Find Fusion Network

Enter
Fusion ID:
Protein names:


Level of PPIs:
or Upload text file:
Update repository
Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: parental proteins MAPK10, COL1A2 (from a repository: Wed Feb 22 08:42:36 2017)
Examples

Cytoscape Web will replace the contents your graph
PPI Properties:

Click on nodes
or edges

Layout Tree
Circle
Radial
Force Directed
Preset
Export graph
PDF file
SVG file
SIF file
XML file
GraphML file

Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)61
The number (and %) of the onco-proteins17 (27.87 %)
The number (and %) of the tumor suppressors11 (18.03 %)
Total number of binary PPIs (saturation %)187 (10.22 %)
The number (and %) of affected PPIs60 (32.09 %)
The number of possible different fusions13
PPI diameter5
PPI radius3
The average degree of PPI5.180
Assortativity coefficient-0.1770
The network average Clustering coefficient0.434
The number (and %) of a zero Clustering coefficients15 (24.59 %)
The number (and %) of a zero Betweenness Centrality21 (34.43 %)

ACTIVE INTERACTORS


List of the fusions

PPI for parental proteins: MAPK10,COL1A2 All fusions
Proteins found in more fusions IMPDH2 (see 2 fusions); CREBBP (see 6 fusions); UBQLN1 (see 2 fusions); APP (see 4 fusions); MCL1 (see 2 fusions); COL1A1/PDGFB (see 19 fusions); COL1A2/COL1A1 (see 1 fusions); DDX5 (see 1 fusions); COL1A1 (see 11 fusions); EZR (see 2 fusions); MAPK9 (see 3 fusions); TP53 (see 3 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 MAPK10parental protein430.0851920.191Pkinase (PF00069, IPR000719): Protein kinase domain
2 COL1A2parental protein170.037904.553COLFI (PF01410, IPR000885, SM00038): Fibrillar collagen C-terminal domain
Collagen (PF01391, IPR008160): Collagen triple helix repeat (20 copies)
DUF1860 (PF08949, IPR015044): Domain of unknown function (DUF1860)
3 APPprotein found in more fusions120.164235.212APP_N (PF02177, IPR015849, SM00006): Amyloid A4 N-terminal heparin-binding
Beta-APP (PF03494, IPR013803): Beta-amyloid peptide (beta-APP)
BUD22 (PF09073, IPR015158): BUD22
IncA (PF04156, IPR007285): IncA protein
Kunitz_BPTI (PF00014, IPR002223, SM00131): Kunitz/Bovine pancreatic trypsin inhibitor domain
APP_amyloid (PF10515, IPR019543): beta-amyloid precursor protein C-terminus
APP_Cu_bd (PF12924, IPR011178): Copper-binding of amyloid precursor, CuBD
APP_E2 (PF12925, IPR024329): E2 domain of amyloid precursor protein
4 ARRB1interactor60.6677.302Arrestin_C (PF02752, IPR011022, SM01017): Arrestin (or S-antigen), C-terminal domain
Arrestin_N (PF00339, IPR011021): Arrestin (or S-antigen), N-terminal domain
5 ARRB2interactor50.7002.786Arrestin_C (PF02752, IPR011022, SM01017): Arrestin (or S-antigen), C-terminal domain
Arrestin_N (PF00339, IPR011021): Arrestin (or S-antigen), N-terminal domain
6 ATF2oncoprotein80.42914.051bZIP_1 (PF00170, IPR004827): bZIP transcription factor
zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type
7 CAMKMTinteractor40.167121.398Methyltransf_16 (PF10294, IPR019410): Lysine methyltransferase
8 CCT2interactor80.393113.474Cpn60_TCP1 (PF00118, IPR002423): TCP-1/cpn60 chaperonin family
