Find Fusion Network

Visualization interactions

Powered by Cytoscape Web for: parental proteins EDARADD, OSMR (from a repository: Thu May 18 06:59:49 2017)

Examples AFF1 MLL ACTN4 + MLLAFF1 + MLLALK + MSNALK + TFGALK + TPM3ALK + TPM4ASXL2 + KAT6AATF1 + FUSBCR + ABL1BCR + FGFR1CCND1 + TACSTD2CD74 + ROS1CDK6 + MLLCOL1A1 + PDGFBCREB3L2 + PPARGCREB3L2 + FUSCREBBP + KAT6ADAZAP1 + MEF2DELL + MLLEPS15 + MLLERG + EWSR1ERG + FUSERG + TMPRSS2ETV5 + TMPRSS2ETV6 + ABL1ETV6 + NTRK3ETV6 + PAX5EWSR1 + FLI1EWSR1 + WT1FOXO1 + PAX3FOXP1 + PAX5FRYL + MLLGAS7 + MLLGMPS + MLLGOLGA5 + RETHOOK3 + RETHOXC13 + NUP98HOXD13 + NUP98MECOM + RUNX1MKL1 + RBM15MLL + MLLT1MLL + MLLT4MLL + MLLT10MLL + PICALMMLLT10 + PICALMNCOA1 + PAX3NIN + PDGFRBNPM1 + RARANRG1 + ODZ4NTRK1 + TFGNUMA1 + RARANUP98 + PHF23PAX5 + ZNF521PBX1 + TCF3RET + TRIM27ROS1 + SLC34A2PML + RARAPRKAR1A + RARAPRKAR1A + RETRUNX1 + RUNX1T1RUNX1 + SH3D19	Cytoscape Web will replace the contents your graph	PPI Properties: Click on nodes or edges
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Statistics and Network structure information

Statistic of PPI Value(s) The number of interactors (fusion and proteins) 20 The number (and %) of the onco-proteins 8 (40.00 %) The number (and %) of the tumor suppressors 3 (15.00 %) Total number of binary PPIs (saturation %) 51 (26.84 %) The number (and %) of affected PPIs 19 (37.25 %) The number of possible different fusions 8 PPI diameter 5 PPI radius 3 The average degree of PPI 3.800 Assortativity coefficient -0.2803 The network average Clustering coefficient 0.561 The number (and %) of a zero Clustering coefficients 4 (20.00 %) The number (and %) of a zero Betweenness Centrality 10 (50.00 %)

ACTIVE INTERACTORS

List of the fusions
PPI for parental proteins: EDARADD,OSMR	All fusions
Proteins found in more fusions	EGFR (see 2 fusions); RNF111 (see 1 fusions); TAB2 (see 1 fusions); TRAF6 (see 1 fusions); GAPDH (see 2 fusions); MAP3K7 (see 7 fusions); BAG3 (see 4 fusions);

