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Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: parental proteins COL4A2, MT-CO1 (from a repository: Tue Aug 20 23:36:39 2019)
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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)44
The number (and %) of the onco-proteins7 (15.91 %)
The number (and %) of the tumor suppressors4 (9.09 %)
Total number of binary PPIs (saturation %)68 (7.19 %)
The number (and %) of affected PPIs43 (63.24 %)
The number of possible different fusions7
PPI diameter5
PPI radius3
The average degree of PPI2.545
Assortativity coefficient-0.6352
The network average Clustering coefficient0.287
The number (and %) of a zero Clustering coefficients27 (61.36 %)
The number (and %) of a zero Betweenness Centrality32 (72.73 %)

ACTIVE INTERACTORS


List of the fusions

Proteins found in more fusions PRDX4 (see 1 fusions); COL4A1 (see 3 fusions); VHL (see 1 fusions); DAZAP2 (see 2 fusions); MT-CO1/MT-CO2 (see 1 fusions); COL4A2 (see 1 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 MT-CO1parental protein170.0441036.000DUF3485 (PF11984, IPR014263): Protein of unknown function (DUF3485)
2 COL4A2parental protein260.0201411.000C4 (PF01413, IPR001442, SM00111): C-terminal tandem repeated domain in type 4 procollagen
Collagen (PF01391, IPR008160): Collagen triple helix repeat (20 copies)
DUF1860 (PF08949, IPR015044): Domain of unknown function (DUF1860)
3 ANXA7suppressor100Annexin (PF00191, IPR018502, SM00335): Annexin
4 ASGR2interactor20417.000UL45 (PF05473, IPR008646): UL45 protein, carbohydrate-binding C-type lectin-like
Lectin_N (PF03954, IPR005640): Hepatic lectin, N-terminal domain
Lectin_C (PF00059, IPR001304, SM00034): Lectin C-type domain
5 C1QBinteractor21.0000C1q (PF00386, IPR001073, SM00110): C1q domain
Collagen (PF01391, IPR008160): Collagen triple helix repeat (20 copies)
6 C1QTNF2interactor21.0000C1q (PF00386, IPR001073, SM00110): C1q domain
Collagen (PF01391, IPR008160): Collagen triple helix repeat (20 copies)
DUF1860 (PF08949, IPR015044): Domain of unknown function (DUF1860)
7 C1QTNF9oncoprotein100C1q (PF00386, IPR001073, SM00110): C1q domain
Collagen (PF01391, IPR008160): Collagen triple helix repeat (20 copies)
DUF1860 (PF08949, IPR015044): Domain of unknown function (DUF1860)
8 CDC42oncoprotein200Ras (PF00071, IPR001806, SM00173): Ras family
9 CELA2Binteractor100Trypsin (PF00089, IPR001254, SM00020): Trypsin
10 CLEC4Ginteractor100ATG16 (PF08614, IPR013923): Autophagy protein 16 (ATG16)
Lectin_C (PF00059, IPR001304, SM00034): Lectin C-type domain
11 CLPSL1interactor100Toxin_3 (PF00537, IPR002061): Scorpion toxin-like domain
12 COL4A1protein found in more fusions31.0000C4 (PF01413, IPR001442, SM00111): C-terminal tandem repeated domain in type 4 procollagen
Collagen (PF01391, IPR008160): Collagen triple helix repeat (20 copies)
DUF1860 (PF08949, IPR015044): Domain of unknown function (DUF1860)
13 COL8A2interactor100C1q (PF00386, IPR001073, SM00110): C1q domain
Collagen (PF01391, IPR008160): Collagen triple helix repeat (20 copies)
14 COL9A1interactor21.0000Collagen (PF01391, IPR008160): Collagen triple helix repeat (20 copies)
DUF826 (PF05696, IPR008544): Protein of unknown function (DUF826)
Laminin_G_2 (PF02210, IPR001791): Laminin G domain
15 COX14interactor100COX14 (PF14880, IPR029208): Cytochrome oxidase c assembly
16 COX4I1interactor30.6671.000COX4 (PF02936, IPR004203): Cytochrome c oxidase subunit IV
17 CSNK2Binteractor31.0000CK_II_beta (PF01214, IPR000704, SM01085): Casein kinase II regulatory subunit
18 DAZAP2protein found in more fusions200DAZAP2 (PF11029, IPR022730): DAZ associated protein 2 (DAZAP2)
19 EDNRAinteractor1007tm_1 (PF00001, IPR000276): 7 transmembrane receptor (rhodopsin family)
20 FAM134Cinteractor100Reticulon (PF02453, IPR003388): Reticulon
