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Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)145
The number (and %) of the onco-proteins54 (37.24 %)
The number (and %) of the tumor suppressors13 (8.97 %)
Total number of binary PPIs (saturation %)596 (5.71 %)
The number (and %) of affected PPIs144 (24.16 %)
The number of possible different fusions45
PPI diameter5
PPI radius3
The average degree of PPI7.228
Assortativity coefficient-0.3347
The network average Clustering coefficient0.501
The number (and %) of a zero Clustering coefficients24 (16.55 %)
The number (and %) of a zero Betweenness Centrality51 (35.17 %)

ACTIVE INTERACTORS


List of the fusions

PPI for parental proteins: HTT,MYO3B All fusions
Proteins found in more fusions CTBP1 (see 2 fusions); TRAF6 (see 1 fusions); HLA-B (see 4 fusions); SYVN1 (see 1 fusions); VCP (see 4 fusions); MED21 (see 1 fusions); HSP90AA1 (see 6 fusions); HMG20A (see 2 fusions); ZDHHC17 (see 2 fusions); SETD2 (see 1 fusions); HUWE1 (see 4 fusions); HSP90AB1 (see 3 fusions); PTGES2 (see 1 fusions); SQSTM1 (see 5 fusions); GRB2 (see 1 fusions); CREB1 (see 1 fusions); MYC (see 2 fusions); SP1 (see 1 fusions); OPTN (see 1 fusions); CREBBP (see 6 fusions); UBQLN1 (see 2 fusions); PSMB7 (see 2 fusions); KAT2B (see 1 fusions); BAG3 (see 4 fusions); PIAS1 (see 3 fusions); ULK1 (see 2 fusions); EGFR (see 2 fusions); PIK3R1 (see 1 fusions); UBQLN2 (see 3 fusions); HTT (see 1 fusions); UBE2E3 (see 5 fusions); FTL (see 5 fusions); TAF4 (see 4 fusions); CHD3 (see 1 fusions); GAPDH/UBQLN1 (see 1 fusions); IKBKB (see 2 fusions); PML (see 4 fusions); PRPF40A (see 2 fusions); ZNF451 (see 1 fusions); HSP90AA1/TUBB (see 1 fusions); PSMC5 (see 2 fusions); CRMP1 (see 1 fusions); TP53 (see 3 fusions); GAPDH (see 5 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 HTTparental protein1410.03516829.358HEAT (PF02985, IPR000357): HEAT repeat
SPX (PF03105, IPR004331): SPX domain
TFIIA (PF03153, IPR004855): Transcription factor IIA, alpha/beta subunit
DUF3652 (PF12372, IPR024613): Huntingtin protein region
Vac14_Fab1_bd (PF12755, IPR032878): Vacuolar 14 Fab1-binding region
HEAT_EZ (PF13513): HEAT-like repeat
HEAT_2 (PF13646): HEAT repeats
2 MYO3Bparental protein30.333286.000IQ (PF00612, IPR000048, SM00015): IQ calmodulin-binding motif
Pkinase (PF00069, IPR000719): Protein kinase domain
Myosin_head (PF00063, IPR001609, SM00242): Myosin head (motor domain)
3 AGO2interactor40.50016.890ArgoL1 (PF08699, IPR014811, SM01163): Argonaute linker 1 domain
PAZ (PF02170, IPR003100, SM00949): PAZ domain
Piwi (PF02171, IPR003165, SM00950): Piwi domain
ArgoN (PF16486, IPR032474): N-terminal domain of argonaute
ArgoMid (PF16487, IPR032473): Mid domain of argonaute
ArgoL2 (PF16488, IPR032472): Argonaute linker 2 domain
4 AMFRoncoprotein80.42910.230CUE (PF02845, IPR003892, SM00546): CUE domain
UbiA (PF01040, IPR000537): UbiA prenyltransferase family
zf-RING_2 (PF13639, IPR001841, SM00184): Ring finger domain
5 AP2A2interactor40.8330.200Adaptin_N (PF01602, IPR002553): Adaptin N terminal region
Alpha_adaptin_C (PF02296, IPR003164): Alpha adaptin AP2, C-terminal domain
Alpha_adaptinC2 (PF02883, IPR008152, SM00809): Adaptin C-terminal domain
HEAT_2 (PF13646): HEAT repeats
6 ATG5interactor21.0000APG5 (PF04106, IPR007239): Autophagy protein Apg5
7 ATP6V1B1interactor100ATP-synt_ab (PF00006, IPR000194): ATP synthase alpha/beta family, nucleotide-binding domain
ATP-synt_ab_N (PF02874, IPR004100): ATP synthase alpha/beta family, beta-barrel domain
DUF3533 (PF12051, IPR022703): Protein of unknown function (DUF3533)
8 AXIN1suppressor90.42925.347Axin_b-cat_bind (PF08833, IPR014936): Axin beta-catenin binding domain
RGS (PF00615, IPR000342, SM00315): Regulator of G protein signaling domain
DIX (PF00778, IPR001158, SM00021): DIX domain
AXIN1_TNKS_BD (PF16646, IPR032101): Axin-1 tankyrase binding domain
9 BAG3oncoprotein140.26960.450BAG (PF02179, IPR003103, SM00264): BAG domain
WW (PF00397, IPR001202, SM00456): WW domain
10 CCDC126interactor100DUF4525 (PF15027, IPR027833): Domain of unknown function (DUF4525)
11 CHD3oncoprotein90.46411.306CHDCT2 (PF08074, IPR012957): CHDCT2 (NUC038) domain
CHDNT (PF08073, IPR012958): CHDNT (NUC034) domain
Chromo (PF00385, IPR023780, SM00298): Chromo (CHRromatin Organisation MOdifier) domain
DUF1086 (PF06461, IPR009462, SM01146): Domain of Unknown Function (DUF1086)
DUF1087 (PF06465, IPR009463, SM01147): Domain of Unknown Function (DUF1087)
DUF1777 (PF08648, IPR013957): Protein of unknown function (DUF1777)
Mito_fiss_reg (PF05308, IPR007972): Mitochondrial fission regulator
FYDLN_acid (PF09538, IPR012644): Protein of unknown function (FYDLN_acid)