List of active interactors

#	Name	Type	Number of PPI (degree)	Clustering Coefficient	Betweenness Centrality	Domains (Pfam, InterPro, SMART): description
1	EDARADD	parental protein	13	0.227	158.667	Death (PF00531, IPR000488, SM00005): Death domain SCO1-SenC (PF02630, IPR003782): SCO1/SenC
2	OSMR	parental protein	6	0.267	70.000	EpoR_lig-bind (PF09067, IPR015152): Erythropoietin receptor, ligand binding fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain Pur_ac_phosph_N (PF16656, IPR015914): Purple acid Phosphatase, N-terminal domain
3	BAG3	oncoprotein	2	0	0	BAG (PF02179, IPR003103, SM00264): BAG domain WW (PF00397, IPR001202, SM00456): WW domain
4	CUL5	suppressor	2	1.000	0	Cullin (PF00888, IPR001373, SM00182): Cullin family GlutR_dimer (PF00745, IPR015896): Glutamyl-tRNAGlu reductase, dimerisation domain Cullin_Nedd8 (PF10557, IPR019559, SM00884): Cullin protein neddylation domain
5	EDAR	interactor	1	0	0	Rifin_STEVOR (PF02009, IPR002858): Rifin/stevor family TNFR_c6 (PF00020, IPR001368, SM00208): TNFR/NGFR cysteine-rich region
6	EGFR	oncoprotein	5	0.333	157.000	Furin-like (PF00757, IPR006211): Furin-like cysteine rich region Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase Recep_L_domain (PF01030, IPR000494): Receptor L domain GAPT (PF11770, IPR021082): GRB2-binding adapter (GAPT) GF_recep_IV (PF14843, IPR032778): Growth factor receptor domain IV
7	ERBB2	oncoprotein	5	0.500	29.000	Furin-like (PF00757, IPR006211): Furin-like cysteine rich region Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase Recep_L_domain (PF01030, IPR000494): Receptor L domain GF_recep_IV (PF14843, IPR032778): Growth factor receptor domain IV
8	GAPDH	oncoprotein	3	1.000	0	Gp_dh_C (PF02800, IPR020829): Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain Gp_dh_N (PF00044, IPR020828, SM00846): Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain OstA (PF03968, IPR005653): OstA-like protein
9	IL6ST	oncoprotein	2	1.000	0	fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain IL6Ra-bind (PF09240, IPR015321): Interleukin-6 receptor alpha chain, binding Lep_receptor_Ig (PF06328, IPR010457): Ig-like C2-type domain Pur_ac_phosph_N (PF16656, IPR015914): Purple acid Phosphatase, N-terminal domain
10	MAP3K7	oncoprotein	5	1.000	0	Mnd1 (PF03962, IPR005647): Mnd1 family Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
11	RNF111	suppressor	4	1.000	0	zf-RING_2 (PF13639, IPR001841, SM00184): Ring finger domain Prok-RING_1 (PF14446): Prokaryotic RING finger family 1 RNF111_N (PF15303, IPR029306): E3 ubiquitin-protein ligase Arkadia N-terminus
12	SDCBP	interactor	2	1.000	0	PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF)
13	SHPRH	suppressor	1	0	0	SNF2_N (PF00176, IPR000330): SNF2 family N-terminal domain Helicase_C (PF00271, IPR001650, SM00490): Helicase conserved C-terminal domain GIT1_C (PF12205, IPR022018): G protein-coupled receptor kinase-interacting protein 1 C term TPR_7 (PF13176, IPR019734): Tetratricopeptide repeat zf-RING_UBOX (PF13445, IPR027370): RING-type zinc-finger
14	SUMO1	interactor	5	0.833	0.667	Rad60-SLD (PF11976, IPR022617): Ubiquitin-2 like Rad60 SUMO-like
15	SUMO1P1	interactor	5	0.667	12.000	NA
16	TAB2	oncoprotein	6	0.800	4.667	CUE (PF02845, IPR003892, SM00546): CUE domain DivIC (PF04977, IPR007060): Septum formation initiator Mnd1 (PF03962, IPR005647): Mnd1 family zf-RanBP (PF00641, IPR001876, SM00547): Zn-finger in Ran binding protein and others
17	TRAF2	interactor	7	0.467	170.333	MATH (PF00917, IPR002083, SM00061): MATH domain Sina (PF03145, IPR018121): Seven in absentia protein family SlyX (PF04102, IPR007236): SlyX zf-C3HC4 (PF00097, IPR018957): Zinc finger, C3HC4 type (RING finger) zf-TRAF (PF02176, IPR001293): TRAF-type zinc finger TRAF_BIRC3_bd (PF16673, IPR032070): TNF receptor-associated factor BIRC3 binding domain zf-C3HC4_5 (PF17121, IPR001841): Zinc finger, C3HC4 type (RING finger)
18	TRAF6	protein found in more fusions	7	0.600	15.667	SlyX (PF04102, IPR007236): SlyX zf-TRAF (PF02176, IPR001293): TRAF-type zinc finger zf-C3HC4_2 (PF13923): Zinc finger, C3HC4 type (RING finger)
19	UBE2I	interactor	7	0.533	6.000	UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme
20	WDYHV1	interactor	1	0	0	Nt_Gln_amidase (PF09764, IPR023128): N-terminal glutamine amidase

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