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Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: parental proteins COL4A6, RBMS3 (from a repository: Wed Jul 31 19:14:11 2019)

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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)15
The number (and %) of the onco-proteins2 (13.33 %)
The number (and %) of the tumor suppressors1 (6.67 %)
Total number of binary PPIs (saturation %)34 (32.38 %)
The number (and %) of affected PPIs13 (38.24 %)
The number of possible different fusions4
PPI diameter5
PPI radius3
The average degree of PPI4.133
Assortativity coefficient0.0153
The network average Clustering coefficient0.620
The number (and %) of a zero Clustering coefficients2 (13.33 %)
The number (and %) of a zero Betweenness Centrality7 (46.67 %)


List of the fusions

PPI for parental proteins: COL4A6,RBMS3 All fusions
Proteins found in more fusions APP (see 5 fusions); VHL (see 1 fusions); SART3 (see 2 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Domains (Pfam, InterPro, SMART): description
1 COL4A6parental protein40.33327.000C4 (PF01413, IPR001442, SM00111): C-terminal tandem repeated domain in type 4 procollagen
Collagen (PF01391, IPR008160): Collagen triple helix repeat (20 copies)
2 RBMS3parental protein90.36145.333RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
3 APPprotein found in more fusions70.26781.500APP_N (PF02177, IPR015849, SM00006): Amyloid A4 N-terminal heparin-binding
Beta-APP (PF03494, IPR013803): Beta-amyloid peptide (beta-APP)
BUD22 (PF09073, IPR015158): BUD22
IncA (PF04156, IPR007285): IncA protein
Kunitz_BPTI (PF00014, IPR002223, SM00131): Kunitz/Bovine pancreatic trypsin inhibitor domain
APP_amyloid (PF10515, IPR019543): beta-amyloid precursor protein C-terminus
APP_Cu_bd (PF12924, IPR011178): Copper-binding of amyloid precursor, CuBD
APP_E2 (PF12925, IPR024329): E2 domain of amyloid precursor protein
4 MRPL19interactor50.70018.333Ribosomal_L19 (PF01245, IPR001857): Ribosomal protein L19
EABR (PF12180, IPR022008): TSG101 and ALIX binding domain of CEP55
5 MRPL30interactor21.0000Ribosomal_L30 (PF00327, IPR016082): Ribosomal protein L30p/L7e
6 MRPL40interactor50.9000.500MRP-L28 (PF09812, IPR019192): Mitochondrial ribosomal protein L28
7 MRPL55interactor41.0000Mitoc_L55 (PF09776, IPR018615): Mitochondrial ribosomal protein L55
8 MRPL58interactor80.50045.667RF-1 (PF00472, IPR000352): RF-1 domain
9 MRPL9interactor70.57112.333Ribosomal_L9_N (PF01281, IPR020070): Ribosomal protein L9, N-terminal domain
10 MRPS18Ainteractor40.66713.333Ribosomal_S18 (PF01084, IPR001648): Ribosomal protein S18
11 NGRNinteractor21.0000Neugrin (PF06413, IPR010487): Neugrin
12 OSMinteractor21.0000LIF_OSM (PF01291, IPR001581, SM00080): LIF / OSM family
Sugarporin_N (PF11471, IPR021570): Maltoporin periplasmic N-terminal extension
13 SART3protein found in more fusions200CENP-H (PF05837, IPR008426): Centromere protein H (CENP-H)
DUF1866 (PF08952, IPR015047, SM01165): Domain of unknown function (DUF1866)
DUF1993 (PF09351, IPR018531): Domain of unknown function (DUF1993)
Lsm_interact (PF05391, IPR008669): Lsm interaction motif
Phage_GPD (PF05954): Phage late control gene D protein (GPD)
RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
Suf (PF05843, IPR008847): Suppressor of forked protein (Suf)
TPR_14 (PF13428): Tetratricopeptide repeat
MRI (PF15325, IPR028278): Modulator of retrovirus infection
LSM_int_assoc (PF16605): LSM-interacting associated unstructured
14 SUMF1interactor100FGE-sulfatase (PF03781, IPR005532): Sulfatase-modifying factor enzyme 1
DNA_ligase_IV (PF11411, IPR021536): DNA ligase IV
15 VHLsuppressor31.0000Trypan_PARP (PF05887, IPR008882): Procyclic acidic repetitive protein (PARP)
VHL (PF01847, IPR022772): VHL beta domain
VHL_C (PF17211): VHL box domain

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