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Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: parental proteins RALYL, UPRT (from a repository: Mon Aug 12 12:30:05 2019)
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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)46
The number (and %) of the onco-proteins7 (15.22 %)
The number (and %) of the tumor suppressors3 (6.52 %)
Total number of binary PPIs (saturation %)97 (9.37 %)
The number (and %) of affected PPIs45 (46.39 %)
The number of possible different fusions7
PPI diameter5
PPI radius3
The average degree of PPI3.609
Assortativity coefficient-0.4574
The network average Clustering coefficient0.498
The number (and %) of a zero Clustering coefficients16 (34.78 %)
The number (and %) of a zero Betweenness Centrality30 (65.22 %)

ACTIVE INTERACTORS


List of the fusions

PPI for parental proteins: RALYL,UPRT All fusions
Proteins found in more fusions HNRNPC (see 1 fusions); EWSR1 (see 1 fusions); VHL (see 1 fusions); FXR2 (see 1 fusions); LRRK2 (see 1 fusions); RALYL (see 1 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 RALYLparental protein390.0511785.500RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
TFIIIC_sub6 (PF10419, IPR019481): TFIIIC subunit
CENP-Q (PF13094, IPR025212): CENP-Q, a CENPA-CAD centromere complex subunit
2 UPRTparental protein60.133259.000UPRTase (PF14681, IPR029057): Uracil phosphoribosyltransferase
3 AEBP2interactor21.0000Bindin (PF02084, IPR000775): Bindin
Herpes_PAP (PF03325, IPR004997): Herpesvirus polymerase accessory protein
zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type
Spt5_N (PF11942, IPR022581): Spt5 transcription elongation factor, acidic N-terminal
zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain
WRNPLPNID (PF15017): Putative WW-binding domain and destruction box
DUF4764 (PF15961, IPR031885): Domain of unknown function (DUF4764)
4 AENinteractor100RNase_T (PF00929, IPR013520): Exonuclease
5 AQRinteractor50.7003.000AAA_11 (PF13086): AAA domain
AAA_12 (PF13087): AAA domain
AAA_30 (PF13604): AAA domain
Mif2_N (PF15624, IPR028929): Kinetochore CENP-C fungal homologue, Mif2, N-terminal
Aquarius_N (PF16399, IPR032174): Intron-binding protein aquarius N-terminus
6 BYSLinteractor31.0000Bystin (PF05291, IPR007955): Bystin
MEA1 (PF06910, IPR009685): Male enhanced antigen 1 (MEA1)
7 C20orf27interactor100DUF4517 (PF15006, IPR026794): Domain of unknown function (DUF4517)
8 CCDC12interactor31.0000cwf18 (PF08315, IPR013169): cwf18 pre-mRNA splicing factor
9 CCDC85Binteractor70.4769.667CCDC85 (PF10226, IPR019359): CCDC85 family
10 CCDC9interactor100IncA (PF04156, IPR007285): IncA protein
NOA36 (PF06524, IPR010531): NOA36 protein
DUF2098 (PF09871, IPR019209): Uncharacterized protein conserved in archaea (DUF2098)
MSA-2c (PF12238, IPR021060): Merozoite surface antigen 2c
DUF4594 (PF15266, IPR029336): Domain of unknown function (DUF4594)
11 CDC40interactor50.8001.333AF-4 (PF05110, IPR007797): AF-4 proto-oncoprotein
WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
12 CEP170P1interactor31.0000NA
13 CRNKL1interactor60.7332.833NRDE-2 (PF08424, IPR013633): NRDE-2, necessary for RNA interference
HAT (PF02184, IPR003107, SM00386): HAT (Half-A-TPR) repeat
Mad3_BUB1_I (PF08311, IPR013212, SM00777): Mad3/BUB1 homology region 1
Suf (PF05843, IPR008847): Suppressor of forked protein (Suf)
U3_assoc_6 (PF08640, IPR013949): U3 small nucleolar RNA-associated protein 6
TPR_14 (PF13428): Tetratricopeptide repeat
TPR_16 (PF13432): Tetratricopeptide repeat
