1 |
U2AF2 | parental protein | 349 | 0.094 | 47314.084 | RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Transformer (PF06495, IPR010519): Fruit fly transformer protein |
2 |
NACC2 | parental protein | 11 | 0.667 | 24.297 | BTB (PF00651, IPR013069, SM00225): BTB/POZ domain BEN (PF10523, IPR018379, SM01025): BEN domain |
3 |
ACIN1 | interactor | 41 | 0.440 | 80.104 | Calc_CGRP_IAPP (PF00214, IPR021116): Calcitonin / CGRP / IAPP family CENP-B_dimeris (PF09026, IPR015115): Centromere protein B dimerisation domain DUF755 (PF05501, IPR008474): Domain of unknown function (DUF755) OAD_gamma (PF04277, IPR005899): Oxaloacetate decarboxylase, gamma chain Pinin_SDK_memA (PF04696, IPR006786): pinin/SDK/memA/ protein conserved region Ribosomal_60s (PF00428, IPR001813): 60s Acidic ribosomal protein RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) SAP (PF02037, IPR003034, SM00513): SAP domain V_ATPase_I (PF01496, IPR002490): V-type ATPase 116kDa subunit family FAM27 (PF15832, IPR031672): FAM27 D and E protein family DUF4746 (PF15928, IPR031827): Domain of unknown function (DUF4746) RSB_motif (PF16294, IPR032552): RNSP1-SAP18 binding (RSB) motif SWIRM-assoc_2 (PF16496, IPR032450): SWIRM-associated domain at the N-terminal |
4 |
AES | protein found in more fusions | 11 | 0.244 | 15.403 | TLE_N (PF03920, IPR005617): Groucho/TLE N-terminal Q-rich domain |
5 |
AHNAK | suppressor | 24 | 0.435 | 38.543 | DUF945 (PF06097, IPR010352): Bacterial protein of unknown function (DUF945) ELFV_dehydrog_N (PF02812, IPR006097): Glu/Leu/Phe/Val dehydrogenase, dimerisation domain T2SSN (PF01203, IPR022792): Type II secretion system (T2SS), protein N PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF) TT_ORF2a (PF08197, IPR013267): pORF2a truncated protein DUF2993 (PF11209, IPR021373): Protein of unknown function (DUF2993) DUF4097 (PF13349, IPR025164): Putative adhesin Ntox37 (PF15535, IPR029108): Bacterial toxin 37 |
6 |
AK2 | interactor | 8 | 0.714 | 2.306 | ADK (PF00406, IPR000850): Adenylate kinase AAA_33 (PF13671): AAA domain |
7 |
ALYREF | interactor | 42 | 0.483 | 76.015 | FYTT (PF07078, IPR009782): Forty-two-three protein RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) FoP_duplication (PF13865, IPR025715): C-terminal duplication domain of Friend of PRMT1 |
8 |
ANP32A | suppressor | 10 | 0.444 | 10.443 | SDA1 (PF05285, IPR007949): SDA1 LRR_4 (PF12799, IPR025875): Leucine Rich repeats (2 copies) LRR_9 (PF14580): Leucine-rich repeat |
9 |
ANXA1 | suppressor | 12 | 0.527 | 6.288 | Annexin (PF00191, IPR018502, SM00335): Annexin |
10 |
ANXA2 | interactor | 19 | 0.497 | 20.655 | Annexin (PF00191, IPR018502, SM00335): Annexin |
11 |
ANXA5 | oncoprotein | 12 | 0.470 | 8.544 | Annexin (PF00191, IPR018502, SM00335): Annexin |
12 |
ANXA6 | interactor | 6 | 0.733 | 1.559 | Annexin (PF00191, IPR018502, SM00335): Annexin |
13 |
APBB1 | interactor | 28 | 0.268 | 86.152 | PID (PF00640, IPR006020, SM00462): Phosphotyrosine interaction domain (PTB/PID) WW (PF00397, IPR001202, SM00456): WW domain RNA_pol_3_Rpc31 (PF11705, IPR024661): DNA-directed RNA polymerase III subunit Rpc31 PID_2 (PF14719, IPR006020): Phosphotyrosine interaction domain (PTB/PID) |
14 |
APOA1 | interactor | 3 | 1.000 | 0 | ApoA-II (PF04711, IPR006801): Apolipoprotein A-II (ApoA-II) Apolipoprotein (PF01442, IPR000074): Apolipoprotein A1/A4/E domain Gp-FAR-1 (PF05823, IPR008632): Nematode fatty acid retinoid binding protein (Gp-FAR-1) |
15 |
ARHGDIA | interactor | 20 | 0.386 | 41.542 | Rho_GDI (PF02115, IPR000406): RHO protein GDP dissociation inhibitor |
16 |
ARHGDIB | interactor | 3 | 0.667 | 0.667 | Rho_GDI (PF02115, IPR000406): RHO protein GDP dissociation inhibitor |
17 |
ARPC1B | interactor | 6 | 0.600 | 2.619 | WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat |
18 |
ATIC | oncoprotein | 12 | 0.439 | 8.745 | AICARFT_IMPCHas (PF01808, IPR002695, SM00798): AICARFT/IMPCHase bienzyme MGS (PF02142, IPR011607, SM00851): MGS-like domain |
19 |
ATXN1 | protein found in more fusions | 14 | 0.282 | 33.262 | AXH (PF08517, IPR013723, SM00536): Ataxin-1 and HBP1 module (AXH) Spt20 (PF12090, IPR021950): Spt20 family ATXN-1_C (PF12547, IPR020997): Capicua transcriptional repressor modulator Cnd1_N (PF12922, IPR024324): non-SMC mitotic condensation complex subunit 1, N-term |
20 |
BARD1 | suppressor | 48 | 0.266 | 193.737 | BRCT (PF00533, IPR001357, SM00292): BRCA1 C Terminus (BRCT) domain Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies) Ank_5 (PF13857): Ankyrin repeats (many copies) zf-RING_6 (PF14835): zf-RING of BARD1-type protein BRCT_2 (PF16589, IPR001357): BRCT domain, a BRCA1 C-terminus domain |