9 CCT6Binteractor40.6673.690Cpn60_TCP1 (PF00118, IPR002423): TCP-1/cpn60 chaperonin family
10 CCT7interactor70.52438.302Cpn60_TCP1 (PF00118, IPR002423): TCP-1/cpn60 chaperonin family
11 CDKN1Bsuppressor100CDI (PF02234, IPR003175): Cyclin-dependent kinase inhibitor
Multi-haem_cyto (PF13447): Seven times multi-haem cytochrome CxxCH
12 CDKN2Asuppressor50.60082.937Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies)
Ank_5 (PF13857): Ankyrin repeats (many copies)
13 CDKN2AIPinteractor2028.239XTBD (PF11952, IPR021859): XRN-Two Binding Domain, XTBD
14 CDKN2Csuppressor30.6671.400Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies)
Ank_5 (PF13857): Ankyrin repeats (many copies)
15 CEP290interactor21.0000ATG16 (PF08614, IPR013923): Autophagy protein 16 (ATG16)
DivIC (PF04977, IPR007060): Septum formation initiator
DUF16 (PF01519, IPR002862): Protein of unknown function DUF16
DUF641 (PF04859, IPR006943): Plant protein of unknown function (DUF641)
Fez1 (PF06818): Fez1
HALZ (PF02183, IPR003106, SM00340): Homeobox associated leucine zipper
HemY_N (PF07219, IPR010817): HemY protein N-terminus
Cnn_1N (PF07989, IPR012943): Centrosomin N-terminal motif 1
Mnd1 (PF03962, IPR005647): Mnd1 family
NPV_P10 (PF05531, IPR008702): Nucleopolyhedrovirus P10 protein
OmpH (PF03938, IPR005632, SM00935): Outer membrane protein (OmpH-like)
Pox_A_type_inc (PF04508, IPR007596): Viral A-type inclusion protein repeat
Reo_sigmaC (PF04582, IPR007662): Reovirus sigma C capsid protein
Rho_Binding (PF08912, IPR015008): Rho Binding
Sec20 (PF03908, IPR005606): Sec20
Sec2p (PF06428, IPR009449): GDP/GTP exchange factor Sec2p
Spc7 (PF08317, IPR013253, SM00787): Spc7 kinetochore protein
Swi5 (PF07061, IPR010760): Swi5
TBPIP (PF07106, IPR010776): Tat binding protein 1(TBP-1)-interacting protein (TBPIP)
TSC22 (PF01166, IPR000580): TSC-22/dip/bun family
Uso1_p115_C (PF04871, IPR006955): Uso1 / p115 like vesicle tethering protein, C terminal region
CENP-F_leu_zip (PF10473, IPR019513): Leucine-rich repeats of kinetochore protein Cenp-F/LEK1
LIDHydrolase (PF10230, IPR019363): Lipid-droplet associated hydrolase
KxDL (PF10241, IPR019371): Uncharacterized conserved protein
bZIP_2 (PF07716, IPR004827, SM00338): Basic region leucine zipper
ADIP (PF11559, IPR021622): Afadin- and alpha -actinin-Binding
PRKG1_interact (PF15898, IPR031775): cGMP-dependent protein kinase interacting domain
FAM76 (PF16046, IPR032017): FAM76 protein
TolA_bind_tri (PF16331, IPR032519): TolA binding protein trimerisation
CEP209_CC5 (PF16574, IPR032321): Coiled-coil region of centrosome protein CE290
16 COL1A1oncoprotein60.40021.732COLFI (PF01410, IPR000885, SM00038): Fibrillar collagen C-terminal domain
Collagen (PF01391, IPR008160): Collagen triple helix repeat (20 copies)
VWC (PF00093, IPR001007, SM00214): von Willebrand factor type C domain
EKLF_TAD1 (PF16832, IPR031786): Erythroid krueppel-like transcription factor, transactivation 1
17 COMTinteractor100Methyltransf_3 (PF01596, IPR002935): O-methyltransferase
18 CREBBPsuppressor100.44451.262Creb_binding (PF09030, IPR014744): Creb binding
