Find Fusion Network

Visualization interactions

Powered by Cytoscape Web for: parental proteins COL4A2, SMG7 (from a repository: Mon Aug 5 14:10:30 2019)

Examples AFF1 MLL ACTN4 + MLLAFF1 + MLLALK + MSNALK + TFGALK + TPM3ALK + TPM4ASXL2 + KAT6AATF1 + FUSBCR + ABL1BCR + FGFR1CCND1 + TACSTD2CD74 + ROS1CDK6 + MLLCOL1A1 + PDGFBCREB3L2 + PPARGCREB3L2 + FUSCREBBP + KAT6ADAZAP1 + MEF2DELL + MLLEPS15 + MLLERG + EWSR1ERG + FUSERG + TMPRSS2ETV5 + TMPRSS2ETV6 + ABL1ETV6 + NTRK3ETV6 + PAX5EWSR1 + FLI1EWSR1 + WT1FOXO1 + PAX3FOXP1 + PAX5FRYL + MLLGAS7 + MLLGMPS + MLLGOLGA5 + RETHOOK3 + RETHOXC13 + NUP98HOXD13 + NUP98MECOM + RUNX1MKL1 + RBM15MLL + MLLT1MLL + MLLT4MLL + MLLT10MLL + PICALMMLLT10 + PICALMNCOA1 + PAX3NIN + PDGFRBNPM1 + RARANRG1 + ODZ4NTRK1 + TFGNUMA1 + RARANUP98 + PHF23PAX5 + ZNF521PBX1 + TCF3RET + TRIM27ROS1 + SLC34A2PML + RARAPRKAR1A + RARAPRKAR1A + RETRUNX1 + RUNX1T1RUNX1 + SH3D19	Cytoscape Web will replace the contents your graph	PPI Properties: Click on nodes or edges
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Statistics and Network structure information

Statistic of PPI Value(s) The number of interactors (fusion and proteins) 52 The number (and %) of the onco-proteins 11 (21.15 %) The number (and %) of the tumor suppressors 4 (7.69 %) Total number of binary PPIs (saturation %) 143 (10.78 %) The number (and %) of affected PPIs 51 (35.66 %) The number of possible different fusions 7 PPI diameter 5 PPI radius 3 The average degree of PPI 4.885 Assortativity coefficient -0.4565 The network average Clustering coefficient 0.410 The number (and %) of a zero Clustering coefficients 18 (34.62 %) The number (and %) of a zero Betweenness Centrality 21 (40.38 %)

ACTIVE INTERACTORS

List of the fusions
PPI for parental proteins: SMG7,COL4A2	All fusions
Proteins found in more fusions	SSX2IP (see 1 fusions); SMG6 (see 1 fusions); DAZAP2 (see 2 fusions); COL4A2 (see 1 fusions); COL4A1 (see 3 fusions); VHL (see 1 fusions);