21 |
BCAS2 | interactor | 29 | 0.559 | 28.743 | BCAS2 (PF05700, IPR008409): Breast carcinoma amplified sequence 2 (BCAS2) ZapB (PF06005, IPR009252): Cell division protein ZapB |
22 |
BEND7 | interactor | 2 | 0 | 0 | BEN (PF10523, IPR018379, SM01025): BEN domain |
23 |
CALCOCO2 | interactor | 7 | 0.467 | 4.484 | bZIP_1 (PF00170, IPR004827): bZIP transcription factor CALCOCO1 (PF07888, IPR012852): Calcium binding and coiled-coil domain (CALCOCO1) like DUF641 (PF04859, IPR006943): Plant protein of unknown function (DUF641) OmpH (PF03938, IPR005632, SM00935): Outer membrane protein (OmpH-like) Jnk-SapK_ap_N (PF09744, IPR019143): JNK_SAPK-associated protein-1 GAS (PF13851, IPR025593): Growth-arrest specific micro-tubule binding zf-C2H2_4 (PF13894): C2H2-type zinc finger |
24 |
CALM1 | interactor | 24 | 0.406 | 27.070 | EF-hand_7 (PF13499, IPR011992): EF-hand domain pair |
25 |
CALR | oncoprotein | 28 | 0.413 | 53.812 | Calreticulin (PF00262, IPR001580): Calreticulin family DDHD (PF02862, IPR004177, SM01127): DDHD domain |
26 |
CAND1 | interactor | 130 | 0.259 | 1192.659 | Adaptin_N (PF01602, IPR002553): Adaptin N terminal region DUF1981 (PF09324, IPR015403): Domain of unknown function (DUF1981) HEAT (PF02985, IPR000357): HEAT repeat TIP120 (PF08623, IPR013932): TATA-binding protein interacting (TIP20) RTP1_C1 (PF10363, IPR019451): Required for nuclear transport of RNA pol II C-terminus 1 DUF3385 (PF11865, IPR024585): Domain of unknown function (DUF3385) MMS19_C (PF12460, IPR024687): RNAPII transcription regulator C-terminal Cnd1 (PF12717, IPR032682): non-SMC mitotic condensation complex subunit 1 Vac14_Fab1_bd (PF12755, IPR032878): Vacuolar 14 Fab1-binding region HEAT_EZ (PF13513): HEAT-like repeat HEAT_2 (PF13646): HEAT repeats MMS19_N (PF14500): Dos2-interacting transcription regulator of RNA-Pol-II |
27 |
CANX | interactor | 28 | 0.455 | 38.342 | Calreticulin (PF00262, IPR001580): Calreticulin family DUF1510 (PF07423, IPR009988): Protein of unknown function (DUF1510) TRAP_alpha (PF03896, IPR005595): Translocon-associated protein (TRAP), alpha subunit |
28 |
CAP1 | interactor | 11 | 0.467 | 7.394 | CAP_C (PF08603, IPR013912): Adenylate cyclase associated (CAP) C terminal CAP_N (PF01213, IPR013992): Adenylate cyclase associated (CAP) N terminal Mito_fiss_reg (PF05308, IPR007972): Mitochondrial fission regulator |
29 |
CAPZB | interactor | 10 | 0.600 | 1.248 | Cytochrom_B562 (PF07361, IPR009155): Cytochrome b562 F_actin_cap_B (PF01115, IPR001698): F-actin capping protein, beta subunit |
30 |
CCAR1 | suppressor | 12 | 0.424 | 6.993 | Cucumo_2B (PF03263, IPR004946): Cucumovirus protein 2B DUF1777 (PF08648, IPR013957): Protein of unknown function (DUF1777) DUF972 (PF06156, IPR010377): Protein of unknown function (DUF972) IncA (PF04156, IPR007285): IncA protein Presenilin (PF01080, IPR001108): Presenilin SAP (PF02037, IPR003034, SM00513): SAP domain FimP (PF09766, IPR019163): Fms-interacting protein DBC1 (PF14443, IPR025954, SM01122): DBC1 DUF4407 (PF14362, IPR025519): Domain of unknown function (DUF4407) S1-like (PF14444, IPR025223): S1-like DUF4481 (PF14800, IPR028054): Domain of unknown function (DUF4481) FAM176 (PF14851): FAM176 family |
31 |
CCT2 | interactor | 32 | 0.468 | 76.784 | Cpn60_TCP1 (PF00118, IPR002423): TCP-1/cpn60 chaperonin family |
32 |
CCT6A | interactor | 20 | 0.516 | 30.669 | Cpn60_TCP1 (PF00118, IPR002423): TCP-1/cpn60 chaperonin family |
33 |
CCT8 | interactor | 19 | 0.591 | 20.548 | Cpn60_TCP1 (PF00118, IPR002423): TCP-1/cpn60 chaperonin family |
34 |
CDC37 | protein found in more fusions | 29 | 0.312 | 84.812 | CDC37_C (PF08564, IPR013873, SM01069): Cdc37 C terminal domain CDC37_M (PF08565, IPR013874, SM01070): Cdc37 Hsp90 binding domain CDC37_N (PF03234, IPR013855, SM01071): Cdc37 N terminal kinase binding Rho_Binding (PF08912, IPR015008): Rho Binding TMF_DNA_bd (PF12329, IPR022092): TATA element modulatory factor 1 DNA binding |
35 |
CDC5L | interactor | 117 | 0.272 | 1279.638 | OmpH (PF03938, IPR005632, SM00935): Outer membrane protein (OmpH-like) Pox_A_type_inc (PF04508, IPR007596): Viral A-type inclusion protein repeat Cir_N (PF10197, IPR019339, SM01083): N-terminal domain of CBF1 interacting co-repressor CIR Myb_DNA-binding (PF00249, IPR001005, SM00717): Myb-like DNA-binding domain Myb_Cef (PF11831, IPR021786): pre-mRNA splicing factor component Myb_DNA-bind_6 (PF13921): Myb-like DNA-binding domain |
