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Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: parental proteins FUNDC1 (from a repository: Mon Dec 9 12:55:52 2019)
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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)16
The number (and %) of the onco-proteins4 (25.00 %)
The number (and %) of the tumor suppressors1 (6.25 %)
Total number of binary PPIs (saturation %)25 (20.83 %)
The number (and %) of affected PPIs15 (60.00 %)
The number of possible different fusions4
PPI diameter2
PPI radius1
The average degree of PPI2.500
Assortativity coefficient-0.5245
The network average Clustering coefficient0.295
The number (and %) of a zero Clustering coefficients9 (56.25 %)
The number (and %) of a zero Betweenness Centrality11 (68.75 %)

ACTIVE INTERACTORS


List of the fusions

PPI for parental proteins: FUNDC1 All fusions
Proteins found in more fusions CTBP1 (see 2 fusions); CTBP2 (see 2 fusions); SNX1 (see 1 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 FUNDC1parental protein150.048197.333FUN14 (PF04930, IPR007014): FUN14 family
2 CTBP1protein found in more fusions31.00002-Hacid_dh_C (PF02826, IPR006140): D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain
Cellsynth_D (PF03500, IPR022798): Cellulose synthase subunit D
3 CTBP2protein found in more fusions31.00002-Hacid_dh_C (PF02826, IPR006140): D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain
4 EHHADHinteractor1002-Hacid_dh_C (PF02826, IPR006140): D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain
3HCDH (PF00725, IPR006108): 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain
3HCDH_N (PF02737, IPR006176): 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain
ECH_1 (PF00378, IPR001753): Enoyl-CoA hydratase/isomerase
5 FUNDC2interactor200FUN14 (PF04930, IPR007014): FUN14 family
6 GABARAPL1interactor30.6670.667Atg8 (PF02991, IPR004241): Autophagy protein Atg8 ubiquitin like
VitD-bind_III (PF09164, IPR015247): Vitamin D binding protein, domain III
7 GABARAPL2interactor30.6670.667Atg8 (PF02991, IPR004241): Autophagy protein Atg8 ubiquitin like
8 MAP1LC3Ainteractor30.6670.667Atg8 (PF02991, IPR004241): Autophagy protein Atg8 ubiquitin like
9 MAP1LC3Binteractor30.6670.667Atg8 (PF02991, IPR004241): Autophagy protein Atg8 ubiquitin like
10 MTERF3interactor100mTERF (PF02536, IPR003690, SM00733): mTERF
Pex14_N (PF04695, IPR006785): Peroxisomal membrane anchor protein (Pex14p) conserved region
11 SENP2interactor100Peptidase_C48 (PF02902, IPR003653): Ulp1 protease family, C-terminal catalytic domain
12 SH3GLB1suppressor200BAR (PF03114, IPR004148, SM00721): BAR domain
SH3_9 (PF14604, IPR001452): Variant SH3 domain
13 SLC25A46interactor100Mito_carr (PF00153, IPR018108): Mitochondrial carrier protein
14 SNX1protein found in more fusions200PX (PF00787, IPR001683, SM00312): PX domain
Sorting_nexin (PF03700, IPR005329): Sorting nexin, N-terminal domain
Vps5 (PF09325, IPR015404): Vps5 C terminal like
15 TUFMinteractor100GTP_EFTU (PF00009, IPR000795): Elongation factor Tu GTP binding domain
GTP_EFTU_D2 (PF03144, IPR004161): Elongation factor Tu domain 2
GTP_EFTU_D3 (PF03143, IPR004160): Elongation factor Tu C-terminal domain
16 YES1oncoprotein100Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
SH2 (PF00017, IPR000980, SM00252): SH2 domain
YdjC (PF04794, IPR006879): YdjC-like protein
SH3_1 (PF00018, IPR001452, SM00326): SH3 domain

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