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Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: parental proteins FUNDC1, PTBP3 (from a repository: Wed Aug 14 01:23:06 2019)
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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)32
The number (and %) of the onco-proteins9 (28.12 %)
The number (and %) of the tumor suppressors4 (12.50 %)
Total number of binary PPIs (saturation %)86 (17.34 %)
The number (and %) of affected PPIs30 (34.88 %)
The number of possible different fusions6
PPI diameter5
PPI radius3
The average degree of PPI4.688
Assortativity coefficient-0.2658
The network average Clustering coefficient0.324
The number (and %) of a zero Clustering coefficients9 (28.12 %)
The number (and %) of a zero Betweenness Centrality7 (21.88 %)

ACTIVE INTERACTORS


List of the fusions

PPI for parental proteins: FUNDC1,PTBP3 All fusions
Proteins found in more fusions MATR3 (see 4 fusions); CTBP1 (see 2 fusions); CTBP2 (see 2 fusions); APP (see 5 fusions); SNX1 (see 1 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 FUNDC1parental protein150.048314.713FUN14 (PF04930, IPR007014): FUN14 family
2 PTBP3parental protein150.210247.152RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
RRM_5 (PF13893): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
3 APPprotein found in more fusions110.044159.784APP_N (PF02177, IPR015849, SM00006): Amyloid A4 N-terminal heparin-binding
Beta-APP (PF03494, IPR013803): Beta-amyloid peptide (beta-APP)
BUD22 (PF09073, IPR015158): BUD22
IncA (PF04156, IPR007285): IncA protein
Kunitz_BPTI (PF00014, IPR002223, SM00131): Kunitz/Bovine pancreatic trypsin inhibitor domain
APP_amyloid (PF10515, IPR019543): beta-amyloid precursor protein C-terminus
APP_Cu_bd (PF12924, IPR011178): Copper-binding of amyloid precursor, CuBD
APP_E2 (PF12925, IPR024329): E2 domain of amyloid precursor protein
4 BMI1oncoprotein60.40014.510zf-C3HC4_2 (PF13923): Zinc finger, C3HC4 type (RING finger)
RAWUL (PF16207, IPR032443): RAWUL domain RING finger- and WD40-associated ubiquitin-like
5 CALUinteractor30.33312.606EF-hand_6 (PF13405, IPR002048): EF-hand domain
EF-hand_7 (PF13499, IPR011992): EF-hand domain pair
EF-hand_8 (PF13833, IPR002048): EF-hand domain pair
6 CDC5Linteractor60.5008.515OmpH (PF03938, IPR005632, SM00935): Outer membrane protein (OmpH-like)
Pox_A_type_inc (PF04508, IPR007596): Viral A-type inclusion protein repeat
Cir_N (PF10197, IPR019339, SM01083): N-terminal domain of CBF1 interacting co-repressor CIR
Myb_DNA-binding (PF00249, IPR001005, SM00717): Myb-like DNA-binding domain
Myb_Cef (PF11831, IPR021786): pre-mRNA splicing factor component
Myb_DNA-bind_6 (PF13921): Myb-like DNA-binding domain
7 CDH2interactor31.0000Cadherin_C (PF01049, IPR000233): Cadherin cytoplasmic region
Cadherin_pro (PF08758, IPR014868, SM01055): Cadherin prodomain like
Cadherin (PF00028, IPR002126, SM00112): Cadherin domain
EphA2_TM (PF14575, IPR027936): Ephrin type-A receptor 2 transmembrane domain
Cadherin_3 (PF16184): Cadherin-like
8 CHEK1suppressor30.6673.733Pkinase (PF00069, IPR000719): Protein kinase domain
9 CTBP1protein found in more fusions40.3338.4732-Hacid_dh_C (PF02826, IPR006140): D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain
Cellsynth_D (PF03500, IPR022798): Cellulose synthase subunit D
10 CTBP2protein found in more fusions40.3338.3512-Hacid_dh_C (PF02826, IPR006140): D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain
11 EHHADHinteractor1002-Hacid_dh_C (PF02826, IPR006140): D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain
3HCDH (PF00725, IPR006108): 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain
3HCDH_N (PF02737, IPR006176): 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain
ECH_1 (PF00378, IPR001753): Enoyl-CoA hydratase/isomerase