14 CWF19L1interactor100CwfJ_C_1 (PF04677, IPR006768): Protein similar to CwfJ C-terminus 1
CwfJ_C_2 (PF04676, IPR006767): Protein similar to CwfJ C-terminus 2
Metallophos_3 (PF14582, IPR029461): Metallophosphoesterase, calcineurin superfamily
15 DGCR14interactor21.0000Es2 (PF09751, IPR019148): Nuclear protein Es2
16 ELAVL2interactor100RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
17 EWSR1oncoprotein40.6671.000RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
SVS_QK (PF10578, IPR018942): Seminal vesicle protein repeat
zf-RanBP (PF00641, IPR001876, SM00547): Zn-finger in Ran binding protein and others
FoP_duplication (PF13865, IPR025715): C-terminal duplication domain of Friend of PRMT1
Keratin_2_head (PF16208, IPR032444): Keratin type II head
18 FBXW7suppressor30532.000Mem_trans (PF03547, IPR004776): Membrane transport protein
WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
Nup160 (PF11715, IPR021717): Nucleoporin Nup120/160
F-box-like (PF12937, IPR001810): F-box-like
19 FXR2protein found in more fusions90.35717.667Agenet (PF05641, IPR008395, SM00743): Agenet domain
REV (PF00424, IPR000625): REV protein (anti-repression trans-activator protein)
KH_1 (PF00013, IPR004088, SM00322): KH domain
FXMRP1_C_core (PF12235, IPR022034): Fragile X-related 1 protein core C terminal
FXR_C1 (PF16096, IPR032172): Fragile X-related 1 protein C-terminal region 2
20 HNRNPCprotein found in more fusions90.35717.000APG6 (PF04111, IPR007243): Autophagy protein Apg6
RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
SURF2 (PF05477, IPR008833): Surfeit locus protein 2 (SURF2)
21 IRF2BP2oncoprotein100zf-C3HC4 (PF00097, IPR018957): Zinc finger, C3HC4 type (RING finger)
IRF-2BP1_2 (PF11261, IPR022750): Interferon regulatory factor 2-binding protein zinc finger
DUF3729 (PF12526, IPR022202): Protein of unknown function (DUF3729)
Bd3614_N (PF14442, IPR025854): Bd3614-like deaminase N-terminal
22 ISY1interactor70.7332.500Isy1 (PF06246, IPR009360): Isy1-like splicing family
23 LMO3oncoprotein40.6672.000LIM (PF00412, IPR001781, SM00132): LIM domain
24 LRRK2oncoprotein200Arm (PF00514, IPR000225, SM00185): Armadillo/beta-catenin-like repeat
ATP-synt_ab (PF00006, IPR000194): ATP synthase alpha/beta family, nucleotide-binding domain
DUF1043 (PF06295, IPR009386): Protein of unknown function (DUF1043)
T2SSE (PF00437, IPR001482): Type II/IV secretion system protein
Roc (PF08477, IPR013684): Ras of Complex, Roc, domain of DAPkinase
Pkinase (PF00069, IPR000719): Protein kinase domain
Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies)
LRR_4 (PF12799, IPR025875): Leucine Rich repeats (2 copies)
PQQ_2 (PF13360, IPR002372): PQQ-like domain
LRR_8 (PF13855, IPR001611): Leucine rich repeat
COR (PF16095, IPR032171): C-terminal of Roc, COR, domain
25 MCRS1interactor31.0000FHA (PF00498, IPR000253, SM00240): FHA domain
MCRS_N (PF13325, IPR025999): N-terminal region of micro-spherule protein
26 MPPED1interactor40.333469.000Metallophos (PF00149, IPR004843): Calcineurin-like phosphoesterase
27 PNNsuppressor100Aconitase_C (PF00694, IPR000573): Aconitase C-terminal domain
Herpes_capsid (PF06112, IPR009299): Gammaherpesvirus capsid protein
Pinin_SDK_memA (PF04696, IPR006786): pinin/SDK/memA/ protein conserved region
Pinin_SDK_N (PF04697, IPR006787): pinin/SDK conserved region
Trypan_PARP (PF05887, IPR008882): Procyclic acidic repetitive protein (PARP)
28 PRKRAinteractor200dsrm (PF00035, IPR014720, SM00358): Double-stranded RNA binding motif
Staufen_C (PF16482, IPR032478): Staufen C-terminal domain