PHD (PF00628, IPR019787, SM00249): PHD-finger
Ribosomal_60s (PF00428, IPR001813): 60s Acidic ribosomal protein
SMN (PF06003, IPR010304): Survival motor neuron protein (SMN)
SNF2_N (PF00176, IPR000330): SNF2 family N-terminal domain
Helicase_C (PF00271, IPR001650, SM00490): Helicase conserved C-terminal domain
DUF2956 (PF11169, IPR021339): Protein of unknown function (DUF2956)
FAM176 (PF14851): FAM176 family
12 CHUKsuppressor140.46243.461Pkinase (PF00069, IPR000719): Protein kinase domain
IKKbetaNEMObind (PF12179, IPR022007): I-kappa-kinase-beta NEMO binding domain
13 CREB1oncoprotein110.42217.404bZIP_1 (PF00170, IPR004827): bZIP transcription factor
pKID (PF02173, IPR003102): pKID domain
DUF4988 (PF16378, IPR032149): Domain of unknown function
14 CREBBPsuppressor190.42555.041Creb_binding (PF09030, IPR014744): Creb binding
DUF902 (PF06001, IPR010303): Domain of Unknown Function (DUF902)
Forkhead_N (PF08430, IPR013638): Forkhead N-terminal region
KIX (PF02172, IPR003101): KIX domain
MAS20 (PF02064, IPR002056): MAS20 protein import receptor
TPX2 (PF06886, IPR027329): Targeting protein for Xklp2 (TPX2)
zf-TAZ (PF02135, IPR000197, SM00551): TAZ zinc finger
ANAPC_CDC26 (PF10471, IPR018860): Anaphase-promoting complex APC subunit CDC26
HAT_KAT11 (PF08214, IPR013178): Histone acetylation protein
Bromodomain (PF00439, IPR001487, SM00297): Bromodomain
ZZ (PF00569, IPR000433, SM00291): Zinc finger, ZZ type
DUF3729 (PF12526, IPR022202): Protein of unknown function (DUF3729)
DUF4834 (PF16118, IPR032272): Domain of unknown function (DUF4834)
15 CRMP1protein found in more fusions50.6671.561Amidohydro_1 (PF01979, IPR006680): Amidohydrolase family
Amidohydro_3 (PF07969, IPR013108): Amidohydrolase family
16 CTBP1protein found in more fusions110.48911.6572-Hacid_dh_C (PF02826, IPR006140): D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain
Cellsynth_D (PF03500, IPR022798): Cellulose synthase subunit D
17 CTNNB1oncoprotein170.30150.349Arm (PF00514, IPR000225, SM00185): Armadillo/beta-catenin-like repeat
Atx10homo_assoc (PF09759, IPR019156): Spinocerebellar ataxia type 10 protein domain
DUF3361 (PF11841, IPR024574): Domain of unknown function (DUF3361)
HEAT_EZ (PF13513): HEAT-like repeat
18 DNAJA1interactor70.76210.710DnaJ (PF00226, IPR001623, SM00271): DnaJ domain
DnaJ_C (PF01556, IPR002939): DnaJ C terminal domain
19 DNAJB1suppressor50.7001.515DnaJ (PF00226, IPR001623, SM00271): DnaJ domain
DnaJ_C (PF01556, IPR002939): DnaJ C terminal domain
20 DNALI1interactor31.0000Ax_dynein_light (PF10211, IPR019347): Axonemal dynein light chain
21 DPPA4interactor80.33310.368Ribosomal_L40e (PF01020, IPR001975): Ribosomal L40e family
DCR (PF14047, IPR025891): Dppa2/4 conserved region
Dppa2_A (PF14049, IPR025892): Dppa2/4 conserved region in higher vertebrates
22 DUSP10oncoprotein100DSPc (PF00782, IPR020422, SM00195): Dual specificity phosphatase, catalytic domain
Rhodanese (PF00581, IPR001763, SM00450): Rhodanese-like domain
23 ECH1interactor30.6670.667ECH_1 (PF00378, IPR001753): Enoyl-CoA hydratase/isomerase
24 EGFRoncoprotein270.252200.569Furin-like (PF00757, IPR006211): Furin-like cysteine rich region
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
Recep_L_domain (PF01030, IPR000494): Receptor L domain
GAPT (PF11770, IPR021082): GRB2-binding adapter (GAPT)
GF_recep_IV (PF14843, IPR032778): Growth factor receptor domain IV
25 ERCC6Linteractor21.0000SNF2_N (PF00176, IPR000330): SNF2 family N-terminal domain
TPR_2 (PF07719, IPR013105): Tetratricopeptide repeat
Helicase_C (PF00271, IPR001650, SM00490): Helicase conserved C-terminal domain
TPR_11 (PF13414, IPR011990): TPR repeat
26 ETV4oncoprotein100Ets (PF00178, IPR000418, SM00413): Ets-domain
ETS_PEA3_N (PF04621, IPR006715): PEA3 subfamily ETS-domain transcription factor N terminal domain
27 EVLoncoprotein70.4007.834VASP_tetra (PF08776, IPR014885): VASP tetramerisation domain
WH1 (PF00568, IPR000697, SM00461): WH1 domain
28 F8A1interactor100SNAP (PF14938): Soluble NSF attachment protein, SNAP
29 FAM71F1interactor100DUF3699 (PF12480, IPR022168): Protein of unknown function (DUF3699)
30 FEZ1interactor40.6671.000FEZ (PF07763, IPR011680): FEZ-like protein
DUF5102 (PF17104, IPR031355): Domain of unknown function (DUF5102)
31 FICDinteractor100Fic (PF02661, IPR003812): Fic/DOC family
TPR_2 (PF07719, IPR013105): Tetratricopeptide repeat
32 FTLprotein found in more fusions40.6670.810Ferritin (PF00210, IPR008331): Ferritin-like domain
33 GAPDHoncoprotein160.44863.052Gp_dh_C (PF02800, IPR020829): Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain
Gp_dh_N (PF00044, IPR020828, SM00846): Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain
