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Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: parental proteins MKLN1, COL5A2 (from a repository: Fri Nov 30 03:56:24 2018)
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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)28
The number (and %) of the onco-proteins8 (28.57 %)
The number (and %) of the tumor suppressors3 (10.71 %)
Total number of binary PPIs (saturation %)90 (23.81 %)
The number (and %) of affected PPIs27 (30.00 %)
The number of possible different fusions6
PPI diameter5
PPI radius3
The average degree of PPI5.786
Assortativity coefficient-0.4065
The network average Clustering coefficient0.647
The number (and %) of a zero Clustering coefficients5 (17.86 %)
The number (and %) of a zero Betweenness Centrality17 (60.71 %)

ACTIVE INTERACTORS


List of the fusions

Proteins found in more fusions RANBP9 (see 2 fusions); EWSR1 (see 2 fusions); MKLN1 (see 2 fusions); MYC (see 2 fusions); TGM2 (see 4 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 MKLN1parental protein250.196374.767Muskelin_N (PF06588, IPR010565): Muskelin N-terminus
Kelch_1 (PF01344, IPR006652, SM00612): Kelch motif
Kelch_3 (PF13415): Galactose oxidase, central domain
Kelch_5 (PF13854): Kelch motif
Kelch_6 (PF13964): Kelch motif
2 COL5A2parental protein2052.000COLFI (PF01410, IPR000885, SM00038): Fibrillar collagen C-terminal domain
Collagen (PF01391, IPR008160): Collagen triple helix repeat (20 copies)
VWC (PF00093, IPR001007, SM00214): von Willebrand factor type C domain
3 ADCYAP1interactor21.0000Hormone_2 (PF00123, IPR000532, SM00070): Peptide hormone
4 DYNC1H1interactor40.6672.000AAA_5 (PF07728, IPR011704): AAA domain (dynein-related subfamily)
DHC_N1 (PF08385, IPR013594): Dynein heavy chain, N-terminal region 1
DHC_N2 (PF08393, IPR013602): Dynein heavy chain, N-terminal region 2
DUF1664 (PF07889, IPR012458): Protein of unknown function (DUF1664)
DUF948 (PF06103, IPR009293): Bacterial protein of unknown function (DUF948)
Dynein_heavy (PF03028, IPR004273): Dynein heavy chain and region D6 of dynein motor
Fib_alpha (PF08702, IPR012290): Fibrinogen alpha/beta chain family
AAA_6 (PF12774): Hydrolytic ATP binding site of dynein motor region D1
AAA_7 (PF12775): P-loop containing dynein motor region D3
MT (PF12777, IPR024743): Microtubule-binding stalk of dynein motor
AAA_8 (PF12780, IPR024317): P-loop containing dynein motor region D4
AAA_9 (PF12781): ATP-binding dynein motor region D5
5 ELAVL1oncoprotein60.400146.000RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
6 EWSR1oncoprotein30100.000RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
SVS_QK (PF10578, IPR018942): Seminal vesicle protein repeat
zf-RanBP (PF00641, IPR001876, SM00547): Zn-finger in Ran binding protein and others
FoP_duplication (PF13865, IPR025715): C-terminal duplication domain of Friend of PRMT1
Keratin_2_head (PF16208, IPR032444): Keratin type II head
7 GDNFinteractor41.0000TGF_beta (PF00019, IPR001839, SM00204): Transforming growth factor beta like domain
8 GGHoncoprotein200Peptidase_C26 (PF07722, IPR011697): Peptidase C26
9 GID8interactor150.41870.267LisH (PF08513, IPR013720, SM00667): LisH
CLTH (PF10607, IPR024964): CTLH/CRA C-terminal to LisH motif domain
10 GLIPR1L2interactor41.0000DUF1510 (PF07423, IPR009988): Protein of unknown function (DUF1510)