DUF902 (PF06001, IPR010303): Domain of Unknown Function (DUF902)
Forkhead_N (PF08430, IPR013638): Forkhead N-terminal region
KIX (PF02172, IPR003101): KIX domain
MAS20 (PF02064, IPR002056): MAS20 protein import receptor
TPX2 (PF06886, IPR027329): Targeting protein for Xklp2 (TPX2)
zf-TAZ (PF02135, IPR000197, SM00551): TAZ zinc finger
ANAPC_CDC26 (PF10471, IPR018860): Anaphase-promoting complex APC subunit CDC26
HAT_KAT11 (PF08214, IPR013178): Histone acetylation protein
Bromodomain (PF00439, IPR001487, SM00297): Bromodomain
ZZ (PF00569, IPR000433, SM00291): Zinc finger, ZZ type
DUF3729 (PF12526, IPR022202): Protein of unknown function (DUF3729)
DUF4834 (PF16118, IPR032272): Domain of unknown function (DUF4834)
19 DDX5oncoprotein70.53336.094DEAD (PF00270, IPR011545): DEAD/DEAH box helicase
P68HR (PF08061, IPR012587): P68HR (NUC004) repeat
ResIII (PF04851, IPR006935): Type III restriction enzyme, res subunit
Helicase_C (PF00271, IPR001650, SM00490): Helicase conserved C-terminal domain
20 DUSP1suppressor21.0000DSPc (PF00782, IPR020422, SM00195): Dual specificity phosphatase, catalytic domain
Rhodanese (PF00581, IPR001763, SM00450): Rhodanese-like domain
21 DUSP10oncoprotein21.0000DSPc (PF00782, IPR020422, SM00195): Dual specificity phosphatase, catalytic domain
Rhodanese (PF00581, IPR001763, SM00450): Rhodanese-like domain
22 DUSP16interactor40.50031.396DSPc (PF00782, IPR020422, SM00195): Dual specificity phosphatase, catalytic domain
Rhodanese (PF00581, IPR001763, SM00450): Rhodanese-like domain
23 ELK1oncoprotein60.6002.627Ets (PF00178, IPR000418, SM00413): Ets-domain
Ribosomal_L12_N (PF16320, IPR008932): Ribosomal protein L7/L12 dimerisation domain
24 ERAL1interactor21.0000GTP_EFTU (PF00009, IPR000795): Elongation factor Tu GTP binding domain
MMR_HSR1 (PF01926, IPR006073): 50S ribosome-binding GTPase
KH_1 (PF00013, IPR004088, SM00322): KH domain
25 EZRprotein found in more fusions40.6671.000DUF106 (PF01956, IPR002809): Integral membrane protein DUF106
ERM (PF00769, IPR011259): Ezrin/radixin/moesin family
FERM_C (PF09380, IPR018980): FERM C-terminal PH-like domain
FERM_M (PF00373, IPR019748): FERM central domain
FERM_N (PF09379, IPR018979): FERM N-terminal domain
26 FBXW7suppressor50109.621Mem_trans (PF03547, IPR004776): Membrane transport protein
WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
Nup160 (PF11715, IPR021717): Nucleoporin Nup120/160
F-box-like (PF12937, IPR001810): F-box-like
27 GCH1interactor31.0000GTP_cyclohydroI (PF01227, IPR020602): GTP cyclohydrolase I
28 GTF3C1interactor100B-block_TFIIIC (PF04182, IPR007309): B-block binding subunit of TFIIIC
29 HAX1interactor2040.204Mlf1IP (PF10248, IPR019376): Myelodysplasia-myeloid leukemia factor 1-interacting protein
30 HDAC1suppressor140.39781.640FSAP_sig_propep (PF03032, IPR004275): Frog skin active peptide family signal and propeptide
Hist_deacetyl (PF00850, IPR023801): Histone deacetylase domain
31 HDAC9interactor60.9000.487Hist_deacetyl (PF00850, IPR023801): Histone deacetylase domain
SAE2 (PF08573, IPR013882): DNA repair protein endonuclease SAE2/CtIP C-terminus