OstA (PF03968, IPR005653): OstA-like protein
34 GGA2interactor21.0000Alpha_adaptinC2 (PF02883, IPR008152, SM00809): Adaptin C-terminal domain
GAT (PF03127, IPR004152): GAT domain
VHS (PF00790, IPR002014, SM00288): VHS domain
35 GIT1interactor50.5002.843ArfGap (PF01412, IPR001164, SM00105): Putative GTPase activating protein for Arf
Fib_alpha (PF08702, IPR012290): Fibrinogen alpha/beta chain family
GIT_SHD (PF08518, IPR013724, SM00555): Spa2 homology domain (SHD) of GIT
GIT1_C (PF12205, IPR022018): G protein-coupled receptor kinase-interacting protein 1 C term
Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies)
FlxA (PF14282, IPR025577): FlxA-like protein
GIT_CC (PF16559, IPR032352): GIT coiled-coil Rho guanine nucleotide exchange factor
36 GOLPH3Linteractor30.6671.143GPP34 (PF05719, IPR008628): Golgi phosphoprotein 3 (GPP34)
37 GPRASP2interactor30.6671.176Arm_2 (PF04826, IPR006911): Armadillo-like
DUF3020 (PF11223, IPR021386): Protein of unknown function (DUF3020)
PH_4 (PF15404): Pleckstrin homology domain
38 GRB2oncoprotein190.301112.847SH2 (PF00017, IPR000980, SM00252): SH2 domain
SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
DUF5093 (PF17011, IPR031533): Domain of unknown function (DUF5093)
39 GRM1interactor31.00007tm_3 (PF00003, IPR017978): 7 transmembrane sweet-taste receptor of 3 GCPR
ANF_receptor (PF01094, IPR001828): Receptor family ligand binding region
NCD3G (PF07562, IPR011500): Nine Cysteines Domain of family 3 GPCR
DUF2318 (PF10080, IPR018758): Predicted membrane protein (DUF2318)
GluR_Homer-bdg (PF10606, IPR019588): Homer-binding domain of metabotropic glutamate receptor
40 HAP1interactor70.33310.000HAP1_N (PF04849, IPR006933): HAP1 N-terminal conserved region
DUF2052 (PF09747, IPR018613): Coiled-coil domain containing protein (DUF2052)
RNA_pol_3_Rpc31 (PF11705, IPR024661): DNA-directed RNA polymerase III subunit Rpc31
DUF3682 (PF12446, IPR022152): Protein of unknown function (DUF3682)
41 HBS1Linteractor100HBS1_N (PF08938, IPR015033): HBS1 N-terminus
GTP_EFTU (PF00009, IPR000795): Elongation factor Tu GTP binding domain
GTP_EFTU_D2 (PF03144, IPR004161): Elongation factor Tu domain 2
GTP_EFTU_D3 (PF03143, IPR004160): Elongation factor Tu C-terminal domain
42 HEY2interactor30.6670.667Hairy_orange (PF07527, IPR003650): Hairy Orange
HLH (PF00010, IPR011598, SM00353): Helix-loop-helix DNA-binding domain
TAT_signal (PF10518, IPR019546): TAT (twin-arginine translocation) pathway signal sequence
43 HEYLinteractor100Hairy_orange (PF07527, IPR003650): Hairy Orange
HLH (PF00010, IPR011598, SM00353): Helix-loop-helix DNA-binding domain
44 HIP1oncoprotein200ANTH (PF07651, IPR011417): ANTH domain
Reo_sigmaC (PF04582, IPR007662): Reovirus sigma C capsid protein
Ribosomal_S2 (PF00318, IPR001865): Ribosomal protein S2
I_LWEQ (PF01608, IPR002558, SM00307): I/LWEQ domain
HIP1_clath_bdg (PF16515, IPR032422): Clathrin-binding domain of Huntingtin-interacting protein 1
45 HIST1H3Hinteractor21.0000Histone (PF00125, IPR007125): Core histone H2A/H2B/H3/H4
46 HLA-Boncoprotein31.0000MHC_I (PF00129, IPR001039): Class I Histocompatibility antigen, domains alpha 1 and 2
MHC_I_C (PF06623, IPR010579): MHC_I C-terminus
C1-set (PF07654, IPR003597, SM00407): Immunoglobulin C1-set domain
47 HMG20Aprotein found in more fusions200DUF1764 (PF08576, IPR013885): Eukaryotic protein of unknown function (DUF1764)
DUF812 (PF05667, IPR008530): Protein of unknown function (DUF812)
MlaC (PF05494, IPR008869): MlaC protein
HMG_box (PF00505, IPR009071, SM00398): HMG (high mobility group) box
48 HMGA1oncoprotein90.52821.539AT_hook (PF02178, IPR017956, SM00384): AT hook motif
DUF2239 (PF09998, IPR018715): Uncharacterized protein conserved in bacteria (DUF2239)
49 HOXC11oncoprotein21.0000DUF3528 (PF12045, IPR021918): Protein of unknown function (DUF3528)
50 HOXC4interactor21.0000Homeobox (PF00046, IPR001356, SM00389): Homeobox domain
51 HSP90AA1oncoprotein230.286384.531HATPase_c (PF02518, IPR003594, SM00387): Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
HSP90 (PF00183, IPR001404): Hsp90 protein
52 HSP90AB1oncoprotein160.61023.513HATPase_c (PF02518, IPR003594, SM00387): Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
HSP90 (PF00183, IPR001404): Hsp90 protein
53 HSPA8oncoprotein160.46749.806HSP70 (PF00012, IPR013126): Hsp70 protein
54 HUWE1oncoprotein190.333114.156BUD22 (PF09073, IPR015158): BUD22
DUF908 (PF06012, IPR010309): Domain of Unknown Function (DUF908)
DUF913 (PF06025, IPR010314): Domain of Unknown Function (DUF913)
FdhE (PF04216, IPR006452): Protein involved in formate dehydrogenase formation
HABP4_PAI-RBP1 (PF04774, IPR006861): Hyaluronan / mRNA binding family