List of active interactors

#	Name	Type	Number of PPI (degree)	Clustering Coefficient	Betweenness Centrality	Domains (Pfam, InterPro, SMART): description
1	SMG7	parental protein	25	0.203	670.235	TFIIA (PF03153, IPR004855): Transcription factor IIA, alpha/beta subunit EST1 (PF10374, IPR019458): Telomerase activating protein Est1 EST1_DNA_bind (PF10373, IPR018834): Est1 DNA/RNA binding domain
2	COL4A2	parental protein	26	0.020	1252.870	C4 (PF01413, IPR001442, SM00111): C-terminal tandem repeated domain in type 4 procollagen Collagen (PF01391, IPR008160): Collagen triple helix repeat (20 copies) DUF1860 (PF08949, IPR015044): Domain of unknown function (DUF1860)
3	ANXA7	suppressor	2	0	40.716	Annexin (PF00191, IPR018502, SM00335): Annexin
4	BTRC	oncoprotein	9	0.429	145.318	WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat Beta-TrCP_D (PF12125, IPR021977, SM01028): D domain of beta-TrCP ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain F-box-like (PF12937, IPR001810): F-box-like
5	C1QB	interactor	2	1.000	0	C1q (PF00386, IPR001073, SM00110): C1q domain Collagen (PF01391, IPR008160): Collagen triple helix repeat (20 copies)
6	C1QTNF2	interactor	2	1.000	0	C1q (PF00386, IPR001073, SM00110): C1q domain Collagen (PF01391, IPR008160): Collagen triple helix repeat (20 copies) DUF1860 (PF08949, IPR015044): Domain of unknown function (DUF1860)
7	C1QTNF9	oncoprotein	2	0	86.763	C1q (PF00386, IPR001073, SM00110): C1q domain Collagen (PF01391, IPR008160): Collagen triple helix repeat (20 copies) DUF1860 (PF08949, IPR015044): Domain of unknown function (DUF1860)
8	CELA2B	interactor	1	0	0	Trypsin (PF00089, IPR001254, SM00020): Trypsin
9	CENPJ	interactor	9	0.472	12.233	DASH_Hsk3 (PF08227, IPR013183): DASH complex subunit Hsk3 like DUF1795 (PF08786, IPR014894): Domain of unknown function (DUF1795) DUF972 (PF06156, IPR010377): Protein of unknown function (DUF972) Rota_VP2 (PF05087, IPR007779): Rotavirus VP2 protein Tcp10_C (PF07202, IPR009852): T-complex protein 10 C-terminus TSC22 (PF01166, IPR000580): TSC-22/dip/bun family AAA_23 (PF13476): AAA domain DUF4140 (PF13600, IPR025554): N-terminal domain of unknown function (DUF4140)
10	CEP128	interactor	10	0.467	28.711	DUF1129 (PF06570, IPR009214): Protein of unknown function (DUF1129) DUF1664 (PF07889, IPR012458): Protein of unknown function (DUF1664) ERM (PF00769, IPR011259): Ezrin/radixin/moesin family Reo_sigmaC (PF04582, IPR007662): Reovirus sigma C capsid protein SpoOE-like (PF09388, IPR018540): Spo0E like sporulation regulatory protein DUF2968 (PF11180, IPR021350): Protein of unknown function (DUF2968) TraF_2 (PF13729, IPR032811): F plasmid transfer operon, TraF, protein GAS (PF13851, IPR025593): Growth-arrest specific micro-tubule binding DUF4200 (PF13863, IPR025252): Domain of unknown function (DUF4200) DUF4404 (PF14357, IPR025516): Domain of unknown function (DUF4404) HAUS6_N (PF14661, IPR028163): HAUS augmin-like complex subunit 6 N-terminus HIP1_clath_bdg (PF16515, IPR032422): Clathrin-binding domain of Huntingtin-interacting protein 1