36 |
CDV3 | interactor | 5 | 0.700 | 2.431 | TraT (PF05818, IPR008874): Enterobacterial TraT complement resistance protein CDV3 (PF15359, IPR026806): Carnitine deficiency-associated protein 3 |
37 |
CERK | interactor | 4 | 0.833 | 0.286 | DAGK_cat (PF00781, IPR001206, SM00046): Diacylglycerol kinase catalytic domain |
38 |
CFL1 | protein found in more fusions | 26 | 0.335 | 75.521 | Cofilin_ADF (PF00241, IPR002108, SM00102): Cofilin/tropomyosin-type actin-binding protein |
39 |
CHD4 | oncoprotein | 24 | 0.486 | 140.341 | CDC27 (PF09507, IPR019038): DNA polymerase subunit Cdc27 CHDCT2 (PF08074, IPR012957): CHDCT2 (NUC038) domain CHDNT (PF08073, IPR012958): CHDNT (NUC034) domain Chromo (PF00385, IPR023780, SM00298): Chromo (CHRromatin Organisation MOdifier) domain DTHCT (PF08070, IPR012542): DTHCT (NUC029) region DUF1086 (PF06461, IPR009462, SM01146): Domain of Unknown Function (DUF1086) DUF1087 (PF06465, IPR009463, SM01147): Domain of Unknown Function (DUF1087) PHD (PF00628, IPR019787, SM00249): PHD-finger Ribosomal_60s (PF00428, IPR001813): 60s Acidic ribosomal protein SNF2_N (PF00176, IPR000330): SNF2 family N-terminal domain Helicase_C (PF00271, IPR001650, SM00490): Helicase conserved C-terminal domain FAM176 (PF14851): FAM176 family Coilin_N (PF15862, IPR031722): Coilin N-terminus |
40 |
CHD8 | oncoprotein | 9 | 0.500 | 4.674 | BUD22 (PF09073, IPR015158): BUD22 CHDCT2 (PF08074, IPR012957): CHDCT2 (NUC038) domain Chromo (PF00385, IPR023780, SM00298): Chromo (CHRromatin Organisation MOdifier) domain SelP_N (PF04592, IPR007671): Selenoprotein P, N terminal region SNF2_N (PF00176, IPR000330): SNF2 family N-terminal domain BRK (PF07533, IPR006576, SM00592): BRK domain SR-25 (PF10500, IPR019532): Nuclear RNA-splicing-associated protein Helicase_C (PF00271, IPR001650, SM00490): Helicase conserved C-terminal domain FAM176 (PF14851): FAM176 family Myb_DNA-bind_7 (PF15963): Myb DNA-binding like |
41 |
CHERP | interactor | 20 | 0.537 | 14.319 | CTD_bind (PF04818, IPR006903): RNA polymerase II-binding domain. G-patch (PF01585, IPR000467, SM00443): G-patch domain HpaP (PF09483, IPR013390): Type III secretion protein (HpaP) SRP-alpha_N (PF04086, IPR007222): Signal recognition particle, alpha subunit, N-terminal TFIIA (PF03153, IPR004855): Transcription factor IIA, alpha/beta subunit TP2 (PF01254, IPR000678): Nuclear transition protein 2 Apt1 (PF10351, IPR019443): Golgi-body localisation protein domain Surp (PF01805, IPR000061, SM00648): Surp module |
42 |
CHIC2 | oncoprotein | 2 | 1.000 | 0 | Erf4 (PF10256, IPR019383): Golgin subfamily A member 7/ERF4 family |
43 |
CHTOP | interactor | 8 | 0.643 | 0.585 | API5 (PF05918, IPR008383): Apoptosis inhibitory protein 5 (API5) Lamprin (PF06403, IPR009437): Lamprin FoP_duplication (PF13865, IPR025715): C-terminal duplication domain of Friend of PRMT1 |
44 |
CLIC1 | interactor | 8 | 0.607 | 3.968 | GST_N_2 (PF13409, IPR004045): Glutathione S-transferase, N-terminal domain GST_C_2 (PF13410): Glutathione S-transferase, C-terminal domain |
45 |
CLTC | oncoprotein | 30 | 0.425 | 57.340 | Clathrin-link (PF09268, IPR015348): Clathrin, heavy-chain linker Clathrin_propel (PF01394, IPR022365): Clathrin propeller repeat Clathrin (PF00637, IPR000547, SM00299): Region in Clathrin and VPS Clathrin_H_link (PF13838): Clathrin-H-link |
46 |
CNN2 | interactor | 5 | 0.500 | 3.153 | Calponin (PF00402, IPR000557): Calponin family repeat CH (PF00307, IPR001715, SM00033): Calponin homology (CH) domain |
47 |
COPS5 | protein found in more fusions | 128 | 0.240 | 1236.733 | JAB (PF01398, IPR000555, SM00232): JAB1/Mov34/MPN/PAD-1 ubiquitin protease |
48 |
CORO1A | oncoprotein | 3 | 0.667 | 1.000 | DUF1899 (PF08953, IPR015048, SM01166): Domain of unknown function (DUF1899) Trimer_CC (PF08954, IPR015049, SM01167): Trimerisation motif WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain WD40_4 (PF16300): Type of WD40 repeat |
49 |
COX7A2L | interactor | 2 | 1.000 | 0 | COX7a (PF02238, IPR003177): Cytochrome c oxidase subunit VII |
50 |
CPSF6 | interactor | 26 | 0.495 | 19.671 | RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) PRP38_assoc (PF12871, IPR024767): Pre-mRNA-splicing factor 38-associated hydrophilic C-term PRIMA1 (PF16101): Proline-rich membrane anchor 1 |
51 |
CUL1 | suppressor | 119 | 0.261 | 1145.482 | Cullin (PF00888, IPR001373, SM00182): Cullin family Cullin_Nedd8 (PF10557, IPR019559, SM00884): Cullin protein neddylation domain |
52 |
