Find Fusion Network

Enter
Fusion ID:
Protein names:


Level of PPIs:
or Upload text file:
Update repository
Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: parental proteins COL4A2, SORCS1 (from a repository: Thu Feb 9 01:03:30 2017)
Examples

Cytoscape Web will replace the contents your graph
PPI Properties:

Click on nodes
or edges

Layout Tree
Circle
Radial
Force Directed
Preset
Export graph
PDF file
SVG file
SIF file
XML file
GraphML file

Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)28
The number (and %) of the onco-proteins4 (14.29 %)
The number (and %) of the tumor suppressors4 (14.29 %)
Total number of binary PPIs (saturation %)40 (10.58 %)
The number (and %) of affected PPIs27 (67.50 %)
The number of possible different fusions5
PPI diameter2
PPI radiusinf
The average degree of PPI2.286
Assortativity coefficient-0.6457
The network average Clustering coefficient0.253
The number (and %) of a zero Clustering coefficients19 (67.86 %)
The number (and %) of a zero Betweenness Centrality25 (89.29 %)

ACTIVE INTERACTORS


List of the fusions

Proteins found in more fusions VHL (see 1 fusions); DAZAP2 (see 2 fusions); COL4A1 (see 3 fusions); COL4A2 (see 1 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 SORCS1parental protein100PKD (PF00801, IPR000601, SM00089): PKD domain
Sortilin_C (PF15901, IPR031777): Sortilin, neurotensin receptor 3, C-terminal
Sortilin-Vps10 (PF15902, IPR031778): Sortilin, neurotensin receptor 3
2 COL4A2parental protein260.020581.000C4 (PF01413, IPR001442, SM00111): C-terminal tandem repeated domain in type 4 procollagen
Collagen (PF01391, IPR008160): Collagen triple helix repeat (20 copies)
DUF1860 (PF08949, IPR015044): Domain of unknown function (DUF1860)
3 ANXA7suppressor100Annexin (PF00191, IPR018502, SM00335): Annexin
4 C1QBinteractor21.0000C1q (PF00386, IPR001073, SM00110): C1q domain
Collagen (PF01391, IPR008160): Collagen triple helix repeat (20 copies)
5 C1QTNF2interactor21.0000C1q (PF00386, IPR001073, SM00110): C1q domain
Collagen (PF01391, IPR008160): Collagen triple helix repeat (20 copies)
DUF1860 (PF08949, IPR015044): Domain of unknown function (DUF1860)
6 C1QTNF9oncoprotein100C1q (PF00386, IPR001073, SM00110): C1q domain
Collagen (PF01391, IPR008160): Collagen triple helix repeat (20 copies)
DUF1860 (PF08949, IPR015044): Domain of unknown function (DUF1860)
7 CELA2Binteractor100Trypsin (PF00089, IPR001254, SM00020): Trypsin
8 CLPSL1interactor100Toxin_3 (PF00537, IPR002061): Scorpion toxin-like domain
9 COL4A1protein found in more fusions31.0000C4 (PF01413, IPR001442, SM00111): C-terminal tandem repeated domain in type 4 procollagen
Collagen (PF01391, IPR008160): Collagen triple helix repeat (20 copies)
DUF1860 (PF08949, IPR015044): Domain of unknown function (DUF1860)
10 COL8A2interactor100C1q (PF00386, IPR001073, SM00110): C1q domain
Collagen (PF01391, IPR008160): Collagen triple helix repeat (20 copies)
11 COL9A1interactor21.0000Collagen (PF01391, IPR008160): Collagen triple helix repeat (20 copies)
DUF826 (PF05696, IPR008544): Protein of unknown function (DUF826)
Laminin_G_2 (PF02210, IPR001791): Laminin G domain
12 CSNK2Binteractor31.0000CK_II_beta (PF01214, IPR000704, SM01085): Casein kinase II regulatory subunit
13 DAZAP2protein found in more fusions200DAZAP2 (PF11029, IPR022730): DAZ associated protein 2 (DAZAP2)
14 FAM46Ainteractor100NTP_transf_7 (PF07984, IPR012937, SM01153): Nucleotidyltransferase
15 FBXO6interactor100FBA (PF04300, IPR007397): F-box associated region
F-box-like (PF12937, IPR001810): F-box-like
16 FGL1interactor100Fibrinogen_C (PF00147, IPR002181, SM00186): Fibrinogen beta and gamma chains, C-terminal globular domain
17 ITLN2interactor100Fibrinogen_C (PF00147, IPR002181, SM00186): Fibrinogen beta and gamma chains, C-terminal globular domain
18 PTPRKsuppressor30.6671.000fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain
I-set (PF07679, IPR013098): Immunoglobulin I-set domain
MAM (PF00629, IPR000998, SM00137): MAM domain, meprin/A5/mu
Protocadherin (PF08374, IPR013585): Protocadherin
Y_phosphatase (PF00102, IPR000242, SM00194): Protein-tyrosine phosphatase
19 SEMG1interactor100Semenogelin (PF05474, IPR008836): Semenogelin
20 SERPINA6interactor100Serpin (PF00079, IPR023796, SM00093): Serpin (serine protease inhibitor)
21 SKILsuppressor200c-SKI_SMAD_bind (PF08782, IPR014890, SM01046): c-SKI Smad4 binding domain
DUF489 (PF04356, IPR007451): Protein of unknown function (DUF489)
DUF972 (PF06156, IPR010377): Protein of unknown function (DUF972)
Neur_chan_memb (PF02932, IPR006029): Neurotransmitter-gated ion-channel transmembrane region
Ski_Sno (PF02437, IPR003380): SKI/SNO/DAC family
DUF2115 (PF09888, IPR019215): Uncharacterized protein conserved in archaea (DUF2115)
22 SMN1interactor200SMN (PF06003, IPR010304): Survival motor neuron protein (SMN)
23 SORT1interactor100Sortilin_C (PF15901, IPR031777): Sortilin, neurotensin receptor 3, C-terminal
Sortilin-Vps10 (PF15902, IPR031778): Sortilin, neurotensin receptor 3
24 STBD1interactor100CBM_20 (PF00686, IPR002044): Starch binding domain
25 TK1oncoprotein31.0000TK (PF00265, IPR001267, SM00203): Thymidine kinase
26 TMEM25interactor100C2-set_2 (PF08205, IPR013162): CD80-like C2-set immunoglobulin domain
Ig_3 (PF13927): Immunoglobulin domain
DUF4674 (PF15719, IPR029779): Domain of unknown function (DUF4674)
27 TNPO3interactor100HEAT (PF02985, IPR000357): HEAT repeat
IFRD (PF05004, IPR007701): Interferon-related developmental regulator (IFRD)
Xpo1 (PF08389, IPR013598): Exportin 1-like protein
28 VHLsuppressor60.4006.000Trypan_PARP (PF05887, IPR008882): Procyclic acidic repetitive protein (PARP)
VHL (PF01847, IPR022772): von Hippel-Lindau disease tumour suppressor protein
VHL_C (PF17211): VHL box domain

B a c k    t o    T o p ⇑