HDAC4_Gln (PF12203, IPR024643): Glutamine rich N terminal domain of histone deacetylase 4
CEP19 (PF14933, IPR029412): CEP19-like protein
32 IMPDH2protein found in more fusions200IMPDH (PF00478, IPR001093): IMP dehydrogenase / GMP reductase domain
33 JUNoncoprotein120.40086.025bZIP_1 (PF00170, IPR004827): bZIP transcription factor
Jun (PF03957, IPR005643): Jun-like transcription factor
34 KIF26Ainteractor21.0000CAP_N (PF01213, IPR013992): Adenylate cyclase associated (CAP) N terminal
Totivirus_coat (PF05518, IPR008871): Totivirus coat protein
Kinesin (PF00225, IPR001752, SM00129): Kinesin motor domain
35 LDHAinteractor70.200109.785Ldh_1_C (PF02866, IPR022383): lactate/malate dehydrogenase, alpha/beta C-terminal domain
Ldh_1_N (PF00056, IPR001236): lactate/malate dehydrogenase, NAD binding domain
36 LIG4interactor50.100112.302APG17 (PF04108, IPR007240): Autophagy protein Apg17
BRCT (PF00533, IPR001357, SM00292): BRCA1 C Terminus (BRCT) domain
DNA_ligase_A_C (PF04679, IPR012309): ATP dependent DNA ligase C terminal region
DNA_ligase_A_M (PF01068, IPR012310): ATP dependent DNA ligase domain
DNA_ligase_A_N (PF04675, IPR012308): DNA ligase N terminus
DNA_ligase_IV (PF11411, IPR021536): DNA ligase IV
RTT107_BRCT_5 (PF16770, IPR001357): Regulator of Ty1 transposition protein 107 BRCT domain
37 MAP2K4suppressor90.50023.984Pkinase (PF00069, IPR000719): Protein kinase domain
38 MAPK8IP2interactor70.46713.414BUD22 (PF09073, IPR015158): BUD22
CENP-B_dimeris (PF09026, IPR015115): Centromere protein B dimerisation domain
PID (PF00640, IPR006020, SM00462): Phosphotyrosine interaction domain (PTB/PID)
Spt5_N (PF11942, IPR022581): Spt5 transcription elongation factor, acidic N-terminal
SH3_9 (PF14604, IPR001452): Variant SH3 domain
39 MAPK8IP3interactor40.8330.500Trypan_PARP (PF05887, IPR008882): Procyclic acidic repetitive protein (PARP)
Jnk-SapK_ap_N (PF09744, IPR019143): JNK_SAPK-associated protein-1
Rootletin (PF15035): Ciliary rootlet component, centrosome cohesion
UPF0449 (PF15136, IPR028227): Uncharacterised protein family UPF0449
JIP_LZII (PF16471, IPR032486): JNK-interacting protein leucine zipper II
40 MAPK9suppressor190.209259.622Pkinase (PF00069, IPR000719): Protein kinase domain
Kinase-like (PF14531, IPR027916): Kinase-like
41 MCL1oncoprotein40.33326.439Bcl-2 (PF00452, IPR026298): Apoptosis regulator proteins, Bcl-2 family
42 MSNoncoprotein31.0000DUF883 (PF05957, IPR010279): Bacterial protein of unknown function (DUF883)
ERM (PF00769, IPR011259): Ezrin/radixin/moesin family
FERM_C (PF09380, IPR018980): FERM C-terminal PH-like domain
FERM_M (PF00373, IPR019748): FERM central domain
FERM_N (PF09379, IPR018979): FERM N-terminal domain
43 MYOCinteractor200IncA (PF04156, IPR007285): IncA protein
OLF (PF02191, IPR003112, SM00284): Olfactomedin-like domain
44 PAN2interactor40.50078.206RNase_T (PF00929, IPR013520): Exonuclease
UCH_1 (PF13423, IPR001394): Ubiquitin carboxyl-terminal hydrolase
WD40_like (PF17005, IPR031544): WD40-like domain
45 PDGFAoncoprotein21.0000PDGF (PF00341, IPR000072, SM00141): PDGF/VEGF domain