29 PSMF1interactor31.0000PI31_Prot_C (PF08577, IPR013886): PI31 proteasome regulator
PI31_Prot_N (PF11566, IPR021625): PI31 proteasome regulator N-terminal
30 PYROXD1interactor100Pyr_redox_2 (PF07992, IPR023753): Pyridine nucleotide-disulphide oxidoreductase
31 RALYinteractor21.0000RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
SelK_SelG (PF10961, IPR024491): Selenoprotein SelK_SelG
32 RBM22interactor21.0000FYVE (PF01363, IPR000306, SM00064): FYVE zinc finger
RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
Torus (PF16131, IPR032297): Torus domain
33 RBM41interactor31.0000RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
34 SF3A1interactor40.6672.000TFIIA (PF03153, IPR004855): Transcription factor IIA, alpha/beta subunit
Surp (PF01805, IPR000061, SM00648): Surp module
ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
PRP21_like_P (PF12230, IPR022030): Pre-mRNA splicing factor PRP21 like protein
35 SKA2interactor100SKA2 (PF16740, IPR026762): Spindle and kinetochore-associated protein 2
36 THAP1interactor60.5005.000THAP (PF05485, IPR006612, SM00980): THAP domain
Tho2 (PF11262, IPR021418): Transcription factor/nuclear export subunit protein 2
Cep57_CLD (PF14073, IPR025913): Centrosome localisation domain of Cep57
37 TRAF7oncoprotein100Sina (PF03145, IPR018121): Seven in absentia protein family
WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
zf-TRAF (PF02176, IPR001293): TRAF-type zinc finger
zf-RING_UBOX (PF13445, IPR027370): RING-type zinc-finger
DUF4164 (PF13747, IPR025310): Domain of unknown function (DUF4164)
zf-C3HC4_3 (PF13920): Zinc finger, C3HC4 type (RING finger)
PKcGMP_CC (PF16808, IPR031831): Coiled-coil N-terminus of cGMP-dependent protein kinase
WD40_like (PF17005, IPR031544): WD40-like domain
38 TSNAXinteractor21.0000Translin (PF01997, IPR002848): Translin family
39 UCK1interactor31.0000PRK (PF00485, IPR006083): Phosphoribulokinase / Uridine kinase family
40 UCK2interactor100PRK (PF00485, IPR006083): Phosphoribulokinase / Uridine kinase family
41 UCKL1interactor21.0000PRK (PF00485, IPR006083): Phosphoribulokinase / Uridine kinase family
UPRTase (PF14681, IPR029057): Uracil phosphoribosyltransferase
42 VHLsuppressor31.0000Trypan_PARP (PF05887, IPR008882): Procyclic acidic repetitive protein (PARP)
VHL (PF01847, IPR022772): VHL beta domain
VHL_C (PF17211): VHL box domain
43 XAB2interactor60.7332.500NRDE-2 (PF08424, IPR013633): NRDE-2, necessary for RNA interference
HAT (PF02184, IPR003107, SM00386): HAT (Half-A-TPR) repeat
Suf (PF05843, IPR008847): Suppressor of forked protein (Suf)
TPR_2 (PF07719, IPR013105): Tetratricopeptide repeat
TPR_12 (PF13424): Tetratricopeptide repeat
TPR_14 (PF13428): Tetratricopeptide repeat
TPR_19 (PF14559): Tetratricopeptide repeat
44 YTHDC1interactor100DUF1777 (PF08648, IPR013957): Protein of unknown function (DUF1777)
Merozoite_SPAM (PF07133, IPR010784): Merozoite surface protein (SPAM)
Prothymosin (PF03247, IPR004931): Prothymosin/parathymosin family
YTH (PF04146, IPR007275): YT521-B-like domain
PRP38_assoc (PF12871, IPR024767): Pre-mRNA-splicing factor 38-associated hydrophilic C-term
TFB6 (PF17110, IPR031349): Subunit 11 of the general transcription factor TFIIH
45 ZC3H14interactor100PWI (PF01480, IPR002483, SM00311): PWI domain
zf-CCCH_2 (PF14608): RNA-binding, Nab2-type zinc finger
46 ZNF408interactor31.0000zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type
zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain

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