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Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: parental proteins EDARADD, OSMR (from a repository: Thu May 18 06:59:49 2017)
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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)20
The number (and %) of the onco-proteins8 (40.00 %)
The number (and %) of the tumor suppressors3 (15.00 %)
Total number of binary PPIs (saturation %)51 (26.84 %)
The number (and %) of affected PPIs19 (37.25 %)
The number of possible different fusions8
PPI diameter5
PPI radius3
The average degree of PPI3.800
Assortativity coefficient-0.2803
The network average Clustering coefficient0.561
The number (and %) of a zero Clustering coefficients4 (20.00 %)
The number (and %) of a zero Betweenness Centrality10 (50.00 %)

ACTIVE INTERACTORS


List of the fusions

PPI for parental proteins: EDARADD,OSMR All fusions
Proteins found in more fusions EGFR (see 2 fusions); RNF111 (see 1 fusions); TAB2 (see 1 fusions); TRAF6 (see 1 fusions); GAPDH (see 2 fusions); MAP3K7 (see 7 fusions); BAG3 (see 4 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 EDARADDparental protein130.227158.667Death (PF00531, IPR000488, SM00005): Death domain
SCO1-SenC (PF02630, IPR003782): SCO1/SenC
2 OSMRparental protein60.26770.000EpoR_lig-bind (PF09067, IPR015152): Erythropoietin receptor, ligand binding
fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain
Pur_ac_phosph_N (PF16656, IPR015914): Purple acid Phosphatase, N-terminal domain
3 BAG3oncoprotein200BAG (PF02179, IPR003103, SM00264): BAG domain
WW (PF00397, IPR001202, SM00456): WW domain
4 CUL5suppressor21.0000Cullin (PF00888, IPR001373, SM00182): Cullin family
GlutR_dimer (PF00745, IPR015896): Glutamyl-tRNAGlu reductase, dimerisation domain
Cullin_Nedd8 (PF10557, IPR019559, SM00884): Cullin protein neddylation domain
5 EDARinteractor100Rifin_STEVOR (PF02009, IPR002858): Rifin/stevor family
TNFR_c6 (PF00020, IPR001368, SM00208): TNFR/NGFR cysteine-rich region
6 EGFRoncoprotein50.333157.000Furin-like (PF00757, IPR006211): Furin-like cysteine rich region
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
Recep_L_domain (PF01030, IPR000494): Receptor L domain
GAPT (PF11770, IPR021082): GRB2-binding adapter (GAPT)
GF_recep_IV (PF14843, IPR032778): Growth factor receptor domain IV
7 ERBB2oncoprotein50.50029.000Furin-like (PF00757, IPR006211): Furin-like cysteine rich region
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
Recep_L_domain (PF01030, IPR000494): Receptor L domain
GF_recep_IV (PF14843, IPR032778): Growth factor receptor domain IV
8 GAPDHoncoprotein31.0000Gp_dh_C (PF02800, IPR020829): Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain
Gp_dh_N (PF00044, IPR020828, SM00846): Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain
OstA (PF03968, IPR005653): OstA-like protein
9 IL6SToncoprotein21.0000fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain
IL6Ra-bind (PF09240, IPR015321): Interleukin-6 receptor alpha chain, binding
Lep_receptor_Ig (PF06328, IPR010457): Ig-like C2-type domain
Pur_ac_phosph_N (PF16656, IPR015914): Purple acid Phosphatase, N-terminal domain
10 MAP3K7oncoprotein51.0000Mnd1 (PF03962, IPR005647): Mnd1 family
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
11 RNF111suppressor41.0000zf-RING_2 (PF13639, IPR001841, SM00184): Ring finger domain
Prok-RING_1 (PF14446): Prokaryotic RING finger family 1
RNF111_N (PF15303, IPR029306): E3 ubiquitin-protein ligase Arkadia N-terminus
12 SDCBPinteractor21.0000PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF)
13 SHPRHsuppressor100SNF2_N (PF00176, IPR000330): SNF2 family N-terminal domain
Helicase_C (PF00271, IPR001650, SM00490): Helicase conserved C-terminal domain
GIT1_C (PF12205, IPR022018): G protein-coupled receptor kinase-interacting protein 1 C term
TPR_7 (PF13176, IPR019734): Tetratricopeptide repeat
zf-RING_UBOX (PF13445, IPR027370): RING-type zinc-finger
14 SUMO1interactor50.8330.667Rad60-SLD (PF11976, IPR022617): Ubiquitin-2 like Rad60 SUMO-like
15 SUMO1P1interactor50.66712.000NA
16 TAB2oncoprotein60.8004.667CUE (PF02845, IPR003892, SM00546): CUE domain
DivIC (PF04977, IPR007060): Septum formation initiator
Mnd1 (PF03962, IPR005647): Mnd1 family
zf-RanBP (PF00641, IPR001876, SM00547): Zn-finger in Ran binding protein and others
17 TRAF2interactor70.467170.333MATH (PF00917, IPR002083, SM00061): MATH domain
Sina (PF03145, IPR018121): Seven in absentia protein family
SlyX (PF04102, IPR007236): SlyX
zf-C3HC4 (PF00097, IPR018957): Zinc finger, C3HC4 type (RING finger)
zf-TRAF (PF02176, IPR001293): TRAF-type zinc finger
TRAF_BIRC3_bd (PF16673, IPR032070): TNF receptor-associated factor BIRC3 binding domain
zf-C3HC4_5 (PF17121, IPR001841): Zinc finger, C3HC4 type (RING finger)
18 TRAF6protein found in more fusions70.60015.667SlyX (PF04102, IPR007236): SlyX
zf-TRAF (PF02176, IPR001293): TRAF-type zinc finger
zf-C3HC4_2 (PF13923): Zinc finger, C3HC4 type (RING finger)
19 UBE2Iinteractor70.5336.000UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme
20 WDYHV1interactor100Nt_Gln_amidase (PF09764, IPR023128): N-terminal glutamine amidase

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