type zinc-finger domain
zf-C2H2_6 (PF13912, IPR007087): C2H2-type zinc finger
CpXC (PF14353, IPR025682): CpXC protein
zf-tcix (PF14952, IPR029269): Putative treble-clef, zinc-finger, Zn-binding
FOXP-CC (PF16159, IPR032354): FOXP coiled-coil domain
36 ZNF91oncoprotein100KRAB (PF01352, IPR001909, SM00349): KRAB box
zf-AN1 (PF01428, IPR000058, SM00154): AN1-like Zinc finger
zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type
zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain

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