11	CEP152	interactor	4	0.833	0.286	bZIP_1 (PF00170, IPR004827): bZIP transcription factor CDC37_N (PF03234, IPR013855, SM01071): Cdc37 N terminal kinase binding CENP-H (PF05837, IPR008426): Centromere protein H (CENP-H) DUF641 (PF04859, IPR006943): Plant protein of unknown function (DUF641) ZapB (PF06005, IPR009252): Cell division protein ZapB DUF972 (PF06156, IPR010377): Protein of unknown function (DUF972) Ribosomal_S13 (PF00416, IPR001892): Ribosomal protein S13/S18 FAD-SLDH (PF12318, IPR024651): Membrane bound FAD containing D-sorbitol dehydrogenase YtxH (PF12732, IPR024623): YtxH-like protein ADH_zinc_N_2 (PF13602): Zinc-binding dehydrogenase TolA_bind_tri (PF16331, IPR032519): TolA binding protein trimerisation HIP1_clath_bdg (PF16515, IPR032422): Clathrin-binding domain of Huntingtin-interacting protein 1
12	CEP44	interactor	5	0.600	2.556	DUF16 (PF01519, IPR002862): Protein of unknown function DUF16 NPV_P10 (PF05531, IPR008702): Nucleopolyhedrovirus P10 protein Utp12 (PF04003, IPR007148): Dip2/Utp12 Family CEP44 (PF15007, IPR029157): Centrosomal spindle body, CEP44
13	CEP97	interactor	7	0.619	14.685	IQ (PF00612, IPR000048, SM00015): IQ calmodulin-binding motif LRR_8 (PF13855, IPR001611): Leucine rich repeat LRR_9 (PF14580): Leucine-rich repeat
14	CLPSL1	interactor	1	0	0	Toxin_3 (PF00537, IPR002061): Scorpion toxin-like domain
15	COL4A1	protein found in more fusions	3	1.000	0	C4 (PF01413, IPR001442, SM00111): C-terminal tandem repeated domain in type 4 procollagen Collagen (PF01391, IPR008160): Collagen triple helix repeat (20 copies) DUF1860 (PF08949, IPR015044): Domain of unknown function (DUF1860)
16	COL8A2	interactor	1	0	0	C1q (PF00386, IPR001073, SM00110): C1q domain Collagen (PF01391, IPR008160): Collagen triple helix repeat (20 copies)
17	COL9A1	interactor	2	1.000	0	Collagen (PF01391, IPR008160): Collagen triple helix repeat (20 copies) DUF826 (PF05696, IPR008544): Protein of unknown function (DUF826) Laminin_G_2 (PF02210, IPR001791): Laminin G domain
18	CSNK2B	interactor	6	0.200	425.395	CK_II_beta (PF01214, IPR000704, SM01085): Casein kinase II regulatory subunit
19	DAZAP2	protein found in more fusions	3	0	40.716	DAZAP2 (PF11029, IPR022730): DAZ associated protein 2 (DAZAP2)
20	ELAVL1	oncoprotein	14	0.154	589.189	RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
21	FAM46A	interactor	2	0	40.716	NTP_transf_7 (PF07984, IPR012937, SM01153): Nucleotidyltransferase
22	FBXO6	interactor	1	0	0	FBA (PF04300, IPR007397): F-box associated region F-box-like (PF12937, IPR001810): F-box-like
23	FBXW11	interactor	6	0.700	7.333	WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat Beta-TrCP_D (PF12125, IPR021977, SM01028): D domain of beta-TrCP ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain F-box-like (PF12937, IPR001810): F-box-like
24	FGFR3	oncoprotein	2	0	0	I-set (PF07679, IPR013098): Immunoglobulin I-set domain Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase Ig_3 (PF13927): Immunoglobulin domain Izumo-Ig (PF16706, IPR032699): Izumo-like Immunoglobulin domain
25	FGL1	interactor	1	0	0	Fibrinogen_C (PF00147, IPR002181, SM00186): Fibrinogen beta and gamma chains, C-terminal globular domain
26	HBB	interactor	4	1.000	0	Globin (PF00042, IPR000971): Globin
27	ITLN2	interactor	1	0	0	Fibrinogen_C (PF00147, IPR002181, SM00186): Fibrinogen beta and gamma chains, C-terminal globular domain
28	KLK15	interactor	2	1.000	0	Trypsin (PF00089, IPR001254, SM00020): Trypsin