Ku_C (PF03730, IPR005160): Ku70/Ku80 C-terminal arm
Merozoite_SPAM (PF07133, IPR010784): Merozoite surface protein (SPAM)
Mucin (PF01456, IPR000458): Mucin-like glycoprotein
Nop14 (PF04147, IPR007276): Nop14-like family
PBP_sp32 (PF07222, IPR009865): Proacrosin binding protein sp32
RNA_pol_Rpc4 (PF05132, IPR007811): RNA polymerase III RPC4
TFIIA (PF03153, IPR004855): Transcription factor IIA, alpha/beta subunit
UBA (PF00627, IPR000449, SM00165): UBA/TS-N domain
WWE (PF02825, IPR004170, SM00678): WWE domain
HECT (PF00632, IPR000569, SM00119): HECT-domain (ubiquitin-transferase)
Tim54 (PF11711, IPR021056): Inner membrane protein import complex subunit Tim54
U1snRNP70_N (PF12220, IPR022023): U1 small nuclear ribonucleoprotein of 70kDa MW N terminal
DUF4414 (PF14377, IPR025527): Domain of unknown function (DUF4414)
55 HYPKinteractor21.0000Utp11 (PF03998, IPR007144): Utp11 protein
56 HYPMinteractor21.0000NA
57 IFT20interactor21.0000IFT20 (PF14931, IPR028172): Intraflagellar transport complex B, subunit 20
58 IKBKAPinteractor70.46712.560IKI3 (PF04762, IPR006849): IKI3 family
Clathrin (PF00637, IPR000547, SM00299): Region in Clathrin and VPS
MMU163 (PF17119, IPR031342): Mitochondrial protein up-regulated during meiosis
59 IKBKBprotein found in more fusions130.47026.926FliT (PF05400, IPR008622): Flagellar protein FliT
Glyco_hydro_65m (PF03632, IPR005195): Glycosyl hydrolase family 65 central catalytic domain
Pkinase (PF00069, IPR000719): Protein kinase domain
SlyX (PF04102, IPR007236): SlyX
ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
IKKbetaNEMObind (PF12179, IPR022007): I-kappa-kinase-beta NEMO binding domain
60 IKBKGinteractor150.37460.529CENP-H (PF05837, IPR008426): Centromere protein H (CENP-H)
DUF725 (PF05267, IPR007931): Protein of unknown function (DUF725)
NEMO (PF11577, IPR021063): NF-kappa-B essential modulator NEMO
LLC1 (PF14945, IPR020339): Normal lung function maintenance, Low in Lung Cancer 1 protein
CC2-LZ (PF16516, IPR032419): Leucine zipper of domain CC2 of NEMO, NF-kappa-B essential modulator
61 ING5suppressor30.6671.356ING (PF12998, IPR024610): Inhibitor of growth proteins N-terminal histone-binding
62 ITCHinteractor110.31125.776C2 (PF00168, IPR000008, SM00239): C2 domain
WW (PF00397, IPR001202, SM00456): WW domain
HECT (PF00632, IPR000569, SM00119): HECT-domain (ubiquitin-transferase)
63 KAT2Bprotein found in more fusions110.51124.536Acetyltransf_1 (PF00583, IPR000182): Acetyltransferase (GNAT) family
PCAF_N (PF06466, IPR009464): PCAF (P300/CBP-associated factor) N-terminal domain
Bromodomain (PF00439, IPR001487, SM00297): Bromodomain
64 KIF23interactor40.5002.284DUF730 (PF05325, IPR007989): Protein of unknown function (DUF730)
Kinesin (PF00225, IPR001752, SM00129): Kinesin motor domain
ADIP (PF11559, IPR021622): Afadin- and alpha -actinin-Binding
TMF_DNA_bd (PF12329, IPR022092): TATA element modulatory factor 1 DNA binding
MKLP1_Arf_bdg (PF16540, IPR032384): Arf6-interacting domain of mitotic kinesin-like protein 1
65 LLGL1suppressor21.0000Lgl_C (PF08596, IPR013905): Lethal giant larvae(Lgl) like, C-terminal
LLGL (PF08366, IPR013577): LLGL2
WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
66 MAGEA3interactor100MAGE (PF01454, IPR002190): MAGE family
MAGE_N (PF12440, IPR021072): Melanoma associated antigen family N terminal
67 MAGEB18interactor21.0000MAGE (PF01454, IPR002190): MAGE family
MAGE_N (PF12440, IPR021072): Melanoma associated antigen family N terminal
68 MAGEB6interactor100MAGE (PF01454, IPR002190): MAGE family
MAGE_N (PF12440, IPR021072): Melanoma associated antigen family N terminal
69 MAP1LC3Ainteractor120.33333.558Atg8 (PF02991, IPR004241): Autophagy protein Atg8 ubiquitin like
70 MAP3K10interactor31.0000Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
DUF3552 (PF12072, IPR022711): Domain of unknown function (DUF3552)
SH3_9 (PF14604, IPR001452): Variant SH3 domain
71 MAPK3oncoprotein100.58322.509Pkinase (PF00069, IPR000719): Protein kinase domain
72 MBD1interactor30.6670.400MBD (PF01429, IPR001739, SM00391): Methyl-CpG binding domain
zf-CXXC (PF02008, IPR002857): CXXC zinc finger domain
73 MBD4suppressor100HhH-GPD (PF00730, IPR003265): HhH-GPD superfamily base excision DNA repair protein
MBD (PF01429, IPR001739, SM00391): Methyl-CpG binding domain
74 MED21protein found in more fusions70.5336.774Med21 (PF11221, IPR021384): Subunit 21 of Mediator complex
75 MED31interactor100Med31 (PF05669, IPR008831): SOH1
76 MGRN1interactor30.6670.667zf-C3HC4_3 (PF13920): Zinc finger, C3HC4 type (RING finger)
77 MID1oncoprotein70.33322.184Baculo_PEP_C (PF04513, IPR007601): Baculovirus polyhedron envelope protein, PEP, C terminus
fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain
SPRY (PF00622, IPR003877, SM00449): SPRY domain
DUF2369 (PF10179, IPR019326): Uncharacterised conserved protein (DUF2369)
zf-B_box (PF00643, IPR000315, SM00336): B-box zinc finger
PRY (PF13765, IPR006574, SM00589): SPRY-associated domain
zf-RING_UBOX (PF13445, IPR027370): RING-type zinc-finger
zf-C3HC4_4 (PF15227): zinc finger of C3HC4-type, RING
78 MIPEPinteractor30.33312.367Peptidase_M3 (PF01432, IPR001567): Peptidase family M3
79 MORC3interactor100bZIP_1 (PF00170, IPR004827): bZIP transcription factor
DivIVA (PF05103, IPR007793): DivIVA protein
XkdW (PF09636, IPR019094): XkdW protein
zf-CW (PF07496, IPR011124): CW-type Zinc Finger
DUF2353 (PF09789, IPR019179): Uncharacterized coiled-coil protein (DUF2353)
HATPase_c_3 (PF13589): Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
zf-C4pol (PF14260, IPR025687): C4-type zinc-finger of DNA polymerase delta
80 MRFAP1interactor31.0000MRFAP1 (PF15155, IPR029254): MORF4 family-associated protein1
81 MRFAP1L1interactor41.0000MRFAP1 (PF15155, IPR029254): MORF4 family-associated protein1
82 MYConcoprotein240.217385.341HLH (PF00010, IPR011598, SM00353): Helix-loop-helix DNA-binding domain
Myc-LZ (PF02344, IPR003327): Myc leucine zipper domain
Myc_N (PF01056, IPR012682): Myc amino-terminal region
83 NBR1oncoprotein60.5004.912CENP-B_dimeris (PF09026, IPR015115): Centromere protein B dimerisation domain
PB1 (PF00564, IPR000270, SM00666): PB1 domain
ZZ (PF00569, IPR000433, SM00291): Zinc finger, ZZ type
DUF2681 (PF10883, IPR020274): Protein of unknown function (DUF2681)
N_BRCA1_IG (PF16158, IPR032350): Ig-like domain from next to BRCA1 gene
84 NCOR1oncoprotein110.56431.418BES1_N (PF05687, IPR008540): BES1/BZR1 plant transcription factor, N-terminal
Lamp (PF01299, IPR002000): Lysosome-associated membrane glycoprotein (Lamp)
MAS20 (PF02064, IPR002056): MAS20 protein import receptor
Neur_chan_memb (PF02932, IPR006029): Neurotransmitter-gated ion-channel transmembrane region
Eapp_C (PF10238, IPR019370): E2F-associated phosphoprotein
Hid1 (PF12722): High-temperature-induced dauer-formation protein
Myb_DNA-binding (PF00249, IPR001005, SM00717): Myb-like DNA-binding domain
DUF3915 (PF13054, IPR025026): Protein of unknown function (DUF3915)
GPS2_interact (PF15784, IPR031557): G-protein pathway suppressor 2-interacting domain
DUF4834 (PF16118, IPR032272): Domain of unknown function (DUF4834)
RBR (PF17208): RNA binding Region
85 NEUROD1interactor30.6671.000HLH (PF00010, IPR011598, SM00353): Helix-loop-helix DNA-binding domain
YL1 (PF05764, IPR008895): YL1 nuclear protein
Neuro_bHLH (PF12533, IPR022575): Neuronal helix-loop-helix transcription factor
86 NME4interactor50.5002.333NDK (PF00334, IPR001564, SM00562): Nucleoside diphosphate kinase
87 NUP58interactor40.8330.719Nucleoporin_FG2 (PF15967): Nucleoporin FG repeated region
88 OPTNprotein found in more fusions70.4677.074ARD (PF03079, IPR004313): ARD/ARD' family
bZIP_1 (PF00170, IPR004827): bZIP transcription factor
HALZ (PF02183, IPR003106, SM00340): Homeobox associated leucine zipper
Uso1_p115_C (PF04871, IPR006955): Uso1 / p115 like vesicle tethering protein, C terminal region
NEMO (PF11577, IPR021063): NF-kappa-B essential modulator NEMO
CC2-LZ (PF16516, IPR032419): Leucine zipper of domain CC2 of NEMO, NF-kappa-B essential modulator
89 OSTF1interactor21.0000SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies)
90 PACSIN1interactor50.33312.798FCH (PF00611, IPR001060, SM00055): Fes/CIP4, and EFC/F-BAR homology domain
DUF2605 (PF10792, IPR019728): Protein of unknown function (DUF2605)
DUF4446 (PF14584, IPR027981): Protein of unknown function (DUF4446)
SH3_9 (PF14604, IPR001452): Variant SH3 domain
NPF (PF16601): Rabosyn-5 repeating NPF sequence-motif
91 PEX11Binteractor200PEX11 (PF05648, IPR008733): Peroxisomal biogenesis factor 11 (PEX11)
92 PFN2interactor21.0000Profilin (PF00235, IPR005455, SM00392): Profilin
93 PIAS1suppressor110.42219.699Herpes_capsid (PF06112, IPR009299): Gammaherpesvirus capsid protein
zf-MIZ (PF02891, IPR004181): MIZ/SP-RING zinc finger
PINIT (PF14324, IPR023321): PINIT domain
UPF0544 (PF15749, IPR032739): Uncharacterised protein family UPF0544
94 PIAS4interactor100.37820.118CENP-B_dimeris (PF09026, IPR015115): Centromere protein B dimerisation domain
SAP (PF02037, IPR003034, SM00513): SAP domain
zf-MIZ (PF02891, IPR004181): MIZ/SP-RING zinc finger
PINIT (PF14324, IPR023321): PINIT domain
95 PIK3R1oncoprotein80.38111.136RhoGAP (PF00620, IPR000198, SM00324): RhoGAP domain
SH2 (PF00017, IPR000980, SM00252): SH2 domain
SH3_2 (PF07653, IPR011511): Variant SH3 domain