CUL3 | protein found in more fusions | 168 | 0.202 | 2719.069 | Cullin (PF00888, IPR001373, SM00182): Cullin family Cullin_Nedd8 (PF10557, IPR019559, SM00884): Cullin protein neddylation domain WAC_Acf1_DNA_bd (PF10537, IPR013136): ATP-utilising chromatin assembly and remodelling N-terminal |
53 |
CUL5 | suppressor | 85 | 0.284 | 502.470 | Cullin (PF00888, IPR001373, SM00182): Cullin family GlutR_dimer (PF00745, IPR015896): Glutamyl-tRNAGlu reductase, dimerisation domain Cullin_Nedd8 (PF10557, IPR019559, SM00884): Cullin protein neddylation domain |
54 |
CUL7 | protein found in more fusions | 181 | 0.142 | 4066.210 | ANAPC10 (PF03256, IPR004939): Anaphase-promoting complex, subunit 10 (APC10) Cullin (PF00888, IPR001373, SM00182): Cullin family DUF1918 (PF08940, IPR015035): Domain of unknown function (DUF1918) Cullin_Nedd8 (PF10557, IPR019559, SM00884): Cullin protein neddylation domain Cul7 (PF11515, IPR021097): Mouse development and cellular proliferation protein Cullin-7 |
55 |
DACH1 | suppressor | 5 | 0.500 | 3.372 | DUF508 (PF04370, IPR007465): Domain of unknown function (DUF508) Pap_E4 (PF02711, IPR003861): E4 protein Ribosomal_60s (PF00428, IPR001813): 60s Acidic ribosomal protein Secretin_N_2 (PF07655, IPR011514): Secretin N-terminal domain Ski_Sno (PF02437, IPR003380): SKI/SNO/DAC family Macoilin (PF09726, IPR019130): Transmembrane protein SR-25 (PF10500, IPR019532): Nuclear RNA-splicing-associated protein |
56 |
DARS | interactor | 14 | 0.560 | 6.939 | tRNA-synt_2 (PF00152, IPR004364): tRNA synthetases class II (D, K and N) tRNA_anti-codon (PF01336, IPR004365): OB-fold nucleic acid binding domain |
57 |
DDX17 | protein found in more fusions | 54 | 0.451 | 130.722 | CAP_N (PF01213, IPR013992): Adenylate cyclase associated (CAP) N terminal DEAD (PF00270, IPR011545): DEAD/DEAH box helicase Ferritin (PF00210, IPR008331): Ferritin-like domain GRP (PF07172, IPR010800): Glycine rich protein family Helicase_C (PF00271, IPR001650, SM00490): Helicase conserved C-terminal domain |
58 |
DDX21 | interactor | 44 | 0.388 | 103.710 | CRT10 (PF08728, IPR014839): CRT10 DEAD (PF00270, IPR011545): DEAD/DEAH box helicase GUCT (PF08152, IPR012562): GUCT (NUC152) domain Sulfatase (PF00884, IPR000917): Sulfatase MIP-T3 (PF10243): Microtubule-binding protein MIP-T3 Helicase_C (PF00271, IPR001650, SM00490): Helicase conserved C-terminal domain CPSF100_C (PF13299, IPR025069): Cleavage and polyadenylation factor 2 C-terminal |
59 |
DDX39B | interactor | 21 | 0.490 | 19.981 | DEAD (PF00270, IPR011545): DEAD/DEAH box helicase Helicase_C (PF00271, IPR001650, SM00490): Helicase conserved C-terminal domain |
60 |
DDX3X | suppressor | 44 | 0.378 | 106.916 | DEAD (PF00270, IPR011545): DEAD/DEAH box helicase DUF755 (PF05501, IPR008474): Domain of unknown function (DUF755) Helicase_C (PF00271, IPR001650, SM00490): Helicase conserved C-terminal domain |
61 |
DDX5 | oncoprotein | 71 | 0.412 | 248.008 | DEAD (PF00270, IPR011545): DEAD/DEAH box helicase P68HR (PF08061, IPR012587): P68HR (NUC004) repeat ResIII (PF04851, IPR006935): Type III restriction enzyme, res subunit Helicase_C (PF00271, IPR001650, SM00490): Helicase conserved C-terminal domain |
62 |
DHX15 | interactor | 62 | 0.418 | 246.173 | DEAD (PF00270, IPR011545): DEAD/DEAH box helicase OB_NTP_bind (PF07717, IPR011709): Oligonucleotide/oligosaccharide-binding (OB)-fold DUF1777 (PF08648, IPR013957): Protein of unknown function (DUF1777) HA2 (PF04408, IPR007502, SM00847): Helicase associated domain (HA2) Helicase_C (PF00271, IPR001650, SM00490): Helicase conserved C-terminal domain AAA_29 (PF13555): P-loop containing region of AAA domain |
63 |
DHX9 | oncoprotein | 74 | 0.397 | 300.466 | DEAD (PF00270, IPR011545): DEAD/DEAH box helicase dsrm (PF00035, IPR014720, SM00358): Double-stranded RNA binding motif OB_NTP_bind (PF07717, IPR011709): Oligonucleotide/oligosaccharide-binding (OB)-fold T2SSE (PF00437, IPR001482): Type II/IV secretion system protein HA2 (PF04408, IPR007502, SM00847): Helicase associated domain (HA2) Helicase_C (PF00271, IPR001650, SM00490): Helicase conserved C-terminal domain |
64 |
DPPA2 | interactor | 3 | 1.000 | 0 | SAP (PF02037, IPR003034, SM00513): SAP domain DCR (PF14047, IPR025891): Dppa2/4 conserved region Dppa2_A (PF14049, IPR025892): Dppa2/4 conserved region in higher vertebrates |
65 |
DVL2 | interactor | 11 | 0.400 | 17.328 | DEP (PF00610, IPR000591, SM00049): Domain found in Dishevelled, Egl-10, and Pleckstrin (DEP) Dishevelled (PF02377, IPR003351): Dishevelled specific domain PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF) DIX (PF00778, IPR001158, SM00021): DIX domain Dsh_C (PF12316, IPR024580): Segment polarity protein dishevelled (Dsh) C terminal |