21 FAM46Ainteractor100NTP_transf_7 (PF07984, IPR012937, SM01153): Nucleotidyltransferase
22 FBXO6interactor20433.000FBA (PF04300, IPR007397): F-box associated region
F-box-like (PF12937, IPR001810): F-box-like
23 FGL1interactor100Fibrinogen_C (PF00147, IPR002181, SM00186): Fibrinogen beta and gamma chains, C-terminal globular domain
24 GPR52interactor1007tm_1 (PF00001, IPR000276): 7 transmembrane receptor (rhodopsin family)
25 HSPB2interactor40.6671.000Crystallin (PF00525, IPR003090): Alpha crystallin A chain, N terminal
HSP20 (PF00011, IPR002068): Hsp20/alpha crystallin family
26 ITLN2interactor100Fibrinogen_C (PF00147, IPR002181, SM00186): Fibrinogen beta and gamma chains, C-terminal globular domain
27 LIG4interactor21.0000APG17 (PF04108, IPR007240): Autophagy protein Apg17
BRCT (PF00533, IPR001357, SM00292): BRCA1 C Terminus (BRCT) domain
DNA_ligase_A_C (PF04679, IPR012309): ATP dependent DNA ligase C terminal region
DNA_ligase_A_M (PF01068, IPR012310): ATP dependent DNA ligase domain
DNA_ligase_A_N (PF04675, IPR012308): DNA ligase N terminus
DNA_ligase_IV (PF11411, IPR021536): DNA ligase IV
RTT107_BRCT_5 (PF16770, IPR001357): Regulator of Ty1 transposition protein 107 BRCT domain
28 MEOX2interactor100Homeobox (PF00046, IPR001356, SM00389): Homeobox domain
29 MT-CO2protein found in more fusions40.5003.000COX2 (PF00116, IPR002429): Cytochrome C oxidase subunit II, periplasmic domain
COX2_TM (PF02790, IPR011759): Cytochrome C oxidase subunit II, transmembrane domain
30 NDUFB8interactor21.0000NDUF_B8 (PF05821, IPR008699): NADH-ubiquinone oxidoreductase ASHI subunit (CI-ASHI or NDUFB8)
31 P2RY12interactor20417.0007tm_1 (PF00001, IPR000276): 7 transmembrane receptor (rhodopsin family)
32 PRDX4protein found in more fusions200AhpC-TSA (PF00578, IPR000866): AhpC/TSA family
1-cysPrx_C (PF10417, IPR019479): C-terminal domain of 1-Cys peroxiredoxin
33 PTPRKsuppressor30.6671.000fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain
I-set (PF07679, IPR013098): Immunoglobulin I-set domain
MAM (PF00629, IPR000998, SM00137): MAM domain, meprin/A5/mu
Protocadherin (PF08374, IPR013585): Protocadherin
Y_phosphatase (PF00102, IPR000242, SM00194): Protein-tyrosine phosphatase
34 SEMG1interactor100Semenogelin (PF05474, IPR008836): Semenogelin
35 SERPINA6interactor100Serpin (PF00079, IPR023796, SM00093): Serpin (serine protease inhibitor)
36 SKILsuppressor200c-SKI_SMAD_bind (PF08782, IPR014890, SM01046): c-SKI Smad4 binding domain
DUF489 (PF04356, IPR007451): Protein of unknown function (DUF489)
DUF972 (PF06156, IPR010377): Protein of unknown function (DUF972)
Neur_chan_memb (PF02932, IPR006029): Neurotransmitter-gated ion-channel transmembrane region
Ski_Sno (PF02437, IPR003380): SKI/SNO/DAC family
DUF2115 (PF09888, IPR019215): Uncharacterized protein conserved in archaea (DUF2115)
37 SMN1interactor200SMN (PF06003, IPR010304): Survival motor neuron protein (SMN)
38 SNCAinteractor31.0000Synuclein (PF01387, IPR001058): Synuclein
39 STBD1interactor100CBM_20 (PF00686, IPR002044): Starch binding domain
40 TK1oncoprotein31.0000TK (PF00265, IPR001267, SM00203): Thymidine kinase
41 TMEM25interactor100C2-set_2 (PF08205, IPR013162): CD80-like C2-set immunoglobulin domain
Ig_3 (PF13927): Immunoglobulin domain
DUF4674 (PF15719, IPR029779): Domain of unknown function (DUF4674)
42 TNPO3interactor20433.000HEAT (PF02985, IPR000357): HEAT repeat
IFRD (PF05004, IPR007701): Interferon-related developmental regulator (IFRD)
Xpo1 (PF08389, IPR013598): Exportin 1-like protein
43 UQCRBinteractor30.6671.000UCR_14kD (PF02271, IPR003197): Ubiquinol-cytochrome C reductase complex 14kD subunit
44 VHLsuppressor60.4006.000Trypan_PARP (PF05887, IPR008882): Procyclic acidic repetitive protein (PARP)
VHL (PF01847, IPR022772): VHL beta domain
VHL_C (PF17211): VHL box domain

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