PI3K_P85_iSH2 (PF16454, IPR032498): Phosphatidylinositol 3-kinase regulatory subunit P85 inter-SH2 domain
96 PMLsuppressor140.50031.586zf-B_box (PF00643, IPR000315, SM00336): B-box zinc finger
DUF3583 (PF12126, IPR021978): Protein of unknown function (DUF3583)
zf-C3HC4_3 (PF13920): Zinc finger, C3HC4 type (RING finger)
97 PPP2CAsuppressor100.37825.523Metallophos (PF00149, IPR004843): Calcineurin-like phosphoesterase
STPPase_N (PF16891, IPR031675): Serine-threonine protein phosphatase N-terminal domain
98 PRMT2interactor21.0000PRMT5 (PF05185, IPR025799): PRMT5 arginine-N-methyltransferase
SH3_9 (PF14604, IPR001452): Variant SH3 domain
99 PRPF40Aprotein found in more fusions160.23862.613FF (PF01846, IPR002713, SM00441): FF domain
MCR_alpha (PF02249, IPR009047): Methyl-coenzyme M reductase alpha subunit, C-terminal domain
Transformer (PF06495, IPR010519): Fruit fly transformer protein
WW (PF00397, IPR001202, SM00456): WW domain
YqzE (PF14038, IPR025622): YqzE-like protein
SPT6_acidic (PF14632, IPR028083): Acidic N-terminal SPT6
SRRM_C (PF15230, IPR029360): Serine/arginine repetitive matrix protein C-terminus
SOBP (PF15279, IPR026092): Sine oculis-binding protein
IHABP4_N (PF16174, IPR032381): Intracellular hyaluronan-binding protein 4 N-terminal
100 PRPF40Binteractor100DTHCT (PF08070, IPR012542): DTHCT (NUC029) region
FF (PF01846, IPR002713, SM00441): FF domain
SelP_N (PF04592, IPR007671): Selenoprotein P, N terminal region
TPX2 (PF06886, IPR027329): Targeting protein for Xklp2 (TPX2)
WW (PF00397, IPR001202, SM00456): WW domain
DUF3886 (PF13025, IPR024980): Protein of unknown function (DUF3886)
AAA_33 (PF13671): AAA domain
DUF4337 (PF14235, IPR025570): Domain of unknown function (DUF4337)
BRD4_CDT (PF17105, IPR031354): C-terminal domain of bromodomain protein 4
101 PSMB7protein found in more fusions60.6002.455Proteasome (PF00227, IPR001353): Proteasome subunit
Pr_beta_C (PF12465, IPR024689): Proteasome beta subunits C terminal
102 PSMC5protein found in more fusions150.33060.017AAA (PF00004, IPR003959, SM00382): ATPase family associated with various cellular activities (AAA)
Laminin_II (PF06009, IPR010307): Laminin Domain II
RILP (PF11461, IPR021563): Rab interacting lysosomal protein
AAA_16 (PF13191): AAA ATPase domain
103 PTGES2protein found in more fusions3010.034GST_C_2 (PF13410): Glutathione S-transferase, C-terminal domain
GST_N_3 (PF13417, IPR004045): Glutathione S-transferase, N-terminal domain
104 RAPGEF2interactor100PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF)
RA (PF00788, IPR000159, SM00314): Ras association (RalGDS/AF-6) domain
RasGEF (PF00617, IPR001895, SM00147): RasGEF domain
RasGEF_N (PF00618, IPR000651, SM00229): RasGEF N-terminal motif
cNMP_binding (PF00027, IPR000595, SM00100): Cyclic nucleotide-binding domain
105 RASA1oncoprotein40.6671.667C2 (PF00168, IPR000008, SM00239): C2 domain
PH (PF00169, IPR001849, SM00233): PH domain
RasGAP (PF00616, IPR001936, SM00323): GTPase-activator protein for Ras-like GTPase
SH2 (PF00017, IPR000980, SM00252): SH2 domain
SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
106 RCN2interactor40.8330.250EF-hand_1 (PF00036, IPR002048, SM00054): EF hand
EF-hand_7 (PF13499, IPR011992): EF-hand domain pair
107 RFXANKinteractor31.0000Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies)
108 RNF20interactor40.6670.964Allexi_40kDa (PF05549, IPR008398): Allexivirus 40kDa protein
Atrophin-1 (PF03154, IPR002951): Atrophin-1 family
BRE1 (PF08647, IPR013956): BRE1 E3 ubiquitin ligase
DUF1690 (PF07956, IPR012471): Protein of Unknown function (DUF1690)
HrpB7 (PF09486, IPR013392): Bacterial type III secretion protein (HrpB7)
Trypan_PARP (PF05887, IPR008882): Procyclic acidic repetitive protein (PARP)
Uso1_p115_C (PF04871, IPR006955): Uso1 / p115 like vesicle tethering protein, C terminal region
Sox_N (PF12444, IPR022151): Sox developmental protein N terminal
DUF4200 (PF13863, IPR025252): Domain of unknown function (DUF4200)
zf-C3HC4_3 (PF13920): Zinc finger, C3HC4 type (RING finger)
DUF4407 (PF14362, IPR025519): Domain of unknown function (DUF4407)
Rootletin (PF15035): Ciliary rootlet component, centrosome cohesion
109 RPL4interactor60.6672.052Ribosomal_L4 (PF00573, IPR002136): Ribosomal protein L4/L1 family
Ribos_L4_asso_C (PF14374, IPR025755): 60S ribosomal protein L4 C-terminal domain
110 RPS6KB1interactor60.30014.107Pkinase (PF00069, IPR000719): Protein kinase domain
Pkinase_C (PF00433, IPR017892): Protein kinase C terminal domain
111 SETD2suppressor31.0000DUF1777 (PF08648, IPR013957): Protein of unknown function (DUF1777)
SET (PF00856, IPR001214, SM00317): SET domain
SRI (PF08236, IPR013257): SRI (Set2 Rpb1 interacting) domain