66 |
DYNC1H1 | interactor | 29 | 0.355 | 72.562 | AAA_5 (PF07728, IPR011704): AAA domain (dynein-related subfamily) DHC_N1 (PF08385, IPR013594): Dynein heavy chain, N-terminal region 1 DHC_N2 (PF08393, IPR013602): Dynein heavy chain, N-terminal region 2 DUF1664 (PF07889, IPR012458): Protein of unknown function (DUF1664) DUF948 (PF06103, IPR009293): Bacterial protein of unknown function (DUF948) Dynein_heavy (PF03028, IPR004273): Dynein heavy chain and region D6 of dynein motor Fib_alpha (PF08702, IPR012290): Fibrinogen alpha/beta chain family AAA_6 (PF12774): Hydrolytic ATP binding site of dynein motor region D1 AAA_7 (PF12775): P-loop containing dynein motor region D3 MT (PF12777, IPR024743): Microtubule-binding stalk of dynein motor AAA_8 (PF12780, IPR024317): P-loop containing dynein motor region D4 AAA_9 (PF12781): ATP-binding dynein motor region D5 |
67 |
EED | suppressor | 127 | 0.201 | 1541.958 | WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat Nup160 (PF11715, IPR021717): Nucleoporin Nup120/160 ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain |
68 |
EEF1A1 | suppressor | 68 | 0.319 | 346.981 | GTP_EFTU (PF00009, IPR000795): Elongation factor Tu GTP binding domain GTP_EFTU_D2 (PF03144, IPR004161): Elongation factor Tu domain 2 GTP_EFTU_D3 (PF03143, IPR004160): Elongation factor Tu C-terminal domain |
69 |
EEF1A1P5 | interactor | 3 | 0.667 | 0.087 | NA |
70 |
EEF1D | protein found in more fusions | 25 | 0.460 | 24.612 | EF1_GNE (PF00736, IPR014038, SM00888): EF-1 guanine nucleotide exchange domain EF-1_beta_acid (PF10587, IPR018940): Eukaryotic elongation factor 1 beta central acidic region |
71 |
EEF2 | interactor | 46 | 0.408 | 141.636 | EFG_C (PF00679, IPR000640, SM00838): Elongation factor G C-terminus EFG_IV (PF03764, IPR005517, SM00889): Elongation factor G, domain IV GTP_EFTU (PF00009, IPR000795): Elongation factor Tu GTP binding domain GTP_EFTU_D2 (PF03144, IPR004161): Elongation factor Tu domain 2 EFG_II (PF14492, IPR009022): Elongation Factor G, domain II |
72 |
EFTUD2 | interactor | 56 | 0.472 | 123.563 | EFG_C (PF00679, IPR000640, SM00838): Elongation factor G C-terminus EFG_IV (PF03764, IPR005517, SM00889): Elongation factor G, domain IV GTP_EFTU (PF00009, IPR000795): Elongation factor Tu GTP binding domain GTP_EFTU_D2 (PF03144, IPR004161): Elongation factor Tu domain 2 EFG_II (PF14492, IPR009022): Elongation Factor G, domain II EFTUD2 (PF16004, IPR031950): 116 kDa U5 small nuclear ribonucleoprotein component N-terminus |
73 |
EIF3A | oncoprotein | 16 | 0.475 | 10.429 | DUF1003 (PF06210, IPR010406): Protein of unknown function (DUF1003) Ly49 (PF08391, IPR013600): Ly49-like protein, N-terminal region PCI (PF01399, IPR000717, SM00088): PCI domain AIM3 (PF17096, IPR031370): Altered inheritance of mitochondria protein 3 |
74 |
EIF4A1 | interactor | 24 | 0.547 | 32.759 | DEAD (PF00270, IPR011545): DEAD/DEAH box helicase Helicase_C (PF00271, IPR001650, SM00490): Helicase conserved C-terminal domain |
75 |
EIF4A3 | interactor | 97 | 0.328 | 655.632 | DEAD (PF00270, IPR011545): DEAD/DEAH box helicase Helicase_C (PF00271, IPR001650, SM00490): Helicase conserved C-terminal domain |
76 |
EIF4H | interactor | 15 | 0.514 | 9.350 | eIF-4B (PF06273, IPR010433): Plant specific eukaryotic initiation factor 4B RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) |
77 |
EIF5A | interactor | 13 | 0.603 | 4.615 | EFP_N (PF08207, IPR013185): Elongation factor P (EF-P) KOW-like domain eIF-5a (PF01287, IPR020189): Eukaryotic elongation factor 5A hypusine, DNA-binding OB fold |
78 |
ELAVL1 | oncoprotein | 111 | 0.194 | 2392.251 | RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) |
79 |
EPRS | interactor | 24 | 0.446 | 34.383 | GST_C (PF00043, IPR004046): Glutathione S-transferase, C-terminal domain HGTP_anticodon (PF03129, IPR004154): Anticodon binding domain ProRS-C_1 (PF09180, IPR016061, SM00946): Prolyl-tRNA synthetase, C-terminal tRNA-synt_1c (PF00749, IPR020058): tRNA synthetases class I (E and Q), catalytic domain tRNA-synt_1c_C (PF03950, IPR020059): tRNA synthetases class I (E and Q), anti-codon binding domain tRNA-synt_2b (PF00587, IPR002314): tRNA synthetase class II core domain (G, H, P, S and T) WHEP-TRS (PF00458, IPR000738, SM00991): WHEP-TRS domain |
80 |