29	NINL	interactor	5	0.900	0.286	PD40 (PF07676, IPR011659): WD40-like Beta Propeller Repeat TBCA (PF02970, IPR004226): Tubulin binding cofactor A DUF2389 (PF09493, IPR012663): Tryptophan-rich protein (DUF2389) Golgin_A5 (PF09787, IPR019177): Golgin subfamily A member 5 EF-hand_1 (PF00036, IPR002048, SM00054): EF hand EF-hand_6 (PF13405, IPR002048): EF-hand domain EF-hand_7 (PF13499, IPR011992): EF-hand domain pair GAS (PF13851, IPR025593): Growth-arrest specific micro-tubule binding Muted (PF14942, IPR017243): Organelle biogenesis, Muted-like protein FAM184 (PF15665): Family with sequence similarity 184, A and B TRAF_BIRC3_bd (PF16673, IPR032070): TNF receptor-associated factor BIRC3 binding domain
30	ODF2	interactor	7	0.619	24.000	ATG16 (PF08614, IPR013923): Autophagy protein 16 (ATG16) NAT (PF04768, IPR006855): NAT, N-acetyltransferase, of N-acetylglutamate synthase Invasin_D3 (PF09134, IPR015217): Invasin, domain 3 Mt_ATP-synt_D (PF05873, IPR008689): ATP synthase D chain, mitochondrial (ATP5H) CENP-F_leu_zip (PF10473, IPR019513): Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 TMF_TATA_bd (PF12325, IPR022091): TATA element modulatory factor 1 TATA binding TMF_DNA_bd (PF12329, IPR022092): TATA element modulatory factor 1 DNA binding HIP1_clath_bdg (PF16515, IPR032422): Clathrin-binding domain of Huntingtin-interacting protein 1
31	PCM1	oncoprotein	11	0.527	22.907	FliD_N (PF02465, IPR003481): Flagellar hook-associated protein 2 N-terminus FUSC (PF04632, IPR006726): Fusaric acid resistance protein family IBN_N (PF03810, IPR001494, SM00913): Importin-beta N-terminal domain NPV_P10 (PF05531, IPR008702): Nucleopolyhedrovirus P10 protein Prothymosin (PF03247, IPR004931): Prothymosin/parathymosin family RseA_C (PF03873, IPR005573): Anti sigma-E protein RseA, C-terminal domain TPR_MLP1_2 (PF07926, IPR012929): TPR/MLP1/MLP2-like protein V_ATPase_I (PF01496, IPR002490): V-type ATPase 116kDa subunit family AAA_23 (PF13476): AAA domain zf-C4pol (PF14260, IPR025687): C4-type zinc-finger of DNA polymerase delta PCM1_C (PF15717, IPR031446): Pericentriolar material 1 C terminus DUF4829 (PF16111, IPR032256): Domain of unknown function (DUF4829)
32	PRMT6	interactor	3	1.000	0	Methyltransf_25 (PF13649): Methyltransferase domain
33	PTPRK	suppressor	3	0.667	15.825	fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain I-set (PF07679, IPR013098): Immunoglobulin I-set domain MAM (PF00629, IPR000998, SM00137): MAM domain, meprin/A5/mu Protocadherin (PF08374, IPR013585): Protocadherin Y_phosphatase (PF00102, IPR000242, SM00194): Protein-tyrosine phosphatase
34	RBM8A	interactor	6	0.800	1.333	RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
35	SEC16A	interactor	4	0.500	11.474	APC_r (PF05923): APC repeat Sec16_C (PF12931, IPR024298): Sec23-binding domain of Sec16 Sec16 (PF12932, IPR024340): Vesicle coat trafficking protein Sec16 mid-region
36	SEMG1	interactor	1	0	0	Semenogelin (PF05474, IPR008836): Semenogelin
37	SERPINA6	interactor	1	0	0	Serpin (PF00079, IPR023796, SM00093): Serpin (serine protease inhibitor)
38	SKIL	suppressor	2	0	0	c-SKI_SMAD_bind (PF08782, IPR014890, SM01046): c-SKI Smad4 binding domain DUF489 (PF04356, IPR007451): Protein of unknown function (DUF489) DUF972 (PF06156, IPR010377): Protein of unknown function (DUF972) Neur_chan_memb (PF02932, IPR006029): Neurotransmitter-gated ion-channel transmembrane region Ski_Sno (PF02437, IPR003380): SKI/SNO/DAC family DUF2115 (PF09888, IPR019215): Uncharacterized protein conserved in archaea (DUF2115)