Med26 (PF08711, IPR017923): TFIIS helical bundle-like domain
WW (PF00397, IPR001202, SM00456): WW domain
DUF3592 (PF12158, IPR021994): Protein of unknown function (DUF3592)
112 SH3GL3interactor50.5001.567BAR (PF03114, IPR004148, SM00721): BAR domain
SH3_2 (PF07653, IPR011511): Variant SH3 domain
113 SIAH1suppressor100.27819.801Sina (PF03145, IPR018121): Seven in absentia protein family
114 SP1protein found in more fusions160.37180.080zf-Di19 (PF05605, IPR008598): Drought induced 19 protein (Di19), zinc-binding
Herpes_capsid (PF06112, IPR009299): Gammaherpesvirus capsid protein
zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type
Miga (PF10265, IPR019392): Mitoguardin
zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain
FoP_duplication (PF13865, IPR025715): C-terminal duplication domain of Friend of PRMT1
115 SQSTM1oncoprotein180.228122.790PB1 (PF00564, IPR000270, SM00666): PB1 domain
ZZ (PF00569, IPR000433, SM00291): Zinc finger, ZZ type
UBA_5 (PF16577, IPR015940): UBA domain
116 SYVN1protein found in more fusions70.5335.281Alpha_GJ (PF03229, IPR004913): Alphavirus glycoprotein J
zf-DHHC (PF01529, IPR001594): DHHC palmitoyltransferase
zf-RING_2 (PF13639, IPR001841, SM00184): Ring finger domain
117 TACC1oncoprotein100TACC (PF05010, IPR007707): Transforming acidic coiled-coil-containing protein (TACC)
DUF4613 (PF15390, IPR028041): Domain of unknown function (DUF4613)
118 TAF4protein found in more fusions50.5001.071TAF4 (PF05236, IPR007900): Transcription initiation factor TFIID component TAF4 family
TAFH (PF07531, IPR003894, SM00549): NHR1 homology to TAF
TFIIA (PF03153, IPR004855): Transcription factor IIA, alpha/beta subunit
DUF3729 (PF12526, IPR022202): Protein of unknown function (DUF3729)
119 TCERG1interactor90.38917.333FF (PF01846, IPR002713, SM00441): FF domain
WW (PF00397, IPR001202, SM00456): WW domain
Folliculin (PF11704, IPR021713): Vesicle coat protein involved in Golgi to plasma membrane transport
DUF3807 (PF12720, IPR024526): Protein of unknown function (DUF3807)
DUF3886 (PF13025, IPR024980): Protein of unknown function (DUF3886)
Spore_coat_CotO (PF14153, IPR025439): Spore coat protein CotO
FAM150 (PF15129, IPR029364): FAM150 family
120 TP53suppressor460.162749.578DEC-1_N (PF04625, IPR006719): DEC-1 protein, N-terminal region
P53 (PF00870, IPR011615): P53 DNA-binding domain
P53_tetramer (PF07710, IPR010991): P53 tetramerisation motif
121 TRAF6protein found in more fusions100.38917.376SlyX (PF04102, IPR007236): SlyX
zf-TRAF (PF02176, IPR001293): TRAF-type zinc finger
zf-C3HC4_2 (PF13923): Zinc finger, C3HC4 type (RING finger)
122 TRAFD1interactor21.0000zf-Di19 (PF05605, IPR008598): Drought induced 19 protein (Di19), zinc-binding
DM (PF00751, IPR001275, SM00301): DM DNA binding domain
zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type
zf-C2H2_4 (PF13894): C2H2-type zinc finger
zf-C2HC_2 (PF13913): zinc-finger of a C2HC-type
123 TRIP10interactor31.0000Exonuc_VII_L (PF02601, IPR020579): Exonuclease VII, large subunit
FCH (PF00611, IPR001060, SM00055): Fes/CIP4, and EFC/F-BAR homology domain
Neur_chan_memb (PF02932, IPR006029): Neurotransmitter-gated ion-channel transmembrane region
SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
Lzipper-MIP1 (PF14389, IPR025757): Leucine-zipper of ternary complex factor MIP1
124 TTC23interactor21.0000DUF3856 (PF12968, IPR024552): Domain of Unknown Function (DUF3856)
TPR_12 (PF13424): Tetratricopeptide repeat
125 TUBA1Aoncoprotein110.67326.350Tubulin (PF00091, IPR003008, SM00864): Tubulin/FtsZ family, GTPase domain
Tubulin_C (PF03953, IPR018316, SM00865): Tubulin C-terminal domain
126 TUBBprotein found in more fusions150.57143.696Tubulin (PF00091, IPR003008, SM00864): Tubulin/FtsZ family, GTPase domain
Tubulin_C (PF03953, IPR018316, SM00865): Tubulin C-terminal domain
127 UBAC1interactor21.0000CENP-H (PF05837, IPR008426): Centromere protein H (CENP-H)
Ribosomal_60s (PF00428, IPR001813): 60s Acidic ribosomal protein
UBA (PF00627, IPR000449, SM00165): UBA/TS-N domain
HEAT_2 (PF13646): HEAT repeats
Rad60-SLD_2 (PF13881): Ubiquitin-2 like Rad60 SUMO-like
128 UBE2E3protein found in more fusions50.5002.000UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme
129 UBE2Kinteractor100.26725.094UBA (PF00627, IPR000449, SM00165): UBA/TS-N domain
UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme
130 UBQLN1protein found in more fusions90.42913.157Clathrin-link (PF09268, IPR015348): Clathrin, heavy-chain linker
UBA (PF00627, IPR000449, SM00165): UBA/TS-N domain
XPC-binding (PF09280, IPR015360): XPC-binding domain
ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
Fur_reg_FbpB (PF13040, IPR025004): Fur-regulated basic protein B