EPS8 | oncoprotein | 5 | 0 | 10.867 | DEC-1_N (PF04625, IPR006719): DEC-1 protein, N-terminal region Mito_fiss_reg (PF05308, IPR007972): Mitochondrial fission regulator PTB (PF08416, IPR013625): Phosphotyrosine-binding domain SAM_PNT (PF02198, IPR003118, SM00251): Sterile alpha motif (SAM)/Pointed domain SH3_1 (PF00018, IPR001452, SM00326): SH3 domain |
81 |
ESR1 | suppressor | 126 | 0.176 | 1880.584 | Oest_recep (PF02159, IPR001292): Oestrogen receptor zf-C4 (PF00105, IPR001628, SM00399): Zinc finger, C4 type (two domains) Hormone_recep (PF00104, IPR000536, SM00430): Ligand-binding domain of nuclear hormone receptor ESR1_C (PF12743, IPR024736): Oestrogen-type nuclear receptor final C-terminal |
82 |
ESYT1 | interactor | 3 | 0.667 | 0.044 | C2 (PF00168, IPR000008, SM00239): C2 domain SMP_LBD (PF17047, IPR031468): Synaptotagmin-like mitochondrial-lipid-binding domain |
83 |
EVL | oncoprotein | 7 | 0.467 | 3.218 | VASP_tetra (PF08776, IPR014885): VASP tetramerisation domain WH1 (PF00568, IPR000697, SM00461): WH1 domain |
84 |
EWSR1 | oncoprotein | 98 | 0.215 | 1378.470 | RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) SVS_QK (PF10578, IPR018942): Seminal vesicle protein repeat zf-RanBP (PF00641, IPR001876, SM00547): Zn-finger in Ran binding protein and others FoP_duplication (PF13865, IPR025715): C-terminal duplication domain of Friend of PRMT1 Keratin_2_head (PF16208, IPR032444): Keratin type II head |
85 |
EZH2 | suppressor | 63 | 0.237 | 369.400 | CDC45 (PF02724, IPR003874): CDC45-like protein TCR (PF03638, IPR005172, SM01114): Tesmin/TSO1-like CXC domain, cysteine-rich domain SET (PF00856, IPR001214, SM00317): SET domain EZH2_WD-Binding (PF11616, IPR021654): WD repeat binding protein EZH2 Spt5_N (PF11942, IPR022581): Spt5 transcription elongation factor, acidic N-terminal |
86 |
EZR | protein found in more fusions | 27 | 0.345 | 88.226 | DUF106 (PF01956, IPR002809): Integral membrane protein DUF106 ERM (PF00769, IPR011259): Ezrin/radixin/moesin family FERM_C (PF09380, IPR018980): FERM C-terminal PH-like domain FERM_M (PF00373, IPR019748): FERM central domain FERM_N (PF09379, IPR018979): FERM N-terminal domain |
87 |
FABP5 | interactor | 11 | 0.673 | 6.104 | Lipocalin (PF00061, IPR000566): Lipocalin / cytosolic fatty-acid binding protein family |
88 |
FAM107B | interactor | 2 | 1.000 | 0 | DUF1151 (PF06625, IPR009533): Protein of unknown function (DUF1151) SAE2 (PF08573, IPR013882): DNA repair protein endonuclease SAE2/CtIP C-terminus |
89 |
FBL | interactor | 36 | 0.503 | 38.457 | Fibrillarin (PF01269, IPR000692): Fibrillarin |
90 |
FLOT1 | interactor | 8 | 0.571 | 3.110 | CrtC (PF07143, IPR010791): CrtC N-terminal lipocalin domain Band_7 (PF01145, IPR001107, SM00244): SPFH domain / Band 7 family Flot (PF15975, IPR031905): Flotillin |
91 |
FLOT2 | interactor | 9 | 0.500 | 6.125 | YjbH (PF06082, IPR010344): Exopolysaccharide biosynthesis protein YbjH Band_7 (PF01145, IPR001107, SM00244): SPFH domain / Band 7 family Flot (PF15975, IPR031905): Flotillin |
92 |
FOXP3 | suppressor | 7 | 0.190 | 25.419 | Forkhead (PF00250, IPR001766, SM00339): Forkhead domain FOXP-CC (PF16159, IPR032354): FOXP coiled-coil domain |
93 |
FUBP1 | oncoprotein | 22 | 0.446 | 39.852 | DUF1897 (PF09005, IPR015096): Domain of unknown function (DUF1897) KH_1 (PF00013, IPR004088, SM00322): KH domain CYSTM (PF12734, IPR028144): Cysteine-rich TM module stress tolerance |
94 |
GANAB | suppressor | 16 | 0.475 | 26.557 | Glyco_hydro_31 (PF01055, IPR000322): Glycosyl hydrolases family 31 Gal_mutarotas_2 (PF13802, IPR025887): Galactose mutarotase-like DUF5110 (PF17137): Domain of unknown function (DUF5110) |
95 |
GBP1 | suppressor | 1 | 0 | 0 | GBP (PF02263, IPR015894): Guanylate-binding protein, N-terminal domain GBP_C (PF02841, IPR003191): Guanylate-binding protein, C-terminal domain |
96 |
GBP2 | interactor | 2 | 1.000 | 0 | GBP (PF02263, IPR015894): Guanylate-binding protein, N-terminal domain GBP_C (PF02841, IPR003191): Guanylate-binding protein, C-terminal domain |
97 |
GDI2 | interactor | 8 | 0.571 | 2.410 | GDI (PF00996, IPR018203): GDP dissociation inhibitor |
98 |
GIGYF2 | interactor | 14 | 0.560 | 4.453 | DUF1764 (PF08576, IPR013885): Eukaryotic protein of unknown function (DUF1764) GYF (PF02213, IPR003169, SM00444): GYF domain Macoilin (PF09726, IPR019130): Transmembrane protein Activator_LAG-3 (PF11498, IPR021587): Transcriptional activator LAG-3 DUF3801 (PF12687, IPR024234): Protein of unknown function (DUF3801) PRP38_assoc (PF12871, IPR024767): Pre-mRNA-splicing factor 38-associated hydrophilic C-term AAA_23 (PF13476): AAA domain ARGLU (PF15346): Arginine and glutamate-rich 1 PRTase_3 (PF15610, IPR028944): PRTase ComF-like Ferlin_C (PF16165, IPR032362): Ferlin C-terminus |