CAP (PF00188, IPR014044, SM00198): Cysteine-rich secretory protein family
11 GPS2oncoprotein41.0000G_path_suppress (PF15991, IPR026094): G-protein pathway suppressor
12 HLA-DPB1interactor41.0000MHC_II_beta (PF00969, IPR000353, SM00921): Class II histocompatibility antigen, beta domain
C1-set (PF07654, IPR003597, SM00407): Immunoglobulin C1-set domain
13 IFI30oncoprotein100GILT (PF03227, IPR004911): Gamma interferon inducible lysosomal thiol reductase (GILT)
14 MAEAinteractor130.50019.100Mic1 (PF07035, IPR009755): Colon cancer-associated protein Mic1-like
CLTH (PF10607, IPR024964): CTLH/CRA C-terminal to LisH motif domain
15 MMP7interactor51.0000Peptidase_M10 (PF00413, IPR001818): Matrixin
PG_binding_1 (PF01471, IPR002477): Putative peptidoglycan binding domain
16 MRPL4interactor61.0000Ribosomal_L4 (PF00573, IPR002136): Ribosomal protein L4/L1 family
17 MYConcoprotein50.5009.000HLH (PF00010, IPR011598, SM00353): Helix-loop-helix DNA-binding domain
Myc-LZ (PF02344, IPR003327): Myc leucine zipper domain
Myc_N (PF01056, IPR012682): Myc amino-terminal region
18 NR1H3interactor21.0000zf-C4 (PF00105, IPR001628, SM00399): Zinc finger, C4 type (two domains)
Hormone_recep (PF00104, IPR000536, SM00430): Ligand-binding domain of nuclear hormone receptor
19 PRG2interactor51.0000Lectin_C (PF00059, IPR001304, SM00034): Lectin C-type domain
DUF4628 (PF15429, IPR027851): Domain of unknown function (DUF4628)
20 PTGER3interactor21.00007tm_1 (PF00001, IPR000276): 7 transmembrane receptor (rhodopsin family)
FtsX (PF02687, IPR003838): FtsX-like permease family
21 RANBP9suppressor170.36753.433Mito_fiss_reg (PF05308, IPR007972): Mitochondrial fission regulator
LisH (PF08513, IPR013720, SM00667): LisH
SPRY (PF00622, IPR003877, SM00449): SPRY domain
CLTH (PF10607, IPR024964): CTLH/CRA C-terminal to LisH motif domain
22 RMND5Ainteractor140.46224.767CLTH (PF10607, IPR024964): CTLH/CRA C-terminal to LisH motif domain
zf-RING_UBOX (PF13445, IPR027370): RING-type zinc-finger
SnoaL_4 (PF13577, IPR009959): SnoaL-like domain
23 RNPS1interactor50.6008.667RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
DUF2457 (PF10446, IPR018853): Protein of unknown function (DUF2457)
Macoilin (PF09726, IPR019130): Transmembrane protein
24 SFRP2suppressor41.0000NTR (PF01759, IPR018933, SM00206): UNC-6/NTR/C345C module
Fz (PF01392, IPR020067, SM00063): Fz domain
25 SOX2oncoprotein71.0000HMG_box (PF00505, IPR009071, SM00398): HMG (high mobility group) box
SOXp (PF12336, IPR022097): SOX transcription factor
26 TDGF1suppressor51.0000CFC (PF09443, IPR019011): Cripto_Frl-1_Cryptic (CFC)
EGF (PF00008, IPR000742, SM00181): EGF-like domain
27 TGM2protein found in more fusions200Transglut_C (PF00927, IPR008958): Transglutaminase family, C-terminal ig like domain
Transglut_N (PF00868, IPR001102): Transglutaminase family
Transglut_core (PF01841, IPR002931, SM00460): Transglutaminase-like superfamily
28 UNKinteractor31.0000MbeD_MobD (PF04899, IPR006983): MbeD/MobD like
NUDE_C (PF04880, IPR006964): NUDE protein, C-terminal conserved region
zf-CCCH (PF00642, IPR000571): Zinc finger C-x8-C-x5-C-x3-H type (and similar)
DUF3450 (PF11932, IPR016866): Protein of unknown function (DUF3450)
zf-C3HC4_3 (PF13920): Zinc finger, C3HC4 type (RING finger)
zf-CCCH_2 (PF14608): RNA-binding, Nab2-type zinc finger
Torus (PF16131, IPR032297): Torus domain

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