FAM199X (PF15814, IPR029672): Protein family FAM199X
131 UBQLN2protein found in more fusions70.4677.125Clathrin-link (PF09268, IPR015348): Clathrin, heavy-chain linker
Collagen (PF01391, IPR008160): Collagen triple helix repeat (20 copies)
TFIIA (PF03153, IPR004855): Transcription factor IIA, alpha/beta subunit
UBA (PF00627, IPR000449, SM00165): UBA/TS-N domain
XPC-binding (PF09280, IPR015360): XPC-binding domain
ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
SUZ (PF12752, IPR024771): SUZ domain
Fur_reg_FbpB (PF13040, IPR025004): Fur-regulated basic protein B
132 ULK1protein found in more fusions50.8330.500Pkinase (PF00069, IPR000719): Protein kinase domain
DUF3543 (PF12063, IPR022708): Domain of unknown function (DUF3543)
RCDG1 (PF15725, IPR031457): Renal cancer differentiation gene 1 protein
133 UPF3Ainteractor100Smg4_UPF3 (PF03467, IPR005120): Smg-4/UPF3 family
DDRGK (PF09756, IPR019153, SM01128): DDRGK domain
134 USP14interactor21.0000UCH (PF00443, IPR001394): Ubiquitin carboxyl-terminal hydrolase
ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
135 USP8interactor60.5004.462DUF1510 (PF07423, IPR009988): Protein of unknown function (DUF1510)
USP8_dimer (PF08969, IPR015063): USP8 dimerisation domain
SET (PF00856, IPR001214, SM00317): SET domain
UCH (PF00443, IPR001394): Ubiquitin carboxyl-terminal hydrolase
Rhodanese (PF00581, IPR001763, SM00450): Rhodanese-like domain
NAM-associated (PF14303, IPR029466): No apical meristem-associated C-terminal domain
136 UTP14Ainteractor40.6671.200Utp14 (PF04615, IPR006709): Utp14 protein
137 VCPprotein found in more fusions240.206221.423AAA (PF00004, IPR003959, SM00382): ATPase family associated with various cellular activities (AAA)
CDC48_2 (PF02933, IPR004201, SM01072): Cell division protein 48 (CDC48), domain 2
CDC48_N (PF02359, IPR003338, SM01073): Cell division protein 48 (CDC48), N-terminal domain
TniB (PF05621, IPR008868): Bacterial TniB protein
Vps4_C (PF09336, IPR015415): Vps4 C terminal oligomerisation domain
DUF3944 (PF13099, IPR025217): Domain of unknown function (DUF3944)
138 XAGE3interactor100GAGE (PF05831, IPR008625): GAGE protein
139 XRCC6oncoprotein110.37847.212Ku (PF02735, IPR006164, SM00559): Ku70/Ku80 beta-barrel domain
Ku_C (PF03730, IPR005160): Ku70/Ku80 C-terminal arm
Ku_N (PF03731, IPR005161): Ku70/Ku80 N-terminal alpha/beta domain
SAP (PF02037, IPR003034, SM00513): SAP domain
140 ZDHHC17protein found in more fusions200.111150.167zf-DHHC (PF01529, IPR001594): DHHC palmitoyltransferase
Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies)
Ank_3 (PF13606, IPR002110): Ankyrin repeat
Ank_4 (PF13637): Ankyrin repeats (many copies)
141 ZFC3H1interactor21.0000Bap31 (PF05529, IPR008417): B-cell receptor-associated protein 31-like
LMBR1 (PF04791, IPR006876): LMBR1-like membrane protein
TPR_1 (PF00515, IPR001440): Tetratricopeptide repeat
DUF2277 (PF10041, IPR018735): Uncharacterized conserved protein (DUF2277)
zf-C3H1 (PF10650, IPR019607, SM00356): Putative zinc-finger domain
DUF2570 (PF10828, IPR022538): Protein of unknown function (DUF2570)
TPR_14 (PF13428): Tetratricopeptide repeat
TPR_19 (PF14559): Tetratricopeptide repeat
FNIP_N (PF14636, IPR028084): Folliculin-interacting protein N-terminus
142 ZFYVE19interactor30.6671.000Cwf_Cwc_15 (PF04889, IPR006973): Cwf15/Cwc15 cell cycle control protein
DUF1690 (PF07956, IPR012471): Protein of Unknown function (DUF1690)
FYVE (PF01363, IPR000306, SM00064): FYVE zinc finger
Rpr2 (PF04032, IPR007175): RNAse P Rpr2/Rpp21/SNM1 subunit domain
zf-B_box (PF00643, IPR000315, SM00336): B-box zinc finger
143 ZMAT2interactor100Cgr1 (PF03879, IPR005579): Cgr1 family
zf-C2H2_jaz (PF12171, IPR022755): Zinc-finger double-stranded RNA-binding
144 ZNF451protein found in more fusions50.8330.500zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type
EPL1 (PF10513, IPR019542): Enhancer of polycomb-like
zf-C2H2_jaz (PF12171, IPR022755): Zinc-finger double-stranded RNA-binding
zf-C2H2_2 (PF12756, IPR015880): C2H2 type zinc-finger (2 copies)
zf-met (PF12874): Zinc-finger of C2H2 type
zf-C2H2_4 (PF13894): C2H2-type zinc finger
Cys_rich_KTR (PF14205, IPR025957): Cysteine-rich KTR
FOXP-CC (PF16159, IPR032354): FOXP coiled-coil domain
145 ZNF655interactor30.6671.000Asr (PF06392, IPR009435): Acid shock protein repeat
Chordopox_RPO7 (PF05864, IPR008448): Chordopoxvirus DNA-directed RNA polymerase 7 kDa polypeptide (RPO7)
zf-AN1 (PF01428, IPR000058, SM00154): AN1-like Zinc finger
zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type
zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain

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