99 |
GLIS2 | interactor | 2 | 1.000 | 0 | zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain FOXP-CC (PF16159, IPR032354): FOXP coiled-coil domain |
100 |
GLUD1 | interactor | 6 | 0.667 | 0.118 | ELFV_dehydrog (PF00208, IPR006096, SM00839): Glutamate/Leucine/Phenylalanine/Valine dehydrogenase ELFV_dehydrog_N (PF02812, IPR006097): Glu/Leu/Phe/Val dehydrogenase, dimerisation domain SF3b10 (PF07189, IPR009846): Splicing factor 3B subunit 10 (SF3b10) |
101 |
GMFG | interactor | 1 | 0 | 0 | Cofilin_ADF (PF00241, IPR002108, SM00102): Cofilin/tropomyosin-type actin-binding protein |
102 |
GNAI2 | oncoprotein | 9 | 0.472 | 4.379 | G-alpha (PF00503, IPR001019, SM00275): G-protein alpha subunit |
103 |
GOT2 | oncoprotein | 5 | 0.700 | 0.759 | Aminotran_1_2 (PF00155, IPR004839): Aminotransferase class I and II |
104 |
GPI | interactor | 10 | 0.556 | 6.645 | PGI (PF00342, IPR001672): Phosphoglucose isomerase |
105 |
H2AFJ | interactor | 3 | 1.000 | 0 | Histone (PF00125, IPR007125): Core histone H2A/H2B/H3/H4 Histone_H2A_C (PF16211, IPR032454): C-terminus of histone H2A |
106 |
HCLS1 | interactor | 3 | 0.667 | 1.000 | HS1_rep (PF02218, IPR003134): Repeat in HS1/Cortactin SH3_1 (PF00018, IPR001452, SM00326): SH3 domain DUF3886 (PF13025, IPR024980): Protein of unknown function (DUF3886) TMEM210 (PF15195, IPR028123): TMEM210 family SPESP1 (PF15754, IPR026743): Sperm equatorial segment protein 1 |
107 |
HDAC1 | suppressor | 42 | 0.230 | 462.377 | FSAP_sig_propep (PF03032, IPR004275): Frog skin active peptide family signal and propeptide Hist_deacetyl (PF00850, IPR023801): Histone deacetylase domain |
108 |
HDAC2 | suppressor | 37 | 0.378 | 366.256 | Hist_deacetyl (PF00850, IPR023801): Histone deacetylase domain NARP1 (PF12569, IPR021183): NMDA receptor-regulated protein 1 |
109 |
HDGF | interactor | 40 | 0.290 | 111.565 | PWWP (PF00855, IPR000313, SM00293): PWWP domain |
110 |
HINT1 | suppressor | 14 | 0.423 | 19.969 | HIT (PF01230, IPR001310): HIT domain |
111 |
HK1 | interactor | 6 | 0.667 | 1.183 | Hexokinase_1 (PF00349, IPR022672): Hexokinase Hexokinase_2 (PF03727, IPR022673): Hexokinase |
112 |
HLA-DMA | interactor | 1 | 0 | 0 | MHC_II_alpha (PF00993, IPR001003, SM00920): Class II histocompatibility antigen, alpha domain C1-set (PF07654, IPR003597, SM00407): Immunoglobulin C1-set domain C1-set_C (PF16196, IPR032431): C1-set C-terminal domain |
113 |
HMGB1 | oncoprotein | 10 | 0.400 | 10.598 | HMG_box_2 (PF09011, IPR009071): HMG-box domain NOA36 (PF06524, IPR010531): NOA36 protein HMG_box (PF00505, IPR009071, SM00398): HMG (high mobility group) box |
114 |
HMGB2 | interactor | 6 | 0.600 | 1.765 | HMG_box_2 (PF09011, IPR009071): HMG-box domain NOA36 (PF06524, IPR010531): NOA36 protein HMG_box (PF00505, IPR009071, SM00398): HMG (high mobility group) box |
115 |
HN1L | interactor | 2 | 1.000 | 0 | JUPITER (PF17054): Microtubule-Associated protein Jupiter |
116 |
HNRNPA0 | interactor | 43 | 0.602 | 49.255 | SAP130_C (PF16014, IPR031963): Histone deacetylase complex subunit SAP130 C-terminus |
117 |
HNRNPA1 | interactor | 114 | 0.305 | 927.983 | RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) HnRNPA1 (PF11627, IPR021662): Nuclear factor hnRNPA1 |
118 |
HNRNPA2B1 | oncoprotein | 50 | 0.458 | 248.307 | RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) |
119 |
HNRNPA3 | oncoprotein | 48 | 0.505 | 76.732 | IATP (PF04568, IPR007648): Mitochondrial ATPase inhibitor, IATP RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) FoP_duplication (PF13865, IPR025715): C-terminal duplication domain of Friend of PRMT1 |
120 |
HNRNPAB | interactor | 35 | 0.541 | 48.963 | CBFNT (PF08143, IPR012956): CBFNT (NUC161) domain GRP (PF07172, IPR010800): Glycine rich protein family NID (PF07292, IPR009909): Nmi/IFP 35 domain (NID) RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) DUF2462 (PF09495, IPR019034): Protein of unknown function (DUF2462) |
121 |
HNRNPC | protein found in more fusions | 58 | 0.432 | 381.651 | APG6 (PF04111, IPR007243): Autophagy protein Apg6 RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) SURF2 (PF05477, IPR008833): Surfeit locus protein 2 (SURF2) |
122 |
HNRNPD | oncoprotein | 60 | 0.407 | 216.446 | CBFNT (PF08143, IPR012956): CBFNT (NUC161) domain NID (PF07292, IPR009909): Nmi/IFP 35 domain (NID) RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Keratin_2_head (PF16208, IPR032444): Keratin type II head |