39	SMG1	interactor	5	0.667	11.167	Baculo_PEP_C (PF04513, IPR007601): Baculovirus polyhedron envelope protein, PEP, C terminus DUF948 (PF06103, IPR009293): Bacterial protein of unknown function (DUF948) FATC (PF02260, IPR003152): FATC domain HEAT (PF02985, IPR000357): HEAT repeat FRB_dom (PF08771, IPR009076): FKBP12-rapamycin binding domain Xpo1 (PF08389, IPR013598): Exportin 1-like protein KxDL (PF10241, IPR019371): Uncharacterized conserved protein XhlA (PF10779, IPR019715): Haemolysin XhlA PI3_PI4_kinase (PF00454, IPR000403, SM00146): Phosphatidylinositol 3- and 4-kinase SMG1 (PF15785, IPR031559): Serine/threonine-protein kinase smg-1
40	SMG6	oncoprotein	5	1.000	0	EST1 (PF10374, IPR019458): Telomerase activating protein Est1 EST1_DNA_bind (PF10373, IPR018834): Est1 DNA/RNA binding domain PIN_4 (PF13638, IPR002716): PIN domain
41	SMN1	interactor	3	0	82.229	SMN (PF06003, IPR010304): Survival motor neuron protein (SMN)
42	SPICE1	interactor	7	0.619	9.607	SPICE (PF15678, IPR031387): Centriole duplication and mitotic chromosome congression ANXA2R (PF15721, IPR031449): Annexin-2 receptor JIP_LZII (PF16471, IPR032486): JNK-interacting protein leucine zipper II
43	SSX2IP	protein found in more fusions	12	0.473	59.933	ZapB (PF06005, IPR009252): Cell division protein ZapB ERM (PF00769, IPR011259): Ezrin/radixin/moesin family Surfac_D-trimer (PF09006, IPR015097): Lung surfactant protein D coiled-coil trimerisation ADIP (PF11559, IPR021622): Afadin- and alpha -actinin-Binding YqzH (PF14164, IPR025546): YqzH-like protein
44	STBD1	interactor	1	0	0	CBM_20 (PF00686, IPR002044): Starch binding domain
45	STIL	oncoprotein	7	0.619	8.549	STIL_N (PF15253, IPR026123): SCL-interrupting locus protein N-terminus
46	TK1	oncoprotein	3	1.000	0	TK (PF00265, IPR001267, SM00203): Thymidine kinase
47	TMEM25	interactor	1	0	0	C2-set_2 (PF08205, IPR013162): CD80-like C2-set immunoglobulin domain Ig_3 (PF13927): Immunoglobulin domain DUF4674 (PF15719, IPR029779): Domain of unknown function (DUF4674)
48	TNPO3	interactor	2	0	40.716	HEAT (PF02985, IPR000357): HEAT repeat IFRD (PF05004, IPR007701): Interferon-related developmental regulator (IFRD) Xpo1 (PF08389, IPR013598): Exportin 1-like protein
49	TSNAX	interactor	3	0.333	89.263	Translin (PF01997, IPR002848): Translin family
50	UPF1	interactor	9	0.361	172.175	UPF1_Zn_bind (PF09416, IPR018999): RNA helicase (UPF2 interacting domain) AAA_11 (PF13086): AAA domain AAA_12 (PF13087): AAA domain
51	VHL	suppressor	7	0.267	200.049	Trypan_PARP (PF05887, IPR008882): Procyclic acidic repetitive protein (PARP) VHL (PF01847, IPR022772): VHL beta domain VHL_C (PF17211): VHL box domain
52	XPO1	interactor	9	0.250	242.765	CRM1_C (PF08767, IPR014877, SM01102): CRM1 C terminal Hydrolase_3 (PF08282, IPR023214): haloacid dehalogenase-like hydrolase IBN_N (PF03810, IPR001494, SM00913): Importin-beta N-terminal domain Xpo1 (PF08389, IPR013598): Exportin 1-like protein Vac14_Fab1_bd (PF12755, IPR032878): Vacuolar 14 Fab1-binding region

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