12 ELAVL1oncoprotein80.09580.349RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
13 FUNDC2interactor200FUN14 (PF04930, IPR007014): FUN14 family
14 GABARAPL1interactor30.6671.033Atg8 (PF02991, IPR004241): Autophagy protein Atg8 ubiquitin like
VitD-bind_III (PF09164, IPR015247): Vitamin D binding protein, domain III
15 GABARAPL2interactor50.20034.784Atg8 (PF02991, IPR004241): Autophagy protein Atg8 ubiquitin like
16 ILF2interactor100.31168.788DZF (PF07528, IPR006561, SM00572): DZF domain
17 ILF3oncoprotein70.5718.411dsrm (PF00035, IPR014720, SM00358): Double-stranded RNA binding motif
DZF (PF07528, IPR006561, SM00572): DZF domain
18 MAP1LC3Ainteractor50.20048.687Atg8 (PF02991, IPR004241): Autophagy protein Atg8 ubiquitin like
19 MAP1LC3Binteractor30.6671.033Atg8 (PF02991, IPR004241): Autophagy protein Atg8 ubiquitin like
20 MATR3protein found in more fusions60.60029.898DUF1777 (PF08648, IPR013957): Protein of unknown function (DUF1777)
RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
zf-U1 (PF06220, IPR013085, SM00451): U1 zinc finger
Tim54 (PF11711, IPR021056): Inner membrane protein import complex subunit Tim54
zf-C2H2_jaz (PF12171, IPR022755): Zinc-finger double-stranded RNA-binding
RRM_5 (PF13893): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
FAM60A (PF15396, IPR026065): Protein Family FAM60A
21 MTERF3interactor3023.506mTERF (PF02536, IPR003690, SM00733): mTERF
Pex14_N (PF04695, IPR006785): Peroxisomal membrane anchor protein (Pex14p) conserved region
22 NENFinteractor50.60012.605Cyt-b5 (PF00173, IPR001199, SM01117): Cytochrome b5-like Heme/Steroid binding domain
23 NOTCH1suppressor31.0000Ank (PF00023, IPR002110, SM00248): Ankyrin repeat
EGF (PF00008, IPR000742, SM00181): EGF-like domain
EGF_2 (PF07974, IPR013111): EGF-like domain
EGF_alliinase (PF04863, IPR006947): Alliinase EGF-like domain
EGF_CA (PF07645, IPR001881, SM00179): Calcium-binding EGF domain
NOD (PF06816, IPR010660): NOTCH protein
NODP (PF07684, IPR011656): NOTCH protein
TFIIA (PF03153, IPR004855): Transcription factor IIA, alpha/beta subunit
Notch (PF00066, IPR000800, SM00004): LNR domain
DUF3454 (PF11936, IPR024600): Domain of unknown function (DUF3454)
hEGF (PF12661, IPR013032): Human growth factor-like EGF
cEGF (PF12662, IPR026823): Complement Clr-like EGF-like
Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies)
24 PPWD1interactor100DUF505 (PF04458, IPR007548): Protein of unknown function (DUF505)
Pro_isomerase (PF00160, IPR002130): Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD
WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
25 PRKCDBPsuppressor80.42933.515A1_Propeptide (PF07966, IPR012848): A1 Propeptide
PTRF_SDPR (PF15237, IPR026752): PTRF/SDPR family
26 SENP2interactor3011.575Peptidase_C48 (PF02902, IPR003653): Ulp1 protease family, C-terminal catalytic domain
27 SH3GLB1suppressor4026.340BAR (PF03114, IPR004148, SM00721): BAR domain
SH3_9 (PF14604, IPR001452): Variant SH3 domain
28 SLC25A46interactor100Mito_carr (PF00153, IPR018108): Mitochondrial carrier protein
29 SNX1protein found in more fusions304.684PX (PF00787, IPR001683, SM00312): PX domain
Sorting_nexin (PF03700, IPR005329): Sorting nexin, N-terminal domain
Vps5 (PF09325, IPR015404): Vps5 C terminal like
30 TUFMinteractor40.16760.476GTP_EFTU (PF00009, IPR000795): Elongation factor Tu GTP binding domain
GTP_EFTU_D2 (PF03144, IPR004161): Elongation factor Tu domain 2
GTP_EFTU_D3 (PF03143, IPR004160): Elongation factor Tu C-terminal domain
31 TXN2interactor31.0000Thioredoxin (PF00085, IPR013766): Thioredoxin
32 YES1oncoprotein3022.477Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
SH2 (PF00017, IPR000980, SM00252): SH2 domain
YdjC (PF04794, IPR006879): YdjC-like protein
SH3_1 (PF00018, IPR001452, SM00326): SH3 domain

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