123 |
HNRNPDL | interactor | 44 | 0.532 | 70.922 | CBFNT (PF08143, IPR012956): CBFNT (NUC161) domain RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) |
124 |
HNRNPF | interactor | 44 | 0.566 | 67.325 | RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Spot_14 (PF07084, IPR009786): Thyroid hormone-inducible hepatic protein Spot 14 zf-RNPHF (PF08080, IPR012996): RNPHF zinc finger |
125 |
HNRNPH1 | oncoprotein | 54 | 0.512 | 114.224 | RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) zf-RNPHF (PF08080, IPR012996): RNPHF zinc finger |
126 |
HNRNPK | oncoprotein | 83 | 0.383 | 437.769 | ROKNT (PF08067, IPR012987): ROKNT (NUC014) domain KH_1 (PF00013, IPR004088, SM00322): KH domain |
127 |
HNRNPL | protein found in more fusions | 48 | 0.515 | 86.658 | RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Dscam_C (PF12355, IPR021012): Down syndrome cell adhesion molecule C terminal RRM_5 (PF13893): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) |
128 |
HNRNPM | interactor | 75 | 0.379 | 298.953 | RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) HnRNP_M (PF11532, IPR024666): Heterogeneous nuclear ribonucleoprotein M Collagen_mid (PF15984, IPR031929): Bacterial collagen, middle region |
129 |
HNRNPR | interactor | 74 | 0.433 | 294.185 | RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Limkain-b1 (PF11608, IPR024582): Limkain b1 |
130 |
HNRNPU | interactor | 101 | 0.336 | 630.086 | CDC45 (PF02724, IPR003874): CDC45-like protein Ribosomal_60s (PF00428, IPR001813): 60s Acidic ribosomal protein SAP (PF02037, IPR003034, SM00513): SAP domain SPRY (PF00622, IPR003877, SM00449): SPRY domain AAA_33 (PF13671): AAA domain WRNPLPNID (PF15017): Putative WW-binding domain and destruction box |
131 |
HSP90AA1 | oncoprotein | 61 | 0.324 | 337.202 | HATPase_c (PF02518, IPR003594, SM00387): Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HSP90 (PF00183, IPR001404): Hsp90 protein |
132 |
HSP90AB1 | oncoprotein | 53 | 0.353 | 217.064 | HATPase_c (PF02518, IPR003594, SM00387): Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HSP90 (PF00183, IPR001404): Hsp90 protein |
133 |
HSP90B1 | suppressor | 33 | 0.420 | 60.602 | CobT (PF06213, IPR006538): Cobalamin biosynthesis protein CobT HATPase_c (PF02518, IPR003594, SM00387): Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HSP90 (PF00183, IPR001404): Hsp90 protein Sigma70_ner (PF04546, IPR007631): Sigma-70, non-essential region |
134 |
HSPA1A | interactor | 35 | 0.434 | 236.777 | HSP70 (PF00012, IPR013126): Hsp70 protein |
135 |
HSPA5 | oncoprotein | 71 | 0.349 | 390.825 | HSP70 (PF00012, IPR013126): Hsp70 protein |
136 |
HSPA8 | oncoprotein | 49 | 0.359 | 239.457 | HSP70 (PF00012, IPR013126): Hsp70 protein |
137 |
HSPA9 | oncoprotein | 32 | 0.466 | 50.812 | HSP70 (PF00012, IPR013126): Hsp70 protein |
138 |
HSPD1 | suppressor | 38 | 0.432 | 133.786 | Cpn60_TCP1 (PF00118, IPR002423): TCP-1/cpn60 chaperonin family |
139 |
HSPE1 | interactor | 29 | 0.249 | 159.169 | Cpn10 (PF00166, IPR020818, SM00883): Chaperonin 10 Kd subunit |
140 |
HSPH1 | oncoprotein | 24 | 0.449 | 43.079 | HSP70 (PF00012, IPR013126): Hsp70 protein SICA_alpha (PF12887, IPR024290): SICA extracellular alpha domain |
141 |
HUWE1 | oncoprotein | 105 | 0.159 | 1555.828 | BUD22 (PF09073, IPR015158): BUD22 DUF908 (PF06012, IPR010309): Domain of Unknown Function (DUF908) DUF913 (PF06025, IPR010314): Domain of Unknown Function (DUF913) FdhE (PF04216, IPR006452): Protein involved in formate dehydrogenase formation HABP4_PAI-RBP1 (PF04774, IPR006861): Hyaluronan / mRNA binding family Ku_C (PF03730, IPR005160): Ku70/Ku80 C-terminal arm Merozoite_SPAM (PF07133, IPR010784): Merozoite surface protein (SPAM) Mucin (PF01456, IPR000458): Mucin-like glycoprotein Nop14 (PF04147, IPR007276): Nop14-like family PBP_sp32 (PF07222, IPR009865): Proacrosin binding protein sp32 RNA_pol_Rpc4 (PF05132, IPR007811): RNA polymerase III RPC4 TFIIA (PF03153, IPR004855): Transcription factor IIA, alpha/beta subunit UBA (PF00627, IPR000449, SM00165): UBA/TS-N domain WWE (PF02825, IPR004170, SM00678): WWE domain HECT (PF00632, IPR000569, SM00119): HECT-domain (ubiquitin-transferase) Tim54 (PF11711, IPR021056): Inner membrane protein import complex subunit Tim54 U1snRNP70_N (PF12220, IPR022023): U1 small nuclear ribonucleoprotein of 70kDa MW N terminal DUF4414 (PF14377, IPR025527): Domain of unknown function (DUF4414) |
142 |
IFI16 | suppressor | 25 | 0.197 | 98.585 | HIN (PF02760, |