PDGF_N (PF04692, IPR006782): Platelet-derived growth factor, N terminal region
SyrA (PF11089, IPR024239): Exopolysaccharide production repressor
46 PDGFBoncoprotein31.0000PDGF (PF00341, IPR000072, SM00141): PDGF/VEGF domain
PDGF_N (PF04692, IPR006782): Platelet-derived growth factor, N terminal region
47 PKMYT1interactor100Pkinase (PF00069, IPR000719): Protein kinase domain
48 PLIN2interactor100Perilipin (PF03036, IPR004279): Perilipin family
49 RAB5Aoncoprotein3065.910Ras (PF00071, IPR001806, SM00173): Ras family
50 RDXinteractor21.0000ERM (PF00769, IPR011259): Ezrin/radixin/moesin family
FERM_C (PF09380, IPR018980): FERM C-terminal PH-like domain
FERM_M (PF00373, IPR019748): FERM central domain
FERM_N (PF09379, IPR018979): FERM N-terminal domain
51 RELAoncoprotein80.57147.236DEC-1_N (PF04625, IPR006719): DEC-1 protein, N-terminal region
RHD_DNA_bind (PF00554, IPR011539): Rel homology DNA-binding domain
RHD_dimer (PF16179, IPR032397): Rel homology dimerisation domain
52 SERPINB5suppressor30.333161.412Serpin (PF00079, IPR023796, SM00093): Serpin (serine protease inhibitor)
53 SGTAinteractor100TOM20_plant (PF06552, IPR010547): Plant specific mitochondrial import receptor subunit TOM20
TPR_1 (PF00515, IPR001440): Tetratricopeptide repeat
XPC-binding (PF09280, IPR015360): XPC-binding domain
TPR_17 (PF13431): Tetratricopeptide repeat
SGTA_dimer (PF16546, IPR032374): Homodimerisation domain of SGTA
54 SH3BP5interactor30.6670.762SH3BP5 (PF05276, IPR007940): SH3 domain-binding protein 5 (SH3BP5)
55 SHBGoncoprotein200Laminin_G_1 (PF00054, IPR001791): Laminin G domain
Laminin_G_2 (PF02210, IPR001791): Laminin G domain
56 TNIP1interactor200ATG16 (PF08614, IPR013923): Autophagy protein 16 (ATG16)
DUF724 (PF05266, IPR007930): Protein of unknown function (DUF724)
Filament (PF00038, IPR001664): Intermediate filament protein
HALZ (PF02183, IPR003106, SM00340): Homeobox associated leucine zipper
TPR_MLP1_2 (PF07926, IPR012929): TPR/MLP1/MLP2-like protein
DUF4201 (PF13870, IPR025254): Domain of unknown function (DUF4201)
FlxA (PF14282, IPR025577): FlxA-like protein
CC2-LZ (PF16516, IPR032419): Leucine zipper of domain CC2 of NEMO, NF-kappa-B essential modulator
57 TP53suppressor150.297155.034DEC-1_N (PF04625, IPR006719): DEC-1 protein, N-terminal region
P53 (PF00870, IPR011615): P53 DNA-binding domain
P53_tetramer (PF07710, IPR010991): P53 tetramerisation motif
58 UBQLN1protein found in more fusions4056.827Clathrin-link (PF09268, IPR015348): Clathrin, heavy-chain linker
UBA (PF00627, IPR000449, SM00165): UBA/TS-N domain
XPC-binding (PF09280, IPR015360): XPC-binding domain
ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
Fur_reg_FbpB (PF13040, IPR025004): Fur-regulated basic protein B
FAM199X (PF15814, IPR029672): Protein family FAM199X
59 UNC119interactor40.33337.434GMP_PDE_delta (PF05351, IPR008015): GMP-PDE, delta subunit
60 WDR62interactor31.0000eIF2A (PF08662, IPR013979): Eukaryotic translation initiation factor eIF2A
WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
61 ZWINTinteractor60.200101.512Zwint (PF15556, IPR029092): ZW10 interactor

B a c k    t o    T o p ⇑